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Mechanistic safety assessment via multi-omic characterisation of systemic pathway perturbations following in vivo MAT2A inhibition Fogal, Valentina; Michopoulos, Filippos; Jarnuczak, Andrew F.; Hamza, Ghaith M.; Harlfinger, Stephanie; Davey, Paul; Hulme, Heather; Atkinson, Stephen J.; Gabrowski, Piotr; Cheung, Tony; Grondine, Michael; Hoover, Clare; Rose, Jonathan; Bray, Chandler; Foster, Alison J.; Askin, Sean; Majumder, Muntasir Mamun; Fitzpatrick, Paul; Miele, Eric; Macdonald, Ruth; Keun, Hector C.; Coen, Muireann Share Save
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Multi-parametric single cell evaluation defines distinct drug responses in healthy hematologic cells that are retained in corresponding malignant cell types Majumder, Muntasir M.; Leppa, Aino-Maija; Hellesoy, Monica; Dowling, Paul; Malyutina, Alina; Kopperud, Reidun; Bazou, Despina; Andersson, Emma; Parsons, Alun; Tang, Jing; Kallioniemi, Olli; Mustjoki, Satu; O'Gorman, Peter; Wennerberg, Krister; Porkka, Kimmo; Gjertsen, Bjorn T.; Heckman, Caroline A. Share Save
Precision systems medicine in acute myeloid leukemia: real-time translation of tailored therapeutic opportunities arising from ex-vivo drug sensitivity testing and molecular profiling Malani, Disha; Kumar, Ashwni; Yadav, Bhagwan; Kontro, Mika; Potdar, Swapnil; Bruck, Oscar; Kytola, Sari; Saarela, Jani; Eldfors, Samuli; Karjalainen, Riikka; Majumder, Muntasir M.; Vastrik, Imre; Ellonen, Pekka; Kankainen, Matti; Suvela, Minna; Knappila, Siv; Parson, Alun; Palva, Aino; Mattila, Pirkko; Kulesskiy, Evgeny; Turunen, Laura; Laamanen, Karoliina; Lehtinen, Elina; Nurmi, Maria; Suomi, Katja; Muruimagi, Astrid; Gjertsen, Bjorn T.; Mustjoki, Satu; Anders, Simon; Wolf, Maija; Aittokallio, Tero; Wennerberg, Krister; Heckman, Caroline; Porkka, Kimmo; Kallioniemi, Olli Share Save
Dasatinib and navitoclax act synergistically to target NUP98-NSD1+/FLT3-ITD+ acute myeloid leukemia Kivioja, Jarno L.; Thanasopoulou, Angeliki; Kumar, Ashwini; Kontro, Mika; Yadav, Bhagwan; Majumder, Muntasir M.; Javarappa, Komal K.; Eldfors, Samuli; Schwaller, Juerg; Porkka, Kimmo; Heckman, Caroline A. Share Save
Discovery and clinical implementation of individualized therapies in acute myeloid leukemia based on ex vivo drug sensitivity testing and multi-omics profiling Malani, Disha; Kumar, Ashwini; Yadav, Bhagwan; Kontro, Mika; Potdar, Swapnil; Bruck, Oscar; Kytola, Sari; Saarela, Jani; Eldfors, Samuli; Ojamies, Poojitha; Riikka, Karjalainen; Majumder, Muntasir Mamun; Vastrik, Imre; Ellonen, Pekka; Kankainen, Matti; Suvela, Minna; Knappila, Siv; Parson, Alun; Palva, Aino; Mattila, Pirkko; Kulesskiy, Evgeny; Turunen, Laura; Laamanen, Karoliina; Lehtinen, Elina; Mikkonen, Piia; Nurmi, Maria; Timonen, Sanna; Murumagi, Astrid; Gjersten, Bjorn Tore; Mustjoki, Satu; Aittokallio, Tero; Wennerberg, Krister; Anders, Simon; Wolf, Maija; Heckman, Caroline; Porkka, Kimmo; Kallioniemi, Olli Share Save
