Not logged in Sitravatinib in patients with solid tumors selected by molecular alterations: results from a Phase Ib study Bazhenova, Lyudmila; Kim, Dong-Wan; Cho, Byoung Chul; Goel, Sanjay; Heist, Rebecca; Werner, Theresa L.; Eaton, Keith D.; Wang, Judy S.; Pant, Shubham; Adkins, Douglas R.; Blakely, Collin M.; Yan, Xiaohong; Neuteboom, Saskia; Christensen, James G.; Chao, Richard; Bauer, Todd Share Save
Functional Dissection of the Highly Plastic Basal Cell State in Pancreatic Cancer Singhal, Anupriya; Styers, Hannah C.; Rub, Jonathan; Li, Zhuxuan; Tarcan, Zeynep; Hallin, Jill; Basturk, Olca; Yaeger, Rona; Christensen, James G.; Betel, Doron; Yan, Yan; de Stanchina, Elisa; Tammela, Tuomas Share Save
Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer Dilly, Julien; Hoffman, Megan T.; Abbassi, Laleh; Li, Ziyue; Paradiso, Francesca; Parent, Brendan D.; Hennessey, Connor J.; Jordan, Alexander C.; Morgado, Micaela; Dasgupta, Shatavisha; Uribe, Giselle A.; Yang, Annan; Kapner, Kevin S.; Hambitzer, Felix P.; Qiang, Li; Feng, Hanrong; Geisberg, Jacob; Wang, Junning; Evans, Kyle E.; Lyu, Hengyu; Schalck, Aislyn; Feng, Ningping; Lopez, Anastasia M.; Bristow, Christopher A.; Kim, Michael P.; Rajapakshe, Kimal I.; Bahrambeigi, Vahid; Roth, Jennifer A.; Garg, Kavita; Guerrero, Paola A.; Stanger, Ben Z.; Cristea, Simona; Lowe, Scott W.; Baslan, Timour; Van Allen, Eliezer M.; Mancias, Joseph D.; Chan, Emily; Anderson, Abraham; Katlinskaya, Yuliya V.; Shalek, Alex K.; Hong, David S.; Pant, Shubham; Hallin, Jill; Anderes, Kenna; Olson, Peter; Heffernan, Timothy P.; Chugh, Seema; Christensen, James G.; Maitra, Anirban; Wolpin, Brian M.; Raghavan, Srivatsan; Nowak, Jonathan A.; Winter, Peter S.; Dougan, Stephanie K.; Aguirre, Andrew J. Share Save
A Classical Epithelial State Drives Acute Resistance to KRAS Inhibition in Pancreatic Cancer Singhal, Anupriya; Styers, Hannah C.; Rub, Jonathan; Li, Zhuxuan; Torborg, Stefan R.; Kim, Jung Yun; Grbovic-Huezo, Olivera; Feng, Huijin; Tarcan, Zeynep Cagla; Ozkan, Hulya Sahin; Hallin, Jill; Basturk, Olca; Yaeger, Rona; Christensen, James G.; Betel, Doron; Yan, Yan; Chio, Iok In Christine; de Stanchina, Elisa; Tammela, Tuomas Share Save
The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading Sudhakar, Niranjan; Yan, Larry; Qiryaqos, Fadia; Engstrom, Lars D.; Laguer, Jade; Calinisan, Andrew; Hebbert, Allan; Waters, Laura; Moya, Krystal; Bowcut, Vickie; Vegar, Laura; Ketcham, John M.; Ivetac, Anthony; Smith, Christopher R.; Lawson, J. David; Rahbaek, Lisa; Clarine, Jeffrey; Nguyen, Natalie; Saechao, Barbara; Parker, Cody; Elliott, Adam J.; Vanderpool, Darin; He, Leo; Hover, Laura D.; Fernandez-Banet, Julio; Coma, Silvia; Pachter, Jonathan A.; Hallin, Jill; Marx, Matthew A.; Briere, David M.; Christensen, James G.; Olson, Peter; Haling, Jacob; Khare, Shilpi Share Save
