Not logged inA phase 1b multicenter study of anti-TIM3 (S095018/Sym023) in combination with anti-PD1 (Sym021) in patients with advanced/metastatic recurrent biliary tract cancer
Ghiringhelli, Francois; Kim, Richard; Macarulla, Teresa; Moreno, Irene; Razak, Albiruni; Rodon, Jordi; Liao, Chih-Yi; Marron, Thomas; Raimbourg, Judith; Kaplon, Helene; Geromini, Julia; Harouki, Najah; Rodrigues, Christelle; Darcel, Pauline; Skartved, Niels Jorgen; Hald, Rikke; Lopez-Ravnborg, Daleen; He, Peng; Ianopoulos, Xenophon; Askoxylakis, Vasileios; Lakhani, Nehal J.; Davis, Sarah; Mahipal, Amit .png)
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SaveMolecular and early clinical characterization of the anti-CD73 antibody S095024 (Sym024)Spreafico, Anna; Ahnert, Jordi R.; Sommerhalder, David; Almena-Carrasco, Maria; Crochemore, Najah Harouki; Ianopulos, Xenophon; Jakobsen, Janus S.; Armbruster, Emily; Delmas, Audrey; Georges, Amedee des; Frohlich, Camilla; Geronimi, Julia; Grandal, Michael M.; Hansen, Randi W.; Lantto, Johan; Legrand, Julie; Levasseur, Franck; Riva, Matteo; Rodrigues, Christelle; Seif, Vanessa; Askoxylakis, Vasileios; Lakhani, Nehal Share Save A phase 2, multicenter, open-label study of anti-LAG-3 ieramilimab in combination with anti-PD-1 spartalizumab in patients with advanced solid malignanciesLin, Chia-Chi; Garralda, Elena; Schoeffski, Patrick; Hong, David S.; Siu, Lillian L.; Martin, Miguel; Maur, Michela; Hui, Rina; Soo, Ross A.; Chiu, Joanne; Zhang, Tian; Ma, Brigette; Kyi, Chrisann; Tan, Daniel S. W.; Cassier, Philippe A.; Sarantopoulos, John; Weickhardt, Andrew; Carvajal, Richard D.; Spratlin, Jennifer; Esaki, Taito; Rolland, Frederic; Akerley, Wallace; Deschler-Baier, Barbara; Rispoli, Lawrence; Samant, Tanay S.; Chowdhury, Niladri Roy; Gusenleitner, Daniel; Kwak, Eunice L.; Askoxylakis, Vasileios; De Braud, Filippo Share Save A FIRST IN-HUMAN, MULTICENTER, OPEN-LABEL, DOSE-FINDING PHASE 1 STUDY OF THE IMMUNE STIMULATOR ANTIBODY CONJUGATE NJH395 IN PATIENTS WITH NONBREAST HER2+ADVANCED MALIGNANCIESJanku, Filip; Han, Sae-Won; Doi, Toshihiko; Ajani, Jaffer; Kuboki, Yasutoshi; Mahling, Ping; Subramanian, Kulandayan; Pelletier, Marc; Askoxylakis, Vasileios; Siena, Salvatore Share Save Targeting EphA2 in Bladder Cancer Using a Novel Antibody-Directed NanotherapeuticKamoun, Walid; Swindell, Elden; Pien, Christine; Luus, Lia; Cain, Jason; Pham, Minh; Kandela, Irawati; Huang, Zhaohua Richard; Tipparaju, Suresh K.; Koshkaryev, Alexander; Askoxylakis, Vasileios; Kirpotin, Dmitri B.; Bloom, Troy; Mino-Kenudson, Mari; Marks, James D.; Zalutskaya, Alena; Bshara, Wiam; Morrison, Carl; Drummond, Daryl C. Share Save Synergy between EphA2-ILs-DTXp, a Novel EphA2-Targeted Nanoliposomal Taxane, and PD-1 Inhibitors in Preclinical Tumor ModelsKamoun, Walid S.; Dugast, Anne-Sophie; Suchy, James J.; Grabow, Stephanie; Fulton, Ross B.; Sampson, James F.; Luus, Lia; Santiago, Michael; Koshkaryev, Alexander; Sun, Gang; Askoxylakis, Vasileios; Tam, Eric; Huang, Zhaohua Richard; Drummond, Daryl C.; Sawyer, Andrew J. Share Save Dual targeting of IGF-1R and ErbB3 as a potential therapeutic regimen for ovarian cancerCamblin, Adam J.; Tan, Gege; Curley, Michael D.; Yannatos, Isabel; Iadevaia, Sergio; Rimkunas, Victoria; Mino-Kenudson, Mari; Bloom, Troy; Schoeberl, Birgit; Drummond, Daryl C.; Lugovskoy, Alexey A.; Louis, Chrystal U.; Askoxylakis, Vasileios Share Save Antitumour activity and tolerability of an EphA2-targeted nanotherapeutic in multiple mouse modelsKamoun, Walid S.; Kirpotin, Dmitri B.; Huang, Zhaohua Richard; Tipparaju, Suresh K.; Noble, Charles O.; Hayes, Mark E.; Luus, Lia; Koshkaryev, Alexander; Kim, Jaeyeon; Olivier, Ken; Kornaga, Tad; Oyama, Shinji; Askoxylakis, Vasileios; Pien, Christine; Kuesters, Geoffrey; Dumont, Nancy; Lugovskoy, Alexey A.; Schihl, Sarah A.; Wilton, John H.; Geddie, Melissa