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David Leys

University of Manchester

66H-index
371Paper Count
1.1WCitation Count
Published Papers 132
Publication Date
Integrated structural dynamics uncover a new B12 photoreceptor activation mode
errNature
IF48.5
err2026-02-04
err0
PREAI
errRonald Rios-Santacruz; Harshwardhan Poddar; Kevin Pounot; Derren J. Heyes; Nicolas Coquelle; Megan J. Mackintosh; Linus O. Johannissen; Sara Schianchi; Laura N. Jeffreys; Elke De Zitter; Rory Munro; Martin Appleby; Danny Axford; Emma V. Beale; Matthew J. Cliff; María C. Dávila-Miliani; Sylvain Engilberge; Guillaume Gotthard; Kyprianos Hadjidemetriou; Samantha J. O. Hardman; Sam Horrell; Jochen S. Hub; Kotone Ishihara; Sofia Jaho; Gabriel Karras; Machika Kataoka; Ryohei Kawakami; Thomas Mason; Hideo Okumura; Shigeki Owada; Robin L. Owen; Antoine Royant; Annica Saaret; Michiyo Sakuma; Muralidharan Shanmugam; Hiroshi Sugimoto; Kensuke Tono; Ninon Zala; John H. Beale; Takehiko Tosha; Jacques-Philippe Colletier; Matteo Levantino; Sam Hay; Pawel M. Kozlowski; David Leys; Nigel S. Scrutton; Martin Weik; Giorgio Schirò
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Structure and Mechanism of PhdC, a Prenylated-Flavin Maturase
err2025-12-01
err0
errOAAI
errWhittall, Dominic R.; Box, Henry G.; Payne, Karl A. P.; Marshall, Stephen A.; Leys, David
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Fragment-Based Development of Small Molecule Inhibitors Targeting Mycobacterium tuberculosis Cholesterol Metabolism
err2025-07-14
err0
errOAAI
errMadeline E. Kavanagh; Kirsty J. McLean; Sophie H. Gilbert; Cecilia N. Amadi; Matthew Snee; Richard B. Tunnicliffe; Kriti Arora; Helena I. M. Boshoff; Alexander Fanourakis; Maria Jose Rebollo-Lopez; Fatima Ortega; Colin W. Levy; Andrew W. Munro; David Leys; Chris Abell; Anthony G. Coyne
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SignatureFinder enables sequence mining to identify cobalamin-dependent photoreceptor proteins
err2024-12-24
err0
errOAAI
errYu, Yuqi; Jeffreys, Laura N.; Poddar, Harshwardhan; Hill, Adam; Johannissen, Linus; Dai, Fanzhuo; Sakuma, Michiyo; Leys, David; Heyes, Derren J.; Zhang, Shaowei; Scrutton, Nigel S.
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Photocobilins integrate B12 and bilin photochemistry for enzyme control
err2024-03-28
err2
errOAAI
errZhang, Shaowei; Jeffreys, Laura N.; Poddar, Harshwardhan; Yu, Yuqi; Liu, Chuanyang; Patel, Kaylee; Johannissen, Linus O.; Zhu, Lingyun; Cliff, Matthew J.; Yan, Cunyu; Schiro, Giorgio; Weik, Martin; Sakuma, Michiyo; Levy, Colin W.; Leys, David; Heyes, Derren J.; Scrutton, Nigel S.
