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SaveOptimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding
Liang, Jun; Lambrecht, Michael J.; Arenzana, Teresita L.; Aubert-Nicol, Samuel; Bao, Linda; Broccatelli, Fabio; Cai, Jianping; Eidenschenk, Celine; Everett, Christine; Garner, Thomas; Gruber, Felix; Haghshenas, Pouyan; Huestis, Malcolm P.; Hsu, Peter L.; Kou, Ponien; Jakalian, Araz; Larouche-Gauthier, Robin; Leclerc, Jean-Philippe; Leung, Dennis H.; Martin, Aaron; Murray, Jeremy; Prangley, Madeleine; Rutz, Sascha; Kakiuchi-Kiyota, Satoko; Satz, Alexander Lee; Skelton, Nicholas J.; Steffek, Micah; Stoffler, Daniel; Sudhamsu, Jawahar; Tan, Sophia; Wang, Jian; Wang, Shouliang; Wang, Qiuyue; Wendorff, Timothy J.; Wichert, Moreno; Yadav, Arun; Yu, Christine; Wang, Xiaojing Share Save Share Save Share Save Share Save Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a Pyridopyridazinone pan-RAF Kinase InhibitorHuestis, Malcolm P.; Dela Cruz, Darlene; DiPasquale, Antonio G.; Durk, Matthew R.; Eigenbrot, Charles; Gibbons, Paul; Gobbi, Alberto; Hunsaker, Thomas L.; La, Hank; Leung, Dennis H.; Liu, Wendy; Malek, Shiva; Merchant, Mark; Moffat, John G.; Muli, Christine S.; Orr, Christine J.; Parr, Brendan T.; Shanahan, Frances; Sneeringer, Christopher J.; Wang, Weiru; Yen, Ivana; Yin, Jianping; Siu, Michael; Rudolph, Joachim Share Save Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3H)-quinazolinone Aryl Urea pan-RAF Kinase InhibitorHuestis, Malcolm P.; Dela Cruz, Darlene; DiPasquale, Antonio G.; Durk, Matthew R.; Eigenbrot, Charles; Gibbons, Paul; Gobbi, Alberto; Hunsaker, Thomas L.; La, Hank; Leung, Dennis H.; Liu, Wendy; Malek, Shiva; Merchant, Mark; Moffat, John G.; Muli, Christine S.; Orr, Christine J.; Parr, Brendan T.; Shanahan, Frances; Sneeringer, Christopher J.; Wang, Weiru; Yen, Ivana; Yin, Jianping; Siu, Michael; Rudolph, Joachim Share Save Share Save Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell ViabilityLadi, Ena; Everett, Christine; Stivala, Craig E.; Daniels, Blake E.; Durk, Matthew R.; Harris, Seth F.; Huestis, Malcolm P.; Purkey, Hans E.; Staben, Steven T.; Augustin, Martin; Blaesse, Michael; Steinbacher, Stefan; Eidenschenk, Celine; Pappu, Rajita; Siu, Michael Share Save Share Save Share Save Discovery of Dual Leucine Zipper Kinase (DLK, MAP3K12) Inhibitors with Activity in Neurodegeneration ModelsPatel, Snahel; Cohen, Frederick; Dean, Brian J.; De La Torre, Kelly; Deshmukh, Gauri; Estrada, Anthony A.; Ghosh, Arundhati Sengupta; Gibbons, Paul; Gustafson, Amy; Huestis, Malcolm P.; Le Pichon, Claire E.; Lin, Han; Liu, Wendy; Liu, Xingrong; Liu, Yichin; Ly, Cuong Q.; Lyssikatos, Joseph P.; Ma, Changyou; Scearce-Levie, Kimberly; Shin, Young G.; Solanoy, Hilda; Stark, Kimberly L.; Wang, Jian; Wang, Bei; Zhao, Xianrui; Lewcock, Joseph W.; Siu, Michael Share Save Share Save Share Save Share Save Share Save Share Save 
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