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The oncolytic adenovirus RGDOX sensitizes the anti-tumor efficacy of immune checkpoint blockades in murine melanoma brain metastases models Du, Yi; Singh, Sanjay; Duran, Alejandra; Ban, Kechen; Wu, Xizi; Ene, Chibawanye; Gumin, Joy; Jiang, Hong; Peng, David; Gomez, Javier; Sebastian, Manu; Nayyar, Naema; Brastianos, Priscilla; Tawbi, Hussein; Davies, Michael; Lang, Frederick; Gomez-Manzano, Candelaria; Fueyo-Margareto, Juan; Alvarez-Breckenridge, Christopher Share Save
Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance Thatikonda, Venu; Lyu, Hengyu; Jurado, Sabine; Kostyrko, Kaja; Bristow, Christopher A.; Albrecht, Christoph; Alpar, Donat; Arnhof, Heribert; Bergner, Oliver; Bosch, Karin; Feng, Ningping; Gao, Sisi; Gerlach, Daniel; Gmachl, Michael; Hinkel, Melanie; Lieb, Simone; Jeschko, Astrid; Machado, Annette A.; Madensky, Thomas; Marszalek, Ethan D.; Mahendra, Mikhila; Melo-Zainzinger, Gabriella; Molkentine, Jessica M.; Jaeger, Philipp A.; Peng, David H.; Schenk, Robyn L.; Sorokin, Alexey; Strauss, Sandra; Trapani, Francesca; Kopetz, Scott; Vellano, Christopher P.; Petronczki, Mark; Kraut, Norbert; Heffernan, Timothy P.; Marszalek, Joseph R.; Pearson, Mark; Waizenegger, Irene C.; Hofmann, Marco H. Share Save
KRASmulti inhibitor BI 3706674 shows efficacy in KRAS-driven preclinical models of cancer that supports clinical testing in patients with tumors harbouring KRASG12V mutations and KRAS wild-type amplifications Tedeschi, Antonio; Peng, David H.; Schischlik, Fiorella; Herdeis, Lorenz; Schaaf, Otmar; Santoro, Valeria; Gerlach, Daniel; Savarese, Fabio; Lipp, Jesse; Haslinger, Christian; Rocchetti, Francesca; Popow, Johannes; Huber, Heinrich J.; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Broeker, Joachim; Wunber, Tobias; Gmachl, Michael; Rumpel, Klaus; Rees, Matthew; Ron, Melissa; Roth, Jennifer; Williams, Mariah; Deckard, Charles; Ramamoorthy, Vandhana; Daniele, Joseph R.; Ajani, Jaffer A.; Meric-Bernstam, Funda; Kopetz, Scott; Kim, Michael; Gibbons, Don L.; Vellano, Christopher P.; Marszalek, Joseph R.; Heffernan, Timothy P.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Rudolph, Dorothea Share Save
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Intravenous gentamicin therapy induces functional type VII collagen in patients with recessive dystrophic epidermolysis bullosa: an open-label clinical trial Woodley, David T.; Hao, Michelle; Kwong, Andrew; Levian, Brandon; Cogan, Jon; Hou, Yingping; Mosallaei, Daniel; Kleinman, Elana; Zheng, Kate; Chung, Claire; Kim, Gene; Peng, David; Chen, Mei Share Save
BI KRASmulti, a first-in-class, orally bioavailable and direct inhibitor of diverse oncogenic KRAS variants drives tumor regression in KRAS G12V-driven preclinical models Peng, David H.; Tedeschi, Antonio; Herdeis, Lorenz; Savarese, Fabio; Rocchetti, Francesca; Johannes, Popow; Huber, Heinrich J.; Melillo, Nicola; Dickinson, Jake; Mistry, Hitesh B.; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Broker, Joachim; Wunberg, Tobias; Schischlik, Fiorella; Lipp, Jesse; Ramamoorthy, Vandhana; Daniele, Joseph R.; Kopetz, Scott; Kim, Michael; Gibbons, Don L.; Vellano, Christopher P.; Marszalek, Joseph R.; Heffernan, Timothy P.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Rudolph, Dorothea Share Save
