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Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists (vol 13, 942, 2022) Wu, Margaret; Carballo-Jane, Ester; Zhou, Haihong; Zafian, Peter; Dai, Ge; Liu, Mindy; Lao, Julie; Kelly, Terri; Shao, Dan; Gorski, Judith; Pissarnitski, Dmitri; Kekec, Ahmet; Chen, Ying; Previs, Stephen F.; Scapin, Giovanna; Gomez-Llorente, Yacob; Hollingsworth, Scott A.; Yan, Lin; Feng, Danqing; Huo, Pei; Walford, Geoffrey; Erion, Mark D.; Kelley, David E.; Lin, Songnian; Mu, James Share Save
Discovery of Insulin Receptor Partial Agonists MK-5160 and MK-1092 as Novel Basal Insulins with Potential to Improve Therapeutic Index Pissarnitski, Dmitri A.; Kekec, Ahmet; Yan, Lin; Zhu, Yuping; Feng, Danqing D.; Huo, Pei; Madsen-Duggan, Christina; Moyes, Christopher R.; Nargund, Ravi P.; Kelly, Terri; Zhang, Xiaoping; Carballo-Jane, Ester; Gorski, Judith; Zafian, Peter; Qatanani, Mo; Kaarsholm, Niels; Meng, Fanyu; Jia, Xiujuan; Lee, Keun-Joong; Wang, Weixun; Xu, Sherrie; Hohn, Michael J.; Iammarino, Michael J.; McCoy, Mark A.; Okoh, Grace A.; Liang, Yingkai; Hollingsworth, Scott A.; Erion, Mark D.; Kelley, David E.; Garbaccio, Robert M.; Zhang, Amy; Mu, James; Lin, Songnian Share Save
Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists Wu, Margaret; Carballo-Jane, Ester; Zhou, Haihong; Zafian, Peter; Dai, Ge; Liu, Mindy; Lao, Julie; Kelly, Terri; Shao, Dan; Gorski, Judith; Pissarnitski, Dmitri; Kekec, Ahmet; Chen, Ying; Previs, Stephen F.; Scapin, Giovanna; Llorente, Yacob Gomez; Hollingsworth, Scott A.; Yan, Lin; Feng, Danqing; Huo, Pei; Walford, Geoffrey; Erion, Mark D.; Kelley, David E.; Lin, Songnian; Mu, James Share Save
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PAN-AMPK Activation Improves Renal Function in a Rat Model of Progressive Diabetic Nephropathy Zhou, Xiaoyan; Muise, Eric S.; Haimbach, Robin; Sebhat, Iyassu K.; Zhu, Yonghua; Liu, Franklin; Souza, Sandra C.; Kan, Yanqing; Pinto, Shirly; Kelley, David E.; Hoek, Maarten Share Save
Clinical Evaluation of MK-2640: An Insulin Analog With Glucose-Responsive Properties Krug, Alexander W.; Visser, Sandra A. G.; Tsai, Kuenhi; Kandala, Bhargava; Fancourt, Craig; Thornton, Bob; Morrow, Linda; Kaarsholm, Niels C.; Bernstein, Harold S.; Stoch, S. Aubrey; Crutchlow, Michael; Kelley, David E.; Iwamoto, Marian Share Save
GPR119 Agonism Increases Glucagon Secretion During Insulin-Induced Hypoglycemia Li, Nina Xiaoyan; Brown, Stacey; Kowalski, Tim; Wu, Margaret; Yang, Liming; Dai, Ge; Petrov, Aleksandr; Ding, Yuyan; Dlugos, Tamara; Wood, Harold B.; Wang, Liangsu; Erion, Mark; Sherwin, Robert; Kelley, David E. Share Save
Native Oxyntomodulin Has Significant Glucoregulatory Effects Independent of Weight Loss in Obese Humans With and Without Type 2 Diabetes Shankar, Sudha S.; Shankar, R. Ravi; Mixson, Lori A.; Miller, Deborah L.; Pramanik, Barnali; O'Dowd, Amy K.; Williams, Donna M.; Frederick, Clay B.; Beals, Chan R.; Stoch, S. Aubrey; Steinberg, Helmut O.; Kelley, David E. Share Save
Superior Glycemic Control With a Glucose-Responsive Insulin Analog: Hepatic and Nonhepatic Impacts Moore, Mary Courtney; Kelley, David E.; Camacho, Raul C.; Zafian, Peter; Ye, Tian; Lin, Songnian; Kaarsholm, Niels C.; Nargund, Ravi; Kelly, Terri M.; Van Heek, Margaret; Previs, Stephen F.; Moyes, Christopher; Smith, Marta S.; Farmer, Ben; Williams, Phil; Cherrington, Alan D. Share Save
