Not logged in Inhibition of an Alzheimer's disease-associated form of necroptosis rescues neuronal death in mouse models Koper, Marta J.; Moonen, Sebastiaan; Ronisz, Alicja; Ospitalieri, Simona; Callaerts-Vegh, Zsuzsanna; T'Syen, Dries; Rabe, Sabine; Staufenbiel, Matthias; De Strooper, Bart; Balusu, Sriram; Thal, Dietmar Rudolf Share Save
Signatures of glial activity can be detected in the CSF proteome Eninger, Timo; Mueller, Stephan A.; Bacioglu, Mehtap; Schweighauser, Manuel; Lambert, Marius; Maia, Luis F.; Neher, Jonas J.; Hornfeck, Sarah M.; Obermueller, Ulrike; Kleinberger, Gernot; Haass, Christian; Kahle, Philipp J.; Staufenbiel, Matthias; Ping, Lingyan; Duong, Duc M.; Levey, Allan, I; Seyfried, Nicholas T.; Lichtenthaler, Stefan F.; Jucker, Mathias; Kaeser, Stephan A. Share Save
Synthesis of the Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor NB-360 Rueeger, Heinrich; Lueoend, Rainer; Machauer, Rainer; Veenstra, Siem J.; Holzer, Philipp; Hurth, Konstanze; Voegtle, Markus; Frederiksen, Mathias; Rondeau, Jean-Michel; Tintelnot-Blomley, Marina; Jacobson, Laura H.; Staufenbiel, Matthias; Laue, Grit; Neumann, Ulf Share Save
Early Aβ reduction prevents progression of cerebral amyloid angiopathy Schelle, Juliane; Wegenast-Braun, Bettina M.; Fritschi, Sarah K.; Kaeser, Stephan A.; Jaehrling, Nina; Eicke, Daniel; Skodras, Angelos; Beschorner, Natalie; Obermueller, Ulrike; Haesler, Lisa M.; Wolfer, David P.; Mueggler, Thomas; Shimshek, Derya R.; Neumann, Ulf; Dodt, Hans-Ulrich; Staufenbiel, Matthias; Jucker, Mathias Share Save
Aβ-induced acceleration of Alzheimer-related τ-pathology spreading and its association with prion protein Gomes, Luis Aragao; Hipp, Silvia Andrea; Upadhaya, Ajeet Rijal; Balakrishnan, Karthikeyan; Ospitalieri, Simona; Koper, Marta J.; Largo-Barrientos, Pablo; Uytterhoeven, Valerie; Reichwald, Julia; Rabe, Sabine; Vandenberghe, Rik; von Arnim, Christine A. F.; Tousseyn, Thomas; Feederle, Regina; Giudici, Camilla; Willem, Michael; Staufenbiel, Matthias; Thal, Dietmar Rudolf Share Save
Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing Dinamarca, Margarita C.; Raveh, Adi; Schneider, Andy; Fritzius, Thorsten; Frueh, Simon; Rem, Pascal D.; Stawarski, Michal; Lalanne, Txomin; Turecek, Rostislav; Choo, Myeongjeong; Besseyrias, Valerie; Bildl, Wolfgang; Bentrop, Detlef; Staufenbiel, Matthias; Gassmann, Martin; Fakler, Bernd; Schwenk, Jochen; Bettler, Bernhard Share Save
The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease Neumann, Ulf; Ufer, Mike; Jacobson, Laura H.; Rouzade-Dominguez, Marie-Laure; Huledal, Gunilla; Kolly, Carine; Luond, Rainer M.; Machauer, Rainer; Veenstra, Siem J.; Hurth, Konstanze; Rueeger, Heinrich; Tintelnot-Blomley, Marina; Staufenbiel, Matthias; Shimshek, Derya R.; Perrot, Ludovic; Frieauff, Wilfried; Dubost, Valerie; Schiller, Hilmar; Vogg, Barbara; Beltz, Karen; Avrameas, Alexandre; Kretz, Sandrine; Pezous, Nicole; Rondeau, Jean-Michel; Beckmann, Nicolau; Hartmann, Andreas; Vormfelde, Stefan; David, Olivier J.; Galli, Bruno; Ramos, Rita; Graf, Ana; Lopez, Cristina Lopez Share Save
Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease Rasmussen, Jay; Mahler, Jasmin; Beschorner, Natalie; Kaeser, Stephan A.; Haesler, Lisa M.; Baumann, Frank; Nystrom, Sofie; Portelius, Erik; Blennow, Kaj; Lashley, Tammaryn; Fox, Nick C.; Sepulveda-Falla, Diego; Glatzel, Markus; Oblak, Adrian L.; Ghetti, Bernardino; Nilsson, K. Peter R.; Hammarstrom, Per; Staufenbiel, Matthias; Walker, Lary C.; Jucker, Mathias Share Save