BI KRASmulti, a first-in-class, orally bioavailable and direct inhibitor of diverse oncogenic KRAS variants drives tumor regression in preclinical models and validates wild-type amplified KRAS as a therapeutic target Tedeschi, Antonio; Herdeis, Lorenz; Santoro, Valeria; Savarese, Fabio; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Broker, Joachim; Wunberg, Tobias; Gmachl, Michael; Klaus, Rumpel; Schischlik, Fiorella; Lipp, Jesse; Peng, David H.; Williams, Mariah; Deckard, Charles; Ramamoorthy, Vandhana; Daniele, Joseph R.; Ajani, Jaffer A.; Meric-Bernstam, Funda; Vellano, Christopher R.; Marszalek, Joseph R.; Heffernan, Timothy P.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Rudolph, Dorothea Share Save
Targeting immunosuppressive Ly6C+classical monocytes reverses anti-PD-1/CTLA-4 immunotherapy resistance Rodriguez, B. Leticia; Chen, Limo; Li, Yanli; Miao, Shucheng; Peng, David H.; Fradette, Jared J.; Diao, Lixia; Konen, Jessica M.; Alvarez, Frank R. Rojas; Solis, Luisa M.; Yi, Xiaohui; Padhye, Aparna; Gibson, Laura A.; Ochieng, Joshua K.; Zhou, Xiaofei; Wang, Jing; Gibbons, Don L. Share Save
Targeting HER2 Exon 20 Insertion-Mutant Lung Adenocarcinoma with a Novel Tyrosine Kinase Inhibitor Mobocertinib Han, Han; Li, Shuai; Chen, Ting; Fitzgerald, Michael; Liu, Shengwu; Peng, Chengwei; Tang, Kwan Ho; Cao, Shougen; Chouitar, Johara; Wu, Jiansheng; Peng, David; Deng, Jiehui; Gao, Zhendong; Baker, Theresa E.; Li, Fei; Zhang, Hua; Pan, Yuanwang; Ding, Hailin; Hu, Hai; Pyon, Val; Thakurdin, Cassandra; Papadopoulos, Eleni; Tang, Sittinon; Gonzalvez, Francois; Chen, Haiquan; Rivera, Victor M.; Brake, Rachael; Vincent, Sylvie; Wong, Kwok-Kin Share Save
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Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma Sun, Yun-Fan; Wu, Liang; Liu, Shi-Ping; Jiang, Miao-Miao; Hu, Bo; Zhou, Kai-Qian; Guo, Wei; Xu, Yang; Zhong, Yu; Zhou, Xiao-Rui; Zhang, Ze-Fan; Liu, Geng; Liu, Sheng; Shi, Ying-Hong; Ji, Yuan; Du, Min; Li, Nan-Nan; Li, Gui-Bo; Zhao, Zhi-Kun; Huang, Xiao-Yun; Xu, Li-Qin; Yu, Qi-Chao; Peng, David H.; Qiu, Shuang-Jian; Sun, Hui-Chuan; Dean, Michael; Wang, Xiang-Dong; Chung, Wen-Yuan; Dennison, Ashley R.; Zhou, Jian; Hou, Yong; Fan, Jia; Yang, Xin-Rong Share Save
ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1-mutant lung cancer Deng, Jiehui; Thennavan, Aatish; Dolgalev, Igor; Chen, Ting; Li, Jie; Marzio, Antonio; Poirier, John T.; Peng, David H.; Bulatovic, Mirna; Mukhopadhyay, Subhadip; Silver, Heather; Papadopoulos, Eleni; Pyon, Val; Thakurdin, Cassandra; Han, Han; Li, Fei; Li, Shuai; Ding, Hailin; Hu, Hai; Pan, Yuanwang; Weerasekara, Vajira; Jiang, Baishan; Wang, Eric S.; Ahearn, Ian; Philips, Mark; Papagiannakopoulos, Thales; Tsirigos, Aristotelis; Rothenberg, Eli; Gainor, Justin; Freeman, Gordon J.; Rudin, Charles M.; Gray, Nathanael S.; Hammerman, Peter S.; Pagano, Michele; Heymach, John V.; Perou, Charles M.; Bardeesy, Nabeel; Wong, Kwok-Kin Share Save
