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CARD14 signalosome formation is associated with its endosomal relocation and mTORC1-induced keratinocyte proliferation O'Sullivan, Paul A.; Aidarova, Aigerim; Afonina, Inna S.; Manils, Joan; Thurston, Teresa L. M.; Instrell, Rachael; Howell, Michael; Boeing, Stefan; Ranawana, Sashini; Herpels, Melanie B.; Chetian, Riwia; Bassa, Matilda; Flynn, Helen; Frith, David; Snijders, Ambrosius P.; Howes, Ashleigh; Beyaert, Rudi; Bowcock, Anne M.; Ley, Steven C. Share Save
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Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome Lana-Elola, Eva; Aoidi, Rifdat; Llorian, Miriam; Gibbins, Dorota; Buechsenschuetz, Callan; Bussi, Claudio; Flynn, Helen; Gilmore, Tegan; Watson-Scales, Sheona; Hansen, Marie Haugsten; Hayward, Darryl; Song, Ok-Ryul; Brault, Veronique; Herault, Yann; Deau, Emmanuel; Meijer, Laurent; Snijders, Ambrosius P.; Gutierrez, Maximiliano G.; Fisher, Elizabeth M. C.; Tybulewicz, Victor L. J. Share Save
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SYK ubiquitination by CBL E3 ligases restrains cross-presentation of dead cell-associated antigens by type 1 dendritic cells Henry, Conor M.; Castellanos, Carlos A.; Buck, Michael D.; Giampazolias, Evangelos; Frederico, Bruno; Cardoso, Ana; Rogers, Neil C.; Schulz, Oliver; Lee, Sonia; Canton, Johnathan; Faull, Peter; Snijders, Ambrosius P.; Mohapatra, Bhopal; Band, Hamid; Sousa, Caetano Reis e Share Save
A chemoproteomic platform for selective deubiquitinase inhibitor discovery Cookson, Rosa; Vuorinen, Aini; Pettinger, Jonathan; Kennedy, Cassandra R.; Kirkpatrick, Joanna M.; Peltier-Heap, Rachel E.; Powell, Andrew; Snijders, Ambrosius P.; Skehel, Mark; House, David; Rittinger, Katrin; Bush, Jacob T. Share Save
The yeast RNA methylation complex consists of conserved yet reconfigured components with m6A-dependent and independent roles Ensinck, Imke; Maman, Alexander; Albihlal, Waleed S.; Lassandro, Michelangelo; Salzano, Giulia; Sideri, Theodora; Howell, Steven A.; Calvani, Enrica; Patel, Harshil; Bushkin, Guy; Ralser, Markus; Snijders, Ambrosius P.; Skehel, Mark; Casanal, Ana; Schwartz, Schraga; van Werven, Folkert J. Share Save
A malaria parasite phospholipase facilitates efficient asexual blood stage egress Ramaprasad, Abhinay A.; Burda, Paul-Christian; Koussis, Konstantinos; Thomas, James A.; Pietsch, Emma I.; Calvani, Enrica P.; Howell, Steven; MacRae, James J.; Snijders, Ambrosius; Gilberger, Tim-Wolf; Blackman, Michael Share Save
Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration Rosianu, Flavia; Mihaylov, Simeon R.; Eder, Noreen; Martiniuc, Antonie; Claxton, Suzanne; Flynn, Helen R.; Jalal, Shamsinar; Domart, Marie-Charlotte; Collinson, Lucy; Skehel, Mark; Snijders, Ambrosius P.; Krause, Matthias; Tooze, Sharon A.; Ultanir, Sila K. Share Save
N6-methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast Varier, Radhika A.; Sideri, Theodora; Capitanchik, Charlotte; Manova, Zornitsa; Calvani, Enrica; Rossi, Alice; Edupuganti, Raghu R.; Ensinck, Imke; Chan, Vincent W. C.; Patel, Harshil; Kirkpatrick, Joanna; Faull, Peter; Snijders, Ambrosius P.; Vermeulen, Michiel; Ralser, Markus; Ule, Jernej; Luscombe, Nicholas M.; van Werven, Folkert J. Share Save
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit Willis, Nicky J.; Mahy, William; Sipthorp, James; Zhao, Yuguang; Woodward, Hannah L.; Atkinson, Benjamin N.; Bayle, Elliott D.; Svensson, Fredrik; Frew, Sarah; Jeganathan, Fiona; Monaghan, Amy; Benvegnu, Stefano; Jolly, Sarah; Vecchia, Luca; Ruza, Reinis R.; Kjaer, Svend; Howell, Steven; Snijders, Ambrosius P.; Bictash, Magda; Salinas, Patricia C.; Vincent, Jean-Paul; Jones, E. Yvonne; Whiting, Paul; Fish, Paul, V Share Save
USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer Nelson, Jessica K.; Thin, May Zaw; Evan, Theodore; Howell, Steven; Wu, Mary; Almeida, Bruna; Legrave, Nathalie; Koenis, Duco S.; Koifman, Gabriela; Sugimoto, Yoichiro; Sopena, Miriam Llorian; MacRae, James; Nye, Emma; Howell, Michael; Snijders, Ambrosius P.; Prachalias, Andreas; Zen, Yoh; Sarker, Debashis; Behrens, Axel Share Save
Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study Fendler, Annika; Au, Lewis; Shepherd, Scott T. C.; Byrne, Fiona; Cerrone, Maddalena; Boos, Laura Amanda; Rzeniewicz, Karolina; Gordon, William; Shum, Benjamin; Gerard, Camille L.; Ward, Barry; Xie, Wenyi; Schmitt, Andreas M.; Joharatnam-Hogan, Nalinie; Cornish, Georgina H.; Pule, Martin; Mekkaoui, Leila; Ng, Kevin W.; Carlyle, Eleanor; Edmonds, Kim; Del Rosario, Lyra; Sarker, Sarah; Lingard, Karla; Mangwende, Mary; Holt, Lucy; Ahmod, Hamid; Stone, Richard; Gomes, Camila; Flynn, Helen R.; Agua-Doce, Ana; Hobson, Philip; Caidan, Simon; Howell, Michael; Wu, Mary; Goldstone, Robert; Crawford, Margaret; Cubitt, Laura; Patel, Harshil; Gavrielides, Mike; Nye, Emma; Snijders, Ambrosius P.; MacRae, James, I; Nicod, Jerome; Gronthoud, Firza; Shea, Robyn L.; Messiou, Christina; Cunningham, David; Chau, Ian; Starling, Naureen; Turner, Nicholas; Welsh, Liam; van As, Nicholas; Jones, Robin L.; Droney, Joanne; Banerjee, Susana; Tatham, Kate C.; Jhanji, Shaman; O'Brien, Mary; Curtis, Olivia; Harrington, Kevin; Bhide, Shreerang; Bazin, Jessica; Robinson, Anna; Stephenson, Clemency; Slattery, Tim; Khan, Yasir; Tippu, Zayd; Leslie, Isla; Gennatas, Spyridon; Okines, Alicia; Reid, Alison; Young, Kate; Furness, Andrew J. S.; Pickering, Lisa; Gandhi, Sonia; Gamblin, Steve; Swanton, Charles; Nicholson, Emma; Kumar, Sacheen; Yousaf, Nadia; Wilkinson, Katalin A.; Swerdlow, Anthony; Harvey, Ruth; Kassiotis, George; Larkin, James; Wilkinson, Robert J.; Turajlic, Samra Share Save
Development of a fluorogenic ADAMTS-7 substrate Santamaria, Salvatore; Buemi, Frederic; Nuti, Elisa; Cuffaro, Doretta; De Vita, Elena; Tuccinardi, Tiziano; Rossello, Armando; Howell, Steven; Mehmood, Shahid; Snijders, Ambrosius P.; de Groot, Rens Share Save
Translation stress and collided ribosomes are co-activators of cGAS Wan, Li; Juszkiewicz, Szymon; Blears, Daniel; Bajpe, Prashanth Kumar; Han, Zhong; Faull, Peter; Mitter, Richard; Stewart, Aengus; Snijders, Ambrosius P.; Hegde, Ramanujan S.; Svejstrup, Jesper Q. Share Save
Nascent RNA antagonizes the interaction of a set of regulatory proteins with chromatin Skalska, Lenka; Begley, Victoria; Beltran, Manuel; Lukauskas, Saulius; Khandelwal, Garima; Faull, Peter; Bhamra, Amandeep; Tavares, Manuel; Wellman, Rachel; Tvardovskiy, Andrey; Foster, Benjamin M.; de los Mozos, Igor Ruiz; Herrero, Javier; Surinova, Silvia; Snijders, Ambrosius P.; Bartke, Till; Jenner, Richard G. Share Save
Notum deacylates octanoylated ghrelin Zhao, Yuguang; Schuhmacher, Laura-Nadine; Roberts, Morgan; Kakugawa, Satoshi; Bineva-Todd, Ganka; Howell, Steve; O'Reilly, Nicola; Perret, Christine; Snijders, Ambrosius P.; Vincent, Jean-Paul; Jones, E. Yvonne Share Save
Phosphoproteomic identification of ULK substrates reveals VPS15-dependent ULK/VPS34 interplay in the regulation of autophagy Mercer, Thomas John; Ohashi, Yohei; Boeing, Stefan; Jefferies, Harold Bj; De Tito, Stefano; Flynn, Helen; Tremel, Shirley; Zhang, Wenxin; Wirth, Martina; Frith, David; Snijders, Ambrosius P.; Williams, Roger Lee; Tooze, Sharon A. Share Save
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