Not logged in Treatment and prevention of pathological mitochondrial dysfunction in retinal degeneration and in photoreceptor injury Moos, Walter H.; V. Faller, Douglas; Glavas, Ioannis P.; Harpp, David N.; Kamperi, Natalia; Kanara, Iphigenia; Kodukula, Krishna; Mavrakis, Anastasios N.; Pernokas, Julie; Pernokas, Mark; Pinkert, Carl A.; Powers, Whitney R.; Sampani, Konstantina; Steliou, Kosta; Tamvakopoulos, Constantin; Vavvas, Demetrios G.; Zamboni, Robert J.; Chen, Xiaohong Share Save
Pathogenic mitochondrial dysfunction and metabolic abnormalities Moos, Walter H.; Faller, Douglas V.; Glavas, Ioannis P.; Harpp, David N.; Kamperi, Natalia; Kanara, Iphigenia; Kodukula, Krishna; Mavrakis, Anastasios N.; Pernokas, Julie; Pernokas, Mark; Pinkert, Carl A.; Powers, Whitney R.; Steliou, Kosta; Tamvakopoulos, Constantin; Vavvas, Demetrios G.; Zamboni, Robert J.; Sampani, Konstantina Share Save
Epigenetic treatment of dermatologic disorders Moos, Walter H.; Faller, Douglas V.; Glavas, Ioannis P.; Harpp, David N.; Kanara, Iphigenia; Pinkert, Carl A.; Powers, Whitney R.; Sampani, Konstantina; Steliou, Kosta; Vavvas, Demetrios G.; Kodukula, Krishna; Zamboni, Robert J. Share Save
Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis Miller, Mark; Pal, Arindom; Albusairi, Wabel; Joo, Hyun; Pappas, Bever; Tuhin, Md Tariqul Haque; Liang, Dengpan; Jampala, Raghavendra; Liu, Fang; Khan, Jared; Faaij, Marjon; Park, Miki; Chan, William; Graef, Isabella; Zamboni, Robert; Kumar, Neil; Fox, Jonathan; Sinha, Uma; Alhamadsheh, Mamoun Share Save
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Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor Riendeau, D; Percival, MD; Boyce, S; Brideau, C; Charleson, S; Cromlish, W; Ethier, D; Evans, J; Falgueyret, JP; FordHutchinson, AW; Gordon, R; Greig, G; Gresser, M; Guay, J; Kargman, S; Leger, S; Mancini, JA; ONeill, G; Ouellet, M; Rodger, IW; Therien, M; Wang, Z; Webb, JK; Wong, E; Xu, L; Young, RN; Zamboni, R; Prasit, P; Chan, CC Share Save
Neuroprotective effects of M826, a reversible caspase-3 inhibitor, in the rat malonate model of Huntington's disease Toulmond, S; Tang, K; Bureau, Y; Ashdown, H; Degen, S; O'Donnell, R; Tam, J; Han, YX; Colucci, J; Giroux, A; Zhu, YX; Boucher, M; Pikounis, B; Xanthoudakis, S; Roy, S; Rigby, M; Zamboni, R; Robertson, GS; Ng, GYK; Nicholson, DW; Flückiger, JP Share Save
Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524) Sturino, Claudio F.; O'Neill, Gary; Lachance, Nicolas; Boyd, Michael; Berthelette, Carl; Labelle, Marc; Li, Lianhai; Roy, Bruno; Scheigetz, John; Tsou, Nancy; Aubin, Yves; Bateman, Kevin P.; Chauret, Nathalie; Day, Stephen H.; Levesque, Jean-Francois; Seto, Carmai; Silva, Jose H.; Trimble, Laird A.; Carriere, Marie-Claude; Denis, Danielle; Greig, Gillian; Kargman, Stacia; Lamontagne, Sonia; Mathieu, Marie-Claude; Sawyer, Nicole; Slipetz, Deborah; Abraham, William M.; Jones, Tom; McAuliffe, Malia; Piechuta, Hana; Nicoll-Griffith, Deborah A.; Wang, Zhaoyin; Zamboni, Robert; Young, Robert N.; Metters, Kathleen M. Share Save
A caspase active site probe reveals high fractional inhibition needed to block DNA fragmentation Méthot, N; Vaillancourt, JP; Huang, JQ; Colucci, J; Han, YX; Ménard, S; Zamboni, R; Toulmond, S; Nicholson, DW; Roy, S Share Save
Reducing the peptidyl features of caspase-3 inhibitors: A structural analysis Becker, JW; Rotonda, J; Soisson, SM; Aspiotis, R; Bayly, C; Francoeur, S; Gallant, M; Garcia-Calvo, M; Giroux, A; Grimm, E; Han, YX; McKay, D; Nicholson, DW; Peterson, E; Renaud, J; Roy, S; Thornberry, N; Zamboni, R Share Save
Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics Méthot, N; Huang, JQ; Coulombe, N; Vaillancourt, JP; Rasper, D; Tam, J; Han, YX; Colucci, J; Zamboni, R; Xanthoudakis, S; Toulmond, S; Nicholson, DW; Roy, S Share Save
Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury Han, BH; Xu, DG; Choi, JJ; Han, YX; Xanthoudakis, S; Roy, S; Tam, J; Vaillancourt, J; Colucci, J; Siman, R; Giroux, A; Robertson, GS; Zamboni, R; Nicholson, DW; Holtzman, DM Share Save
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DEVELOPMENT OF A NOVEL SERIES OF STYRYLQUINOLINE COMPOUNDS AS HIGH-AFFINITY LEUKOTRIENE-D4 RECEPTOR ANTAGONISTS - SYNTHETIC AND STRUCTURE ACTIVITY STUDIES LEADING TO THE DISCOVERY OF (+/-)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)-(E)-ETHENYL]PHENYL][[3-(DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]PROPIONIC ACID ZAMBONI, R; BELLEY, M; CHAMPION, E; CHARETTE, L; DEHAVEN, R; FRENETTE, R; GAUTHIER, JY; JONES, TR; LEGER, S; MASSON, P; MCFARLANE, CS; METTERS, K; PONG, SS; PIECHUTA, H; ROKACH, J; THERIEN, M; WILLIAMS, HWR; YOUNG, RN Share Save
The YRD motif is a major determinant of substrate and inhibitor specificity in T-cell protein-tyrosine phosphatase Asante-Appiah, E; Ball, K; Bateman, K; Skorey, K; Friesen, R; Desponts, C; Payette, P; Bayly, C; Zamboni, R; Scapin, G; Ramachandran, C; Kennedy, BP Share Save
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