Larry K. Keefer - Publications, H-index & Citations

Back

Larry K. Keefer

national institutes of health (nih) - usa

67H-index

550Paper Count

1.7WCitation Count

Published Papers 115

Publication Date

Cancer Cell-Directed Drug Delivery and Chemopotentiating Effects by GSTP1-Activated Nitric Oxide (NO)-Releasing Prodrug

BIOPHYSICAL JOURNAL

IF3.1

2016-02-01

OAAI

Kumari, Vandana; Holland, Ryan J.; Luthers, Christina E.; Dyba, Marzena A.; Tarasov, Sergey G.; Saavedra, Joseph E.; Keefer, Larry K.; Ji, Xinhua

Save

PABA/NO lead optimization: Improved targeting of cytotoxicity to glutathione S-transferase P1-overexpressing cancer cells

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2015-08-01

PREAI

Kim, Youseung; Maciag, Anna E.; Cao, Zhao; Deschamps, Jeffrey R.; Saavedra, Joseph E.; Keefer, Larry K.; Holland, Ryan J.

Save

Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2015-07-29

253

OAAI

Cortese-Krott, Miriam M.; Kuhnle, Gunter G. C.; Dyson, Alex; Fernandez, Bernadette O.; Grman, Marian; DuMond, Jenna F.; Barrow, Mark P.; McLeod, George; Nakagawa, Hidehiko; Ondrias, Karol; Nagy, Peter; King, S. Bruce; Saavedra, Joseph E.; Keefer, Larry K.; Singer, Mervyn; Kelm, Malte; Butler, Anthony R.; Feelisch, Martin

Save

The liver-selective NO donor, V-PYRRO/NO, protects against liver steatosis and improves postprandial glucose tolerance in mice fed high fat diet

BIOCHEMICAL PHARMACOLOGY

IF5.6

2015-02-01

PREAI

Maslak, Edyta; Zabielski, Piotr; Kochan, Kamila; Kus, Kamil; Jasztal, Agnieszka; Sitek, Barbara; Proniewski, Bartosz; Wojcik, Tomasz; Gula, Katarzyna; Kij, Agnieszka; Walczak, Maria; Baranska, Malgorzata; Chabowski, Adrian; Holland, Ryan J.; Saavedra, Joseph E.; Keefer, Larry K.; Chlopicki, Stefan

Save

Assay Reproducibility and Interindividual Variation for 15 Serum Estrogens and Estrogen Metabolites Measured by Liquid Chromatography-Tandem Mass Spectrometry

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

IF3.4

2014-12-02

OAAI

Fuhrman, Barbara J.; Xu, Xia; Falk, Roni T.; Dallal, Cher M.; Veenstra, Timothy D.; Keefer, Larry K.; Graubard, Barry I.; Brinton, Louise A.; Ziegler, Regina G.; Gierach, Gretchen L.

Save

Analysis of the HNO and NO donating properties of alicyclic amine diazeniumdiolates

NITRIC OXIDE-BIOLOGY AND CHEMISTRY

IF3.2

2014-11-01

OAAI

Bharadwaj, Gaurav; Benini, Patricia G. Z.; Basudhar, Debashree; Ramos-Colon, Cyf N.; Johnson, Gail M.; Larriva, Marti M.; Keefer, Larry K.; Andrei, Daniela; Miranda, Katrina M.

Save

Direct Reaction of Amides with Nitric Oxide To Form Diazeniumdiolates

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2014-09-22

OAAI

Holland, Ryan J.; Klose, John R.; Deschamps, Jeffrey R.; Cao, Zhao; Keefer, Larry K.; Saavedra, Joseph E.

Save

Aminolysis of an N-Diazeniumdiolated Amidine as an Approach to Diazeniumdiolated Ammonia

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2014-05-05

OAAI

Biswas, Debanjan; Hrabie, Joseph A.; Saavedra, Joseph E.; Cao, Zhao; Keefer, Larry K.; Ivanic, Joseph; Holland, Ryan J.

Save

Nitric Oxide (NO) Releasing Poly ADP-ribose Polymerase 1 (PARP-1) Inhibitors Targeted to Glutathione S-Transferase P1-Overexpressing Cancer Cells

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-02-25

OAAI

Maciag, Anna E.; Holland, Ryan J.; Kim, Youseung; Kumari, Vandana; Luthers, Christina E.; Sehareen, Waheed S.; Biswas, Debanjan; Morris, Nicole L.; Ji, Xinhua; Anderson, Lucy M.; Saavedra, Joseph E.; Keefer, Larry K.