BACE inhibition-dependent repair of Alzheimer's pathophysiology Keskin, Aylin D.; Kekus, Maja; Adelsberger, Helmuth; Neumann, Ulf; Shimshek, Derya R.; Song, Beomjong; Zott, Benedikt; Peng, Tingying; Foerstl, Hans; Staufenbiel, Matthias; Nelken, Israel; Sakmann, Bert; Konnerth, Arthur; Busche, Marc Aurel Share Save
Aβ seeding potency peaks in the early stages of cerebral β-amyloidosis Ye, Lan; Rasmussen, Jay; Kaeser, Stephan A.; Marzesco, Anne-Marie; Obermueller, Ulrike; Mahler, Jasmin; Schelle, Juliane; Odenthal, Joerg; Krueger, Christian; Fritschi, Sarah K.; Walker, Lary C.; Staufenbiel, Matthias; Baumann, Frank; Jucker, Mathias Share Save
Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition Schelle, Juliane; Haesler, Lisa M.; Goepfert, Jens C.; Joos, Thomas O.; Vanderstichele, Hugo; Stoops, Erik; Mandelkow, Eva-Maria; Neumann, Ulf; Shimshek, Derya R.; Staufenbiel, Matthias; Jucker, Mathias; Kaeser, Stephan A. Share Save
Longitudinal noninvasive magnetic resonance imaging of brain microhemorrhages in BACE inhibitore-treated APP transgenic mice Beckmann, Nicolau; Doelemeyer, Arno; Zurbruegg, Stefan; Bigot, Karine; Theil, Diethilde; Frieauff, Wilfried; Kolly, Carine; Moulin, Pierre; Neddermann, Daniel; Kreutzer, Robert; Perrot, Ludovic; Brzak, Irena; Jacobson, Laura H.; Staufenbiel, Matthias; Neumann, Ulf; Shimshek, Derya R. Share Save
Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases (vol 91, pg 56, 2016) Bacioglu, Mehtap; Maia, Luis F.; Preische, Oliver; Schelle, Juliane; Apel, Anja; Kaeser, Stephan A.; Schweighauser, Manuel; Eninger, Timo; Lambert, Marius; Pilotto, Andrea; Shimshek, Derya R.; Neumann, Ulf; Kahle, Philipp J.; Staufenbiel, Matthias; Neumann, Manuela; Maetzler, Walter; Kuhle, Jens; Jucker, Mathias Share Save
Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases Bacioglu, Mehtap; Maia, Luis F.; Preische, Oliver; Schelle, Juliane; Apel, Anja; Kaeser, Stephan A.; Schweighauser, Manuel; Eninger, Timo; Lambert, Marius; Pilotto, Andrea; Shimshek, Derya R.; Neumann, Ulf; Kahle, Philipp J.; Staufenbiel, Matthias; Neumann, Manuela; Maetzler, Walter; Kuhle, Jens; Jucker, Mathias Share Save
Share Save
Share Save
Co-expression of truncated and full-length tau induces severe neurotoxicity Ozcelik, S.; Sprenger, F.; Skachokova, Z.; Fraser, G.; Abramowski, D.; Clavaguera, F.; Probst, A.; Frank, S.; Mueller, M.; Staufenbiel, M.; Goedert, M.; Tolnay, M.; Winkler, D. T. Share Save
A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice Neumann, Ulf; Rueeger, Heinrich; Machauer, Rainer; Veenstra, Siem Jacob; Lueoend, Rainer M.; Tintelnot-Blomley, Marina; Laue, Grit; Beltz, Karen; Vogg, Barbara; Schmid, Peter; Frieauff, Wilfried; Shimshek, Derya R.; Staufenbiel, Matthias; Jacobson, Laura H. Share Save
Impact of amyloid β aggregate maturation on antibody treatment in APP23 mice Balakrishnan, Karthikeyan; Upadhaya, Ajeet Rijal; Steinmetz, Julia; Reichwald, Julia; Abramowski, Dorothee; Faendrich, Marcus; Kumar, Sathish; Yamaguchi, Haruyasu; Walter, Jochen; Staufenbiel, Matthias; Thal, Dietmar Rudolf Share Save
Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice Mahler, Jasmin; Morales-Corraliza, Jose; Stolz, Julia; Skodras, Angelos; Radde, Rebecca; Duma, Carmen C.; Eisele, Yvonne S.; Mazzella, Matthew J.; Wong, Harrison; Klunk, William E.; Nilsson, K. Peter R.; Staufenbiel, Matthias; Mathews, Paul M.; Jucker, Mathias; Wegenast-Braun, Bettina M. Share Save
.png){kind=icon}
.png){kind=icon}
Not logged in.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
