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Mapping Disease Transitions from Premalignant, Asymptomatic to Advanced Myeloma through Integrative Epigenomic and Transcriptional Analyses Kurowska, Aleksandra; Bantan, Azari; Shuwaikan, Raghad; Cenzano, Itziar; Aguirre-Ruiz, Paula; Miranda, Estibaliz; Garate, Leire; Vilas-Zornoza, Amaia; San-Martin, Patxi; Larrayoz, Marta; Gomez-Echarte, Nahia; Ariceta, Benat; Ortiz, Daniel Soto; Sobahy, Turki; Martin-Subero, Jose Ignacio; Lagani, Vincenzo; Tegner, Jesper; Martinez-Climent, Jose A.; Agirre, Xabier; Arrazola, Mikel Hernaez; Prosper, Felipe; Gomez-Cabrero, David Share Save
BET inhibitors downregulate the expression of the essentiallncRNA SMILO in multiple myeloma through regulation of the transcription factor FLI1 Gomez-Echarte, Nahia; San Jose-Eneriz, Edurne; Carrasco-Leon, Arantxa; Barrena, Naroa; Miranda, Estibaliz; Garate, Leire; Garcia-Torre, Beatriz; Alonso-Moreno, Sandra; Gimenez-Camino, Naroa; Urizar-Compains, Estibaliz; Olaverri-Mendizabal, Danel; Aguirre-Ruiz, Paula; Ariceta, Benat; Tamariz-Amador, Luis-Esteban; Rodriguez-Otero, Paula; Planes, Francisco J.; Belver, Laura; Martin-Subero, Jose Ignacio; Prosper, Felipe; Agirre, Xabier Share Save
Epigenetic-based differentiation therapy for Acute Myeloid Leukemia San Jose-Eneriz, Edurne; Gimenez-Camino, Naroa; Rabal, Obdulia; Garate, Leire; Miranda, Estibaliz; Gomez-Echarte, Nahia; Garcia, Fernando; Charalampopoulou, Stella; Saez, Elena; Vilas-Zornoza, Amaia; San Martin-Uriz, Patxi; Valcarcel, Luis V.; Barrena, Naroa; Alignani, Diego; Tamariz-Amador, Luis Esteban; Perez-Ruiz, Ana; Hilscher, Sebastian; Schutkowski, Mike; Alfonso-Pierola, Ana; Martinez-Calle, Nicolas; Larrayoz, Maria Jose; Paiva, Bruno; Calasanz, Maria Jose; Munoz, Javier; Isasa, Marta; Martin-Subero, Jose Ignacio; Pineda-Lucena, Antonio; Oyarzabal, Julen; Agirre, Xabier; Prosper, Felipe Share Save
Revealing cell populations catching the early stages of human embryo development in naive pluripotent stem cell cultures Moya-Jodar, Marta; Ullate-Agote, Asier; Barlabe, Paula; Rodriguez-Madoz, Juan Roberto; Abizanda, Gloria; Barreda, Carolina; Carvajal-Vergara, Xonia; Vilas-Zornoza, Amaia; Romero, Juan Pablo; Garate, Leire; Agirre, Xabier; Coppiello, Giulia; Prosper, Felipe; Aranguren, Xabier L. Share Save
Landscape and clinical significance of long noncoding RNAs involved in multiple myeloma expressed fusion transcripts Amundarain, Ane; Valcarcel, Luis V.; Ordonez, Raquel; Garate, Leire; Miranda, Estibaliz; Cendoya, Xabier; Carrasco-Leon, Arantxa; Calasanz, Maria Jose; Paiva, Bruno; Meydan, Cem; Mason, Christopher E.; Melnick, Ari; Rodriguez-Otero, Paula; Martin-Subero, Jose I.; San Miguel, Jesus; Planes, Francisco J.; Prosper, Felipe; Agirre, Xabier Share Save
Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with In Vivo Efficacy in Multiple Myeloma Rabal, Obdulia; San Jose-Eneriz, Edurne; Agirre, Xabier; Antonio Sanchez-Arias, Juan; de Miguel, Irene; Ordonez, Raquel; Garate, Leire; Miranda, Estibaliz; Saez, Elena; Vilas-Zornoza, Amaia; Pineda-Lucena, Antonio; Estella, Ander; Zhang, Feifei; Wu, Wei; Xu, Musheng; Prosper, Felipe; Oyarzabal, Julen Share Save
