Not logged inTherapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results
Crespo-Garcia, Sergio; Fournier, Frederik; Diaz-Marin, Roberto; Klier, Sharon; Ragusa, Derek; Masaki, Lauren; Cagnone, Gael; Blot, Guillaume; Hafiane, Ikhlas; Dejda, Agnieszka; Rizk, Rana; Juneau, Rachel; Buscarlet, Manuel; Chorfi, Sarah; Patel, Priyanka; Beltran, Pedro J.; Joyal, Jean-Sebastien; Rezende, Flavio A.; Hata, Masayuki; Nguyen, Alex; Sullivan, Lynne; Damiano, Jason; Wilson, Ariel M.; Mallette, Frederick A.; David, Nathaniel E.; Ghosh, Anirvan; Tsuruda, Pamela R.; Dananberg, Jamie; Sapieha, Przemyslaw .png)
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SaveHIF1α-dependent hypoxia response in myeloid cells requires IRE1αMawambo, Gaelle; Oubaha, Malika; Ichiyama, Yusuke; Blot, Guillaume; Crespo-Garcia, Sergio; Dejda, Agnieszka; Binet, Francois; Diaz-Marin, Roberto; Sawchyn, Christina; Sergeev, Mikhail; Juneau, Rachel; Kaufman, Randal J.; Affar, El Bachir; Mallette, Frederick A.; Wilson, Ariel M.; Sapieha, Przemyslaw Share Save Share Save Myeloid-resident neuropilin-1 promotes choroidal neovascularization while mitigating inflammationAndriessen, Elisabeth M. M. A.; Binet, Francois; Fournier, Frederik; Hata, Masayuki; Dejda, Agnieszka; Mawambo, Gaelle; Crespo-Garcia, Sergio; Pilon, Frederique; Buscarlet, Manuel; Beauchemin, Karine; Bougie, Veronique; Cumberlidge, Garth; Wilson, Ariel M.; Bourgault, Steve; Rezende, Flavio A.; Beaulieu, Normand; Delisle, Jean-Sebastien; Sapieha, Przemyslaw Share Save Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibitionCrespo-Garcia, Sergio; Tsuruda, Pamela R.; Dejda, Agnieszka; Ryan, Rathi D.; Fournier, Frederik; Chaney, Shawnta Y.; Pilon, Frederique; Dogan, Taner; Cagnone, Gael; Patel, Priyanka; Buscarlet, Manuel; Dasgupta, Sonali; Girouard, Gabrielle; Rao, Surabhi R.; Wilson, Ariel M.; O'Brien, Robert; Juneau, Rachel; Guber, Vera; Dubrac, Alexandre; Beausejour, Christian; Armstrong, Scott; Mallette, Frederick A.; Yohn, Christopher B.; Joyal, Jean-Sebastien; Marquess, Dan; Beltran, Pedro J.; Sapieha, Przemyslaw Share Save Share Save NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathyMiloudi, Khalil; Oubaha, Malika; Menard, Catherine; Dejda, Agnieszka; Guber, Vera; Cagnone, Gael; Wilson, Ariel M.; Tetreault, Nicolas; Mawambo, Gaelle; Binet, Francois; Chidiac, Rony; Delisle, Chantal; Buscarlet, Manuel; Cerani, Agustin; Crespo-Garcia, Sergio; Bentley, Katie; Rezende, Flavio; Joyal, Jean-Sebastien; Mallette, Frederick A.; Gratton, Jean-Philippe; Larrivee, Bruno; Sapieha, Przemyslaw Share Save Share Save Neuropilin-1 expression in adipose tissue macrophages protects against obesity and metabolic syndromeWilson, Ariel Molly; Shao, Zhuo; Grenier, Vanessa; Mawambo, Gaelle; Daudelin, Jean-Francois; Dejda, Agnieszka; Pilon, Frederique; Popovic, Natalija; Boulet, Salix; Parinot, Celia; Oubaha, Malika; Labrecque, Nathalie; de Guire, Vincent; Laplante, Mathieu; Lettre, Guillaume; Sennlaub, Florian; Joyal, Jean-Sebastien; Meunier, Michel; Sapieha, Przemyslaw Share Save Effect of human very low-density lipoproteins on cardiotrophin-like cytokine factor 1 (CLCF1) activityPasquin, Sarah; Chehboun, Salma; Dejda, Agnieszka; Meliani, Yasmine; Savin, Virginia; Warner, Gregory J.; Bosse, Roger; Tormo, Aurelie; Mayer, Gaetan; Sharma, Mukut; Sapieha, Przemyslaw; Martel, Catherine; Gauchat, Jean-Francois Share Save Share Save Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathyOubaha, Malika; Miloudi, Khalil; Dejda, Agnieszka; Guber, Vera; Mawambo, Gaelle; Germain, Marie-Anne; Bourdel, Guillaume; Popovic, Natalija; Rezende, Flavio A.; Kaufman, Randal J.; Mallette, Frederick A.; Sapieha, Przemyslaw Share Save Truncated netrin-1 contributes to pathological vascular permeability in diabetic retinopathyMiloudi, Khalil; Binet, Francois; Wilson, Ariel; Cerani, Agustin; Oubaha, Malika; Menard, Catherine; Henriques, Sullivan; Mawambo, Gaelle; Dejda, Agnieszka; Phuong Trang Nguyen; Rezende, Flavio A.; Bourgault, Steve; Kennedy, Timothy E.; Sapieha, Przemyslaw Share Save Neuropilin-1-Expressing Microglia Are Associated With Nascent Retinal Vasculature Yet Dispensable for Developmental AngiogenesisDejda, Agnieszka; Mawambo, Gaelle; Daudelin, Jean-Francois; Miloudi, Khalil; Akla, Naoufal; Patel, Chintan; Andriessen, Elisabeth M. M. A.; Labrecque, Nathalie; Sennlaub, Florian; Sapieha, Przemyslaw Share Save Neuropilin-1 mediates myeloid cell chemoattraction and influences retinal neuroimmune crosstalkDejda, Agnieszka; Mawambo, Gaelle; Cerani, Agustin; Miloudi, Khalil; Shao, Zhuo; Daudelin, Jean-Francois; Boulet, Salix; Oubaha, Malika; Beaudoin, Felix; Akla, Naoufal; Henriques, Sullivan; Menard, Catherine; Stahl, Andreas; Delisle, Jean-Sebastien; Rezende, Flavio A.; Labrecque, Nathalie; Sapieha, Przemyslaw Share Save Neuron-Derived Semaphorin 3A Is an Early Inducer of Vascular Permeability in Diabetic Retinopathy via Neuropilin-1Cerani, Agustin; Tetreault, Nicolas; Menard, Catherine; Lapalme, Eric; Patel, Chintan; Sitaras, Nicholas; Beaudoin, Felix; Leboeuf, Dominique; De Guire, Vincent; Binet, Francois; Dejda, Agnieszka; Rezende, Flavio A.; Miloudi, Khalil; Sapieha, Przemyslaw Share Save Share Save Share Save Share Save Share Save 
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