Not logged inTherapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results
Crespo-Garcia, Sergio; Fournier, Frederik; Diaz-Marin, Roberto; Klier, Sharon; Ragusa, Derek; Masaki, Lauren; Cagnone, Gael; Blot, Guillaume; Hafiane, Ikhlas; Dejda, Agnieszka; Rizk, Rana; Juneau, Rachel; Buscarlet, Manuel; Chorfi, Sarah; Patel, Priyanka; Beltran, Pedro J.; Joyal, Jean-Sebastien; Rezende, Flavio A.; Hata, Masayuki; Nguyen, Alex; Sullivan, Lynne; Damiano, Jason; Wilson, Ariel M.; Mallette, Frederick A.; David, Nathaniel E.; Ghosh, Anirvan; Tsuruda, Pamela R.; Dananberg, Jamie; Sapieha, Przemyslaw .png)
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SaveShare Save Early-life peripheral infections reprogram retinal microglia and aggravate neovascular age-related macular degeneration in later lifeHata, Masayuki; Hata, Maki; Andriessen, Elisabeth M. M. A.; Juneau, Rachel; Pilon, Frederique; Crespo-Garcia, Sergio; Diaz-Marin, Roberto; Guber, Vera; Binet, Francois; Fournier, Frederik; Buscarlet, Manuel; Grou, Caroline; Calderon, Virginie; Heckel, Emilie; Melichar, Heather J.; Joyal, Jean-Sebastien; Wilson, Ariel M.; Sapieha, Przemyslaw Share Save Share Save Myeloid-resident neuropilin-1 promotes choroidal neovascularization while mitigating inflammationAndriessen, Elisabeth M. M. A.; Binet, Francois; Fournier, Frederik; Hata, Masayuki; Dejda, Agnieszka; Mawambo, Gaelle; Crespo-Garcia, Sergio; Pilon, Frederique; Buscarlet, Manuel; Beauchemin, Karine; Bougie, Veronique; Cumberlidge, Garth; Wilson, Ariel M.; Bourgault, Steve; Rezende, Flavio A.; Beaulieu, Normand; Delisle, Jean-Sebastien; Sapieha, Przemyslaw Share Save Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibitionCrespo-Garcia, Sergio; Tsuruda, Pamela R.; Dejda, Agnieszka; Ryan, Rathi D.; Fournier, Frederik; Chaney, Shawnta Y.; Pilon, Frederique; Dogan, Taner; Cagnone, Gael; Patel, Priyanka; Buscarlet, Manuel; Dasgupta, Sonali; Girouard, Gabrielle; Rao, Surabhi R.; Wilson, Ariel M.; O'Brien, Robert; Juneau, Rachel; Guber, Vera; Dubrac, Alexandre; Beausejour, Christian; Armstrong, Scott; Mallette, Frederick A.; Yohn, Christopher B.; Joyal, Jean-Sebastien; Marquess, Dan; Beltran, Pedro J.; Sapieha, Przemyslaw Share Save Share Save High-sensitivity C-reactive protein is associated with clonal hematopoiesis of indeterminate potentialBusque, Lambert; Sun, Maxine; Buscarlet, Manuel; Ayachi, Sami; Zada, Yassamin Feroz; Provost, Sylvie; Bourgoin, Vincent; Mollica, Luigina; Meisel, Marlies; Hinterleitner, Reinhard; Jabri, Bana; Dube, Marie-Pierre; Tardif, Jean-Claude Share Save NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathyMiloudi, Khalil; Oubaha, Malika; Menard, Catherine; Dejda, Agnieszka; Guber, Vera; Cagnone, Gael; Wilson, Ariel M.; Tetreault, Nicolas; Mawambo, Gaelle; Binet, Francois; Chidiac, Rony; Delisle, Chantal; Buscarlet, Manuel; Cerani, Agustin; Crespo-Garcia, Sergio; Bentley, Katie; Rezende, Flavio; Joyal, Jean-Sebastien; Mallette, Frederick A.; Gratton, Jean-Philippe; Larrivee, Bruno; Sapieha, Przemyslaw Share Save Share Save Prolyl isomerase Pin1 and protein kinase HIPK2 cooperate to promote cortical neurogenesis by suppressing Groucho/TLE: Hes1-mediated inhibition of neuronal differentiationCiarapica, R.; Methot, L.; Tang, Y.; Lo, R.; Dali, R.; Buscarlet, M.; Locatelli, F.; del Sal, G.; Rota, R.; Stifani, S. Share Save Share Save Share Save 
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