Characterization of complete lncRNAs transcriptome reveals the functional and clinical impact of lncRNAs in multiple myeloma Carrasco-Leon, Arantxa; Ezponda, Teresa; Meydan, Cem; Valcarcel, Luis V.; Ordonez, Raquel; Kulis, Marta; Garate, Leire; Miranda, Estibaliz; Segura, Victor; Guruceaga, Elisabeth; Vilas-Zornoza, Amaia; Alignani, Diego; Pascual, Marien; Amundarain, Ane; Castro-Labrador, Laura; San Martin-Uriz, Patxi; El-Omri, Halima; Taha, Ruba Y.; Calasanz, Maria J.; Planes, Francisco J.; Paiva, Bruno; Mason, Christopher E.; San Miguel, Jesus F.; Martin-Subero, Jose, I; Melnick, Ari; Prosper, Felipe; Agirre, Xabier Share Save
Chromatin activation as a unifying principle underlying pathogenic mechanisms in multiple myeloma Ordonez, Raquel; Kulis, Marta; Russinol, Nuria; Chapaprieta, Vicente; Carrasco-Leon, Arantxa; Garcia-Torre, Beatriz; Charalampopoulou, Stella; Clot, Guillem; Beekman, Renee; Meydan, Cem; Duran-Ferrer, Marti; Verdaguer-Dot, Nuria; Vilarrasa-Blasi, Roser; Soler-Vila, Paula; Garate, Leire; Miranda, Estibaliz; San Jose-Eneriz, Edurne; Rodriguez-Madoz, Juan R.; Ezponda, Teresa; Martinez-Turrilas, Rebeca; Vilas-Zornoza, Amaia; Lara-Astiaso, David; Dupere-Richer, Daphne; Martens, Joost H. A.; El-Omri, Halima; Taha, Ruba Y.; Calasanz, Maria J.; Paiva, Bruno; San Miguel, Jesus; Flicek, Paul; Gut, Ivo; Melnick, Ari; Mitsiades, Constantine S.; Licht, Jonathan D.; Campo, Elias; Stunnenberg, Hendrik G.; Agirre, Xabier; Prosper, Felipe; Martin-Subero, Jose, I Share Save
Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression Segovia, Cristina; San Jose-Eneriz, Edurne; Munera-Maravilla, Ester; Martinez-Fernandez, Monica; Garate, Leire; Miranda, Estibaliz; Vilas-Zornoza, Amaia; Lodewijk, Iris; Rubio, Carolina; Segrelles, Carmen; Vitores Valcarcel, Luis; Rabal, Obdulia; Casares, Noelia; Bernardini, Alejandra; Suarez-Cabrera, Cristian; Lopez-Calderon, Fernando F.; Fortes, Puri; Casado, Jose A.; Duenas, Marta; Villacampa, Felipe; Jose Lasarte, Juan; Guerrero-Ramos, Felix; de Velasco, Guillermo; Oyarzabal, Julen; Castellano, Daniel; Agirre, Xabier; Prosper, Felipe; Paramio, Jesus M. Share Save
Long non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response Agirre, Xabier; Meydan, Cem; Jiang, Yanwen; Garate, Leire; Doane, Ashley S.; Li, Zhuoning; Verma, Akanksha; Paiva, Bruno; Martin-Subero, Jose I.; Elemento, Olivier; Mason, Christopher E.; Prosper, Felipe; Melnick, Ari Share Save
Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy Rabal, Obdulia; San Jose-Eneriz, Edurne; Agirre, Xabier; Antonio Sanchez-Arias, Juan; Vilas-Zornoza, Amaia; Ugarte, Ana; de Miguel, Irene; Miranda, Estibaliz; Garate, Leire; Fraga, Mario; Santamarina, Pablo; Fernandez Perez, Raul; Ordonez, Raquel; Saez, Elena; Roa, Sergio; Jose Garcia-Barchino, Maria; Angel Martinez-Climent, Jose; Liu, Yingying; Wu, Wei; Xu, Musheng; Prosper, Felipe; Oyarzabal, Julen Share Save
