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Design and Characterization of a Novel Intravitreal Dual-Transgene Genetic Medicine for Neovascular Retinopathies Calton, Melissa A.; Croze, Roxanne H.; Burns, Christian; Beliakoff, Ghezal; Vazin, Tandis; Szymanski, Paul; Schmitt, Christopher; Klein, Austin; Leong, Meredith; Quezada, Melissa; Holt, Jenny; Bolender, Gabe; Barglow, Katherine; Khoday, Devi; Mason, Thomas; Delaria, Katherine; Hassanipour, Mohammad; Kotterman, Melissa; Khanani, Arshad M.; Schaffer, David; Francis, Peter; Kirn, David Share Save
Thrombotic microangiopathy following systemic AAV administration is dependent on anti-capsid antibodies Salabarria, Stephanie M.; Corti, Manuela; Coleman, Kirsten E.; Wichman, Megan B.; Berthy, Julie A.; D'Souza, Precilla; Tifft, Cynthia J.; Herzog, Roland W.; Elder, Melissa E.; Shoemaker, Lawrence R.; Leon-Astudillo, Carmen; Tavakkoli, Fatemeh; Kirn, David H.; Schwartz, Jonathan D.; Byrne, Barry J. Share Save
Transduction and AGA expression by 4D-310, an AAV genetic medicine, in the hearts and kidneys of nonhuman primates and Gla knockout mice: Efficient delivery to cardiomyocytes and glomeruli, including podocytes Sullivan, Theodore; Tucker, Sarah; Nguyen, Kien; Croze, Roxanne; Song, An; Whittlesey, Kevin; Francis, Peter; Kirn, David Share Save
Cardiac effects of 4D-310 in adults with Fabry disease in a phase 1/2 clinical trial: Functional, quality of life, and imaging endpoints in patients with 12 months of follow up Schiffmann, Raphael; Goker-Alpan, Ozlem; Vockley, Jerry; Wilcox, William R.; Ortiz, Damara; Nie, Molly; Shen, Jinsong; Tavakkoli, Fatemeh; Kirn, David; Fishman, Robert Share Save
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Oncolytic Vaccinia Virus Gene Modification and Cytokine Expression Effects on Tumor Infection, Immune Response, and Killing Inoue, Tomoyoshi; Byrne, Thomas; Inoue, Mitsuko; Tait, Madeline E.; Wall, Patrick; Wang, Annabel; Dermyer, Michael R.; Laklai, Hanane; Binder, Joseph J.; Lees, Clare; Hollingsworth, Robert; Maruri-Avidal, Liliana; Kirn, David H.; McDonald, Donald M. Share Save
Vaccinia-based oncolytic immunotherapy Pexastimogene Devacirepvec in patients with advanced hepatocellular carcinoma after sorafenib failure: a randomized multicenter Phase IIb trial (TRAVERSE) Moehler, M.; Heo, J.; Lee, H. C.; Tak, W. Y.; Chao, Y.; Paik, S. W.; Yim, H. J.; Byun, K. S.; Baron, A.; Ungerechts, G.; Jonker, D.; Ruo, L.; Cho, M.; Kaubisch, A.; Wege, H.; Merle, P.; Ebert, O.; Habersetzer, F.; Blanc, J. F.; Rosmorduc, Olivier; Lencioni, R.; Patt, R.; Leen, A. M.; Foerster, F.; Homerin, M.; Stojkowitz, N.; Lusky, M.; Limacher, J. M.; Hennequi, M.; Gaspar, N.; McFadden, B.; De Silva, N.; Shen, D.; Pelusio, A.; Kirn, D. H.; Breitbach, C. J.; Burke, J. M. Share Save
Amplification of Oncolytic Vaccinia Virus Widespread Tumor Cell Killing by Sunitinib through Multiple Mechanisms Kim, Minah; Nitschke, Maximilian; Sennino, Barbara; Murer, Patrizia; Schriver, Brian J.; Bell, Alexander; Subramanian, Aishwarya; McDonald, Corry E.; Wang, Jiahu; Cha, Howard; Bourgeois-Daigneault, Marie-Claude; Kirn, David H.; Bell, John C.; De Silva, Naomi; Breitbach, Caroline J.; McDonald, Donald M. Share Save
Intratumoral injection of the oncolytic immunotherapeutic Pexa-Vec (JX-594) in liver tumors and hepatocellular carcinoma: Recommendations for clinical practice Lencioni, R.; Kim, C. W.; Rose, S. C.; Breitbach, C. J.; Burke, J. M.; Hickman, T.; Kirn, D. H.; Stojkowitz, N.; Lusky, M.; Homerin, M. Share Save
