Not logged in MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells (vol 3, e01763, 2014) Wang, Yubao; Li, Young-Mi; Baitsch, Lukas; Huang, Alan; Xiang, Yi; Tong, Haoxuan; Lako, Ana; Thanh Von; Choi, Christine; Lim, Elgene; Min, Junxia; Li, Li; Stegmeier, Frank; Schlegel, Robert; Eck, Michael J.; Gray, Nathanael S.; Mitchison, Timothy J.; Zhao, Jean J. Share Save
The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation Ferraro, Gino B.; Kodack, David P.; Askoxylakis, Vasileios; Sheng, Qing; Badeaux, Mark; Goel, Shom; Qi, Xiaolong; Shankaraiah, Ram; Cao, Alexander Z.; Ramjiawan, Rakesh R.; Bezwada, Divya; Patel, Bhushankumar; Song, Youngchul; Costa, Carlotta; Naxerova, Kamila; Wong, Christina; Kloepper, Jonas; Das, Rita; Tam, Angela; Tanboon, Jantima; Duda, Dan G.; Miller, Ryan C.; Siegel, Marni B.; Anders, Carey K.; Sanders, Melinda; Estrada, Valeria M.; Schlegel, Robert; Arteaga, Carlos L.; Brachtel, Elena; Huang, Alan; Fukumura, Dai; Engelman, Jeffrey A.; Jain, Rakesh K. Share Save
The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation Kodack, David P.; Askoxylakis, Vasileios; Ferraro, Gino B.; Sheng, Qing; Badeaux, Mark; Goel, Shom; Qi, Xiaolong; Shankaraiah, Ram; Cao, Z. Alexander; Ramjiawan, Rakesh R.; Bezwada, Divya; Patel, Bhushankumar; Song, Yongchul; Costa, Carlotta; Naxerova, Kamila; Wong, Christina S. F.; Kloepper, Jonas; Das, Rita; Tam, Angela; Tanboon, Jantima; Duda, Dan G.; Miller, C. Ryan; Siegel, Marni B.; Anders, Carey K.; Sanders, Melinda; Estrada, Monica V.; Schlegel, Robert; Arteaga, Carlos L.; Brachtel, Elena; Huang, Alan; Fukumura, Dai; Engelman, Jeffrey A.; Jain, Rakesh K. Share Save
High-Order Drug Combinations Are Required to Effectively Kill Colorectal Cancer Cells Horn, Thomas; Ferretti, Stephane; Ebel, Nicolas; Tam, Angela; Ho, Samuel; Harbinski, Fred; Farsidjani, Ali; Zubrowski, Matthew; Sellers, William R.; Schlegel, Robert; Porter, Dale; Morris, Erick; Wuerthner, Jens; Jeay, Sebastien; Greshock, Joel; Halilovic, Ensar; Garraway, Levi A.; Caponigro, Giordano; Lehar, Joseph Share Save
High order drug combinations are required to effectively kill colorectal cancer cells Horn, Thomas; Ferretti, Stephane; Ebel, Nicolas; Tam, Angela; Ho, Samuel; Harbinski, Fred; Farsidjani, Ali; Zubrowski, Matt; Sellers, William R.; Schlegel, Robert; Porter, Dale; Morris, Erick; Wuerthner, Jens; Jeay, Sebastien; Greshock, Joel; Halilovic, Ensar; Garraway, Levi A.; Caponigro, Giordano; Lehar, Joseph Share Save
Activation of MET via Diverse Exon 14 Splicing Alterations Occurs in Multiple Tumor Types and Confers Clinical Sensitivity to MET Inhibitors Frampton, Garrett M.; Ali, Siraj M.; Rosenzweig, Mark; Chmielecki, Juliann; Lu, Xinyuan; Bauer, Todd M.; Akimov, Mikhail; Bufill, Jose A.; Lee, Carrie; Jentz, David; Hoover, Rick; Ou, Sai-Hong Ignatius; Salgia, Ravi; Brennan, Tim; Chalmers, Zachary R.; Jaeger, Savina; Huang, Alan; Elvin, Julia A.; Erlich, Rachel; Fichtenholtz, Alex; Gowen, Kyle A.; Greenbowe, Joel; Johnson, Adrienne; Khaira, Depinder; McMahon, Caitlin; Sanford, Eric M.; Roels, Steven; White, Jared; Greshock, Joel; Schlegel, Robert; Lipson, Doron; Yelensky, Roman; Morosini, Deborah; Ross, Jeffrey S.; Collisson, Eric; Peters, Malte; Stephens, Philip J.; Miller, Vincent A. Share Save
Evaluation of PD-L1 mRNA and protein expression in non-small cell lung and hepatocellular carcinoma Jaeger, Savina; Lee, Benjamin H.; Mosher, Rebecca; Shebnova, Olga; Wang, Yan; Yu, Yenyen; Yang, David; Murakami, Masato; Greshock, Joel; Schlegel, Robert; Boral, Anthony; Cao, Zhu Alexander Share Save
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Loss of Tuberous Sclerosis Complex 2 (TSC2) Is Frequent in Hepatocellular Carcinoma and Predicts Response to mTORC1 Inhibitor Everolimus Huynh, Hung; Hao, Huai-Xiang; Chan, Stephen L.; Chen, David; Ong, Richard; Soo, Khee Chee; Pochanard, Panisa; Yang, David; Ruddy, David; Liu, Manway; Derti, Adnan; Balak, Marissa N.; Palmer, Michael R.; Wang, Yan; Lee, Benjamin H.; Sellami, Dalila; Zhu, Andrew X.; Schlegel, Robert; Huang, Alan Share Save
