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R

Randal J. Kaufman

Sanford Burnham Prebys Medical Discovery Institute

158H-index
639Paper Count
10.3WCitation Count
Published Papers 240
Publication Date
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Metformin triggers ATF4-mediated UPRmt and COX-2 inflammation in adipocytes
errBiochimica et Biophysica Acta-Molecular Cell Research
IF3.7
err2026-07-16
err0
errOAAI
errJuthakorn Poothong; Chutipong Chiamkunakorn; Wichit Suthammarak; Teva Phanaksri; Prasert Auewarakul; Jing Yong; Randal J. Kaufman
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errSave
Factor VIII originates primarily from anatomically distinct subsets of liver sinusoidal endothelial cells
errBlood Advances
IF7.1
err2026-02-05
err0
errOAAI
errPaige E. Severeid; Audrey Kapelanski-Lamoureux; Cynthia Lebeaupin; Peter Metrakos; Anthoula Lazaris; Wenjun Zhang; Chandrashekhar A. Kubal; Renzhi Han; Sreevani Arisa; Oded Danziger; Brad R. Rosenberg; Eleftherios Michailidis; Charles M. Rice; Ype P. de Jong; Randal J. Kaufman; Roland W. Herzog; Radoslaw Kaczmarek
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errSave
Activated ATF6α is a hepatic tumour driver restricting immunosurveillance
errNature
IF48.5
err2026-02-04
err0
errOAAI
errXin Li; Cynthia Lebeaupin; Aikaterini Kadianaki; Clementine Druelle-Cedano; Niklas Vesper; Charlotte Rennert; Júlia Huguet-Pradell; Borja Gomez Ramos; Chaofan Fan; Robert Stefan Piecyk; Laimdota Zizmare; Pierluigi Ramadori; Luqing Li; Lukas Frick; Menjie Qiu; Cangang Zhang; Luiza Martins Nascentes Melo; Vikas Prakash Ranvir; Peng Shen; Johannes Hanselmann; Jan Kosla; Mirian Fernández-Vaquero; Mihael Vucur; Praveen Baskaran; Xuanwen Bao; Olivia I. Coleman; Yingyue Tang; Miray Cetin; Zhouji Chen; Insook Jang; Stefania Del Prete; Mohammad Rahbari; Peng Zhang; Timothy V. Pham; Yushan Hou; Aihua Sun; Li Gu; Laura C. Kim; Ulrike Rothermel; Danijela Heide; Adnan Ali; Suchira Gallage; Nana Talvard-Balland; Marta Piqué-Gili; Albert Gris-Oliver; Alessio Bevilacqua; Lisa Schlicker; Alec Duffey; Kristian Unger; Marta Szydlowska; Jenny Hetzer; Duncan T. Odom; Tim Machauer; Daniele Bucci; Pooja Sant; Jun-Hoe Lee; Jonas Rösler; Sven W. Meckelmann; Johannes Schreck; Sue Murray; M. Celeste Simon; Sven Nahnsen; Almut Schulze; Ping-Chih Ho; Manfred Jugold; Kai Breuhahn; Jan-Philipp Mallm; Peter Schirmacher; Susanne Roth; Nuh Rahbari; Darjus F. Tschaharganeh; Stephanie Roessler; Benjamin Goeppert; Bertram Bengsch; Geoffroy Andrieux; Melanie Boerries; Nisar P. Malek; Marco Prinz; Achim Weber; Robert Zeiser; Pablo Tamayo; Peter Bronsert; Konrad Kurowski; Robert Thimme; Detian Yuan; Rafael Carretero; Tom Luedde; Roser Pinyol; Felix J. Hartmann; Michael Karin; Alpaslan Tasdogan; Christoph Trautwein; Moritz Mall; Maike Hofmann; Josep M. Llovet; Dirk Haller; Randal J. Kaufman; Mathias Heikenwälder
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errSave
Tapasin assembly surveillance by the RNF185/Membralin ubiquitin ligase complex regulates MHC-I surface expression
errNATURE COMMUNICATIONS
IF15.7
err2024-10-01
err0
errOAAI
errvan de Weijer, Michael L.; Samanta, Krishna; Sergejevs, Nikita; Jiang, Lulin; Duenas, Maria Emilia; Heunis, Tiaan; Huang, Timothy Y.; Kaufman, Randal J.; Trost, Matthias; Sanyal, Sumana; Cowley, Sally A.; Carvalho, Pedro