Engineering Glucose Responsiveness Into Insulin (vol 67, pg 299, 2018) Kaarsholm, Niels C.; Lin, Songnian; Yan, Lin; Kelly, Theresa; van Heek, Margaret; Mu, James; Wu, Margaret; Dai, Ge; Cui, Yan; Zhu, Yonghua; Carballo-Jane, Ester; Reddy, Vijay; Zafian, Peter; Huo, Pei; Shi, Shuai; Antochshuk, Valentyn; Ogawa, Aimie; Liu, Franklin; Souza, Sandra C.; Seghezzi, Wolfgang; Duffy, Joseph L.; Erion, Mark; Nargund, Ravi P.; Kelley, David E. Share Save
Prospective evaluation of insulin and incretin dynamics in obese adults with and without diabetes for 2 years after Roux-en-Y gastric bypass Purnell, Jonathan Q.; Johnson, Geoffrey S.; Wahed, Abdus S.; Dalla Man, Chiara; Piccinini, Francesca; Cobelli, Claudio; Prigeon, Ronald L.; Goodpaster, Bret H.; Kelley, David E.; Staten, Myrlene A.; Foster-Schubert, Karen E.; Cummings, David E.; Flum, David R.; Courcoulas, Anita P.; Havel, Peter J.; Wolfe, Bruce M. Share Save
A glucose-responsive insulin therapy protects animals against hypoglycemia Yang, Ruojing; Wu, Margaret; Lin, Songnian; Nargund, Ravi P.; Li, Xinghai; Kelly, Theresa; Yan, Lin; Dai, Ge; Qian, Ying; Dallas-Yang, Qing; Fischer, Paul A.; Cui, Yan; Shen, Xiaolan; Huo, Pei; Feng, Danqing Dennis; Erion, Mark D.; Kelley, David E.; Mu, James Share Save
Engineering Glucose Responsiveness Into Insulin Kaarsholm, Niels C.; Lin, Songnian; Yan, Lin; Kelly, Theresa; van Heek, Margaret; Mu, James; Wu, Margaret; Dai, Ge; Cui, Yan; Zhu, Yonghua; Carballo-Jane, Ester; Reddy, Vijay; Zafian, Peter; Huo, Pei; Shi, Shuai; Antochshuk, Valentyn; Ogawa, Aimie; Liu, Franklin; Souza, Sandra C.; Seghezzi, Wolfgang; Duffy, Joseph L.; Erion, Mark; Nargund, Ravi P.; Kelley, David E. Share Save
Enhancing Studies of Pharmacodynamic Mechanisms via Measurements of Metabolic Flux: Fundamental Concepts and Guiding Principles for Using Stable Isotope Tracers Daurio, Natalie A.; Wang, Sheng-Ping; Chen, Ying; Zhou, Haihong; McLaren, David G.; Roddy, Thomas P.; Johns, Douglas G.; Milot, Denise; Kasumov, Takhar; Erion, Mark D.; Kelley, David E.; Previs, Stephen F. Share Save
Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation (vol 26, pg 394, 2017) Kim, Chai-Wan; Addy, Carol; Kusunoki, Jun; Anderson, Norma N.; Deja, Stanislaw; Fu, Xiaorong; Burgess, Shawn C.; Li, Cai; Ruddy, Marcie; Chakravarthy, Manu; Previs, Steve; Milstein, Stuart; Fitzgerald, Kevin; Kelley, David E.; Horton, Jay D. Share Save
Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation Kim, Chai-Wan; Addy, Carol; Kusunoki, Jun; Anderson, Norma N.; Deja, Stanislaw; Fu, Xiaorong; Burgess, Shawn C.; Li, Cai; Chakravarthy, Manu; Previs, Steve; Milstein, Stuart; Fitzgerald, Kevin; Kelley, David E.; Horton, Jay D. Share Save
GPR120 suppresses adipose tissue lipolysis and synergizes with GPR40 in antidiabetic efficacy Satapati, Santhosh; Qian, Ying; Wu, Margaret S.; Petrov, Aleksandr; Dai, Ge; Wang, Sheng-ping; Zhu, Yonghua; Shen, Xiaolan; Muise, Eric S.; Chen, Ying; Zycband, Emanuel; Weinglass, Adam; Di Salvo, Jerry; Debenham, John S.; Cox, Jason M.; Lan, Ping; Shah, Vinit; Previs, Stephen F.; Erion, Mark; Kelley, David E.; Wang, Liangsu; Howard, Andrew D.; Shang, Jin Share Save
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