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Alexander C. Lewis

university of oxford

12H-index
33Paper Count
651Citation Count
Published Papers 14
Publication Date
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Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia
errCell
IF42.5
err2025-11-19
err0
errOAAI
errAlexander C. Lewis; Emily Gruber; Rheana Franich; Jessica Armstrong; Madison J. Kelly; Carlos M. Opazo; Yau C. Low; Léa Flippe; Kevin Wijanarko; Caitlin L. Rowe; Celeste H. Mawal; Alexandra Birrell; Joan So; Srimayee Vaidyanathan; Keziah Ting; Liana N. Semcesen; Karena Last; Ching-Seng Ang; Giovanna Pomilio; Fiona C. Brown
errShare
errSave
Cost-effectiveness of pramipexole augmentation for acute phase and maintenance therapy of treatment-resistant depression compared to placebo augmentation: economic evaluation of the PAX-D randomised controlled trial
errThe Lancet Regional Health - Europe
IF0
err2025-11-17
err0
errOAAI
errAgata Łaszewska; Timea Helter; Ashley Baldwin; Anthony J. Cleare; Philip J. Cowen; Jonathan Evans; Quentin J.M. Huys; Micheal Kurkar; Alexander C. Lewis; Neil Nixon; Abhinav Rastogi; Stuart Watson; John R. Geddes; Michael Browning; Judit Simon
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errSave
Pramipexole augmentation for the acute phase of treatment-resistant, unipolar depression: a placebo-controlled, double-blind, randomised trial in the UK
errlancet psychiatry
IF0
err2025-06-29
err0
errOAAI
errMichael Browning; Philip J Cowen; Ushma Galal; Ashley Baldwin; Anthony J Cleare; Jonathan Evans; Quentin J M Huys; David Kessler; Micheal Kurkar; Neil Nixon; Abhinav Rastogi; Stuart Watson; Ly-Mee Yu; Sam Mort; Judit Simon; Agata Laszewska; Alexander C Lewis; Sophie M Roberts; Victoria Fiske; Lisa M Frending; Catherine Money; Beata R Godlewska; Howard T Ryland; Don Chamith Halahakoon; Laurence Astill Wright; Barbara Salas; Apoorva Peddada; Mourad Wahba; Katharine S Taylor; Jess Kerr-Gaffney; Duncan Swiffen; Caroline Zangani; Katharine A Smith; Catherine J Harmer; John R Geddes
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errSave
Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells
errCELL REPORTS
IF6.9
err2022-08-01
err9
errOAAI
errGruber, Emily; So, Joan; Lewis, Alexander C.; Franich, Rheana; Cole, Rachel; Martelotto, Luciano G.; Rogers, Amy J.; Vidacs, Eva; Fraser, Peter; Stanley, Kym; Jones, Lisa; Trigos, Anna; Thio, Niko; Li, Jason; Nicolay, Brandon; Daigle, Scott; Tron, Adriana E.; Hyer, Marc L.; Shortt, Jake; Johnstone, Ricky W.; Kats, Lev M.
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errSave
Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia
errEMBO MOLECULAR MEDICINE
IF8.3
err2022-05-06
err12
errOAAI
errSo, Joan; Lewis, Alexander C.; Smith, Lorey K.; Stanley, Kym; Franich, Rheana; Yoannidis, David; Pijpers, Lizzy; Dominguez, Pilar; Hogg, Simon J.; Vervoort, Stephin J.; Brown, Fiona C.; Johnstone, Ricky W.; McDonald, Gabrielle; Ulanet, Danielle B.; Murtie, Josh; Gruber, Emily; Kats, Lev M.
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errSave
Integrated clinical and genomic evaluation of guadecitabine (SGI-110) in peripheral T-cell lymphoma
errLEUKEMIA
IF13.4
err2022-04-22
err14
errOAAI
errWong, Jonathan; Gruber, Emily; Maher, Belinda; Waltham, Mark; Sabouri-Thompson, Zahra; Jong, Ian; Luong, Quinton; Levy, Sidney; Kumar, Beena; Brasacchio, Daniella; Jia, Wendy; So, Joan; Skinner, Hugh; Lewis, Alexander; Hogg, Simon J.; Vervoort, Stephin; DiCorleto, Carmen; Uhe, Micheleine; Gamgee, Jeanette; Opat, Stephen; Gregory, Gareth P.; Polekhina, Galina; Reynolds, John; Hawkes, Eliza A.; Kailainathan, Gajan; Gasiorowski, Robin; Kats, Lev M.; Shortt, Jake
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errSave
The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism
errSCIENTIFIC REPORTS
IF3.9
err2022-01-10
err11
errOAAI
errPitman, Melissa R.; Lewis, Alexander C.; Davies, Lorena T.; Moretti, Paul A. B.; Anderson, Dovile; Creek, Darren J.; Powell, Jason A.; Pitson, Stuart M.
