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KRASmulti inhibition and checkpoint targeting therapy show strong combination potential in KRAS wild-type and KRASG12V-driven syngeneic mouse models of pancreatic cancer Ebner, F.; Krolo, A.; Artemov, A.; Hubmann, M.; Hajto, A.; Oslislok, M.; Baumann, I.; Egermann, W.; Chylinski, K.; Tedeschi, A.; Lipp, J.; Kraut, N.; Pearson, M.; Pisarsky, L.; Rudolph, D.; Aichinger, M. Share Save
Genetic dependencies associated with transcription factor activities in human cancer cell lines Thatikonda, Venu; Supper, Verena; Wachter, Johannes; Kaya, Onur; Kombara, Anju; Bilgilier, Ceren; Ravichandran, Madhwesh C.; Lipp, Jesse J.; Sharma, Rahul; Badertscher, Lukas; Boghossian, Andrew S.; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; Grosche, Sarah; Ller, Ralph A. Neumu euro; Mauri, Barbara Mair Federico; Popa, Alexandra Share Save
KRASmulti inhibitor BI 3706674 shows efficacy in KRAS-driven preclinical models of cancer that supports clinical testing in patients with tumors harbouring KRASG12V mutations and KRAS wild-type amplifications Tedeschi, Antonio; Peng, David H.; Schischlik, Fiorella; Herdeis, Lorenz; Schaaf, Otmar; Santoro, Valeria; Gerlach, Daniel; Savarese, Fabio; Lipp, Jesse; Haslinger, Christian; Rocchetti, Francesca; Popow, Johannes; Huber, Heinrich J.; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Broeker, Joachim; Wunber, Tobias; Gmachl, Michael; Rumpel, Klaus; Rees, Matthew; Ron, Melissa; Roth, Jennifer; Williams, Mariah; Deckard, Charles; Ramamoorthy, Vandhana; Daniele, Joseph R.; Ajani, Jaffer A.; Meric-Bernstam, Funda; Kopetz, Scott; Kim, Michael; Gibbons, Don L.; Vellano, Christopher P.; Marszalek, Joseph R.; Heffernan, Timothy P.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Rudolph, Dorothea Share Save
KRASmulti inhibitor BI 3706674, an orally bioavailable, direct inhibitor of diverse oncogenic KRAS variants drives tumor regression in KRASG12V-driven preclinical models Peng, David Hwa; Tedeschi, Antonio; Herdeis, Lorenz; Schaaf, Otmar; Savarese, Fabio; Rocchetti, Francesca; Popow, Johannes; Huber, Heinrich J.; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Broeker, Joachim; Wunberg, Tobias; Schischlik, Firoella; Lipp, Jesse; Williams, Mariah; Chandler, Vaness; Deckard, Charles E.; Ramamoorthy, Vandhana; Daniele, Joseph R.; Kopetz, Scott; Kim, Michael; Gibbons, Don L.; Vellano, Christopher P.; Marszalek, Joseph R.; Heffernan, TImothy P.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Rudolph, Dorothea Share Save
Development and characterisation of KRASmulti inhibitors for the treatment of KRAS mutant pancreatic ductal adenocarcinoma Tedeschi, Antonio; Schaaf, Otmar; Gmachl, Michael; Herdeis, Lorenz; Rocchetti, Francesca; Popow, Johannes; Schischlik, Fiorella; Gerlach, Daniel; Lipp, Jesse; Broker, Joachim; Mantoulidis, Andreas; Smethurst, Chris; Kessler, Dirk; Boettcher, Jark; Wunberg, Tobias; Santoro, Valeria; Waterson, Alex; Phan, Jason; Little, Andrew; Abbott, Jason; Sun, Qi; Fesik, Stephen; Mcconnell, Darryl; Pearson, Mark A.; Kraut, Norbert; Rudolph, Dorothea Share Save
Determinants of sensitivity to BI KRASmulti inhibitor using high-throughput in-vitro drug screens Schischlik, Fiorella; Tedeschi, Antonio; Rudolph, Dorothea; Gerlach, Daniel; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Herdeis, Lorenz; Broeker, Joachim; Wunberg, Tobias; Boghossian, Andrew S.; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Haslinger, Christian; Lipp, Jesse Share Save
