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Design and Development of DNA Damage Chemical Inducers of Proximity for Targeted Cancer Therapy Qiu, Tian; Lee, Yeuan Ting; Dwyer, Brendan G.; Tan, Yi Jer; Chen, Ting; Romero, Bryan A.; Wang, Yanlan; Deng, Jiehui; Zhang, Tinghu; Crabtree, Gerald R.; Hinshaw, Stephen M.; Wong, Kwok-Kin; Gray, Nathanael S. Share Save
Discovery of bivalent small molecule degraders of cyclin-dependent kinase 7 (CDK7) Ji, Wenzhi; Du, Guangyan; Jiang, Jie; Lu, Wenchao; Mills, Caitlin E.; Yuan, Linjie; Jiang, Fen; He, Zhixiang; Bradshaw, Gary A.; Chung, Mirra; Jiang, Zixuan; Byun, Woong Sub; Hinshaw, Stephen M.; Zhang, Tinghu; Gray, Nathanael S. Share Save
Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism Liu, Han-Yuan; Li, Zhengnian; Reindl, Theresia; He, Zhixiang; Qiu, Xueer; Golden, Ryan P.; Donovan, Katherine A.; Bailey, Adam; Fischer, Eric S.; Zhang, Tinghu; Gray, Nathanael S.; Yang, Priscilla L. Share Save
Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality Li, Zhengnian; Jiang, Jie; Ficarro, Scott B.; Beyett, Tyler S.; To, Ciric; Tavares, Isidoro; Zhu, Yingde; Li, Jiaqi; Eck, Michael J.; Janne, Pasi A.; Marto, Jarrod A.; Zhang, Tinghu; Che, Jianwei; Gray, Nathanael S. Share Save
ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases Li, Zhengnian; Lu, Wenchao; Beyett, Tyler S.; Ficarro, Scott B.; Jiang, Jie; Tse, Jason; Kim, Audrey Yong-Ju; Marto, Jarrod A.; Che, Jianwei; Janne, Pasi A.; Eck, Michael J.; Zhang, Tinghu; Gray, Nathanael S. Share Save
Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy Mukhopadhyay, Suman; Huang, Hsin-Yi; Lin, Ziyan; Ranieri, Michela; Li, Shuai; Sahu, Soumyadip; Liu, Yingzhuo; Ban, Yi; Guidry, Kayla; Hu, Hai; Lopez, Alfonso; Sherman, Fiona; Tan, Yi Jer; Lee, Yeuan Ting; Armstrong, Amanda P.; Dolgalev, Igor; Sahu, Priyanka; Zhang, Tinghu; Lu, Wenchao; Gray, Nathanael S.; Christensen, James G.; Tang, Tracy T.; Velcheti, Vamsidhar; Khodadadi-Jamayran, Alireza; Wong, Kwok-Kin; Neel, Benjamin G. Share Save
New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation Arwood, Matthew L.; Liu, Yao; Harkins, Shannon K.; Weinstock, David M.; Yang, Lei; Stevenson, Kristen E.; Plana, Olivia D.; Dong, Jingyun; Cirka, Haley; Jones, Kristen L.; Virtanen, Anniina T.; Gupta, Dikshat G.; Ceas, Amanda; Lawney, Brian; Yoda, Akinori; Leahy, Catharine; Hao, Mingfeng; He, Zhixiang; Choi, Hwan Geun; Wang, Yaning; Silvennoinen, Olli; Hubbard, Stevan R.; Zhang, Tinghu; Gray, Nathanael S.; Li, Loretta S. Share Save
Catalytic Degraders Effectively Address Kinase Site Mutations in EML4-ALK Oncogenic Fusions Gao, Yang; Jiang, Baishan; Kim, Hellen; Berberich, Matthew J.; Che, Jianwei; Donovan, Katherine A.; Hatcher, John M.; Huerta, Fidel; Kwiatkowski, Nicholas P.; Liu, Yingpeng; Liuni, Peter P.; Metivier, Rebecca J.; Murali, Vineeth K.; Nowak, Radoslaw P.; Zhang, Tinghu; Fischer, Eric S.; Gray, Nathanael S.; Jones, Lyn H. Share Save
Structure-Based Design of Y-Shaped Covalent TEAD Inhibitors Lu, Wenchao; Fan, Mengyang; Ji, Wenzhi; Tse, Jason; You, Inchul; Ficarro, Scott B.; Tavares, Isidoro; Che, Jianwei; Kim, Audrey Y.; Zhu, Xijun; Boghossian, Andrew; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; Hinshaw, Stephen M.; Nabet, Behnam; Corsello, Steven M.; Kwiatkowski, Nicholas; Marto, Jarrod A.; Zhang, Tinghu; Gray, Nathanael S. Share Save
Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1 Lu, Wenchao; Liu, Yao; Gao, Yang; Geng, Qixiang; Gurbani, Deepak; Li, Lianbo; Ficarro, Scott B.; Meyer, Cynthia J.; Sinha, Dhiraj; You, Inchul; Tse, Jason; He, Zhixiang; Ji, Wenzhi; Che, Jianwei; Kim, Audrey Y.; Yu, Tengteng; Wen, Kenneth; Anderson, Kenneth C.; Marto, Jarrod A.; Westover, Kenneth D.; Zhang, Tinghu; Gray, Nathanael S. Share Save
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor Darabedian, Narek; Ji, Wenzhi; Fan, Mengyang; Lin, Shan; Seo, Hyuk-Soo; Vinogradova, Ekaterina V. V.; Yaron, Tomer M. M.; Mills, Evanna L. L.; Xiao, Haopeng; Senkane, Kristine; Huntsman, Emily M. M.; Johnson, Jared L. L.; Che, Jianwei; Cantley, Lewis C. C.; Cravatt, Benjamin F. F.; Dhe-Paganon, Sirano; Stegmaier, Kimberly; Zhang, Tinghu; Gray, Nathanael S. S.; Chouchani, Edward T. T. Share Save
Development of potent and selective degraders of PI5P4Kγ Ji, Wenzhi; Wang, Eric S.; Manz, Theresa D.; Jiang, Jie; Donovan, Katherine A.; Abulaiti, Xianmixinuer; Fischer, Eric S.; Cantley, Lewis C.; Zhang, Tinghu; Gray, Nathanael S. Share Save
Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling Fan, Mengyang; Lu, Wenchao; Che, Jianwei; Kwiatkowski, Nicholas P.; Gao, Yang; Seo, Hyuk-Soo; Ficarro, Scott B.; Gokhale, Prafulla C.; Liu, Yao; Geffken, Ezekiel A.; Lakhani, Jimit; Song, Kijun; Kuljanin, Miljan; Ji, Wenzhi; Jiang, Jie; He, Zhixiang; Tse, Jason; Boghossian, Andrew S.; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; Mancias, Joseph D.; Marto, Jarrod A.; Dhe-Paganon, Sirano; Zhang, Tinghu; Gray, Nathanael S. Share Save
Exploring the target scope of KEAP1 E3 ligase-based PROTACs Du, Guangyan; Jiang, Jie; Henning, Nathaniel J.; Safaee, Nozhat; Koide, Eriko; Nowak, Radoslaw P.; Donovan, Katherine A.; Yoon, Hojong; You, Inchul; Yue, Hong; Eleuteri, Nicholas A.; He, Zhixiang; Li, Zhengnian; Huang, Hubert T.; Che, Jianwei; Nabet, Behnam; Zhang, Tinghu; Fischer, Eric S.; Gray, Nathanael S. Share Save
Synthesis and Structure-Activity relationships of cyclin-dependent kinase 11 inhibitors based on a diaminothiazole scaffold Li, Zhengnian; Ishida, Ryosuke; Liu, Yan; Wang, Jinhua; Li, Yina; Gao, Yang; Jiang, Jie; Che, Jianwei; Sheltzer, Jason M.; Robers, Matthew B.; Zhang, Tinghu; Westover, Kenneth D.; Nabet, Behnam; Gray, Nathanael S. Share Save
Targeting transcription in heart failure via CDK7/12/13 inhibition Hsu, Austin; Duan, Qiming; Day, Daniel S.; Luo, Xin; McMahon, Sarah; Huang, Yu; Feldman, Zachary B.; Jiang, Zhen; Zhang, Tinghu; Liang, Yanke; Alexanian, Michael; Padmanabhan, Arun; Brown, Jonathan D.; Lin, Charles Y.; Gray, Nathanael S.; Young, Richard A.; Bruneau, Benoit G.; Haldar, Saptarsi M. Share Save
A preclinical platform for assessing antitumor effects and systemic toxicities of cancer drug targets Li, Xiang; Huang, Chun-Hao; Sanchez-Rivera, Francisco J.; Kennedy, Margaret C.; Tschaharganeh, Darjus F.; Morris, John P.; Montinaro, Antonella; O'Rourke, Kevin P.; Banito, Ana; Wilkinson, John E.; Chen, Chi-Chao; Ho, Yu-Jui; Dow, Lukas E.; Tian, Sha; Luan, Wei; de Stanchina, Elisa; Zhang, Tinghu; Gray, Nathanael S.; Walczak, Henning; Lowe, Scott W. Share Save
Synergistic Anti-Tumor Effect of Combining Selective CDK7 and BRD4 Inhibition in Neuroblastoma Gao, Yang; Volegova, Marina; Nasholm, Nicole; Das, Sanjukta; Kwiatkowski, Nicholas; Abraham, Brian J.; Zhang, Tinghu; Gray, Nathanael S.; Gustafson, Clay; Krajewska, Malgorzata; George, Rani E. Share Save
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