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J

Julian G. Hurdle

University of Tennessee Health Science Center

31H-index
80Paper Count
3.5KCitation Count
Published Papers 47
Publication Date
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Structural and Biochemical Characterization of Fusobacterium nucleatum Enoyl-ACP Reductase II (FabK) Reveals the Basis for Bacterial Species-Specific Inhibition
errACS BIO & MED CHEM AU
IF4.3
err2025-11-01
err0
PREAI
errAvad, Kristiana; Alaidi, Osama; Okpomo, Destiny; Pavel, Fahad Bin Aziz; Doran, Darcy; Matheson, Madeline; Sun, Dianqing; Hurdle, Julian; Hevener, Kirk E.
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The microbiome-restorative potential of ibezapolstat for the treatment of Clostridioides difficile infection is predicted through variant PolC-type DNA polymerase III in Lachnospiraceae and Oscillospiraceae
errANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
err2025-02-21
err0
errOAAI
errMcpherson, Jacob K.; Hurdle, Julian G.; Baker, Matthew L.; Hussain, Tahir; Kumar, Ashok; Garey, Kevin W.
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Fidaxomicin resistance in Clostridioides difficile: a systematic review and predictive modeling with RNA polymerase binding sites
errANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
err2024-12-05
err0
PREAI
errLe, ThanhPhuong M.; Eubank, Taryn A.; Mckelvey, Ann M.; Cao, Xinyun; Hurdle, Julian G.; Garey, Kevin W.
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Chemical genetic analysis of enoxolone inhibition of Clostridioides difficile toxin production reveals adenine deaminase and ATP synthase as antivirulence targets
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-11-01
err0
errOAAI
errMarreddy, Ravi K. R.; Phelps, Gregory A.; Churion, Kelly; Picker, Jonathan; Powell, Reid; Cherian, Philip T.; Bowling, John J.; Stephan, Clifford C.; Lee, Richard E.; Hurdle, Julian G.
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Reduced Vancomycin Susceptibility in Clostridioides difficile Is Associated With Specific Ribotypes
errOPEN FORUM INFECTIOUS DISEASES
IF3.8
err2024-10-10
err1
errOAAI
errEubank, Taryn A.; Dureja, Chetna; Gonzales-Luna, Anne J.; Hurdle, Julian G.; Garey, Kevin W.
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errSave
Evaluation of Fusobacterium nucleatum Enoyl-ACP Reductase (FabK) as a Narrow-Spectrum Drug Target
errACS INFECTIOUS DISEASES
IF3.8
err2024-04-10
err1
errOAAI
errRutherford, Jacob T.; Avad, Kristiana; Dureja, Chetna; Norseeda, Krissada; Gc, Bibek; Wu, Chenggang; Sun, Dianqing; Hevener, Kirk E.; Hurdle, Julian G.
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In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy
errANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
err2024-03-06
err3
errOAAI
errDureja, Chetna; Rutherford, Jacob T.; Pavel, Fahad B. A.; Norseeda, Krissada; Prah, Isaac; Sun, Dianqing; Hevener, Kirk E.; Hurdle, Julian G.
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Reduced Vancomycin Susceptibility in Clostridioides difficile Is Associated With Lower Rates of Initial Cure and Sustained Clinical Response
errCLINICAL INFECTIOUS DISEASES
IF7.3
err2024-02-21
err7
PREAI
errEubank, Taryn A.; Dureja, Chetna; Garey, Kevin W.; Hurdle, Julian G.; Gonzales-Luna, Anne J.
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Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile
errNATURE COMMUNICATIONS
IF15.7
err2023-07-12
err15
errOAAI
errOlaitan, Abiola O.; Dureja, Chetna; Youngblom, Madison A.; Topf, Madeline A.; Shen, Wan-Jou; Gonzales-Luna, Anne J.; Deshpande, Aditi; Hevener, Kirk E.; Freeman, Jane; Wilcox, Mark H.; Palmer, Kelli L.; Garey, Kevin W.; Pepperell, Caitlin S.; Hurdle, Julian G.
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Synthesis and evaluation of phenylimidazole FabK inhibitors as new Anti-C. Difficile agents
errBIOORGANIC & MEDICINAL CHEMISTRY
IF3
err2023-06-01
err3
PREAI
errNorseeda, Krissada; Pavel, Fahad Bin Aziz; Rutherford, Jacob T.; Meer, Humna N.; Dureja, Chetna; Hurdle, Julian G.; Hevener, Kirk E.; Sun, Dianqing
