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William L. Klein

northwestern university

79H-index
259Paper Count
3.2WCitation Count
Published Papers 83
Publication Date
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Identification of a glia-associated amyloid β oligomer subtype and the rescue from reactive astrogliosis by inhibitor NU-9
errALZHEIMERS & DEMENTIA
IF11.1
err2025-12-18
err0
errOAAI
errKranz, Daniel L.; de Leon Velez, Omar; Ulupinar, Emel; Ozdinler, P. Hande; Silverman, Richard B.; Klein, William L.
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Modifications of NU-9, a potent protein aggregation inhibitor. Properties and activity in a cellular model of amyotrophic lateral sclerosis
errBioorganic Chemistry
IF4.7
err2025-11-02
err0
PREAI
errMohamed F. Elmansy; Pedro Soares; Jose Ricardo D. dos Remedios; Raghad Nowar; Susan G. Fox; Anan Yu; William L. Klein; Richard I. Morimoto; Richard B. Silverman
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CaV2.1 mediates presynaptic dysfunction induced by amyloid (3 oligomers
errCELL REPORTS
IF6.9
err2025-04-01
err0
PREAI
errJeans, Alexander F.; Padamsey, Zahid; Collins, Helen; Foster, William; Allison, Sally; Dierksmeier, Steven; Klein, William L.; van den Maagdenberg, Arn M. J. M.; Emptage, Nigel J.
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Amyloid β Proteoforms Elucidated by Quantitative LC/MS in the 5xFAD Mouse Model of Alzheimer's Disease
errJOURNAL OF PROTEOME RESEARCH
IF3.6
err2023-10-17
err1
PREAI
errKandi, Soumya; Cline, Erika N.; Rivera, Brianna M.; Viola, Kirsten L.; Zhu, Jiuhe; Condello, Carlo; Leduc, Richard D.; Klein, William L.; Kelleher, Neil L.; Patrie, Steven M.
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Pharmacological inhibition of plasminogen activator inhibitor-1 prevents memory deficits and reduces neuropathology in APP/PS1 mice
errPSYCHOPHARMACOLOGY
IF3.3
err2023-09-12
err2
PREAI
errRodriguez, Guadalupe; Eren, Mesut; Haupfear, Isabel; Viola, Kirsten L.; Cline, Erika N.; Miyata, Toshio; Klein, William L.; Vaughan, Douglas E.; Dong, Hongxin
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Correction to: Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology (vol 132, 257, 2016)
errACTA NEUROPATHOLOGICA
IF9.3
err2023-08-04
err0
errOAAI
errLauritzen, Inger; Pardossi-Piquard, Raphaelle; Bourgeois, Alexandre; Pagnotta, Sophie; Biferi, Maria-Grazia; Barkats, Martine; Lacor, Pascale; Klein, William; Bauer, Charlotte; Checler, Frederic
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AAV-mediated neuronal expression of an scFv antibody selective for Af3 oligomers protects synapses and rescues memory in Alzheimer models
errMOLECULAR THERAPY
IF12
err2023-02-01
err8
errOAAI
errSelles, Maria Clara; Fortuna, Juliana T. S.; Cercato, Magali C.; Santos, Luis Eduardo; Domett, Luciana; Bitencourt, Andre L. B.; Carraro, Mariane Favero; Souza, Amanda S.; Janickova, Helena; Azevedo, Caroline Vieira; Campos, Henrique Correia; de Souza, Jorge M.; Alves-Leon, Soniza; Prado, Vania F.; Prado, Marco A. M.; Epstein, Alberto L.; Salvetti, Anna; Longo, Beatriz Monteiro; Arancio, Ottavio; Klein, William L.; Sebollela, Adriano; De Felice, Fernanda G.; Jerusalinsky, Diana A.; Ferreira, Sergio T.
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Intrathecal amyloid-beta oligomer administration increases tau phosphorylation in the medial temporal lobe in the African green monkey: A nonhuman primate model of Alzheimer's disease
errNEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
IF3.4
err2022-03-02
err10
PREAI
errWakeman, Dustin R.; Weed, Michael R.; Perez, Sylvia E.; Cline, Erika N.; Viola, Kirsten L.; Wilcox, Kyle C.; Moddrelle, David S.; Nisbett, Ernell Z.; Kurian, Anish M.; Bell, Amanda F.; Pike, Ricaldo; Jacobson, Peer B.; Klein, William L.; Mufson, Elliott J.; Lawrence, Matthew S.; Elsworth, John D.
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Diet-induced Alzheimer's-like syndrome in the rabbit
errALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
IF6.8
err2022-02-01
err2
errOAAI
errWeiss, Craig; Bertolino, Nicola; Procissi, Daniele; Aleppo, Grazia; Smith, Quinn C.; Viola, Kirsten L.; Bartley, Samuel C.; Klein, William L.; Disterhoft, John F.
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Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease
errNATURE COMMUNICATIONS
IF15.7
err2022-01-10
err58
errOAAI
errYang, Yun; Tapias, Victor; Acosta, Diana; Xu, Hui; Chen, Huanlian; Bhawal, Ruchika; Anderson, Elizabeth T.; Ivanova, Elena; Lin, Hening; Sagdullaev, Botir T.; Chen, Jianer; Klein, William L.; Viola, Kirsten L.; Gandy, Sam; Haroutunian, Vahram; Beal, M. Flint; Eliezer, David; Zhang, Sheng; Gibson, Gary E.
