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Androgen receptor inhibition extends PARP inhibitor activity in prostate cancer models beyond BRCA mutations and defects in homologous recombination repair Illuzzi, Giuditta; Galbiati, Alessandro; Staniszewska, Anna D.; Hanson, Robert; Michaloglou, Chrysiis; Cooke, Sophie L.; Uznanska, Karolina; Bialecka, Maja; Solarczyk, Kamil; Dev, Harveer S.; Massie, Charlie E.; Albertella, Mark R.; Leo, Elisabetta; Forment, Josep, V; O'Connor, Mark J. Share Save
Discovery of 6-Fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD9574): A CNS-Penetrant, PARP1-Selective Inhibitor Johannes, Jeffrey W.; Balazs, Amber Y. S.; Barratt, Derek; Bista, Michal; Chuba, Matthew D.; Cosulich, Sabina; Critchlow, Susan E.; Degorce, SebastienL.; Di Fruscia, Paolo; Edmondson, Scott D.; Embrey, Kevin J.; Fawell, Stephen; Ghosh, Avipsa; Gill, Sonja J.; Gunnarsson, Anders; Hande, Sudhir M.; Heightman, Tom D.; Hemsley, Paul; Illuzzi, Giuditta; Lane, Jordan; Larner, Carrie J. B.; Leo, Elisabetta; Liu, Lina; Madin, Andrew; Mcwilliams, Lisa; O'Connor, Mark J.; Orme, Jonathan P.; Pachl, Fiona; Packer, Martin J.; Pei, Xiaohui; Pike, Andy; Schimpl, Marianne; She, Hongyao; Staniszewska, Anna D.; Talbot, Verity; Underwood, Elizabeth; Varnes, Jeffrey G.; Xue, Lin; Yao, Tieguang; Zhang, Ke; Zhang, Andrew X.; Zheng, Xiaolan Share Save
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PARP inhibition is a modulator of anti-tumor immune response in BRCA-deficient tumors Staniszewska, Anna D.; Armenia, Joshua; King, Matthew; Michaloglou, Chrysiis; Reddy, Avinash; Singh, Maneesh; San Martin, Maryann; Prickett, Laura; Wilson, Zena; Proia, Theresa; Russell, Deanna; Thomas, Morgan; Delpuech, Oona; O'Connor, Mark J.; Leo, Elisabetta; Angell, Helen; Valge-Archer, Viia Share Save
Activity and tolerability of combination of trastuzumab deruxtecan with olaparib in preclinical HER2+and HER2-low breast cancer models Proia, Theresa; Wallez, Yann; Bashi, Azadeh Cheraghchi; Wilson, Zena; Randle, Suzanne; Anderton, Mark; Carroll, Danielle; Rasheed, Zeshaan; Pease, J. Elizabeth; Leo, Elisabetta; Mettetal, Jerome Share Save
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VEGF pathway inhibition potentiates PARP inhibitor efficacy in ovarian cancer independent of BRCA status Bizzaro, Francesca; Fuso Nerini, Ilaria; Taylor, Molly A.; Anastasia, Alessia; Russo, Massimo; Damia, Giovanna; Guffanti, Federica; Guana, Francesca; Ostano, Paola; Minoli, Lucia; Hattersley, Maureen M.; Arnold, Stephanie; Ramos-Montoya, Antonio; Williamson, Stuart C.; Galbiati, Alessandro; Urosevic, Jelena; Leo, Elisabetta; Cavallaro, Ugo; Ghilardi, Carmen; Barry, Simon T.; Bani, Maria Rosa; Giavazzi, Raffaella Share Save
Retrospective analysis of Schlafen11 (SLFN11) to predict the outcomes to therapies affecting the DNA damage response Willis, Sophie E.; Winkler, Claudia; Roudier, Martine P.; Baird, Tarrion; Marco-Casanova, Paola; Jones, Emma, V; Rowe, Philip; Rodriguez-Canales, Jaime; Angell, Helen K.; Ng, Felicia S. L.; Waring, Paul M.; Hodgson, Darren; Ledermann, Jonathan A.; Weberpals, Johanne, I; Dean, Emma; Harrington, Elizabeth A.; Barrett, J. Carl; Pierce, Andrew J.; Leo, Elisabetta; Jones, Gemma N. Share Save
