Not logged inPRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma
Giuliani, Virginia; Miller, Meredith A.; Liu, Chiu-Yi; Hartono, Stella R.; Class, Caleb A.; Bristow, Christopher A.; Suzuki, Erika; Sanz, Lionel A.; Gao, Guang; Gay, Jason P.; Feng, Ningping; Rose, Johnathon L.; Tomihara, Hideo; Daniele, Joseph R.; Peoples, Michael D.; Bardenhagen, Jennifer P.; Geck Do, Mary K.; Chang, Qing E.; Vangamudi, Bhavatarini; Vellano, Christopher; Ying, Haoqiang; Deem, Angela K.; Do, Kim-Anh; Genovese, Giannicola; Marszalek, Joseph R.; Kovacs, Jeffrey J.; Kim, Michael; Fleming, Jason B.; Guccione, Ernesto; Viale, Andrea; Maitra, Anirban; Emilia Di Francesco, M.; Yap, Timothy A.; Jones, Philip; Draetta, Giulio; Carugo, Alessandro; Chedin, Frederic; Heffernan, Timothy P. .png)
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SaveAllosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward OsimertinibSun, Yuting; Meyers, Brooke A.; Czako, Barbara; Leonard, Paul; Mseeh, Faika; Harris, Angela L.; Wu, Qi; Johnson, Sarah; Parker, Connor A.; Cross, Jason B.; Di Francesco, Maria Emilia; Bivona, Benjamin J.; Bristow, Christopher A.; Burke, Jason P.; Carrillo, Caroline C.; Carroll, Christopher L.; Chang, Qing; Feng, Ningping; Gao, Guang; Gera, Sonal; Giuliani, Virginia; Huang, Justin K.; Jiang, Yongying; Kang, Zhijun; Kovacs, Jeffrey J.; Liu, Chiu-Yi; Lopez, Anastasia M.; Ma, Xiaoyan; Mandal, Pijus K.; McAfoos, Timothy; Miller, Meredith A.; Mullinax, Robert A.; Peoples, Michael; Ramamoorthy, Vandhana; Seth, Sahil; Spencer, Nakia D.; Suzuki, Erika; Williams, Christopher C.; Yu, Simon S.; Zuniga, Andy M.; Draetta, Giulio F.; Marszalek, Joseph R.; Heffernan, Timothy P.; Kohl, Nancy E.; Jones, Philip Share Save Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical PropertiesSoth, Michael J.; Le, Kang; Di Francesco, Maria Emilia; Hamilton, Matthew M.; Liu, Gang; Burke, Jason P.; Carroll, Chris L.; Kovacs, Jeffrey J.; Bardenhagen, Jennifer P.; Bristow, Christopher A.; Cardozo, Mario; Czako, Barbara; de Stanchina, Elisa; Feng, Ningping; Garvey, Jill R.; Gay, Jason P.; Do, Mary K. Geck; Greer, Jennifer; Han, Michelle; Harris, Angela; Herrera, Zachary; Huang, Sha; Giuliani, Virginia; Jiang, Yongying; Johnson, Sarah B.; Johnson, Troy A.; Kang, Zhijun; Leonard, Paul G.; Liu, Zhen; McAfoos, Timothy; Miller, Meredith; Morlacchi, Pietro; Mullinax, Robert A.; Palmer, Wylie S.; Pang, Jihai; Rogers, Norma; Rudin, Charles M.; Shepard, Hannah E.; Spencer, Nakia D.; Theroff, Jay; Wu, Qi; Xu, Alan; Yau, Ju Anne; Draetta, Giulio; Toniatti, Carlo; Heffernan, Timothy P.; Jones, Philip Share Save A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular NeovascularizationWojnarowicz, Paulina M.; Lima e Silva, Raquel; Ohnaka, Masayuki; Lee, Sang Bae; Chin, Yvette; Kulukian, Anita; Chang, Sung-Hee; Desai, Bina; Escolano, Marta Garcia; Shah, Riddhi; Garcia-Cao, Marta; Xu, Sijia; Kadam, Rashmi; Goldgur, Yehuda; Miller, Meredith A.; Ouerfelli, Ouathek; Yang, Guangli; Arakawa, Tsutomu; Albanese, Steven K.; Garland, William A.; Stoller, Glenn; Chaudhary, Jaideep; Norton, Larry; Soni, Rajesh Kumar; Philip, John; Hendrickson, Ronald C.; Iavarone, Antonio; Dannenberg, Andrew J.; Chodera, John D.; Pavletich, Nikola; Lasorella, Anna; Campochiaro, Peter A.; Benezra, Robert Share Save Inhibition of protein arginine methylation alters RNA metabolism and DNA damage response providing a new therapeutic strategy in pancreatic ductal adenocarcinomaGiuliani, Virginia; Carugo, Alessandro; Miller, Meredith; Sanz, Lionel; Liu, Chiu-Yi; Bristow, Christopher A.; Suzuki, Erika; Class, Caleb A.; Hartono, Stella R.; Gao, Guang; Feng, Ningping; Gay, Jason P.; Vangamudi, Bhavatarini; Marszalek, Joseph R.; Kovacs, Jeffrey; Di Francesco, Maria Emilia; Chedin, Frederic; Jones, Philip; Draetta, Giulio; Heffernan, Timothy Share Save Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative PhosphorylationSun, Yuting; Bandi, Madhavi; Lofton, Timothy; Smith, Melinda; Bristow, Christopher A.; Carugo, Alessandro; Rogers, Norma; Leonard, Paul; Chang, Qing; Mullinax, Robert; Han, Jing; Shi, Xi; Seth, Sahil; Meyers, Brooke A.; Miller, Meredith; Miao, Lili; Ma, Xiaoyan; Feng, Ningping; Giuliani, Virginia; Do, Mary Geck; Czako, Barbara; Palmer, Wylie S.; Mseeh, Faika; Asara, John M.; Jiang, Yongying; Morlacchi, Pietro; Zhao, Shuping; Peoples, Michael; Tieu, Trang N.; Warmoes, Marc O.; Lorenzi, Philip L.; Muller, Florian L.; DePinho, Ronald A.; Draetta, Giulio F.; Toniatti, Carlo; Jones, Philip; Heffernan, Timothy P.; Marszalek, Joseph R. Share Save A small molecule pan Id protein antagonist shows strong antitumor activityWojnarowicz, Paulina M.; Desai, Bina; Chin, Yvette; Lee, Sang Bae; Garcia-Cao, Marta; Ouerfelli, Ouathek; Yang, Guangli; Xu, Sijia; Goldgur, Yehuda; Miller, Meredith A.; Chaudhary, Jaideep; Garland, William A.; Albanese, Steven K.; Soni, Rajesh; Philip, John; Norton, Larry; Rosen, Neal; Hendrickson, Ronald C.; Zhou, Xi Kathy; Iavarone, Antonio; Dannenberg, Andrew J.; Chodera, John D.; Pavletich, Nikola; Lasorella, Anna; Benezra, Robert Share Save Identification of protein arginine methyltransferase 1 as novel epigenetic vulnerability in KRAS/p53 mutant PDAC primary patient modelsGiuliani, Virginia; Vangamudi, Bhavatarini; Suzuki, Erika; Miller, Meredith; Liu, Chiu-Yi; Carugo, Alessandro; Bristow, Christopher; Gao, Guang; Han, Jing; Sun, Yuting; Feng, Ningping; Chang, Edward; Marszalek, Joseph; Kovacs, Jeffrey; Di Francesco, Maria Emilia; Toniatti, Carlo; Heffernan, Timothy; Jones, Philip; Draetta, Giulio Share Save 
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