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Michael J. Emanuele

University of North Carolina

29H-index
128Paper Count
3.7KCitation Count
Published Papers 40
Publication Date
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USP7 inhibition perturbs proteostasis and tumorigenesis in triple-negative breast cancer
errnpj Breast Cancer
IF7.6
err2026-05-23
err0
errOAAI
errAhhyun Kim; Priya Gopalakrishnan; Marina Suárez-Pizarro; Claire C. Chen; Xianxi Wang; Sydney M. McCoy; Nikita Umesh; Angie Mordant; Natalie K. Barker; Laura E. Herring; Rasha T. Kakati; Philip M. Spanheimer; Michael J. Emanuele; Claudia A. Benavente
errShare
errSave
Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22
errNature Communications
IF15.7
err2026-04-23
err0
errOAAI
errKevin C. Robertson; Sascha J. Amann; Tongkun Liu; Adam V. Funk; Xianxi Wang; Irina Grishkovskaya; Aamir Mehmood; John R. Tabor; Jacqueline L. Norris-Drouin; Cheryl H. Arrowsmith; Jon L. Collins; Yinglong Miao; Michael J. Emanuele; David Haselbach; Lindsey I. James; Nicholas G. Brown
errShare
errSave
Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry
errNature
IF48.5
err2025-07-30
err0
errOAAI
errDebasish Paul; Derek L. Bolhuis; Hualong Yan; Sudipto Das; Xia Xu; Christina C. Abbate; Lisa M. M. Jenkins; Michael J. Emanuele; Thorkell Andresson; Jing Huang; John G. Albeck; Nicholas G. Brown; Steven D. Cappell
errShare
errSave
Mechanisms of USP18 specificity toward ISG15 revealed by paralog sequence analysis comparison
errJournal of Biological Chemistry
IF3.9
err2025-07-01
err0
errOAAI
errThomas Bonacci; Derek L. Bolhuis; Nicholas G. Brown; Michael J. Emanuele
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errSave
USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination
errNATURE COMMUNICATIONS
IF15.7
err2025-05-16
err0
errOAAI
errBolhuis, Derek L.; Fleifel, Dalia; Bonacci, Thomas; Wang, Xianxi; Mouery, Brandon L.; Cook, Jeanette Gowen; Brown, Nicholas G.; Emanuele, Michael J.
errShare
errSave
Onvansertib exhibits anti-proliferative and anti-invasive effects in endometrial cancer
errFRONTIERS IN PHARMACOLOGY
IF4.8
err2025-03-17
err0
errOAAI
errSinha, Nikita; Shen, Xiaochang; Haag, Jennifer; Chen, Shuning; Zhang, Haomeng; John, Catherine; Sun, Wenchuan; Emanuele, Michael; Zhou, Chunxiao
errShare
errSave
Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton
errCELL REPORTS
IF6.9
err2024-08-01
err0
errOAAI
errMouery, Ryan D.; Lukasik, Kimberly; Hsu, Carolyn; Bonacci, Thomas; Bolhuis, Derek L.; Wang, Xianxi; Mills, C. Allie; Toomer, E. Drew; Canterbury, Owen G.; Robertson, Kevin C.; Branigan, Timothy B.; Brown, Nicholas G.; Herring, Laura E.; Gupton, Stephanie L.; Emanuele, Michael J.
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errSave
A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins
errNATURE COMMUNICATIONS
IF15.7
err2024-03-20
err0
errOAAI
errLu, Xiuxiu; Chandravanshi, Monika; Sabbasani, Venkata R.; Gaikwad, Snehal; Hughitt, V. Keith; Gyabaah-Kessie, Nana; Scroggins, Bradley T.; Das, Sudipto; Myint, Wazo; Clapp, Michelle E.; Schwieters, Charles D.; Dyba, Marzena A.; Bolhuis, Derek L.; Koscielniak, Janusz W.; Andresson, Thorkell; Emanuele, Michael J.; Brown, Nicholas G.; Matsuo, Hiroshi; Chari, Raj; Citrin, Deborah E.; Mock, Beverly A.; Swenson, Rolf E.; Walters, Kylie J.
errShare
errSave
APC/C and SCFcyclin F Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry (vol 16, 3359, 2016)
errCELL REPORTS
IF6.9
err2024-03-01
err0
errOAAI
errChoudhury, Rajarshi; Bonacci, Thomas; Arceci, Anthony; Lahiri, Debojyoti; Mills, Christine A.; Kernan, Jennifer L.; Branigan, Timothy B.; DeCaprio, James A.; Burke, Daniel J.; Emanuele, Michael J.
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errSave
Friend or foe? Reciprocal regulation between E3 ubiquitin ligases and deubiquitinases
errBIOCHEMICAL SOCIETY TRANSACTIONS
IF4.3
err2024-02-28
err0
errOAAI
errBolhuis, Derek L.; Emanuele, Michael J.; Brown, Nicholas G.
errShare
errSave
Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C)
errNATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
err2023-09-21
err2
errOAAI
errBodrug, Tatyana; Welsh, Kaeli A.; Bolhuis, Derek L.; Paulakonis, Ethan; Martinez-Chacin, Raquel C.; Liu, Bei; Pinkin, Nicholas; Bonacci, Thomas; Cui, Liying; Xu, Pengning; Roscow, Olivia; Amann, Sascha Josef; Grishkovskaya, Irina; Emanuele, Michael J.; Harrison, Joseph S.; Steimel, Joshua P.; Hahn, Klaus M.; Zhang, Wei; Zhong, Ellen D.; Haselbach, David; Brown, Nicholas G.