Detailed Exploration around 4-Aminoquinolines Chemical Space to Navigate the Lysine Methyltransferase G9a and DNA Methyltransferase Biological Spaces Rabal, Obdulia; Antonio Sanchez-Arias, Juan; San Jose-Eneriz, Edurne; Agirre, Xabier; de Miguel, Irene; Garate, Leire; Miranda, Estibaliz; Saez, Elena; Roa, Sergio; Angel Martinez-Climent, Jose; Liu, Yingying; Wu, Wei; Xu, Musheng; Prosper, Felipe; Oyarzabal, Julen Share Save
In-silico gene essentiality analysis of polyamine biosynthesis reveals APRT as a potential target in cancer Pey, Jon; San Jose-Eneriz, Edurne; Carmen Ochoa, Maria; Apaolaza, Inigo; de Atauri, Pedro; Rubio, Angel; Cendoya, Xabier; Miranda, Estibaliz; Garate, Leire; Cascante, Marta; Carracedo, Arkaitz; Agirre, Xabier; Prosper, Felipe; Planes, Francisco J. Share Save
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ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia (vol 25, pg 1862, 2006) Agirre, X.; Roman-Gomez, J.; Jimenez-Velasco, A.; Garate, L.; Montiel-Duarte, C.; Navarro, G.; Vazquez, I.; Zalacain, M.; Calasanz, M. J.; Heiniger, A.; Torres, A.; Minna, J. D.; Prosper, F. Share Save
Preclinical activity of LBH589 alone or in combination with chemotherapy in a xenogeneic mouse model of human acute lymphoblastic leukemia Vilas-Zornoza, A.; Agirre, X.; Abizanda, G.; Moreno, C.; Segura, V.; De Martino Rodriguez, A.; Jose-Eneriz, E. S.; Miranda, E.; Martin-Subero, J. I.; Garate, L.; Blanco-Prieto, M. J.; Garcia de Jalon, J. A.; Rio, P.; Rifon, J.; Cigudosa, J. C.; Martinez-Climent, J. A.; Roman-Gomez, J.; Calasanz, M. J.; Ribera, J. M.; Prosper, F. Share Save
MicroRNA expression profiling in Imatinib-resistant Chronic Myeloid Leukemia patients without clinically significant ABLI-mutations San Jose-Eneriz, Edurne; Roman-Gomez, Jose; Jimenez-Velasco, Antonio; Garate, Leire; Martin, Vanesa; Cordeu, Lucia; Vilas-Zornoza, Amaia; Rodriguez-Otero, Paula; Calasanz, Maria Jose; Prosper, Felipe; Agirre, Xabier Share Save
Epigenetic down-regulation of BIM expression is associated with reduced optimal responses to imatinib treatment in chronic myeloid leukaemia San Jose-Eneriz, Edurne; Agirre, Xabier; Jimenez-Velasco, Antonio; Cordeu, Lucia; Martin, Vanesa; Arqueros, Victor; Garate, Leire; Fresquet, Vicente; Cervantes, Francisco; Martinez-Climent, Jose A.; Heiniger, Anabel; Torres, Antonio; Prosper, Felipe; Roman-Gomez, Jose Share Save
Epigenetic Silencing of the Tumor Suppressor MicroRNA Hsa-miR-124a Regulates CDK6 Expression and Confers a Poor Prognosis in Acute Lymphoblastic Leukemia Agirre, Xabier; Vilas-Zornoza, Amaia; Jimenez-Velasco, Antonio; Ignacio Martin-Subero, Jose; Cordeu, Lucia; Garate, Leire; San Jose-Eneriz, Edurne; Abizanda, Gloria; Rodriguez-Otero, Paula; Fortes, Puri; Rifon, Jose; Bandres, Eva; Jose Calasanz, Maria; Martin, Vanesa; Heiniger, Anabel; Torres, Antonio; Siebert, Reiner; Roman-Gomez, Jose; Prosper, Felipe Share Save
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