Th17 cells contribute to combination MEK inhibitor and anti-PD-L1 therapy resistance in KRAS/p53 mutant lung cancers Peng, David H.; Rodriguez, B. Leticia; Diao, Lixia; Gaudreau, Pierre-Olivier; Padhye, Aparna; Konen, Jessica M.; Ochieng, Joshua K.; Class, Caleb A.; Fradette, Jared J.; Gibson, Laura; Chen, Limo; Wang, Jing; Byers, Lauren A.; Gibbons, Don L. Share Save
The KRASG12C Inhibitor MRTX849 Reconditions the Tumor Immune Microenvironment and Sensitizes Tumors to Checkpoint Inhibitor Therapy Briere, David M.; Li, Shuai; Calinisan, Andrew; Sudhakar, Niranjan; Aranda, Ruth; Hargis, Lauren; Peng, David H.; Deng, Jiehui; Engstrom, Lars D.; Hallin, Jill; Gatto, Sole; Fernandez-Banet, Julio; Pavlicek, Adam; Wong, Kwok-Kin; Christensen, James G.; Olson, Peter Share Save
Dual Inhibition of MEK and AXL Targets Tumor Cell Heterogeneity and Prevents Resistant Outgrowth Mediated by the Epithelial-to-Mesenchymal Transition in NSCLC Konen, Jessica M.; Rodriguez, B. Leticia; Padhye, Aparna; Ochieng, Joshua K.; Gibson, Laura; Diao, Lixia; Fowlkes, Natalie W.; Fradette, Jared J.; Peng, David H.; Cardnell, Robert J.; Kovacs, Jeffrey J.; Wang, Jing; Byers, Lauren A.; Gibbons, Don L. Share Save
AXL Inhibition Induces DNA Damage and Replication Stress in Non-Small Cell Lung Cancer Cells and Promotes Sensitivity to ATR Inhibitors Ramkumar, Kavya; Stewart, C. Allison; Cargill, Kasey R.; Della Corte, Carminia M.; Wang, Qi; Shen, Li; Diao, Lixia; Cardnell, Robert J.; Peng, David H.; Rodriguez, B. Leticia; Fan, You-Hong; Heymach, John, V; Wang, Jing; Gay, Carl M.; Gibbons, Don L.; Byers, Lauren A. Share Save
Establishment and identification of organoids from human circulating colorectal cancer cells Zhang, Long; Mo, Shaobo; Hu, Xiang; Ma, Xiaoji; Jin, Weixiang; Peng, David Haixiang; Zhou, Yu; Liang, Xiaofei; Rao, Xinxin; Xu, Xiaoya; Zhang, Zhen; Hua, Guoqiang; Cai, Sanjun; Li, Yaqi; Peng, Junjie Share Save
Multiomics profiling of primary lung cancers and distant metastases reveals immunosuppression as a common characteristic of tumor cells with metastatic plasticity Lee, Won-Chul; Reuben, Alexandre; Hu, Xin; McGranahan, Nicholas; Chen, Runzhe; Jalali, Ali; Negrao, Marcelo, V; Hubert, Shawna M.; Tang, Chad; Wu, Chia-Chin; San Lucas, Anthony; Roh, Whijae; Suda, Kenichi; Kim, Jihye; Tan, Aik-Choon; Peng, David H.; Lu, Wei; Tang, Ximing; Chow, Chi-Wan; Fujimoto, Junya; Behrens, Carmen; Kalhor, Neda; Fukumura, Kazutaka; Coyle, Marcus; Thornton, Rebecca; Gumbs, Curtis; Li, Jun; Wu, Chang-Jiun; Little, Latasha; Roarty, Emily; Song, Xingzhi; Lee, J. Jack; Sulman, Erik P.; Rao, Ganesh; Swisher, Stephen; Diao, Lixia; Wang, Jing; Heymach, John, V; Huse, Jason T.; Scheet, Paul; Wistuba, Ignacio I.; Gibbons, Don L.; Futreal, P. Andrew; Zhang, Jianhua; Gomez, Daniel; Zhang, Jianjun Share Save
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