Phase 1b Trial of Biweekly Intravenous Pexa-Vec (JX-594), an Oncolytic and Immunotherapeutic Vaccinia Virus in Colorectal Cancer Park, Se Hoon; Breitbach, Caroline J.; Lee, Jeeyun; Park, Joon Oh; Lim, Ho Yeong; Kang, Won Ki; Moon, Anne; Mun, Jae-Hee; Sommermann, Erica M.; Avidal, Liliana Maruri; Patt, Rick; Pelusio, Adina; Burke, James; Hwang, Tae-Ho; Kirn, David; Park, Young Suk Share Save
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Complement Inhibition Prevents Oncolytic Vaccinia Virus Neutralization in Immune Humans and Cynomolgus Macaques Evgin, Laura; Acuna, Sergio A.; de Souza, Christiano Tanese; Marguerie, Monique; Lemay, Chantal G.; Ilkow, Carolina S.; Findlay, C. Scott; Falls, Theresa; Parato, Kelley A.; Hanwell, David; Goldstein, Alyssa; Lopez, Roberto; Lafrance, Sandra; Breitbach, Caroline J.; Kirn, David; Atkins, Harold; Auer, Rebecca C.; Thurman, Joshua M.; Stahl, Gregory L.; Lambris, John D.; Bell, John C.; McCart, J. Andrea Share Save
Phase 1 Study of Intratumoral Pexa-Vec (JX-594), an Oncolytic and Immunotherapeutic Vaccinia Virus, in Pediatric Cancer Patients Cripe, Timothy P.; Ngo, Minhtran C.; Geller, James I.; Louis, Chrystal U.; Currier, Mark A.; Racadio, John M.; Towbin, Alexander J.; Rooney, Cliona M.; Pelusio, Adina; Moon, Anne; Hwang, Tae-Ho; Burke, James M.; Bell, John C.; Kirn, David H.; Breitbach, Caroline J. Share Save
First-in-man Study of Western Reserve Strain Oncolytic Vaccinia Virus: Safety, Systemic Spread, and Antitumor Activity Zeh, Herbert J.; Downs-Canner, Stephanie; McCart, J. Andrea; Guo, Zong Sheng; Rao, Uma N. M.; Ramalingam, Lekshmi; Thorne, Stephen H.; Jones, Heather L.; Kalinski, Pawel; Wieckowski, Eva; O'Malley, Mark E.; Daneshmand, Manijeh; Hu, Kang; Bell, John C.; Hwang, Tae-Ho; Moon, Anne; Breitbach, Caroline J.; Kirn, David H.; Bartlett, David L. Share Save
Oncolytic and Immunotherapeutic Vaccinia Induces Antibody-Mediated Complement-Dependent Cancer Cell Lysis in Humans Kim, Mi Kyung; Breitbach, Caroline J.; Moon, Anne; Heo, Jeong; Lee, Yu Kyoung; Cho, Mong; Lee, Jun Woo; Kim, Seong-Geun; Kang, Dae Hwan; Bell, John C.; Park, Byeong Ho; Kirn, David H.; Hwang, Tae-Ho Share Save
Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans Breitbach, Caroline J.; Arulanandam, Rozanne; De Silva, Naomi; Thorne, Steve H.; Patt, Richard; Daneshmand, Manijeh; Moon, Anne; Ilkow, Carolina; Burke, James; Hwang, Tae-Ho; Heo, Jeong; Cho, Mong; Chen, Hannah; Angarita, Fernando A.; Addison, Christina; McCart, J. Andrea; Bell, John C.; Kirn, David H. Share Save
Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer Heo, Jeong; Reid, Tony; Ruo, Leyo; Breitbach, Caroline J.; Rose, Steven; Bloomston, Mark; Cho, Mong; Lim, Ho Yeong; Chung, Hyun Cheol; Kim, Chang Won; Burke, James; Lencioni, Riccardo; Hickman, Theresa; Moon, Anne; Lee, Yeon Sook; Kim, Mi Kyeong; Daneshmand, Manijeh; Dubois, Kara; Longpre, Lara; Ngo, Minhtran; Rooney, Cliona; Bell, John C.; Rhee, Byung-Geon; Patt, Richard; Hwang, Tae-Ho; Kirn, David H. Share Save
The Oncolytic Poxvirus JX-594 Selectively Replicates in and Destroys Cancer Cells Driven by Genetic Pathways Commonly Activated in Cancers Parato, Kelley A.; Breitbach, Caroline J.; Le Boeuf, Fabrice; Wang, Jiahu; Storbeck, Chris; Ilkow, Carolina; Diallo, Jean-Simon; Falls, Theresa; Burns, Joseph; Garcia, Vanessa; Kanji, Femina; Evgin, Laura; Hu, Kang; Paradis, Francois; Knowles, Shane; Hwang, Tae-Ho; Vanderhyden, Barbara C.; Auer, Rebecca; Kirn, David H.; Bell, John C. Share Save
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