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errSave
VprBP/DCAF1 Regulates the Degradation and Nonproteolytic Activation of the Cell Cycle Transcription Factor FoxM1
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-17
err29
errOAAI
errWang, Xianxi; Arceci, Anthony; Bird, Kelly; Mills, Christine A.; Choudhury, Rajarshi; Kernan, Jennifer L.; Zhou, Chunxiao; Bae-Jump, Victoria; Bowers, Albert; Emanuele, Michael J.
errShare
errSave
Sirtuin 5 Is Regulated by the SCFCyclin F Ubiquitin Ligase and Is Involved in Cell Cycle Control
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-03
err11
errOAAI
errMills, Christine A.; Wang, Xianxi; Bhatt, Dhaval P.; Grimsrud, Paul A.; Matson, Jacob Peter; Lahiri, Debojyoti; Burke, Daniel J.; Cook, Jeanette Gowen; Hirschey, Matthew D.; Emanuele, Michael J.
errShare
errSave
Enabling Genetic Code Expansion and Peptide Macrocyclization in mRNA Display via a Promiscuous Orthogonal Aminoacyl-tRNA Synthetase
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2023-01-11
err10
errOAAI
errIskandar, Sabrina E.; Pelton, Jarrett M.; Wick, Elizaveta T.; Bolhuis, Derek L.; Baldwin, Albert S.; Emanuele, Michael J.; Brown, Nicholas G.; Bowers, Albert A.
errShare
errSave
Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes
errEMBO JOURNAL
IF8.3
err2021-12-23
err12
errOAAI
errWelsh, Kaeli A.; Bolhuis, Derek L.; Nederstigt, Anneroos E.; Boyer, Joshua; Temple, Brenda R. S.; Bonacci, Thomas; Gu, Li; Ordureau, Alban; Harper, J. Wade; Steimel, Joshua P.; Zhang, Qi; Emanuele, Michael J.; Harrison, Joseph S.; Brown, Nicholas G.
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errSave
Dissenting degradation: Deubiquitinases in cell cycle and cancer
errSEMINARS IN CANCER BIOLOGY
IF15.7
err2020-12-01
err87
errOAAI
errBonacci, Thomas; Emanuele, Michael J.
errShare
errSave
Complex Cartography: Regulation of E2F Transcription Factors by Cyclin F and Ubiquitin
errTRENDS IN CELL BIOLOGY
IF18.1
err2020-08-01
err46
errOAAI
errEmanuele, Michael J.; Enrico, Taylor P.; Mouery, Ryan D.; Wasserman, Danit; Nachum, Sapir; Tzur, Amit
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errSave
Thiopeptides Induce Proteasome-Independent Activation of Cellular Mitophagy
errACS CHEMICAL BIOLOGY
IF3.8
err2020-06-26
err12
errOAAI
errBird, Kelly E.; Xander, Christian; Murcia, Sebastian; Schmalstig, Alan A.; Wang, Xianxi; Emanuele, Michael J.; Braunstein, Miriam; Bowers, Albert A.
errShare
errSave
Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming
errNATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
err2020-05-11
err29
errOAAI
errMartinez-Chacin, Raquel C.; Bodrug, Tatyana; Bolhuis, Derek L.; Kedziora, Katarzyna M.; Bonacci, Thomas; Ordureau, Alban; Gibbs, Morgan E.; Weissmann, Florian; Qiao, Renping; Grant, Gavin D.; Cook, Jeanette G.; Peters, Jan-Michael; Harper, J. Wade; Emanuele, Michael J.; Brown, Nicholas G.
errShare
errSave
Cell cycle oscillators underlying orderly proteolysis of E2F8
errMOLECULAR BIOLOGY OF THE CELL
IF2.7
err2020-04-01
err17
errOAAI
errWasserman, Danit; Nachum, Sapir; Cohen, Meital; Enrico, Taylor P.; Noach-Hirsh, Meirav; Parasol, Jasmin; Zomer-Polak, Sarit; Auerbach, Naomi; Sheinberger-Chorni, Evelin; Nevenzal, Hadas; Levi-Dadon, Nofar; Wang, Xianxi; Lahmi, Roxane; Michaely, Efrat; Gerber, Doron; Emanuele, Michael J.; Tzur, Amit
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
M
Michael R. Stratton
H-index: 179 · Papers: 644
S
Stephen J. Elledge
H-index: 172 · Papers: 542
J
J. Wade Harper
H-index: 141 · Papers: 461
C
Curtis C. Harris
H-index: 137 · Papers: 1.3K
K
Katherine A. Hoadley
H-index: 136 · Papers: 790
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