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M

Marcel Ottens

Delft University of Technology

33H-index
288Paper Count
4.4KCitation Count
Published Papers 103
Publication Date
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Towards Rapid Calibration of Bioprocess Quantification Models Using Single Compound Raman Spectra: A Comparison of Four Approaches
errBiotechnology and Bioengineering
IF3.6
err2025-11-01
err0
errOAAI
errMaarten Klaverdijk; Lisa A. Smulders; Marcel Ottens; Marieke E. Klijn
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Using generalized quantitative structure–property relationship (QSPR) models to predict host cell protein retention in ion-exchange chromatography
errJournal of Chemical Technology & Biotechnology
IF0
err2025-09-07
err0
errOAAI
errTim Neijenhuis; Olivier Le Bussy; Geoffroy Geldhof; Marieke E Klijn; Marcel Ottens
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Implicit large eddy simulations for hydrodynamic stress characterization in 125 mL shake flasks for stem cell cultures
errBIOCHEMICAL ENGINEERING JOURNAL
IF3.8
err2025-07-01
err0
errOAAI
errvan Valderen, Ramon D.; Juarez-Garza, Brenda E.; Klijn, Marieke E.; Ottens, Marcel; Haringa, Cees
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Impact of bioreactor process parameters and yeast biomass on Raman spectra
errBiotechnology Progress
IF2.5
err2025-06-16
err0
errOAAI
errMaarten Klaverdijk; Mehrab Nemati; Marcel Ottens; Marieke E. Klijn
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Optimization of multi-column chromatography for capture and polishing at high protein load
errBiotechnology Progress
IF2.5
err2025-06-09
err0
errOAAI
errTiago Castanheira Silva; Madelène Isaksson; Bernt Nilsson; Michel Eppink; Marcel Ottens
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Single compound data supplementation to enhance transferability of fermentation specific Raman spectroscopy models
errANALYTICAL AND BIOANALYTICAL CHEMISTRY
IF3.8
err2025-02-06
err0
errOAAI
errKlaverdijk, Maarten; Ottens, Marcel; Klijn, Marieke E.
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Experimental characterization and prediction of Escherichia coli host cell proteome retention during preparative chromatography
errBIOTECHNOLOGY AND BIOENGINEERING
IF3.6
err2024-09-12
err1
errOAAI
errDisela, Roxana; Neijenhuis, Tim; Le Bussy, Olivier; Geldhof, Geoffroy; Klijn, Marieke; Pabst, Martin; Ottens, Marcel
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Continuous downstream processing
errSEPARATION AND PURIFICATION TECHNOLOGY
IF9
err2024-06-01
err10
errOAAI
errJungbauer, Alois; Satzer, Peter; Duerauer, Astrid; Azevedo, Ana; Aires-Barros, Raquel; Nilsson, Bernt; Farid, Suzy; Goldrick, Stephen; Ottens, Marcel; Sponchioni, Mattia; Lahore, Hector Marcelo Fernandez
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Predicting protein retention in ion-exchange chromatography using an open source QSPR workflow
errBIOTECHNOLOGY JOURNAL
IF3.1
err2024-03-13
err2
errOAAI
errNeijenhuis, Tim; Le Bussy, Olivier; Geldhof, Geoffroy; Klijn, Marieke E.; Ottens, Marcel
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Digital twin in high throughput chromatographic process development for monoclonal antibodies
errJOURNAL OF CHROMATOGRAPHY A
IF4
err2024-02-01
err5
errOAAI
errSilva, Tiago Castanheira; Eppink, Michel; Ottens, Marcel
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Hydrodynamics of expanded bed adsorption studied through CFD-DEM
errCHEMICAL ENGINEERING SCIENCE
IF4.3
err2023-10-01
err5
errOAAI
errNijssen, Tim M. J.; Padding, Johan T.; Ottens, Marcel
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Model-based optimization of multistage ultrafiltration/diafiltration for recovery of canola protein
errFOOD AND BIOPRODUCTS PROCESSING
IF3.4
err2023-08-01
err5
errOAAI
errRizki, Zulhaj; Ravesloot, Richard; van Beckhoven, Ruud; Ottens, Marcel
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Real-time detection of mAb aggregates in an integrated downstream process
errBIOTECHNOLOGY AND BIOENGINEERING
IF3.6
err2023-06-13
err7
errOAAI
errSao Pedro, Mariana N.; Isaksson, Madelene; Gomis-Fons, Joaquin; Eppink, Michel H. M.; Nilsson, Bernt; Ottens, Marcel
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Characterisation of the E. coli HMS174 and BLR host cell proteome to guide purification process development
errBIOTECHNOLOGY JOURNAL
IF3.1
err2023-06-05
err7
errOAAI
errDisela, Roxana; Le Bussy, Olivier; Geldhof, Geoffroy; Pabst, Martin; Ottens, Marcel
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errSave
Model-based optimization approaches for pressure-driven membrane systems
errSEPARATION AND PURIFICATION TECHNOLOGY
IF9
err2023-06-01
err6
errOAAI
errRizki, Zulhaj; Ottens, Marcel
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errSave
Using artificial neural networks to accelerate flowsheet optimization for downstream process development
errBIOTECHNOLOGY AND BIOENGINEERING
IF3.6
err2023-05-31
err7
errOAAI
errKeulen, Daphne; van der Hagen, Erik; Geldhof, Geoffroy; Le Bussy, Olivier; Pabst, Martin; Ottens, Marcel
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errSave
Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage
errNATURE COMMUNICATIONS
IF15.7
err2023-04-06
err6
errOAAI
errRosado-Ramos, Rita; Pocas, Goncalo M.; Marques, Daniela; Foito, Alexandre; Sevillano, David M.; Lopes-da-Silva, Mafalda; Goncalves, Luis G.; Menezes, Regina; Ottens, Marcel; Stewart, Derek; de Opakua, Alain Ibanez; Zweckstetter, Markus; Seabra, Miguel C.; Mendes, Cesar S.; Outeiro, Tiago Fleming; Domingos, Pedro M.; Santos, Claudia N.
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Design of a microfluidic mixer channel: First steps into creating a fluorescent dye-based biosensor for mAb aggregate detection
errBIOTECHNOLOGY JOURNAL
IF3.1
err2022-11-11
err4
errOAAI
errPedro, Mariana N. Sao; Santos, Mafalda S.; Eppink, Michel H. M.; Ottens, Marcel
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Small, smaller, smallest: Miniaturization of chromatographic process development
errJOURNAL OF CHROMATOGRAPHY A
IF4
err2022-10-01
err11
errOAAI
errSilva, Tiago Castanheira; Eppink, Michel; Ottens, Marcel
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Recent advances to accelerate purification process development: A review with a focus on vaccines
errJOURNAL OF CHROMATOGRAPHY A
IF4
err2022-08-01
err16
errOAAI
errKeulen, Daphne; Geldhof, Geoffroy; Le Bussy, Olivier; Pabst, Martin; Ottens, Marcel
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
R
Roger A. Sheldon
H-index: 106 · Papers: 642
O
Oscar P. Kuipers
H-index: 104 · Papers: 706
李
李姗姗 (Shanshan Li)
H-index: 99 · Papers: 1.2K
M
Markus Zweckstetter
H-index: 90 · Papers: 429
W
Wim Jiskoot
H-index: 88 · Papers: 393
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