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Felice C. Lightstone

united states department of energy (doe)

38H-index
212Paper Count
5.9KCitation Count
Published Papers 93
Publication Date
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How KRAS Mutations Impair Intrinsic GTP Hydrolysis: Experimental and Computational Investigations
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2025-11-01
err0
PREAI
errSong, Lin Frank; Rabara, Dana; Bali, Semiha K.; Pei, Jun; Lau, Edmond Y.; Kirshner, Dan; Lightstone, Felice C.; McCormick, Frank; Stephen, Andrew G.; Yang, Yue
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Integrating Ultra-Coarse-Grained Protein Models into Accessible Workflows for Multiscale Molecular Dynamics
errACS Omega
IF4.3
err2025-10-22
err0
errOAAI
errBryce Tu Chi; Stephanie Fulcar; Jonathan Ipe; Olivia Schleifer; Rohan Subramanian; Claire Vlases; Naim Matasci; Konstantia Georgouli; Loïc Pottier; Tim Hsu; Timothy S. Carpenter; Dwight V. Nissley; Felice C. Lightstone; Frederick H. Streitz; Helgi I. Ingólfsson; Fikret Aydin
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Dynamics and lipid membrane coupling of the RAS-RAF complex revealed via multiscale simulations
errBiophysical Journal
IF3.1
err2025-08-22
err0
errOAAI
errTimothy S. Carpenter; Fikret Aydin; Chris Neale; Que N. Van; Xiaohua Zhang; Harsh Bhatia; Jason W. Sidabras; Peter H. Frank; Konstantia Georgouli; Jeremy O.B. Tempkin; Violeta Burns Casamayor; Gulcin Gulten; Rebika Shrestha; Debanjan Goswami; Francesco Di Natale; Joseph R. Chavez; Adam Moody; Joseph Y. Moon; Tomas Oppelstrup; James N. Glosli; Gautham Dharuman; Sergio Wong; Shusen Liu; Nicolas W. Hengartner; Cesar A. López; Kien Nguyen; Christopher B. Stanley; Liam G. Stanton; Lara Patel; Tyler Reddy; Thomas J. Turbyville; Brian Van Essen; Peer-Timo Bremer; Felice C. Lightstone; Andrew G. Stephen; Sandrasegaram Gnanakaran; Frank McCormick; Dwight V. Nissley; Frederick H. Streitz; Helgi I. Ingólfsson
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BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction
errScience
IF45.8
err2025-06-12
err0
PREAI
errDhirendra K. Simanshu; Rui Xu; James P. Stice; Daniel J. Czyzyk; Siyu Feng; John-Paul Denson; Erin Riegler; Yue Yang; Cathy Zhang; Sofia Donovan; Brian P. Smith; Maria Abreu-Blanco; Ming Chen; Cindy Feng; Lijuan Fu; Dana Rabara; Lucy C. Young; Marcin Dyba; Wupeng Yan; Ken Lin; Samar Ghorbanpoorvalukolaie; Erik K. Larsen; Wafa Malik; Allison Champagne; Katie Parker; Jin Hyun Ju; Stevan Jeknic; Dominic Esposito; David M. Turner; Felice C. Lightstone; Bin Wang; Paul M. Wehn; Keshi Wang; Andrew G. Stephen; Anna E. Maciag; Aaron N. Hata; Kerstin W. Sinkevicius; Dwight V. Nissley; Eli M. Wallace; Frank McCormick; Pedro J. Beltran
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Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2025-05-09
err0
errOAAI
errMaciag, Anna E.; Yang, Yue; Sharma, Alok K.; Turner, David M.; Dehart, Caroline J.; Abdelkarim, Hazem; Fan, Lixin; Smith, Brian P.; Kumari, Vandana; Dyba, Marcin; Rigby, Megan; Badillo, Jean A. Castillo; Adams, Lauren; Fornelli, Luca; Fox, Stephen; Brafman, Alla; Turbyville, Thomas; Gillette, William; Messing, Simon; Agamasu, Constance; Wolfe, Andrew L.; Gysin, Stephan; Chan, Albert H.; Simanshu, Dhirendra K.; Esposito, Dominic; Chertov, Oleg; Stephen, Andrew G.; Arkin, Michelle; Renslo, Adam; Kelleher, Neil L.; Gaponenko, Vadim; Lightstone, Felice C.; Nissley, Dwight, V; McCormick, Frank
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Enhanced Exploration of Protein Conformational Space through Integration of Ultra-Coarse-Grained Models to Multiscale Workflows
errJOURNAL OF PHYSICAL CHEMISTRY B
IF2.9
err2025-05-08
err0
errOAAI
errAydin, Fikret; Georgouli, Konstantia; Pottier, Loic; Oppelstrup, Tomas; Carpenter, Timothy S.; Tempkin, Jeremy O. B.; Bremer, Peer-Timo; Nissley, Dwight V.; Streitz, Frederick H.; Lightstone, Felice C.; Ingolfsson, Helgi I.
