Alan C. Sartorelli - Publications, H-index & Citations

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Alan C. Sartorelli

Yale University

64H-index

720Paper Count

1.9WCitation Count

Published Papers 68

Publication Date

MK-2206 sensitizes BRCA-deficient epithelial ovarian adenocarcinoma to cisplatin and olaparib

BMC CANCER

IF3.4

2016-07-27

OAAI

Whicker, Margaret E.; Lin, Z. Ping; Hanna, Ruth; Sartorelli, Alan C.; Ratner, Elena S.

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Triapine potentiates platinum-based combination therapy by disruption of homologous recombination repair

BRITISH JOURNAL OF CANCER

IF6.8

2016-03-10

OAAI

Ratner, Elena S.; Zhu, Yong-Lian; Penketh, Philip G.; Berenblum, Julie; Whicker, Margaret E.; Huang, Pamela H.; Lee, Yashang; Ishiguro, Kimiko; Zhu, Rui; Sartorelli, Alan C.; Lin, Z. Ping

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Antitumor Sulfonylhydrazines: Design, Structure-Activity Relationships, Resistance Mechanisms, and Strategies for Improving Therapeutic Utility

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2015-02-09

PREAI

Shyam, Krishnamurthy; Penketh, Philip G.; Baumann, Raymond P.; Finch, Rick A.; Zhu, Rui; Zhu, Yong-Lian; Sartorelli, Alan C.

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Role of Tcf-DNA binding and the chromatin remodeling factor Brg-1 in the modulation of Wnt activity by butyrate

CELL CYCLE

IF3.4

2014-11-05

OAAI

Bordonaro, Michael; Lazarova, Darina L.; Sartorelli, Alan C.

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Butyrate and Wnt signaling - A possible solution to the puzzle of dietary fiber and colon cancer risk?

CELL CYCLE

IF3.4

2014-10-28

122

PREAI

Bordonaro, Michael; Lazarova, Darina L.; Sartorelli, Alan C.

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Phase I study of perillyl alcohol in patients with refractory malignancies

CANCER BIOLOGY & THERAPY

IF4.6

2014-10-27

PREAI

Murren, JR; Pizzorno, G; DiStasio, SA; McKeon, A; Peccerillo, K; Gollerkari, A; McMurray, W; Burtness, BA; Rutherford, T; Li, X; Ho, PTC; Sartorelli, A

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Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes

BIOCHEMICAL PHARMACOLOGY

IF5.6

2014-10-01

OAAI

Ishiguro, Kimiko; Lin, Z. Ping; Penketh, Philip G.; Shyam, Krishnamurthy; Zhu, Rui; Baumann, Raymond P.; Zhu, Yong-Lian; Sartorelli, Alan C.; Rutherford, Thomas J.; Ratner, Elena S.

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Influence of Glutathione and Glutathione S-transferases on DNA Interstrand Cross-Link Formation by 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine, the Active Anticancer Moiety Generated by Laromustine

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2014-07-17

OAAI

Penketh, Philip G.; Patridge, Eric; Shyam, Krishnamurthy; Baumann, Raymond P.; Zhu, Rui; Ishiguro, Kimiko; Sartorelli, Alan C.

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Influence of Phosphate and Phosphoesters on the Decomposition Pathway of 1,2-Bis(methylsulfonyl)-1-(2-chloroethyhydrazine (90CE), the Active Anticancer Moiety Generated by Laromustine, KS119, and KS119W

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2014-03-24

OAAI

Penketh, Philip G.; Shyam, Krishnamurthy; Zhu, Rui; Baumann, Raymond P.; Ishiguro, Kimiko; Sartorelli, Alan C.

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Triapine Disrupts CtIP-Mediated Homologous Recombination Repair and Sensitizes Ovarian Cancer Cells to PARP and Topoisomerase Inhibitors

MOLECULAR CANCER RESEARCH

IF4.7

2014-03-19

OAAI

Lin, Z. Ping; Ratner, Elena S.; Whicker, Margaret E.; Lee, Yashang; Sartorelli, Alan C.