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The prFMNH2-binding chaperone LpdD assists UbiD decarboxylase activation
err2024-02-01
err2
errOAAI
errGahloth, Deepankar; Fisher, Karl; Marshall, Stephen; Leys, David
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Efficient NADPH-dependent dehalogenation afforded by a self-sufficient reductive dehalogenase
err2023-09-01
err2
errOAAI
errFisher, Karl; Halliwell, Tom; Payne, Karl A. P.; Ragala, Gabriel; Hay, Sam; Rigby, Stephen E. J.; Leys, David
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Redox driven B12-ligand switch drives CarH photoresponse
err2023-08-21
err3
errOAAI
errPoddar, Harshwardhan; Rios-Santacruz, Ronald; Heyes, Derren J. J.; Shanmugam, Muralidharan; Brookfield, Adam; Johannissen, Linus O. O.; Levy, Colin W. W.; Jeffreys, Laura N. N.; Zhang, Shaowei; Sakuma, Michiyo; Colletier, Jacques-Philippe; Hay, Sam; Schiro, Giorgio; Weik, Martin; Scrutton, Nigel S. S.; Leys, David
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Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis
err2023-04-12
err4
errOAAI
errKatariya, Mona M.; Snee, Matthew; Tunnicliffe, Richard B.; Kavanagh, Madeline E.; Boshoff, Helena I. M.; Amadi, Cecilia N.; Levy, Colin W.; Munro, Andrew W.; Abell, Chris; Leys, David; Coyne, Anthony G.; McLean, Kirsty J.
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High-Titer Bio-Styrene Production Afforded by Whole-Cell Cascade Biotransformation
err2023-02-03
err2
errOAAI
errMessiha, Hanan L.; Scrutton, Nigel S.; Leys, David
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A Vitamin B2-Photocatalysed Approach to Methionine Analogues
err2022-11-10
err13
errOAAI
errKnowles, Oliver J.; Johannissen, Linus O.; Crisenza, Giacomo E. M.; Hay, Sam; Leys, David; Procter, David J.
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Biosynthesis of Pyrrole-2-carbaldehyde via Enzymatic CO2 Fixation
err2022-05-14
err4
errOAAI
errTitchiner, Gabriel R.; Marshall, Stephen A.; Miscikas, Herkus; Leys, David
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Enzymatic N-Allylation of Primary and Secondary Amines Using Renewable Cinnamic Acids Enabled by Bacterial Reductive Aminases
err2022-05-06
err11
errOAAI
errAleku, Godwin A.; Titchiner, Gabriel R.; Roberts, George W.; Derrington, Sasha R.; Marshall, James R.; Hollfelder, Florian; Turner, Nicholas J.; Leys, David
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Structural and biochemical characterization of the prenylated flavin mononucleotide-dependent indole-3-carboxylic acid decarboxylase
err2022-04-01
err10
errOAAI
errGahloth, Deepankar; Fisher, Karl; Payne, Karl A. P.; Cliff, Matthew; Levy, Colin; Leys, David
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Prenylated flavins: structures and mechanisms
err2022-02-04
err14
PREAI
errBloor, Samuel; Michurin, Iaroslav; Titchiner, Gabriel R.; Leys, David
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A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen)
err2022-02-01
err6
errOAAI
errFrederickson, Martyn; Selvam, Irwin R.; Evangelopoulos, Dimitrios; McLean, Kirsty J.; Katariya, Mona M.; Tunnicliffe, Richard B.; Campbell, Bethany; Kavanagh, Madeline E.; Charoensutthivarakul, Sitthivut; Blankley, Richard T.; Levy, Colin W.; de Carvalho, Luiz Pedro S.; Leys, David; Munro, Andrew W.; Coyne, Anthony G.; Abell, Chris
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Directed evolution of prenylated FMN-dependent Fdc supports efficient in vivo isobutene production
err2021-09-06
err16
errOAAI
errSaaret, Annica; Villiers, Benoit; Stricher, Francois; Anissimova, Macha; Cadillon, Melodie; Spiess, Reynard; Hay, Sam; Leys, David
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UbiD domain dynamics underpins aromatic decarboxylation
err2021-08-20
err13
errOAAI
errMarshall, Stephen A.; Payne, Karl A. P.; Fisher, Karl; Titchiner, Gabriel R.; Levy, Colin; Hay, Sam; Leys, David
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A Guide to time-resolved structural analysis of light-activated proteins
err2021-05-01
err30
errOAAI
errPoddar, Harshwardhan; Heyes, Derren J.; Schiro, Giorgio; Weik, Martin; Leys, David; Scrutton, Nigel S.
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