L.; Suchy, James; Grabow, Stephanie; Kohli, Neeraj; Reynolds, C. Patrick; Blaydes, Rachel; Zhou, Yu; Sawyer, Andrew J.; Marks, James D.; Drummond, Daryl C. Share Save Dual endothelin receptor inhibition enhances T-DM1 efficacy in brain metastases from HER2-positive breast cancerAskoxylakis, Vasileios; Ferraro, Gino B.; Badeaux, Mark; Kodack, David P.; Kirst, Isabelle; Shankaraiah, Ram C.; Wong, Christina S. F.; Duda, Dan G.; Fukumura, Dai; Jain, Rakesh K. Share Save Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithiumSeano, Giorgio; Nia, Hadi T.; Emblem, Kyrre E.; Datta, Meenal; Ren, Jun; Krishnan, Shanmugarajan; Kloepper, Jonas; Pinho, Marco C.; Ho, William W.; Ghosh, Mitrajit; Askoxylakis, Vasileios; Ferraro, Gino B.; Riedemann, Lars; Gerstner, Elizabeth R.; Batchelor, Tracy T.; Wen, Patrick Y.; Ling, Nancy U.; Grodzinsky, Alan J.; Fukumura, Dai; Huang, Peigen; Baish, James W.; Padera, Timothy P.; Munn, Lance L.; Jain, Rakesh K. Share Save Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruptionArvanitis, Costas D.; Askoxylakis, Vasileios; Guo, Yutong; Detta, Meenal; Kloepper, Jonas; Ferraro, Gino B.; Bernabeu, Miguel O.; Fukumura, Dai; McDannold, Nathan; Jain, Rakesh K. Share Save Targeting EphA2 in bladder cancer using a novel antibody-directed nanotherapeuticKamoun, Walid; Swindell, Elden; Pien, Christine; Luus, Lia; Cain, Jason; Kandela, Irawati; Huang, Richard; Tipparaju, Suresh; Kirpotin, Dmitri; Bshara, Wiam; Askoxylakis, Vasileios; Morrison, Carl; Drummond, Daryl Share Save Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine greenCarr, Jessica A.; Franke, Daniel; Caram, Justin R.; Perkinson, Collin F.; Saif, Mari; Askoxylakis, Vasileios; Datta, Meenal; Fukumura, Dai; Jain, Rakesh K.; Bawendi, Moungi G.; Bruns, Oliver T. Share Save A cerebellar window for intravital imaging of normal and disease states in miceAskoxylakis, Vasileios; Badeaux, Mark; Roberge, Sylvie; Batista, Ana; Kirkpatrick, Ned; Snuderl, Matija; Amoozgar, Zohreh; Seano, Giorgio; Ferraro, Gino B.; Chatterjee, Sampurna; Xu, Lei; Fukumura, Dai; Duda, Dan G.; Jain, Rakesh K. Share Save Share Save Solid stress and elastic energy as measures of tumor mechanopathologyNia, Hadi; Liu, Hao; Seano, Giorgio; Datta, Meenal; Jones, Dennis; Rahbari, Nuh; Incio, Joao; Chauhan, Vikash; Jung, Keehoon; Martin, John; Askoxylakis, Vasileios; Padera, Tim; Fukumura, Dai; Boucher, Yves; Hornicek, Francis; Grodzinsky, Alan; Baish, James; Munn, Lance; Jain, Rakesh Share Save Dual-targeting of IGF-1R and ErbB3 pathways in Ewing's Sarcoma cellular models with istiratumab (MM-141), a bispecific, tetravalent monoclonal antibodyYannatos, Isabel; Camblin, Adam; Li, Zhenhua; Curley, Michael; Tan, Gege; Louis, Chrystal U.; Askoxylakis, Vasileios; Finn, Greg; Schoeberl, Birgit; Nering, Rachel Share Save Mechanisms of synergy of carboplatin and an EphA2-targeted docetaxel antibody-directed nanotherapeuticKamoun, Walid S.; Sawyer, Andrew J.; Pien, Christine; Koshkaryev, Alexander; Luus, Lia; Merrigan, Samantha; Sun, Gang; Kozin, Sergey; Huang, Zhaohua Richard; Tipparaju, Suresh K.; Kirpotin, Dmitri B.; Xu, Hannah; Askoxylakis, Vasileios; Reynolds, Patrick C.; Drummond, Daryl C. Share Save The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activationFerraro, Gino B.; Kodack, David P.; Askoxylakis, Vasileios; Sheng, Qing; Badeaux, Mark; Goel, Shom; Qi, Xiaolong; Shankaraiah, Ram; Cao, Alexander Z.; Ramjiawan, Rakesh R.; Bezwada, Divya; Patel, Bhushankumar; Song, Youngchul; Costa, Carlotta; Naxerova, Kamila; Wong, Christina; Kloepper, Jonas; Das, Rita; Tam, Angela; Tanboon, Jantima; Duda, Dan G.; Miller, Ryan C.; Siegel, Marni B.; Anders, Carey K.; Sanders, Melinda; Estrada, Valeria M.; Schlegel, Robert; Arteaga, Carlos L.; Brachtel, Elena; Huang, Alan; Fukumura, Dai; Engelman, Jeffrey A.; Jain, Rakesh K. Share Save Share Save 
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