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Generating Protein Structures for Pathway Discovery Using Deep Learning
errJOURNAL OF CHEMICAL THEORY AND COMPUTATION
IF5.5
err2024-10-10
err0
errOAAI
errGeorgouli, Konstantia; Stephany, Robert R.; Tempkin, Jeremy O. B.; Santiago, Claudio; Aydin, Fikret; Heimann, Mark A.; Pottier, Loic; Zhang, Xiaohua; Carpenter, Timothy S.; Hsu, Tim; Nissley, Dwight V.; Streitz, Frederick H.; Lightstone, Felice C.; Ingolfsson, Helgi I.; Bremer, Peer-Timo
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BBO-10203, an orally bioavailable small molecule that disrupts the RAS-PI3Kα interaction leading to pAKT and tumor growth inhibition in models of breast, lung and colorectal cancer
errEUROPEAN JOURNAL OF CANCER
IF7.1
err2024-10-01
err0
PREAI
errSimanshu, D.; Xu, R.; Stice, J.; Czyzyk, D.; Feng, S.; Yang, Y.; Denson, J. P.; Riegler, E.; Zhang, C.; Fu, L.; Lin, K.; Lightstone, F. C.; Wang, K.; Stephen, A. G.; Maciag, A. E.; Sinkevicius, K.; Nissley, D. V.; Wallace, E. M.; McCormick, F.; Beltran, P.
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BBO-10203, a first-in-class, orally bioavailable, selective covalent small molecule that inhibits RAS- driven PI3Kalpha activity without affecting glucose metabolism
errCANCER RESEARCH
IF16.6
err2024-05-02
err1
PREAI
errBeltran, Pedro; Dhirendra, Simanshu; Xu, Rui; Chen, Ming; Czyzyk, Daniel; Donovan, Sofia; Feng, Siyu; Feng, Cindy; Fu, Lijuan; Lightstone, Felice; Lin, Ken; Maciag, Anna; Nissley, Dwight; Riegler, Erin; Sinkevicius, Kerstin; Stephen, Andrew; Stice, James; Turner, David; Wang, Bin; Wang, Keshi; Yang, Yue; Zhang, Cathy; McCormick, Frank; Wallace, Eli
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errSave
Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane (vol 7, 242 , 2024)
errCOMMUNICATIONS BIOLOGY
IF5.1
err2024-04-11
err0
errOAAI
errShrestha, Rebika; Carpenter, Timothy S.; Van, Que N.; Agamasu, Constance; Tonelli, Marco; Aydin, Fikret; Chen, De; Gulten, Gulcin; Glosli, James N.; Lopez, Cesar A.; Oppelstrup, Tomas; Neale, Chris; Gnanakaran, Sandrasegaram; Gillette, William K.; Ingolfsson, Helgi I.; Lightstone, Felice C.; Stephen, Andrew G.; Streitz, Frederick H.; Nissley, Dwight V.; Turbyville, Thomas J.
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BBO-8520, a first-in-class, direct inhibitor of KRASG12C (ON), locks GTP-bound KRASG12C in the state 1 conformation resulting in rapid and complete blockade of effector binding
errCANCER RESEARCH
IF16.6
err2024-04-05
err2
PREAI
errMaciag, Anna E.; Stice, James; Wang, Bin; Sharma, Alok; Chan, Albert; Lin, Ken; Singh, Devansh; Dyba, Marcin; Yang, Yue; Setoodeh, Saman; Smith, Brian P.; Rabara, Dana; Zhang, Zuhui; Larsen, Erik K.; Esposito, Dom; Denson, John Paul; Ranieri, Michela; Meynardie, Mary; Mehdizadeh, Sadaf; Alexander, Patrick; Blanco, Maria Abreu; Turner, David; Xu, Rui; Lightstone, Felice C.; Wong, Kwok Kin; Simanshu, Dhirendra; Wang, Keshi; Stephen, Andrew G.; Sinkevicius, Kerstin; Nissley, Dwight V.; Wallace, Eli; McCormick, Frank; Beltran, Pedro J.
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errSave
Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane
errCOMMUNICATIONS BIOLOGY
IF5.1
err2024-02-28
err8
errOAAI
errShrestha, Rebika; Carpenter, Timothy S.; Van, Que N.; Agamasu, Constance; Tonelli, Marco; Aydin, Fikret; Chen, De; Gulten, Gulcin; Glosli, James N.; Lopez, Cesar A.; Oppelstrup, Tomas; Neale, Chris; Gnanakaran, Sandrasegaram; Gillette, William K.; Ingolfsson, Helgi I.; Lightstone, Felice C.; Stephen, Andrew G.; Streitz, Frederick H.; Nissley, Dwight V.; Turbyville, Thomas J.
