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BCKDHA-BCKDHB digenic gene therapy restores metabolic homeostasis in two mouse models and a calf with classic maple syrup urine disease Wang, Jiaming; Poskitt, Laura E.; Gallagher, Jillian; Puffenberger, Erik G.; Wynn, R. Max; Shishodia, Gauri; Chuang, David T.; Beever, Jonathan; Hardin, Donald L.; Brigatti, Karlla W.; Baker, William C.; Gately, Rachael; Bertrand, Stephanie; Rodrigues, Ashlin; Benatti, Hector R.; Taghian, Toloo; Hall, Erin; Prestigiacomo, Rachel; Liang, Jialing; Chen, Gong; Zhou, Xuntao; Ren, Lingzhi; He, Ran; Su, Qin; Xie, Jun; Jiang, Zhong; Gruntman, Alisha; Strauss, Kevin A. Share Save
Bicyclic Inhibitors of Branched-Chain α-Keto Acid Dehydrogenase Kinase (BDK) with In Vivo Activity Liang, Jue; Wang, Xiaoyu; Ortiz, Francisco; Shishodia, Gauri; Liu, Tian; Gao, Chen; Williams, Noelle S.; Chuang, David T.; Wynn, R. Max; Ready, Joseph M. Share Save
Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor Wu, Liangxing; Zhang, Colin; He, Chunhong; Qian, Dingquan; Lu, Liang; Sun, Yaping; Xu, Meizhong; Zhuo, Jincong; Liu, Phillip C. C.; Klabe, Ronald; Wynn, Richard; Covington, Maryanne; Gallagher, Karen; Leffet, Lynn; Bowman, Kevin; Diamond, Sharon; Koblish, Holly; Zhang, Yue; Soloviev, Maxim; Hollis, Gregory; Burn, Timothy C.; Scherle, Peggy; Yeleswaram, Swamy; Huber, Reid; Yao, Wenqing Share Save
A Potent and Selective Dual Inhibitor of AXL and MERTK Possesses Both Immunomodulatory and Tumor-Targeted Activity Rios-Doria, Jonathan; Favata, Margaret; Lasky, Kerri; Feldman, Patricia; Lo, Yvonne; Yang, Gengjie; Stevens, Christina; Wen, Xiaoming; Sehra, Sarita; Katiyar, Kamna; Liu, Ke; Wynn, Richard; Harris, Jennifer J.; Ye, Min; Spitz, Susan; Wang, Xiaozhao; He, Chunhong; Li, Yun-Long; Yao, Wenqing; Covington, Maryanne; Scherle, Peggy; Koblish, Holly Share Save
The structure of importin α and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP-importin α interactions Jung, Hunmin; Takeshima, Tomomi; Nakagawa, Tsutomu; MacMillan, Karen S.; Wynn, R. Max; Wang, Hanzhi; Sakiyama, Haruhiko; Wei, Shuguang; Li, Yang; Bruick, Richard K.; Posner, Bruce A.; De Brabander, Jef K.; Uyeda, Kosaku Share Save
Identification of pAKT as a pharmacodynamic marker for MER kinase in human melanoma G361 cells Chen, Yaoyu; Favata, Margaret; Pusey, Michelle; Li, Jun; Lo, Yvonne; Ye, Min; Wynn, Richard; Wang, Xiaozhao; Yao, Wenqing; Chen, Yingnan Share Save
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Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance Zhou, Meiyi; Shao, Jing; Wu, Cheng-Yang; Shu, Le; Dong, Weibing; Liu, Yunxia; Chen, Mengping; Wynn, R. Max; Wang, Jiqiu; Wang, Ji; Gui, Wen-Jun; Qi, Xiangbing; Lusis, Aldons J.; Li, Zhaoping; Wang, Weiqing; Ning, Guang; Yang, Xia; Chuang, David T.; Wang, Yibin; Sun, Haipeng Share Save
Novel small-molecule antagonists of the PD-1/PD-L1 axis that mediate cell surface PD-L1 dimerization and internalization Liu, Phillip C. C.; Wynn, Richard; Wu, Liangxing; Volgina, Alla; Zolotarjova, Nina; Lin, Luping; Thekkat, Pramod; Margulis, Alex; Klabe, Ronald; Yao, Wenqing; Xiao, Kaijiong; Li, Jingwei; He, Xin; Rupar, Mark; Chang, Hong; Waeltz, Paul; Li, Yanlong; Scherle, Peggy; Huber, Reid; Hollis, Gregory Share Save
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Characterization of INCB081776, a potent and selective dual AXL/MER kinase inhibitor Favata, Margaret; Lasky, Kerri; Lo, Yvonne; Feldman, Patricia; Li, Jun; Chen, Yaoyu; Stevens, Christina; Ye, Min; Wang, Hui; Liu, Ke; Wynn, Richard; Li, Yanlong; Harris, Jennifer; Landman, Robert; Li, Yu; Wang, Xiaozhao; He, Chunhong; Li, Yun-Long; Xue, Chu-Biao; Yao, Wenqing; Rios-Doria, Jonathan; Gao, Zhenhai; Covington, Maryanne; Liu, Xuesong M.; Koblish, Holly; Scherle, Peggy Share Save
Integration of BCAA and Lipid Metabolism by the BCKDH Kinase and Phosphatase White, Phillip J.; Mcgarrah, Robert W., III; Grimsrud, Paul A.; Yang, Wen-Hsuan; Zhang, Guo-Fang; Haldeman, Jonathan M.; Arlotto, Michelle; Ilkayeva, Olga; Wynn, Richard M.; Chuang, David T.; Newgard, Christopher B. Share Save
Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice Wu, Cheng-Yang; Tso, Shih-Chia; Chuang, Jacinta L.; Gui, Wen-Jun; Lou, Mingliang; Sharma, Gaurav; Khemtong, Chalermchai; Qi, Xiangbing; Wynn, R. Max; Chuang, David T. Share Save
A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity Wu, Cheng-Yang; Satapati, Santhosh; Gui, Wenjun; Wynn, R. Max; Sharma, Gaurav; Lou, Mingliang; Qi, Xiangbing; Burgess, Shawn C.; Malloy, Craig; Khemtong, Chalermchai; Sherry, A. Dean; Chuang, David T.; Merritt, Matthew E. Share Save
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The evaluation of INCB059872, an FAD-directed covalent inhibitor of LSD1, in preclinical models of Ewing sarcoma Roman, Valerie Dostalik; Ye, Min; Liu, Huiqing; Diamond, Melody; Chadderton, Antony; Lo, Yvonne; Liu, Xuesong M.; Lu, Jin; He, Chunhong; Wu, Liangxing; Burn, Timothy; Wynn, Richard; Yao, Wenqing; Hollis, Gregory; Hollis, Gregory; Scherle, Peggy; Ruggeri, Bruce; Lee, Sang Hyun Share Save
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