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The Chemical Probes Portal-2024: update on this public resource to support best-practice selection and use of small molecules in biomedical research Sanfelice, Domenico; Antolin, Albert A.; Crisp, Alisa; Chen, Yi; Bellenie, Benjamin; Brennan, Paul E.; Edwards, Aled; Mueller, Susanne; Al-Lazikani, Bissan; Workman, Paul Share Save
canSAR 2024-an update to the public drug discovery knowledgebase Gingrich, Phillip W.; Chitsazi, Rezvan; Biswas, Ansuman; Jiang, Chunjie; Zhao, Li; Tym, Joseph E.; Brammer, Kevin M.; Li, Jun; Shu, Zhigang; Maxwell, David S.; Tacy, Jeffrey A.; Mica, Ioan L.; Darkoh, Michael; di Micco, Patrizio; Russell, Kaitlyn P.; Workman, Paul; Al-Lazikani, Bissan Share Save
Pharmacokinetic and pharmacodynamic evaluation of NXP800, a novel GCN2 activator, in a first in human clinical trial Pacey, Simon; Leung, Ching; Rodney, Simon; DosReis, Ana Filipa Palma; Ruddle, Ruth; Tall, Matthew; Swales, Karen; Poele, Robert Te; Workman, Paul; Marsolini, Diane; Sardone, Megan; Poradosu, Enrique; Shemesh, Shay; Banerji, Udai Share Save
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Discovery of ARID1A loss as a patient biomarker for NXP800-A developmental activator of the integrated stress response (ISR) and inhibitor of the HSF1 pathway in ovarian cancer te Poele, Robert H.; Powers, Marissa; Sharp, Swee; de Billy, Emmanuel; Taskinen, Maria; Pellegrino, Loredana; Gowan, Sharon; Miah, Asadh; Hayes, Angela; Cheeseman, Matthew; Jones, Keith; Eccles, Suzanne; Raynaud, Florence; Clarke, Paul; Workman, Paul Share Save
Using acquired resistance to explore the mechanism of action of the integrated stress response/GCN2 activator NXP800-A new developmental agent for platinum-resistant ARID1A mutant ovarian cancer Powers, Marissa V.; Hodgson, Rachel; Sharp, Swee Y.; Roe, Toby; Allen, K. Elizabeth; Campbell, Susan; te Poele, Robert; Cheeseman, Matthew; Jones, Keith; Clarke, Paul A.; Workman, Paul Share Save
Activation of the integrated stress response by NXP800, an orally available, clinical-stage, investigational agent in ARID1A-mutated, platinum resistant ovarian cancer Powers, Marissa V.; Swap, Swee Y.; te Poele, Robert; Lampraki, Eirini-Maria; Roe, Toby; Pellegrino, Loredana; Taskinen, Maria; Eccles, Suzenne; Raynaud, Florence; Cheeseman, Matthew; Jones, Keith; Clarke, Paul A.; Workman, Paul Share Save
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Results of a phase 1 dose escalation clinical trial of NXP800, a novel GCN2 activator, in patients with advanced or metastatic solid tumors Banerji, Udai; Pacey, Simon; Finkelstein, Karen; Rodney, Simon; DosReis, Ana Filipa Palma; Codaccipisanelli, Giovanni; Sloan, Mark; Raynaud, Florence I.; Ruddle, Ruth; Swales, Karen; Tall, Matthew; Shemesh, Shay; Marsolini, Diane; Sardone, Megan; Hay, Justin; Bliss, Robin; Poradosu, Enrique; Workman, Paul Share Save
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Activation of the integrated stress response by the developmental HSF1 pathway inhibitor NXP800 Powers, Marissa V.; Sharp, Swee Y.; Lampraki, Eirini-Maria; Roe, Toby; Pellegrino, Loredana; Taskinen, Maria; Poele, Robert Te; Raynaud, Florence; Eccles, Suzanne; Cheeseman, Matthew; Jones, Keith; Clarke, Paul A.; Workman, Paul Share Save
HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies Pasqua, A. Elisa; Sharp, Swee Y.; Chessum, Nicola E. A.; Hayes, Angela; Pellegrino, Loredana; Tucker, Michael J.; Miah, Asadh; Wilding, Birgit; Evans, Lindsay E.; Rye, Carl S.; Mok, N. Yi; Liu, Manjuan; Henley, Alan T.; Gowan, Sharon; De Billy, Emmanuel; te Poele, Robert; Powers, Marissa; Eccles, Suzanne A.; Clarke, Paul A.; Raynaud, Florence I.; Workman, Paul; Jones, Keith; Cheeseman, Matthew D. Share Save
Native Size-Exclusion Chromatography-Based Mass Spectrometry Reveals New Components of the Early Heat Shock Protein 90 Inhibition Response Among Limited Global Changes Samant, Rahul S.; Batista, Silvia; Larance, Mark; Ozer, Bugra; Milton, Christopher I.; Bludau, Isabell; Wu, Estelle; Biggins, Laura; Andrews, Simon; Hervieu, Alexia; Johnston, Harvey E.; Al-Lazikhani, Bissan; Lamond, Angus I.; Clarke, Paul A.; Workman, Paul Share Save
canSAR: update to the cancer translational research and drug discovery knowledgebase di Micco, Patrizio; Antolin, Albert A.; Mitsopoulos, Costas; Villasclaras-Fernandez, Eloy; Sanfelice, Domenico; Dolciami, Daniela; Ramagiri, Pradeep; Mica, Ioan L.; Tym, Joseph E.; Gingrich, Philip W.; Hu, Huabin; Workman, Paul; Al-Lazikani, Bissan Share Save
The Chemical Probes Portal: an expert review-based public resource to empower chemical probe assessment, selection and use Antolin, Albert A.; Sanfelice, Domenico; Crisp, Alisa; Fernandez, Eloy Villasclaras; Mica, Ioan L.; Chen, Yi; Collins, Ian; Edwards, Aled; Mueller, Susanne; Al-Lazikani, Bissan; Workman, Paul Share Save
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