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs Johannes, Jeffrey W.; Balazs, Amber; Barratt, Derek; Bista, Michal; Chuba, Matthew D.; Cosulich, Sabina; Critchlow, Susan E.; Degorce, Sebastien L.; Di Fruscia, Paolo; Edmondson, Scott D.; Embrey, Kevin; Fawell, Stephen; Ghosh, Avipsa; Gill, Sonja J.; Gunnarsson, Anders; Hande, Sudhir M.; Heightman, Tom D.; Hemsley, Paul; Illuzzi, Giuditta; Lane, Jordan; Larner, Carrie; Leo, Elisabetta; Liu, Lina; Madin, Andrew; Martin, Scott; McWilliams, Lisa; O'Connor, Mark J.; Orme, Jonathan P.; Pachl, Fiona; Packer, Martin J.; Pei, Xiaohui; Pike, Andrew; Schimpl, Marianne; She, Hongyao; Staniszewska, Anna D.; Talbot, Verity; Underwood, Elizabeth; Varnes, Jeffrey G.; Xue, Lin; Yao, Tieguang; Zhang, Ke; Zhang, Andrew X.; Zheng, Xiaolan Share Save
SLFN11 captures cancer-immunity interactions associated with platinum sensitivity in high-grade serous ovarian cancer Winkler, Claudia; King, Matthew; Berthe, Julie; Ferraioli, Domenico; Garuti, Anna; Grillo, Federica; Rodriguez-Canales, Jaime; Ferrando, Lorenzo; Chopin, Nicolas; Ray-Coquard, Isabelle; Delpuech, Oona; Bedognetti, Davide; Ballestrero, Alberto; Leo, Elisabetta; Zoppoli, Gabriele Share Save
SLFN11 informs on standard of care and novel treatments in a wide range of cancer models Winkler, Claudia; Armenia, Joshua; Jones, Gemma N.; Tobalina, Luis; Sale, Matthew J.; Petreus, Tudor; Baird, Tarrion; Serra, Violeta; Wang, Anderson T.; Lau, Alan; Garnett, Mathew J.; Jaaks, Patricia; Coker, Elizabeth A.; Pierce, Andrew J.; O'Connor, Mark J.; Leo, Elisabetta Share Save
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Mechanistic differentiation of targeted DDR agent combinations Forment, Josep, V; Wijnhoven, Paul; Ramos-Montoya, Antonio; Fok, Jacqueline; Follia, Valeria; Vazquez-Chantada, Mercedes; Oderda, Rajesh; Wilson, Zena; Lau, Alan; Leo, Elisabetta; Durant, Stephen; Cadogan, Elaine; O'Connor, Mark J. Share Save
Anti-tumor and immune effects of olaparib plus /- anti-PD-L1 in preclinical BRCA1mut tumor models Staniszewska, Anna; Armenia, Joshua; King, Matthew; Michaloglou, Chrysiis; Singh, Maneesh; San Martin, Maryann; Wilson, Zena; Proia, Theresa; Delpuech, Oona; O'Connor, Mark; Leo, Elisabetta; Valge-Archer, Viia Share Save
Dose optimization of olaparib plus temozolomide in small cell lung cancer (SCLC) patient-derived xenograft (PDX) models for clinical translation Drapkin, Benjamin J.; Phat, Sarah; Myers, David T.; Zhong, Jun; Yeap, Beow Y.; Leo, Elisabetta; Stansiszewska, Anna; Smith, Aaron; Cadogan, Elaine; Pietanza, Maria C.; Dyson, Nicholas J.; Farago, Anna Share Save
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Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6 McCoull, William; Cheung, Tony; Anderson, Erica; Barton, Peter; Burgess, Jonathan; Byth, Kate; Cao, Qing; Castald, M. Paola; Chen, Huawei; Chiarparin, Elisabetta; Carbajo, Rodrigo J.; Code, Erin; Cowan, Suzanna; Davey, Paul R.; Ferguson, Andrew D.; Fillery, Shaun; Fuller, Nathan O.; Gao, Ning; Hargreaves, David; Howard, Martin R.; Hu, Jun; Kawatkar, Aarti; Kemmitt, Paul D.; Leo, Elisabetta; Molina, Daniel M.; O'Conne', Nichole; Petteruti, Philip; Rasmusson, Timothy; Raubo, Piotr; Rawlins, Philip B.; Ricchiuto, Piero; Robb, Graeme R.; Schenone, Monica; Waring, Michael J.; Zinda, Michael; Fawell, Stephen; Wilson, David M. Share Save
A head-to-head comparison of the properties of five clinical PARP inhibitors identifies new insights that can explain both the observed clinical efficacy and safety profiles Leo, Elisabetta; Johannes, Jeffrey; Illuzzi, Giuditta; Zhang, Andrew; Hemsley, Paul; Bista, Michal J.; Orme, Jonathan P.; Talbot, Verity A.; Narvaez, Ana J.; Underwood, Elizabeth; Pike, Andrew; Nikkila, Jenni K.; Riches, Lucy; Sweeney, Sinbad; Gustafsson, Frida; Cronin, Anna; Ricchiuto, Piero; Roaquin, Debora A.; Pachl, Fiona; Miele, Eric; MacDonald, Ruth; Hawthorne, Glen; Mead, Andrew N.; O'Connor, Mark J. Share Save
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