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Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton Mouery, Ryan D.; Lukasik, Kimberly; Hsu, Carolyn; Bonacci, Thomas; Bolhuis, Derek L.; Wang, Xianxi; Mills, C. Allie; Toomer, E. Drew; Canterbury, Owen G.; Robertson, Kevin C.; Branigan, Timothy B.; Brown, Nicholas G.; Herring, Laura E.; Gupton, Stephanie L.; Emanuele, Michael J. Share Save
A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins Lu, Xiuxiu; Chandravanshi, Monika; Sabbasani, Venkata R.; Gaikwad, Snehal; Hughitt, V. Keith; Gyabaah-Kessie, Nana; Scroggins, Bradley T.; Das, Sudipto; Myint, Wazo; Clapp, Michelle E.; Schwieters, Charles D.; Dyba, Marzena A.; Bolhuis, Derek L.; Koscielniak, Janusz W.; Andresson, Thorkell; Emanuele, Michael J.; Brown, Nicholas G.; Matsuo, Hiroshi; Chari, Raj; Citrin, Deborah E.; Mock, Beverly A.; Swenson, Rolf E.; Walters, Kylie J. Share Save
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The anaphase-promoting complex controls a ubiquitination-phosphoprotein axis in chromatin during neurodevelopment Ledvin, Leya; Gassaway, Brandon M.; Tawil, Jonathan; Urso, Olivia; Pizzo, Donald; Welsh, Kaeli A.; Bolhuis, Derek L.; Fisher, Daniel; Bonni, Azad; Gygi, Steven P.; Brown, Nicholas G.; Ferguson, Cole J. Share Save
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Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C) Bodrug, Tatyana; Welsh, Kaeli A.; Bolhuis, Derek L.; Paulakonis, Ethan; Martinez-Chacin, Raquel C.; Liu, Bei; Pinkin, Nicholas; Bonacci, Thomas; Cui, Liying; Xu, Pengning; Roscow, Olivia; Amann, Sascha Josef; Grishkovskaya, Irina; Emanuele, Michael J.; Harrison, Joseph S.; Steimel, Joshua P.; Hahn, Klaus M.; Zhang, Wei; Zhong, Ellen D.; Haselbach, David; Brown, Nicholas G. Share Save
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Cryo-EM structure of the plant 26S proteasome Kandolf, Susanne; Grishkovskaya, Irina; Belacic, Katarina; Bolhuis, Derek L.; Amann, Sascha; Foster, Brent; Imre, Richard; Mechtler, Karl; Schleiffer, Alexander; Tagare, Hemant D.; Zhong, Ellen D.; Meinhart, Anton; Brown, Nicholas G.; Haselbach, David Share Save
Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes Welsh, Kaeli A.; Bolhuis, Derek L.; Nederstigt, Anneroos E.; Boyer, Joshua; Temple, Brenda R. S.; Bonacci, Thomas; Gu, Li; Ordureau, Alban; Harper, J. Wade; Steimel, Joshua P.; Zhang, Qi; Emanuele, Michael J.; Harrison, Joseph S.; Brown, Nicholas G. Share Save
Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming Martinez-Chacin, Raquel C.; Bodrug, Tatyana; Bolhuis, Derek L.; Kedziora, Katarzyna M.; Bonacci, Thomas; Ordureau, Alban; Gibbs, Morgan E.; Weissmann, Florian; Qiao, Renping; Grant, Gavin D.; Cook, Jeanette G.; Peters, Jan-Michael; Harper, J. Wade; Emanuele, Michael J.; Brown, Nicholas G. Share Save
Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site Watson, Edmond R.; Grace, Christy R. R.; Zhang, Wei; Miller, Darcie J.; Davidson, Iain F.; Prabu, J. Rajan; Yu, Shanshan; Bolhuis, Derek L.; Kulko, Elizaveta T.; Vollrath, Ronnald; Haselbach, David; Stark, Holger; Peters, Jan-Michael; Brown, Nicholas G.; Sidhu, Sachdev S.; Schulman, Brenda A. Share Save
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