BI KRASmulti, a first-in-class, orally bioavailable and direct inhibitor of diverse oncogenic KRAS variants drives tumor regression in KRAS G12V-driven preclinical models Peng, David H.; Tedeschi, Antonio; Herdeis, Lorenz; Savarese, Fabio; Rocchetti, Francesca; Johannes, Popow; Huber, Heinrich J.; Melillo, Nicola; Dickinson, Jake; Mistry, Hitesh B.; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Broker, Joachim; Wunberg, Tobias; Schischlik, Fiorella; Lipp, Jesse; Ramamoorthy, Vandhana; Daniele, Joseph R.; Kopetz, Scott; Kim, Michael; Gibbons, Don L.; Vellano, Christopher P.; Marszalek, Joseph R.; Heffernan, Timothy P.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Rudolph, Dorothea Share Save
BI KRASmulti, a first-in-class, orally bioavailable and direct inhibitor of diverse oncogenic KRAS variants drives tumor regression in preclinical models and validates wild-type amplified KRAS as a therapeutic target Tedeschi, Antonio; Herdeis, Lorenz; Santoro, Valeria; Savarese, Fabio; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Broker, Joachim; Wunberg, Tobias; Gmachl, Michael; Klaus, Rumpel; Schischlik, Fiorella; Lipp, Jesse; Peng, David H.; Williams, Mariah; Deckard, Charles; Ramamoorthy, Vandhana; Daniele, Joseph R.; Ajani, Jaffer A.; Meric-Bernstam, Funda; Vellano, Christopher R.; Marszalek, Joseph R.; Heffernan, Timothy P.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Rudolph, Dorothea Share Save
Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments Martinelli, Paola; Schaaf, Otmar; Mantoulidis, Andreas; Martin, Laetitia J.; Fuchs, Julian E.; Bader, Gerd; Gollner, Andreas; Wolkerstorfer, Bernhard; Rogers, Catherine; Balikci, Esra; Lipp, Jesse J.; Mischerikow, Nikolai; Doebel, Sandra; Gerstberger, Thomas; Sommergruber, Wolfgang; Huber, Kilian V. M.; Boettcher, Jark Share Save
CLIFF, a bioinformatics software tool to explore molecular differences between two sets of cancer cell lines Wernitznig, Andreas; Lipp, Jesse J.; Zichner, Thomas; Gerlach, Daniel; Bauer, Markus J.; Voss, Tilman; Schlattl, Andreas; Haslinger, Christian; Montgomery, Philip G.; Zamanighomi, Mahdi; Sellers, William R.; Kraut, Norbert Share Save
Isolating live cell clones from barcoded populations using CRISPRa-inducible reporters Umkehrer, Christian; Holstein, Felix; Formenti, Laura; Jude, Julian; Froussios, Kimon; Neumann, Tobias; Cronin, Shona M.; Haas, Lisa; Lipp, Jesse J.; Burkard, Thomas R.; Fellner, Michaela; Wiesner, Thomas; Zuber, Johannes; Obenauf, Anna C. Share Save
Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells Lieb, Simone; Blaha-Ostermann, Silvia; Kamper, Elisabeth; Ehrenhoefer-Woelfer, Katharina; Schlattl, Andreas; Wernitznig, Andreas; Lipp, Jesse; Nagasaka, Kota; Bader, Gerd; Neumueller, Ralph; Kraut, Norbert; Pearson, Mark; Woehrle, Simon; Petronczki, Mark Share Save
Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells Lieb, Simone; Blaha-Ostermann, Silvia; Kamper, Elisabeth; Rippka, Janine; Schwarz, Cornelia; Ehrenhoefer-Woelfer, Katharina; Schlattl, Andreas; Wernitznig, Andreas; Lipp, Jesse J.; Nagasaka, Kota; van der Lelij, Petra; Bader, Gerd; Koi, Minoru; Goel, Ajay; Neumueller, Ralph A.; Peters, Jan-Michael; Kraut, Norbert; Pearson, Mark A.; Petronczki, Mark; Woehrle, Simon Share Save
Integrative analysis of pooled CRISPR genetic screens using MAGeCKFlute Wang, Binbin; Wang, Mei; Zhang, Wubing; Xiao, Tengfei; Chen, Chen-Hao; Wu, Alexander; Wu, Feizhen; Traugh, Nicole; Wang, Xiaoqing; Li, Ziyi; Mei, Shenglin; Cui, Yingbo; Shi, Sailing; Lipp, Jesse Jonathan; Hinterndorfer, Matthias; Zuber, Johannes; Brown, Myles; Li, Wei; Liu, X. Shirley Share Save
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