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The Therapeutic and Diagnostic Potential of Amyloid β Oligomers Selective Antibodies to Treat Alzheimer's Disease
errFRONTIERS IN NEUROSCIENCE
IF3.2
err2022-01-03
err16
errOAAI
errViola, Kirsten L.; Bicca, Maira A.; Bebenek, Adrian M.; Kranz, Daniel L.; Nandwana, Vikas; Waters, Emily A.; Haney, Chad R.; Lee, Maxwell; Gupta, Abhay; Brahmbhatt, Zachary; Huang, Weijian; Chang, Ting-Tung; Peck, Anderson; Valdez, Clarissa; Dravid, Vinayak P.; Klein, William L.
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Induction of inverted morphology in brain organoids by vertical-mixing bioreactors
errCOMMUNICATIONS BIOLOGY
IF5.1
err2021-10-22
err20
errOAAI
errDang Ngoc Anh Suong; Imamura, Keiko; Inoue, Ikuyo; Kabai, Ryotaro; Sakamoto, Satoko; Okumura, Tatsuya; Kato, Yoshikazu; Kondo, Takayuki; Yada, Yuichiro; Klein, William L.; Watanabe, Akira; Inoue, Haruhisa
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Identification of intraneuronal amyloid beta oligomers in locus coeruleus neurons of Alzheimer's patients and their potential impact on inhibitory neurotransmitter receptors and neuronal excitability
errNEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
IF3.4
err2020-12-20
err30
errOAAI
errKelly, Louise; Seifi, Mohsen; Ma, Ruolin; Mitchell, Scott J.; Rudolph, Uwe; Viola, Kirsten L.; Klein, William L.; Lambert, Jeremy J.; Swinny, Jerome D.
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Aβ oligomer induced cognitive impairment and evaluation of ACU193-MNS-based MRI in rabbit
errALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
IF6.8
err2020-10-10
err6
errOAAI
errRozema, Nicholas B.; Procissi, Daniele; Bertolino, Nicola; Viola, Kirsten L.; Nandwana, Vikas; Abdul, Nafay; Pribus, Sophia; Dravid, Vinayak; Klein, William L.; Disterhoft, John F.; Weiss, Craig
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Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2020-03-06
err74
errOAAI
errWelikovitch, Lindsay A.; Do Carmo, Sonia; Magloczky, Zsofia; Malcolm, Janice C.; Loke, Janos; Klein, William L.; Freund, Tamas; Cuello, A. Claudio
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The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade
errJOURNAL OF ALZHEIMERS DISEASE
IF3.1
err2018-06-12
err674
errOAAI
errCline, Erika N.; Bicca, Maira Assuncao; Viola, Kirsten L.; Klein, William L.
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The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease
errJOURNAL OF PATHOLOGY
IF5.2
err2018-04-02
err191
errOAAI
errBatista, Andre F.; Forny-Germano, Leticia; Clarke, Julia R.; Lyra e Silva, Natalia M.; Brito-Moreira, Jordano; Boehnke, Susan E.; Winterborn, Andrew; Coe, Brian C.; Lablans, Ann; Vital, Juliana F.; Marques, Suelen A.; Martinez, Ana M. B.; Gralle, Matthias; Holscher, Christian; Klein, William L.; Houzel, Jean-Christophe; Ferreira, Sergio T.; Munoz, Douglas P.; De Felice, Fernanda G.
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Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers
errMOLECULAR BIOLOGY OF THE CELL
IF2.7
err2017-10-01
err79
errOAAI
errPitt, Jason; Wilcox, Kyle C.; Tortelli, Vanessa; Diniz, Luan Pereira; Oliveira, Maira S.; Dobbins, Cassandra; Yu, Xiao-Wen; Nandamuri, Sathwik; Gomes, Flvia C. A.; DiNunno, Nadia; Viola, Kirsten L.; De Felice, Fernanda G.; Ferreira, Sergio T.; Klein, William L.
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Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology
errACTA NEUROPATHOLOGICA
IF9.3
err2017-06-13
err97
errOAAI
errHaure-Mirande, Jean-Vianney; Audrain, Mickael; Fanutza, Tomas; Kim, Soong Ho; Klein, William L.; Glabe, Charles; Readhead, Ben; Dudley, Joel T.; Blitzer, Robert D.; Wang, Minghui; Zhang, Bin; Schadt, Eric E.; Gandy, Sam; Ehrlich, Michelle E.
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Amyloid- oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2017-03-01
err54
errOAAI
errSeixas da Silva, Gisele S.; Melo, Helen M.; Lourenco, Mychael V.; Lyra e Silva, Natalia M.; de Carvalho, Marcelo B.; Alves-Leon, Soniza V.; de Souza, Jorge M.; Klein, William L.; da-Silva, Wagner S.; Ferreira, Sergio T.; De Felice, Fernanda G.
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Research Directions

No research directions
Co-authors
Cooperation Journals
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Eric E. Schadt
H-index: 134 · Papers: 800
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Richard M. Ransohoff
H-index: 129 · Papers: 509
R
Richard P. Van Duyne
H-index: 127 · Papers: 480
S
Steven E. Arnold
H-index: 123 · Papers: 693
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