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Surveillance of Clostridioides difficile Antimicrobial Resistance in the United States
errCLINICAL INFECTIOUS DISEASES
IF7.3
err2023-03-08
err4
errOAAI
errGonzales-Luna, Anne J.; Dureja, Chetna; Eubank, Taryn A.; Garey, Kevin W.; Hurdle, Julian G.
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errSave
Mechanisms and impact of antimicrobial resistance in Clostridioides difficile
errCURRENT OPINION IN MICROBIOLOGY
IF7.5
err2022-04-01
err21
errOAAI
errDureja, Chetna; Olaitan, Abiola O.; Hurdle, Julian G.
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errSave
Genetic Mechanisms of Vancomycin Resistance in Clostridioides difficile: A Systematic Review
errANTIBIOTICS-BASEL
IF4.6
err2022-02-16
err25
errOAAI
errEubank, Taryn A.; Gonzales-Luna, Anne J.; Hurdle, Julian G.; Garey, Kevin W.
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errSave
Ebselen Not Only Inhibits Clostridioides difficile Toxins but Displays Redox-Associated Cellular Killing
errMICROBIOLOGY SPECTRUM
IF3.8
err2021-10-31
err9
errOAAI
errMarreddy, Ravi K. R.; Olaitan, Abiola O.; May, Jordan N.; Dong, Min; Hurdle, Julian G.
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errSave
The Integrity of Heme Is Essential for Reproducible Detection o Metronidazole-Resistant Clostridioides difficile by Agar Dilution Susceptibility Tests
errJOURNAL OF CLINICAL MICROBIOLOGY
IF5.4
err2021-08-18
err19
errOAAI
errWu, Xiaoqian; Shen, Wan-Jou; Deshpande, Aditi; Olaitan, Abiola O.; Palmer, Kelli L.; Garey, Kevin W.; Hurdle, Julian G.
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errSave
Reduced Susceptibility to Metronidazole Is Associated With Initial Clinical Failure in Clostridioides dificile Infection
errOPEN FORUM INFECTIOUS DISEASES
IF3.8
err2021-07-08
err20
errOAAI
errGonzales-Luna, Anne J.; Olaitan, Abiola O.; Shen, Wan-Jou; Deshpande, Aditi; Carlson, Travis J.; Dotson, Kierra M.; Lancaster, Chris; Begum, Khurshida; Alam, M. Jahangir; Hurdle, Julian G.; Garey, Kevin W.
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Chromosomal Resistance to Metronidazole in Clostridioides difficile Can Be Mediated by Epistasis between Iron Homeostasis and Oxidoreductases
errANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
err2020-07-22
err27
errOAAI
errDeshpande, Aditi; Wu, Xiaoqian; Huo, Wenwen; Palmer, Kelli L.; Hurdle, Julian G.
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errSave
Constitutive expression of the cryptic vanGCd operon promotes vancomycin resistance in Clostridioides difficile clinical isolates
errJOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
IF3.6
err2019-12-24
err49
errOAAI
errShen, Wan-Jou; Deshpande, Aditi; Hevener, Kirk E.; Endres, Bradley T.; Garey, Kevin W.; Palmer, Kelli L.; Hurdle, Julian G.
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errSave
Small-Molecule Inhibition of the C. difficile FAS-II Enzyme, FabK, Results in Selective Activity
errACS CHEMICAL BIOLOGY
IF3.8
err2019-06-11
err9
errOAAI
errJones, Jesse A.; Prior, Allan M.; Marreddy, Ravi K. R.; Wahrmund, Rebecca D.; Hurdle, Julian G.; Sun, Dianqing; Hevener, Kirk E.
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errSave
Epidemic Clostridioides difficile Ribotype 027 Lineages: Comparisons of Texas Versus Worldwide Strains
errOPEN FORUM INFECTIOUS DISEASES
IF3.8
err2019-02-09
err12
errOAAI
errEndres, Bradley T.; Begum, Khurshida; Sun, Hua; Walk, Seth T.; Memariani, Ali; Lancaster, Chris; Gonzales-Luna, Anne J.; Dotson, Kierra M.; Basseres, Eugenie; Offiong, Charlene; Tupy, Shawn; Kuper, Kristi; Septimus, Edward; Arafat, Raouf; Alam, M. Jahangir; Zhao, Zhongming; Hurdle, Julian G.; Savidge, Tor C.; Garey, Kevin W.
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Research Directions

No research directions
Co-authors
Cooperation Journals
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Mark H. Wilcox
H-index: 96 · Papers: 717
J
John M. Pezzuto
H-index: 95 · Papers: 656
C
Charles O. Rock
H-index: 92 · Papers: 365
R
Richard Lee
H-index: 91 · Papers: 1.6K
Z
Zhongming Zhao
H-index: 86 · Papers: 1.1K
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