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Triapine sensitizes chemoresistant ovarian cancer cells to platinum therapy

CANCER RESEARCH

IF16.6

2013-04-01

PREAI

Ratner, Elena S.; Whicker, Margaret; Lin, Z. Ping; Sartorelli, Alan C.

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Hypoxia-Selective O6-Alkylguanine-DNA Alkyltransferase Inhibitors: Design, Synthesis, and Evaluation of 6-(Benzyloxy)-2-(aryldiazenyl)-9H-purines as Prodrugs of O6-Benzylguanine

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2013-01-23

OAAI

Zhu, Rui; Baumann, Raymond P.; Penketh, Philip G.; Shyam, Krishnamurthy; Sartorelli, Alan C.

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Tumor-associated mutations in O6-methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality

MOLECULAR CARCINOGENESIS

IF3.2

2012-10-12

OAAI

Lamb, Kristy L.; Liu, Yanfeng; Ishiguro, Kimiko; Kwon, Youngho; Paquet, Nicolas; Sartorelli, Alan C.; Sung, Patrick; Rockwell, Sara; Sweasy, Joann B.

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7-Nitro-4-(phenylthio)benzofurazan is a potent generator of superoxide and hydrogen peroxide

ARCHIVES OF TOXICOLOGY

IF6.9

2012-06-06

OAAI

Patridge, Eric V.; Eriksson, Emma S. E.; Penketh, Philip G.; Baumann, Raymond P.; Zhu, Rui; Shyam, Krishnamurthy; Eriksson, Leif A.; Sartorelli, Alan C.

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A Strategy for Selective O6-Alkylguanine-DNA Alkyltransferase Depletion Under Hypoxic Conditions

CHEMICAL BIOLOGY & DRUG DESIGN

IF3.3

2012-05-23

OAAI

Penketh, Philip G.; Shyam, Krishnamurthy; Baumann, Raymond P.; Ishiguro, Kimiko; Patridge, Eric V.; Zhu, Rui; Sartorelli, Alan C.

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Triapine sensitizes ovarian cancer cells to platinum drugs and PARP inhibitors

CANCER RESEARCH

IF16.6

2012-04-01

PREAI

Lin, Z. Ping; Ratner, Elena S.; Sartorelli, Alan C.

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Reduced Level of Ribonucleotide Reductase R2 Subunits Increases Dependence on Homologous Recombination Repair of Cisplatin-Induced DNA Damage

MOLECULAR PHARMACOLOGY

IF3

2011-12-01

OAAI

Lin, Z. Ping; Lee, Yashang; Lin, Fang; Belcourt, Michael F.; Li, Peining; Cory, Joseph G.; Glazer, Peter M.; Sartorelli, Alan C.

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4-Nitrobenzyloxycarbonyl Derivatives of O6-Benzylguanine as Hypoxia-Activated Prodrug Inhibitors of O6-Alkylguanine-DNA Alkyltransferase (AGT), Which Produces Resistance to Agents Targeting the O-6 Position of DNA Guanine

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2011-10-17

OAAI

Zhu, Rui; Liu, Mao-Chin; Luo, Mei-Zhen; Penketh, Philip G.; Baumann, Raymond P.; Shyam, Krishnamurthy; Sartorelli, Alan C.

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Preclinical Studies of Onrigen in Combination with Radiation

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

IF6.5

2011-10-01

OAAI

Rockwell, S.; Liu, Y.; Glazer, P. M.; Sartorelli, A. C.

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1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119): a Cytotoxic Prodrug with Two Stable Conformations Differing in Biological and Physical Properties

CHEMICAL BIOLOGY & DRUG DESIGN

IF3.3

2011-09-06

OAAI

Penketh, Philip G.; Baumann, Raymond P.; Shyam, Krishnamurthy; Williamson, Hugh S.; Ishiguro, Kimiko; Zhu, Rui; Eriksson, Emma S. E.; Eriksson, Leif A.; Sartorelli, Alan C.

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Research Directions