Not logged inA prototype mRNA LNP neoantigen vaccine remodels the tumour microenvironment of a syngeneic model of glioblastoma
Snelling, Shannon; Pyczek, Joanna; Lun, Xueqing; Manoharan, Varsha; Liu, Jun; Gold, Matthew; Ellestad, Kristofor; Olsen, Kirsten; Wu, Yu; Karpov, Yury; Menon, Haritha; Tan, Yilin; Krishnan, Rajesh; Mahoney, Douglas; Morrissy, A. Sorana; Martin-Orozco, Natalia; Chan, Jennifer A. .png)
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SaveInvestigating EGFRvIII mRNA LNP vaccine-induced re-programming of the GBM TME using the 10x Genomics Visium HD platformManoharan, Varsha Thoppey; Snelling, Shannon; Gill, Gurveer; Nechanitzky, Robert; Lun, Xueqing; Ellestad, Kristofer; Pyczek, Joanna; Olsen, Kirsten; Wu, Yu; Karpov, Yury; Liu, Jun; Gold, Matthew; Menon, Haritha; Tan, Yilin; Krishnan, Rajesh; Mahoney, Douglas; Martin-Orozco, Natalia; Chan, Jennifer; Morrissy, Sorana Share Save A bivalent COVID-19 mRNA vaccine elicited broad immune responses and protection against Omicron subvariants infectionLiu, Jun; Wang, Li; Kurtesi, Alexandra; Budylowski, Patrick; Potts, Kyle G.; Menon, Haritha; Tan, Yilin; Samaan, Philip; Liu, Xinan; Wang, Yisen; Hu, Queenie; Samson, Reuben; Qi, Freda; Evseev, Danyel; John, Cini; Ellestad, Kristofor K.; Fan, Yue; Budiman, Frans; Tohan, Ellaine Riczly; Udayakumar, Suji; Yang, Jennifer; Marcusson, Eric G.; Gingras, Anne-Claude; Mahoney, Douglas J.; Ostrowski, Mario A.; Martin-Orozco, Natalia Share Save AN EGFRVIII RNA-LNP VACCINE PROTOTYPE ACHIEVES TUMOUR CLEARANCE IN A GBM MOUSE MODELSnelling, Shannon; Nechanitzky, Robert; Lun, Xueqing; Ellestad, Kristofer; Pyczek, Joanna; Olsen, Kirsten; Wu, Yu; Karpov, Yury; Liu, Jun; Gold, Matthew; Menon, Haritha; Tan, Yilin; Krishnan, Rajesh; Mahoney, Douglas; Martin-Orozco, Natalia; Chan, Jennifer A. Share Save Next-generation LNPs induce effective anti-tumor T cell responsesMillar, Douglas G.; Gold, Matthew J.; Olsen, Kirsten; Wu, Yu; Karpov, Yury; Nechanitzky, Robert; Menon, Haritha; Krishnan, Rajesh; Georgantas, Robert; Ohashi, Pamela; Martin-Orozco, Natalia Share Save Next-generation mRNA-LNP vaccine prototype achieves tumor clearance in a GBM mouse modelNechanitzky, Robert; Snelling, Shannon Snelling; Ellestad, Kristofor; Lun, Xueqing; Olsen, Kirstin; Wu, Yu; Karpov, Yury; Liu, Jun; Gold, Matthew; Menon, Haritha; Krishnan, Rajesh; Georgantas, Robert; Ohashi, Pamela S.; Mahoney, Douglas J.; Chan, Jennifer A.; Martin-Orozco, Natalia Share Save Comparable safety and non-inferior immunogenicity of the SARS-CoV-2 mRNA vaccine candidate PTX-COVID19-B and BNT162b2 in a phase 2 randomized, observer-blinded studyReiter, Lawrence; Greffrath, Johann; Zidel, Bian; Ostrowski, Mario; Gommerman, Jennifer; Madhi, Shabir A.; Tran, Richard; Martin-Orozco, Natalia; Panicker, Rajesh Krishnan Gopalakrishna; Cooper, Curtis; Pastrak, Aleksandra Share Save Phase I