FGFR-Mediated Reactivation of MAPK Signaling Attenuates Antitumor Effects of Imatinib in Gastrointestinal Stromal Tumors Li, Fang; Huynh, Hung; Li, Xiaoyan; Ruddy, David A.; Wang, Youzhen; Ong, Richard; Chow, Pierce; Qiu, Shumei; Tam, Angela; Rakiec, Daniel P.; Schlegel, Robert; Monahan, John E.; Huang, Alan Share Save
Targeting PIK3CA mutant breast cancer with the combination of PIK3CA-specific inhibitor, BYL719, and IGF1-R antibody, ganitumab Cao, Z. Alexander; Pinzon-Ortiz, Maria; Chen, Yan; Li, Xiaoyan; Beltran, Pedro J.; Gansert, Jennifer; Peters, Malte; Schlegel, Robert; Schumacher, Karl M.; Huang, Alan Share Save
The combination of JAK inhibitor, ruxolitinib, pan-PIM inhibitor, LGH447, and CDK4/6 inhibitor, LEE011, in a preclinical mouse model of myeloproliferative neoplasia Pinzon-Ortiz, Maria; Rong, Xianhui; Saci, Abdel; Schlegel, Robert; Vanasse, Gary; Caponigro, Giordano; Cao, Z. Alexander Share Save
Global chromatin profiling reveals NSD2 mutation in pediatric ALL Chan, Ho Man; Jaffe, Jacob D.; Wang, Yan; Zhang, Jinghui; Huether, Robert; Kryukov, Gregory V.; Bhang, Hyo-eun C.; Taylor, Jordan E.; Hu, Min; Englund, Nathan P.; Yan, Feng; Wang, Zhaofu; McDonald, E. Robert, III; Wei, Lei; Ma, Jing; Easton, John; Yu, Zhengtian; Debeaumount, Rosalie; Gibaja, Veronica; Venkatesan, Kavitha; Schlegel, Robert; Sellers, William R.; Keen, Nicholas; Liu, Jun; Caponigro, Giordano; Barretina, Jordi; Cooke, Vesselina G.; Mullighan, Charles; Carr, Steven A.; Downing, James R.; Garraway, Levi A.; Stegmeier, Frank Share Save
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The Mdm2 inhibitor, NVP-CGM097, in combination with the BRAF inhibitor NVP-LGX818 elicits synergistic antitumor effects in melanoma Wang, Hui Qin; Zubrowski, Matthew; Emerson, Erling; Pradhan, Elina; Jeay, Sebastien; Wiesmann, Marion; Caponigro, Giordano; Wuerthner, Jens; Schlegel, Robert; Cao, Z. Alexander; Huang, Alan; Halilovic, Ensar Share Save
Overcoming resistance to PI3K inhibitors in breast cancer: Results of a pooled shRNA screen and combinatorial drug screen Vora, Sadhna; Elkabets, Moshe; Kim, Nayoon; Costa, Carlotta; Liu, Manway; Li Xiaoyan; Cao, Alex; Schlegel, Robert; Scaltriti, Maurizio; Baselga, Jose; Huang, Alan; Engelman, Jeffrey A. Share Save
MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells Wang, Yubao; Lee, Young-Mi; Baitsch, Lukas; Huang, Alan; Xiang, Yi; Tong, Haoxuan; Lako, Ana; Thanh Von; Choi, Christine; Lim, Elgene; Min, Junxia; Li, Li; Stegmeier, Frank; Schlegel, Robert; Eck, Michael J.; Gray, Nathanael S.; Mitchison, Timothy J.; Zhao, Jean J. Share Save
Characterization of the Novel and Specific PI3Kα Inhibitor NVP-BYL719 and Development of the Patient Stratification Strategy for Clinical Trials Fritsch, Christine; Huang, Alan; Chatenay-Rivauday, Christian; Schnell, Christian; Reddy, Anupama; Liu, Manway; Kauffmann, Audrey; Guthy, Daniel; Erdmann, Dirk; De Pover, Alain; Furet, Pascal; Gao, Hui; Ferretti, Stephane; Wang, Youzhen; Trappe, Joerg; Brachmann, Saskia M.; Maira, Sauveur-Michel; Wilson, Christopher; Boehm, Markus; Garcia-Echeverria, Carlos; Chene, Patrick; Wiesmann, Marion; Cozens, Robert; Lehar, Joseph; Schlegel, Robert; Caravatti, Giorgio; Hofmann, Francesco; Sellers, William R. Share Save
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Overcoming resistance to PI3K inhibitors in PIK3CA mutant breast cancer using CDK4/6 inhibition: Results from a combinatorial drug screen Vora, S. R.; Kim, N.; Costa, C.; Lockerman, E. L.; Li, X.; Chen, Y.; Cao, A.; Pinzon-Ortiz, M.; Liu, M.; Kim, S.; Schlegel, R.; Huang, A.; Engelman, J. A. Share Save
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