Not logged inTAK-500 is a clinical stage immune-cell directed antibody drug conjugate (iADC) inducing STING activation in CCR2-expressing intratumor myeloid cells and favorable immunomodulation
Schalper, Kurt A.; Matsuda, Atsushi; Ganno-Sherwood, Michelle; Maldonado-Lopez, Angel E.; Rosentrater, Emily; Porciuncula, Angelo; Zhang, Dong Mei; Christensen, Camilla L.; Merrigan, Samantha A.; Hatten, Tiquella; Lee, Hong Myung; Lee, Min Young; Dong, Linlin; Huang, Jian; Iartchouk, Natasha; Wang, Jianing; Xu, He; Yoneyama, Tomoki; Piatkov, Konstantin I.; Harbison, Carole E.; Parent, Alex; Lineberry, Neil; Abu-Yousif, Adnan O.; Appleman, Vicky .png)
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SavePRECLINICAL ACTIVITY OF C-C CHEMOKINE RECEPTOR 2 (CCR2)-TARGETED IMMUNE STIMULATING ANTIBODY CONJUGATE (ISAC), MOTIVATING CLINICAL TESTING OF TAK-500Appleman, Vicky; Matsuda, Atsushi; Ganno, Michelle; Lopez, Angel Maldonado; Rosentrater, Emily; Christensen, Camilla; Merrigan, Samantha; Lee, Hong Myung; Lee, Min Young; Dong, Linlin; Huang, Jian; Iartchouk, Natasha; Zhang, Dong Mei; Wang, Jianing; Xu, He; Yoneyama, Tomoki; Piatkov, Konstantin; Harbison, Carole; Abu-Yousif, Adnan Share Save Mechanisms of synergy of carboplatin and an EphA2-targeted docetaxel antibody-directed nanotherapeuticKamoun, Walid S.; Sawyer, Andrew J.; Pien, Christine; Koshkaryev, Alexander; Luus, Lia; Merrigan, Samantha; Sun, Gang; Kozin, Sergey; Huang, Zhaohua Richard; Tipparaju, Suresh K.; Kirpotin, Dmitri B.; Xu, Hannah; Askoxylakis, Vasileios; Reynolds, Patrick C.; Drummond, Daryl C. Share Save 
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