Discovery of ORIC-944, a novel inhibitor of PRC2 with best-in-class properties for the treatment of prostate cancer Marx, Matthew A.; Burns, Aaron C.; Arora, Nidhi; Bobinski, Thomas P.; Briere, David M.; Calinisan, Andrew; Gunn, Robin J.; Ketcham, John M.; Lawson, David; Lee, Matthew; Olson, Peter; Smith, Christopher R.; Sudhakar, Niranjan; Christensen, James G.; Chen, Chelsea X.; Yuen, Natalie; Ulicna, Livia; Duong, Frank; Colas, Christophe; Ramnath, Anjana; Xu, Ron; Maneval, Edna Chow; Multani, Pratik S.; Patel, Rupal; Kumar, Archana; Daemen, Anneleen; Romero, Anthony; Junttila, Melissa R.; Friedman, Lori S. Share Save
ORIC-944, a potent and selective allosteric PRC2 inhibitor with best-in-class properties, demonstrates combination synergy with AR pathway inhibitors in prostate cancer models Daemen, Anneleen; Yuen, Natalie; Wang, Amber; Pankov, Aleksandr; Ulicna, Livia; Chen, Chelsea; Duong, Frank L.; Long, Jason; Marx, Matthew A.; Christensen, James G.; Friedman, Lori S.; Junttila, Melissa R. Share Save
The MTA-cooperative PRMT5 inhibitor, MRTX1719, demonstrates increased antitumor activity in combination with KRAS mutant-selective inhibitors in MTAP del,KRAS-mutant cancers Waters, Laura; Aranda, Ruth; Helu, Xousaen; Vegar, Laura; Moya, Krystal; Calinisan, Andrew; Hebbert, Allan; Hallin, Jill; Vanderpool, Darin; Briere, David M.; Christensen, James G.; Olson, Peter A.; Engstrom, Lars D. Share Save
The SOS1 inhibitor MRTX0902 demonstrates activity across cancer models with mutations in proximal components of the RAS-MAPK pathway Sudhakar, Niranjan; Yan, Larry; Qiryaqos, Fadia; laguer, Jade; Briere, David; Hebbert, Allan; Calinisan, Andrew; Coma, Silvia; Pachter, Jonathan; Christensen, James G.; Olson, Peter; Khare, Shilpi Share Save
Effects of adagrasib on cholesterol, lipid and glucose gene expression regulation in tumor xenograft models and patient samples Shelton, Fabiola; Hoffman, Natalie; Trinh, David; Helu, Xousaen M.; Calinisan, Andrew; Hebbert, Allan; Yan, Larry; Briere, David M.; Hover, Laura; Fernandez-Benet, Julio; Anderes, Kenna; Christensen, James G.; Hallin, Jill; Olson, Peter Share Save
Discovery and characterization of potential drivers of resistance to the KRAS G12D inhibitor, MRTX1133, in cancer cell line models Helu, Xousaen M.; Griffiths, Ellie; Calinisan, Andrew; Hebbert, Allan; Yan, Larry; Hoffman, Natalie; Trinh, David; Hover, Laura; Fernandez-Banet, Julio; Briere, David M.; Lifset, Ella; Olson, Peter; Christensen, James G.; Hallin, Jill Share Save
Impact of KEAP1/STK11 co-mutations and NRF2 signaling on resistance to adagrasib in advanced NSCLC Negrao, Marcelo V.; Molkentine, David; Paula, Alvaro G.; Hover, Laura; Nilsson, Monique; Vokes, Natalie; Engstrom, Lars; Calinisan, Andrew; Waters, Laura; Briere, David M.; Hallin, Jill; Blumenschein, George R.; Skoulidis, Ferdinandos; Kopetz, Scott E.; Hong, David S.; Gibbons, Don L.; Olson, Peter; Christensen, James; Heymach, John V. Share Save
Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein Ketcham, John M.; Harwood, Stephen J.; Aranda, Ruth; Aloiau, Athenea N.; Bobek, Briana M.; Briere, David M.; Burns, Aaron C.; Haatveit, Kersti Caddell; Calinisan, Andrew; Clarine, Jeffery; Elliott, Adam; Engstrom, Lars D.; Gunn, Robin J.; Ivetac, Anthony; Jones, Benjamin; Kuehler, Jon; Lawson, J. David; Nguyen, Natalie; Parker, Cody; Pearson, Kelly E.; Rahbaek, Lisa; Saechao, Barbara; Wang, Xiaolun; Waters, Anna; Waters, Laura; Watkins, Ashlee H.; Olson, Peter; Smith, Christopher R.; Christensen, James G.; Marx, Matthew A. Share Save
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography Smith, Christopher R.; Chen, Dan; Christensen, James G.; Coulombe, Rene; Fethiere, James; Gunn, Robin J.; Hollander, Johan; Jones, Benjamin; Ketcham, John M.; Khare, Shilpi; Kuehler, Jon; Lawson, J. David; Marx, Matthew A.; Olson, Peter; Pearson, Kelly E.; Ren, Cynthia; Tsagris, Denise; Ulaganathan, Thirumalaiselvi; Van't Veer, Inge; Wang, Xiaolun; Ivetac, Anthony Share Save
TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors Edwards, A. Cole; Stalnecker, Clint A.; Morales, Alexis Jean; Taylor, Khalilah E.; Klomp, Jennifer E.; Klomp, Jeffrey A.; Waters, Andrew M.; Sudhakar, Niranjan; Hallin, Jill; Tang, Tracy T.; Olson, Peter; Post, Leonard; Christensen, James G.; Cox, Adrienne D.; Der, Channing J. Share Save
Alveolar Differentiation Drives Resistance to KRAS Inhibition in Lung Adenocarcinoma Li, Zhuxuan; Zhuang, Xueqian; Pan, Chun-Hao; Yan, Yan; Thummalapalli, Rohit; Hallin, Jill; Torborg, Stefan; Singhal, Anupriya; Chang, Jason C.; Manchado, Eusebio; Dow, Lukas E.; Yaeger, Rona; Christensen, James G.; Lowe, Scott W.; Rudin, Charles M.; Joost, Simon; Tammela, Tuomas Share Save
Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy Mukhopadhyay, Suman; Huang, Hsin-Yi; Lin, Ziyan; Ranieri, Michela; Li, Shuai; Sahu, Soumyadip; Liu, Yingzhuo; Ban, Yi; Guidry, Kayla; Hu, Hai; Lopez, Alfonso; Sherman, Fiona; Tan, Yi Jer; Lee, Yeuan Ting; Armstrong, Amanda P.; Dolgalev, Igor; Sahu, Priyanka; Zhang, Tinghu; Lu, Wenchao; Gray, Nathanael S.; Christensen, James G.; Tang, Tracy T.; Velcheti, Vamsidhar; Khodadadi-Jamayran, Alireza; Wong, Kwok-Kin; Neel, Benjamin G. Share Save
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TEAD inhibition overcomes YAP1/TAZ-driven resistance to RAS inhibitors in KRASG12C-mutant cancers Edwards, Alexander C.; Stalnecker, Clint A.; Morales, Alexis J.; Taylor, Khalilah E.; Hallin, Jill; Olson, Peter; Tang, Tracy T.; Engstrom, Lars; Post, Leonard; Christensen, James G.; Cox, Adrienne D.; Der, Channing J. Share Save
Inhibition of KrasG12D with a novel small molecule inhibitor alters the pancreatic cancer microenvironment Kemp, Samantha B.; Cheng, Noah; Markosyan, Nune; Sor, Rina; Kim, Il-Kyu; Hallin, Jill; Shoush, Jason; Quinones, Liz; Brown, Natalie; Bassett, Jared B.; Joshi, Nikhil; Yuan, Salina; Smith, Molly; Vostrejs, William P.; Perez-Vale, Kia Z.; Kahn, Benjamin; Mo, Feiyan; Donahue, Timothy R.; Radu, Caius G.; Clendenin, Cynthia; Christensen, James G.; Vonderheide, Robert H.; Stanger, Ben Z. Share Save
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