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errSave
IRE1α Mediates the Hypertrophic Growth of Cardiomyocytes Through Facilitating the Formation of Initiation Complex to Promote the Translation of TOP-Motif Transcripts
errCIRCULATION
IF38.6
err2024-09-24
err0
errOAAI
errLi, Chao; Li, Shiqian; Zhang, Guangyu; Li, Qinfeng; Song, Weidan; Wang, Xiaoding; Cook, Jane A.; van der Stoel, Miesje; Wright, Bradley W.; Altamirano, Francisco; Niewold, Erica L.; Han, Jungsoo; Kimble, Garrett; Zhang, Pengfei; Luo, Xiang; Urra, Hery; May, Herman I.; Ferdous, Anwarul; Sun, Xue-Nan; Deng, Yingfeng; Ikonen, Elina; Hetz, Claudio; Kaufman, Randal J.; Zhang, Kezhong; Gillette, Thomas G.; Scherer, Philipp E.; Hill, Joseph A.; Chen, Jin; Wang, Zhao V.
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errSave
The IRE1 α /XBP1 pathway sustains cytokine responses of group 3 innate lymphoid cells in inflammatory bowel disease
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2024-05-09
err1
errOAAI
errCao, Siyan; Fachi, Jose L.; Ma, Kaiming; Antonova, Alina Ulezko; Wang, Qianli; Cai, Zhangying; Kaufman, Randal J.; Ciorba, Matthew A.; Deepak, Parakkal; Colonna, Marco
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errSave
ATF6 protects against protein misfolding during cardiac hypertrophy
errJOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
IF4.7
err2024-04-01
err8
PREAI
errHofmann, Christoph; Aghajani, Marjan; Alcock, Cecily D.; Blackwood, Erik A.; Sandmann, Clara; Herzog, Nicole; Gro, Julia; Plate, Lars; Wiseman, R. Luke; Kaufman, Randal J.; Katus, Hugo A.; Jakobi, Tobias; Volkers, Mirko; Glembotski, Christopher C.; Doroudgar, Shirin
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errSave
Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion
errMOLECULAR METABOLISM
IF6.6
err2024-02-01
err5
errOAAI
errChen, Zhouji; Wang, Shiyu; Pottekat, Anita; Duffey, Alec; Jang, Insook; Chang, Benny H.; Cho, Jaehyung; Finck, Brian N.; Davidson, Nicholas O.; Kaufman, Randal J.
errShare
errSave
TLR9-independent CD8+T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling
errMOLECULAR THERAPY
IF12
err2024-02-01
err11
errOAAI
errKumar, Sandeep R. P.; Biswas, Moanaro; Cao, Di; Arisa, Sreevani; Munoz-Melero, Maite; Lam, Anh K.; Pineros, Annie R.; Kapur, Reuben; Kaisho, Tsuneyasu; Kaufman, Randal J.; Xiao, Weidong; Shayakhmetov, Dmitry M.; Terhorst, Cox; de Jong, Ype P.; Herzog, Roland W.
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errSave
Impact of eIF2a phosphorylation on the translational landscape of mouse embryonic stem cells
errCELL REPORTS
IF6.9
err2024-01-01
err3
errOAAI
errAmiri, Mehdi; Kiniry, Stephen J.; Possemato, Anthony P.; Mahmood, Niaz; Basiri, Tayebeh; Dufour, Catherine R.; Tabatabaei, Negar; Deng, Qiyun; Bellucci, Michael A.; Harwalkar, Keerthana; Stokes, Matthew P.; Giguere, Vincent; Kaufman, Randal J.; Yamanaka, Yojiro; Baranov, Pavel V.; Tahmasebi, Soroush; Sonenberg, Nahum
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errSave
Cellular stress and coagulation factor production: when more is not necessarily better
errJOURNAL OF THROMBOSIS AND HAEMOSTASIS
IF5
err2023-12-01
err6
errOAAI
errChen, Zhouji; Herzog, Roland W.; Kaufman, Randal J.