errShare
errSave
Targeting sphingolipid metabolism as an approach for combination therapies in haematological malignancies (vol 4, 72, 2018)
errCELL DEATH DISCOVERY
IF7
err2021-06-18
err0
errOAAI
errLewis, Alexander C.; Wallington-Beddoe, Craig T.; Powell, Jason A.; Pitson, Stuart M.
errShare
errSave
Non-genetic heterogeneity, altered cell fate and differentiation therapy
errEMBO MOLECULAR MEDICINE
IF8.3
err2021-02-08
err23
errOAAI
errLewis, Alexander C.; Kats, Lev M.
errShare
errSave
Clinical MDR1 inhibitors enhance Smac-mimetic bioavailability to kill murine LSCs and improve survival in AML models
errBLOOD ADVANCES
IF7.1
err2020-10-20
err7
errOAAI
errMorrish, Emma; Copeland, Anthony; Moujalled, Donia M.; Powell, Jason A.; Silke, Natasha; Lin, Ann; Jarman, Kate E.; Sandow, Jarrod J.; Ebert, Gregor; Mackiewicz, Liana; Beach, Jessica A.; Christie, Elizabeth L.; Lewis, Alexander C.; Pomilio, Giovanna; Fischer, Karla C.; MacPherson, Laura; Bowtell, David D. L.; Webb, Andrew, I; Pellegrini, Marc; Dawson, Mark A.; Pitson, Stuart M.; Wei, Andrew H.; Silke, John; Brumatti, Gabriela
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errSave
ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism (vol 71, pg 861, 2020)
errNATURE CELL BIOLOGY
IF19.1
err2020-06-04
err4
errOAAI
errBoyle, Sarah Theresa; Poltavets, Valentina; Kular, Jasreen; Pyne, Natasha Theresa; Sandow, Jarrod John; Lewis, Alexander Charles; Murphy, Kendelle Joan; Kolesnikoff, Natasha; Moretti, Paul Andre Bartholomew; Tea, Melinda Nay; Tergaonkar, Vinay; Timpson, Paul; Pitson, Stuart Maxwell; Webb, Andrew Ian; Whitfield, Robert John; Lopez, Angel Francisco; Kochetkova, Marina; Samuel, Michael Susithiran
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errSave
ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism
errNATURE CELL BIOLOGY
IF19.1
err2020-05-25
err52
PREAI
errBoyle, Sarah Theresa; Poltavets, Valentina; Kular, Jasreen; Pyne, Natasha Theresa; Sandow, Jarrod John; Lewis, Alexander Charles; Murphy, Kendelle Joan; Kolesnikoff, Natasha; Moretti, Paul Andre Bartholomew; Tea, Melinda Nay; Tergaonkar, Vinay; Timpson, Paul; Pitson, Stuart Maxwell; Webb, Andrew Ian; Whitfield, Robert John; Lopez, Angel Francisco; Kochetkova, Marina; Samuel, Michael Susithiran
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errSave
Kelch-like protein 5-mediated ubiquitination of lysine 183 promotes proteasomal degradation of sphingosine kinase 1
errBIOCHEMICAL JOURNAL
IF4.3
err2019-11-11
err12
PREAI
errPowell, Jason A.; Pitman, Melissa R.; Zebol, Julia R.; Moretti, Paul A. B.; Neubauer, Heidi A.; Davies, Lorena T.; Lewis, Alexander C.; Dagley, Laura F.; Webb, Andrew, I; Costabile, Maurizio; Pitson, Stuart M.
errShare
errSave
Targeting sphingolipid metabolism as an approach for combination therapies in haematological malignancies
errCELL DEATH DISCOVERY
IF7
err2018-06-28
err67
errOAAI
errLewis, Alexander C.; Wallington-Beddoe, Craig T.; Powell, Jason A.; Pitson, Stuart M.
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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David D.L. Bowtell
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John Geddes
H-index: 105 · Papers: 864
P
Philip J. Cowen
H-index: 102 · Papers: 1.3K
R
Ricky W. Johnstone
H-index: 96 · Papers: 780
J
John Silke
H-index: 91 · Papers: 369
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