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Revealing the mechanism of action of a fi rst-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by 31 P NMR
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-02-01
err10
errOAAI
errSharma, Alok K.; Pei, Jun; Yang, Yue; Dyba, Marcin; Smith, Brian; Rabara, Dana; Larsen, Erik K.; Lightstone, Felice C.; Esposito, Dominic; Stephen, Andrew G.; Wang, Bin; Beltran, Pedro J.; Wallace, Eli; Nissley, Dwight V.; McCormick, Frank; Maciag, Anna E.
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Use of the natural nucleotide, GTP, is essential for the identification of potent, active-state KRASG12C inhibitors that bind in the switch II pocket
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2023-12-01
err0
PREAI
errWang, Bin; Sharma, Alok; Stice, James; Smith, Brian; Dyba, Marcin; Singh, Devansh; Denson, John-Paul; Rabara, Dana; Larsen, Erik; Yang, Yue; Lightstone, Felice C.; Stephen, Andrew; Nissley, Dwight; McCormick, Frank; Wallace, Eli; Maciag, Anna E.; Beltran, Pedro J.
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Clustering Protein Binding Pockets and Identifying Potential Drug Interactions: A Novel Ligand-Based Featurization Method
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2023-10-17
err1
errOAAI
errStevenson, Garrett A.; Kirshner, Dan; Bennion, Brian J.; Yang, Yue; Zhang, Xiaohua; Zemla, Adam; Torres, Marisa W.; Epstein, Aidan; Jones, Derek; Kim, Hyojin; Bennett, W. F. Drew; Wong, Sergio E.; Allen, Jonathan E.; Lightstone, Felice C.
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OFraMP: a fragment-based tool to facilitate the parametrization of large molecules
errJOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
IF3.1
err2023-06-13
err9
errOAAI
errStroet, Martin; Caron, Bertrand; Engler, Martin S. S.; van der Woning, Jimi; Kauffmann, Aude; van Dijk, Marc; El-Kebir, Mohammed; Visscher, Koen M. M.; Holownia, Josef; Macfarlane, Callum; Bennion, Brian J. J.; Gelpi-Dominguez, Svetlana; Lightstone, Felice C. C.; van der Storm, Tijs; Geerke, Daan P. P.; Mark, Alan E. E.; Klau, Gunnar W. W.
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The confluence of machine learning and multiscale simulations
errCURRENT OPINION IN STRUCTURAL BIOLOGY
IF7
err2023-06-01
err8
errOAAI
errBhatia, Harsh; Aydin, Fikret; Carpenter, Timothy S.; Lightstone, Felice C.; Bremer, Peer-Timo; Ingolfsson, Helgi I.; V. Nissley, Dwight; Streitz, Frederick H.
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errSave
Dynamics and lipid interactions of the RAS-RBD-CRD protein complex
errMOLECULAR CANCER RESEARCH
IF4.7
err2023-05-01
err0
PREAI
errLightstone, Felice C.; Carpenter, Timothy S.
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errSave
Machine Learning-Driven Multiscale Modeling: Bridging the Scales with a Next-Generation Simulation Infrastructure
errJOURNAL OF CHEMICAL THEORY AND COMPUTATION
IF5.5
err2023-04-19
err18
errOAAI
errIngolfsson, Helgi I.; Bhatia, Harsh; Aydin, Fikret; Oppelstrup, Tomas; Lopez, Cesar A.; Stanton, Liam G.; Carpenter, Timothy S.; Wong, Sergio; Di Natale, Francesco; Zhang, Xiaohua; Moon, Joseph Y.; Stanley, Christopher B.; Chavez, Joseph R.; Nguyen, Kien; Dharuman, Gautham; Burns, Violetta; Shrestha, Rebika; Goswami, Debanjan; Gulten, Gulcin; Van, Que N.; Ramanathan, Arvind; Van Essen, Brian; Hengartner, Nicolas W.; Stephen, Andrew G.; Turbyville, Thomas; Bremer, Peer-Timo; Gnanakaran, S.; Glosli, James N.; Lightstone, Felice C.; Nissley, Dwight V.; Streitz, Frederick H.
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Dynamic density functional theory of multicomponent cellular membranes
errPHYSICAL REVIEW RESEARCH
IF4.2
err2023-02-06
err5
errOAAI
errStanton, L. G.; Oppelstrup, T.; Carpenter, T. S.; Ingolfsson, H. I.; Surh, M. P.; Lightstone, F. C.; Glosli, J. N.
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Research Directions

No research directions
Co-authors
Cooperation Journals
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Elliott M. Antman
H-index: 169 · Papers: 849
M
Martin Karplus
H-index: 167 · Papers: 981
J
Joseph Loscalzo
H-index: 141 · Papers: 1.0K
K
Kwok‐Kin Wong
H-index: 140 · Papers: 1.7K
C
Charis Eng
H-index: 139 · Papers: 1.2K
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