randomized, observer-blinded, placebo-controlled study of a SARS-CoV-2 mRNA vaccine PTX-COVID19-BMartin-Orozco, Natalia; Vale, Noah; Mihic, Alan; Amor, Talya; Reiter, Lawrence; Arita, Yuko; Samson, Reuben; Hu, Queenie; Gingras, Anne-Claude; Sorenson, Bradley Thomas; Marcusson, Eric Gates; Patel, Piyush Share Save Share Save Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte functionLee, Young-hee; Martin-Orozco, Natalia; Zheng, Peilin; Li, Jing; Zhang, Peng; Tan, Haidong; Park, Hyun Jung; Jeong, Mira; Chang, Seon Hee; Kim, Byung-Seok; Xiong, Wei; Zang, Wenjuan; Guo, Li; Liu, Yang; Dong, Zhong-jun; Overwijk, Willem W.; Hwu, Patrick; Yi, Qing; Kwak, Larry; Yang, Zhiying; Mak, Tak W.; Li, Wei; Radvanyi, Laszlo G.; Ni, Ling; Liu, Dongfang; Dong, Chen Share Save Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5Zhang, Yongliang; Thang Nguyen; Tang, Peng; Kennedy, Norman J.; Jiao, Huipeng; Zhang, Mingliang; Reynolds, Joseph M.; Jaeschke, Anja; Martin-Orozco, Natalia; Chung, Yeonseok; He, Wei-min; Wang, Chen; Jia, Weiping; Ge, Baoxue; Davis, Roger J.; Fiavell, Richard A.; Dong, Chen Share Save IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patientsSim, Geok Choo; Martin-Orozco, Natalia; Jin, Lei; Yang, Yan; Wu, Sheng; Washington, Edwina; Sanders, Deborah; Lacey, Carol; Wang, Yijun; Vence, Luis; Hwu, Patrick; Radvanyi, Laszlo Share Save Bcl6 expression specifies the T follicular helper cell program in vivoLiu, Xindong; Yan, Xiaowei; Zhong, Bo; Nurieva, Roza I.; Wang, Aibo; Wang, Xiaohu; Martin-Orozco, Natalia; Wang, Yihong; Chang, Seon Hee; Esplugues, Enric; Flavell, Richard A.; Tian, Qiang; Dong, Chen Share Save T cells and T cell tumors efficiently generate antigen-specific cytotoxic T cell immunity when modified with an NKT ligandChung, Yeonseok; Lee, Young-Hee; Zhang, Yongliang; Martin-Orozco, Natalia; Yamazaki, Tomohide; Zhou, Dapeng; Kang, Chang-Yuil; Hwu, Patrick; Kwak, Larry W.; Dong, Chen Share Save Share Save Share Save T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor ImmunityMartin-Orozco, Natalia; Muranski, Pawel; Chung, Yeonseok; Yang, Xuexian O.; Yamazaki, Tomohide; Lu, Sijie; Hwu, Patrick; Restifo, Nicholas P.; Overwijk, Willem W.; Dong, Chen Share Save Share Save Cutting Edge: A Critical Role of B and T Lymphocyte Attenuator in Peripheral T Cell Tolerance InductionLiu, Xikui; Alexiou, Maria; Martin-Orozco, Natalia; Chung, Yeonseok; Nurieva, Roza I.; Ma, Li; Tian, Qiang; Kollias, George; Lu, Sijie; Graf, Daniel; Dong, Chen Share Save CCR6 Regulates the Migration of Inflammatory and Regulatory T CellsYamazaki, Tomohide; Yang, Xuexian O.; Chung, Yeonseok; Fukunaga, Atsushi; Nurieva, Roza; Pappu, Bhanu; Martin-Orozco, Natalia; Kang, Hong Soon; Ma, Li; Panopoulos, Athanasia D.; Craig, Suzanne; Watowich, Stephanie S.; Jetten, Anton M.; Tian, Qiang; Dong, Chen Share Save 
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