Save

GSTP1-activated nitric oxide-releasing/PARP inhibitor hybrid prodrugs induce cancer cell death through ROS/RNS, DNA damage, ER stress, and apoptosis.

CANCER RESEARCH

IF16.6

2013-04-01

PREAI

Maciag, Anna E.; Saavedra, Joseph E.; Holland, Ryan J.; Kim, Youseung; Kumari, Vandana; Luthers, Christina E.; Sehareen, Waheed S.; Ji, Xinhua; Anderson, Lucy M.; Keefer, Larry K.

Save

Rolf Preussmann (1928-2012) Obituary

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2013-03-28

PREAI

Eisenbrand, Gerhard; Janzowski, Christine; Hecht, Stephen; Keefer, Larry; Tannenbaum, Steven

Save

Green tea intake is associated with urinary estrogen profiles in Japanese-American women

NUTRITION JOURNAL

IF3.8

2013-02-15

OAAI

Fuhrman, Barbara J.; Pfeiffer, Ruth M.; Wu, Anna H.; Xu, Xia; Keefer, Larry K.; Veenstra, Timothy D.; Ziegler, Regina G.

Save

Nitric oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance

REDOX BIOLOGY

IF11.9

2013-01-01

OAAI

Maciag, Anna E.; Holland, Ryan J.; Cheng, Y. -S. Robert; Rodriguez, Luis G.; Saavedra, Joseph E.; Anderson, Lucy M.; Keefer, Larry K.

Save

O2-Functionalized Methylamine Diazeniumdiolates: Evidence for E ⇆ Z Equilibration in an Acyclic System

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2012-11-20

OAAI

Biswas, Debanjan; Holland, Ryan J.; Deschamps, Jeffrey R.; Cao, Zhao; Keefer, Larry K.; Saavedra, Joseph E.

Save

Cross-Linking Protein Glutathionylation Mediated by O2-Arylated Bis-Diazeniumdiolate Double JS-K

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2012-11-09

OAAI

Holland, Ryan J.; Maciag, Anna E.; Kumar, Varun; Shi, Lei; Saavedra, Joseph E.; Prud'homme, Robert K.; Chakrapani, Harinath; Keefer, Larry K.

Save

Richard Loeppky (1937-2012) Obituary

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2012-05-25

PREAI

Eisenbrand, Gerhard; Gates, Kent S.; Hecht, Stephen S.; Janzowski, Christine; Keefer, Larry K.; Marnett, Lawrence J.; Tannenbaum, Steven R.

Save

Structural modifications modulate stability of glutathione-activated arylated diazeniumdiolate prodrugs

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2012-05-01

OAAI

Nandurdikar, Rahul S.; Maciag, Anna E.; Holland, Ryan J.; Cao, Zhao; Shami, Paul J.; Anderson, Lucy M.; Keefer, Larry K.; Saavedra, Joseph E.

Save

Diazeniumdiolated carbamates: A novel class of nitric oxide donors

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2012-03-01

OAAI

Nandurdikar, Rahul S.; Maciag, Anna E.; Cao, Zhao; Keefer, Larry K.; Saavedra, Joseph E.

Save

JS-K, a Glutathione S-Transferase-Activated Nitric Oxide Donor With Antineoplastic Activity in Malignant Gliomas

NEUROSURGERY

IF3.9

2012-02-01

OAAI

Weyerbrock, Astrid; Osterberg, Nadja; Psarras, Nikolaos; Baumer, Brunhilde; Kogias, Evangelos; Werres, Anna; Bette, Stefanie; Saavedra, Joseph E.; Keefer, Larry K.; Papazoglou, Anna

Save

Urinary Estrogens and Estrogen Metabolites and Subsequent Risk of Breast Cancer among Premenopausal Women

CANCER RESEARCH

IF16.6

2012-01-31

OAAI

Eliassen, A. Heather; Spiegelman, Donna; Xu, Xia; Keefer, Larry K.; Veenstra, Timothy D.; Barbieri, Robert L.; Willett, Walter C.; Hankinson, Susan E.; Ziegler, Regina G.

Save

Research Directions