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Exploring the Therapeutic Potential of Phosphorylated Cis-Tau Antibody in a Pig Model of Traumatic Brain Injury Shin, Samuel S.; Mazandi, Vanessa M.; Schneider, Andrea L. C.; Morton, Sarah; Starr, Jonathan P.; Weeks, M. Katie; Widmann, Nicholas J.; Jang, David H.; Kao, Shih-Han; Ahlijanian, Michael K.; Kilbaugh, Todd J. Share Save
Preclinical characterization and IND-enabling safety studies for PNT001, an antibody that recognizes cis-pT231 tau Foster, Kelly; Manca, Matteo; McClure, Kim; Koivula, Pyry; Trojanowski, John Q.; Havas, Daniel; Chancellor, Sarah; Goldstein, Lee; Brunden, Kurt R.; Kraus, Allison; Ahlijanian, Michael K. Share Save
USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation Rusilowicz-Jones, Emma, V; Jardine, Jane; Kallinos, Andreas; Pinto-Fernandez, Adan; Guenther, Franziska; Giurrandino, Mariacarmela; Barone, Francesco G.; McCarron, Katy; Burke, Christopher J.; Murad, Alejandro; Martinez, Aitor; Marcassa, Elena; Gersch, Malte; Buckmelter, Alexandre J.; Kayser-Bricker, Katherine J.; Lamoliatte, Frederic; Gajbhiye, Akshada; Davis, Simon; Scott, Hannah C.; Murphy, Emma; England, Katherine; Mortiboys, Heather; Komander, David; Trost, Matthias; Kessler, Benedikt M.; Ioannidis, Stephanos; Ahlijanian, Michael K.; Urbe, Sylvie; Clague, Michael J. Share Save
Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481 Boy, Kenneth M.; Guernon, Jason M.; Zuev, Dmitry S.; Xu, Li; Zhang, Yunhui; Shi, Jianliang; Marcin, Lawrence R.; Higgins, Mendi A.; Wu, Yong-Jin; Krishnananthan, Subramaniam; Li, Jianqing; Trehan, Ashok; Smith, Daniel; Toyn, Jeremy H.; Meredith, Jere E.; Burton, Catherine R.; Kimura, S. Roy; Zvyaga, Tatyana; Zhuo, Xiaoliang; Lentz, Kimberley A.; Grace, James E.; Denton, Rex; Morrison, John S.; Mathur, Arvind; Albright, Charles F.; Ahlijanian, Michael K.; Olson, Richard E.; Thompson, Lorin A.; Macor, John E. Share Save
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Synergistic inhibition of Aβ production by combinations of γ-secretase modulators Robertson, Alan S.; Iben, Lawrence G.; Wei, Cong; Meredith, Jere E., Jr.; Drexler, Dieter M.; Banks, Martyn; Vite, Gregory D.; Olson, Richard E.; Thompson, Lorin A.; Albright, Charles F.; Ahlijanian, Michael K.; Toyn, Jeremy H. Share Save
A Functional NaV1.7-NaVAb Chimera with a Reconstituted High-Affinity ProTx-II Binding Site Rajamani, Ramkumar; Wu, Sophie; Rodrigo, Iyoncy; Gao, Mian; Low, Simon; Megson, Lisa; Wensel, David; Pieschl, Rick L.; Post-Munson, Debra J.; Watson, John; Langley, David R.; Ahlijanian, Michael K.; Bristow, Linda J.; Herrington, James Share Save
B-973, a novel piperazine positive allosteric modulator of the α7 nicotinic acetylcholine receptor Post-Munson, Debra J.; Pieschl, Rick L.; Molski, Thaddeus F.; Graef, John D.; Hendricson, Adam W.; Knox, Ronald J.; McDonald, Ivar M.; Olson, Richard E.; Macor, John E.; Weed, Michael R.; Bristow, Linda J.; Kiss, Laszlo; Ahlijanian, Michael K.; Herrington, James Share Save
Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine β-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors Wu, Yong-Jin; Guernon, Jason; Shi, Jianliang; Marcin, Lawrence; Higgins, Mendi; Rajamani, Ramkumar; Muckelbauer, Jodi; Lewis, Hal; Chang, ChiehYing; Camac, Dan; Toyn, Jeremy H.; Ahlijanian, Michael K.; Albright, Charles F.; Macor, John E.; Thompson, Lorin A. Share Save
Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects Toyn, Jeremy H.; Boy, Kenneth M.; Raybon, Joseph; Meredith, Jere E., Jr.; Robertson, Alan S.; Guss, Valerie; Hoque, Nina; Sweeney, Francis; Zhuo, Xiaoliang; Clarke, Wendy; Snow, Kimberly; Denton, R. Rex; Zuev, Dmitry; Thompson, Lorin A.; Morrison, John; Grace, James; Berisha, Flora; Furlong, Michael; Wang, Jun-Sheng; Lentz, Kimberly A.; Padmanabha, Ramesh; Cook, Lynda; Wei, Cong; Drexler, Dieter M.; Macor, John E.; Albright, Charlie F.; Gasior, Maciej; Olson, Richard E.; Hong, Quan; Soares, Holly D.; AbuTarif, Malaz; Ahlijanian, Michael K. Share Save
The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers Soares, Holly D.; Gasior, Maciej; Toyn, Jeremy H.; Wang, Jun-Sheng; Hong, Quan; Berisha, Flora; Furlong, Michael T.; Raybon, Joseph; Lentz, Kimberley A.; Sweeney, Francis; Zheng, Naiyu; Akinsanya, Billy; Berman, Robert M.; Thompson, Lorin A.; Olson, Richard E.; Morrison, John; Drexler, Dieter M.; Macor, John E.; Albright, Charlie F.; Ahlijanian, Michael K.; AbuTarif, Malaz Share Save
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Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents Wu, Yong-Jin; Guernon, Jason; Yang, Fukang; Snyder, Lawrence; Shi, Jianliang; Mcclure, Andrea; Rajamani, Ramkumar; Park, Hyunsoo; Ng, Alicia; Lewis, Hal; Chang, ChiehYing; Carnac, Dan; Toyn, Jeremy H.; Ahlijanian, Michael K.; Albright, Charles F.; Macor, John E.; Thompson, Lorin A. Share Save
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Divergent CSF τ alterations in two common tauopathies: Alzheimer's disease and progressive supranuclear palsy Wagshal, Dana; Sankaranarayanan, Sethu; Guss, Valerie; Hall, Tracey; Berisha, Flora; Lobach, Iryna; Karydas, Anna; Voltarelli, Lisa; Scherling, Carole; Heuer, Hilary; Tartaglia, Maria Carmela; Miller, Zachary; Coppola, Giovanni; Ahlijanian, Michael; Soares, Holly; Kramer, Joel H.; Rabinovici, Gil D.; Rosen, Howard J.; Miller, Bruce L.; Meredith, Jere; Boxer, Adam L. Share Save
Cerebrospinal Fluid Neurofilament Concentration Reflects Disease Severity in Frontotemporal Degeneration Scherling, Carole S.; Hall, Tracey; Berisha, Flora; Klepac, Kristen; Karydas, Anna; Coppola, Giovanni; Kramer, Joel H.; Rabinovici, Gil; Ahlijanian, Michael; Miller, Bruce L.; Seeley, William; Grinberg, Lea T.; Rosen, Howard; Meredith, Jere, Jr.; Boxer, Adam L. Share Save
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Effects of sub-chronic donepezil on brain Abeta and cognition in a mouse model of Alzheimer's disease Easton, Amy; Sankaranarayanan, Sethu; Tanghe, An; Terwel, Dick; Lin, Alan X.; Hoque, Nina; Bourin, Clotilde; Gu, Huidong; Ahlijanian, Michael; Bristow, Linda Share Save
Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice Rogers, Kathryn; Felsenstein, Kevin M.; Hrdlicka, Lori; Tu, Zhiming; Albayya, Faris; Lee, Winnie; Hopp, Sarah; Miller, Mary-Jo; Spaulding, Darcie; Yang, Zhiyong; Hodgdon, Hilliary; Nolan, Scott; Wen, Melody; Costa, Don; Blain, Jean-Francois; Freeman, Emily; De Strooper, Bart; Vulsteke, Veerle; Scrocchi, Louise; Zetterberg, Henrik; Portelius, Erik; Hutter-Paier, Birgit; Havas, Daniel; Ahlijanian, Michael; Flood, Dorothy; Leventhal, Liza; Shapiro, Gideon; Patzke, Holger; Chesworth, Richard; Koenig, Gerhard Share Save
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