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errSave
mRNA translation in astrocytes controls hippocampal long- term synaptic plasticity and memory
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2023-11-28
err3
errOAAI
errSharma, Vijendra; Oliveira, Mauricio M.; Sood, Rapita; Khlaifia, Abdessattar; Lou, Danning; Hooshmandi, Mehdi; Hung, Tzu-Yu; Mahmood, Niaz; Reeves, Maya; Ho-Tieng, David; Cohen, Noah; Cheng, Po-chieh; Rahim, Mir Munir A.; Prager-Khoutorsky, Masha; Kaufman, Randal J.; Rosenblum, Kobi; Lacaille, Jean- Claude; Khoutorsky, Arkady; Klann, Eric; Sonenberg, Nahum
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errSave
Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome
errNEURON
IF15
err2023-10-01
err6
PREAI
errHooshmandi, Mehdi; Sharma, Vijendra; Perez, Carolina Thorn; Sood, Rapita; Krimbacher, Konstanze; Wong, Calvin; Lister, Kevin C.; Guzman, Alba Urena; Bartley, Trevor D.; Rocha, Cecilia; Maussion, Gilles; Nadler, Emma; Roque, Patricia Margarita; Gantois, Ilse; Popic, Jelena; Levesque, Maxime; Kaufman, Randal J.; Avoli, Massimo; Sanz, Elisenda; Nader, Karim; Hagerman, Randi Jenssen; Durcan, Thomas M.; Costa-Mattioli, Mauro; Prager-Khoutorsky, Masha; Lacaille, Jean-Claude; Martinez-Cerdeno, Veronica; Gibson, Jay R.; Huber, Kimberly M.; Sonenberg, Nahum; Gkogkas, Christos G.; Khoutorsky, Arkady
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RGC-specific ATF4 and/or CHOP deletion rescues glaucomatous neurodegeneration and visual function
errMOLECULAR THERAPY-NUCLEIC ACIDS
IF0
err2023-09-01
err10
errOAAI
errFang, Fang; Liu, Pingting; Huang, Haoliang; Feng, Xue; Li, Liang; Sun, Yang; Kaufman, Randal J.; Hu, Yang
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errSave
ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis
errJOURNAL OF HEPATOLOGY
IF33
err2023-08-01
err122
errOAAI
errHe, Feng; Zhang, Peng; Liu, Junlai; Wang, Ruolei; Kaufman, Randal J.; Yaden, Benjamin C.; Karin, Michael
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errSave
HIF1α-dependent hypoxia response in myeloid cells requires IRE1α
errJOURNAL OF NEUROINFLAMMATION
IF10.1
err2023-06-21
err3
errOAAI
errMawambo, Gaelle; Oubaha, Malika; Ichiyama, Yusuke; Blot, Guillaume; Crespo-Garcia, Sergio; Dejda, Agnieszka; Binet, Francois; Diaz-Marin, Roberto; Sawchyn, Christina; Sergeev, Mikhail; Juneau, Rachel; Kaufman, Randal J.; Affar, El Bachir; Mallette, Frederick A.; Wilson, Ariel M.; Sapieha, Przemyslaw
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errSave
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err1.2K
errOAAI
errCullinan, SB; Zhang, D; Hannink, M; Arvisais, E; Kaufman, RJ; Diehl, JA
errShare
errSave
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1α-mediated NF-κB activation and down-regulation of TRAF2 expression
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err724
errOAAI
errHu, P; Han, Z; Couvillon, AD; Kaufman, RJ; Exton, JH
errShare
errSave
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err639
errOAAI
errDeng, J; Lu, PD; Zhang, YH; Scheuner, D; Kaufman, RJ; Sonenberg, N; Harding, HP; Ron, D
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errSave
Phosphorylation of the a subunit of eukaryotic initiation factor 2 is required for activation of NF-κB in response to diverse cellular stresses
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err444
errOAAI
errJiang, HY; Wek, SA; McGrath, BC; Scheuner, D; Kaufman, RJ; Cavener, DR; Wek, RC
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Research Directions

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Co-authors
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H-index: 178 · Papers: 957
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