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Enhanced sensitivity to glucocorticoids in cytarabine-resistant AML Malani, D.; Murumagi, A.; Yadav, B.; Kontro, M.; Eldfors, S.; Kumar, A.; Karjalainen, R.; Majumder, M. M.; Ojamies, P.; Pemovska, T.; Wennerberg, K.; Heckman, C.; Porkka, K.; Wolf, M.; Aittokallio, T.; Kallioniemi, O. Share Save
HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia Kontro, M.; Kumar, A.; Majumder, M. M.; Eldfors, S.; Parsons, A.; Pemovska, T.; Saarela, J.; Yadav, B.; Malani, D.; Floisand, Y.; Hoglund, M.; Remes, K.; Gjertsen, B. T.; Kallioniemi, O.; Wennerberg, K.; Heckman, C. A.; Porkka, K. Share Save
Idelalisib sensitivity and mechanisms of disease progression in relapsed TCF3-PBX1 acute lymphoblastic leukemia Eldfors, S.; Kuusanmaki, H.; Kontro, M.; Majumder, M. M.; Parsons, A.; Edgren, H.; Pemovska, T.; Kallioniemi, O.; Wennerberg, K.; Gokbuget, N.; Burmeister, T.; Porkka, K.; Heckman, C. A. Share Save
Idelalisib sensitivity and mechanisms of disease progression in relapsed TCF3-PBX1 acute lymphoblastic leukemia Eldfors, S.; Kuusanmaki, H.; Kontro, M.; Majumder, M. M.; Parsons, A.; Edgren, H.; Pemovska, T.; Kallioniemi, O.; Wennerberg, K.; Goekbuget, N.; Burmeister, T.; Porkka, K.; Heckman, C. Share Save
Novel drug candidates for blast phase chronic myeloid leukemia from high-throughput drug sensitivity and resistance testing Pietarinen, P. O.; Pemovska, T.; Kontro, M.; Yadav, B.; Mpindi, J. P.; Andersson, E. I.; Majumder, M. M.; Kuusanmaki, H.; Koskenvesa, P.; Kallioniemi, O.; Wennerberg, K.; Heckman, C. A.; Mustjoki, S.; Porkka, K. Share Save
Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies Yadav, Bhagwan; Pemovska, Tea; Szwajda, Agnieszka; Kulesskiy, Evgeny; Kontro, Mika; Karjalainen, Riikka; Majumder, Muntasir Mamun; Malani, Disha; Murumagi, Astrid; Knowles, Jonathan; Porkka, Kimmo; Heckman, Caroline; Kallioniemi, Olli; Wennerberg, Krister; Aittokallio, Tero Share Save
Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia Kontro, M.; Kuusanmaki, H.; Eldfors, S.; Burmeister, T.; Andersson, E. I.; Bruserud, O.; Bruemmendorf, T. H.; Edgren, H.; Gjertsen, B. T.; Itala-Remes, M.; Lagstrom, S.; Lohi, O.; Lundan, T.; Marti, J. M. L.; Majumder, M. M.; Parsons, A.; Pemovska, T.; Rajala, H.; Vettenranta, K.; Kallioniemi, O.; Mustjoki, S.; Porkka, K.; Heckman, C. A. Share Save
Individualized Systems Medicine Strategy to Tailor Treatments for Patients with Chemorefractory Acute Myeloid Leukemia Pemovska, Tea; Kontro, Mika; Yadav, Bhagwan; Edgren, Henrik; Eldfors, Samuli; Szwajda, Agnieszka; Almusa, Henrikki; Bespalov, Maxim M.; Ellonen, Pekka; Elonen, Erkki; Gjertsen, Bjorn T.; Karjalainen, Riikka; Kulesskiy, Evgeny; Lagstrom, Sonja; Lehto, Anna; Lepisto, Maija; Lundan, Tuija; Majumder, Muntasir Mamun; Marti, Jesus M. Lopez; Mattila, Pirkko; Murumagi, Astrid; Mustjoki, Satu; Palva, Aino; Parsons, Alun; Pirttinen, Tero; Ramet, Maria E.; Suvela, Minna; Turunen, Laura; Vastrik, Imre; Wolf, Maija; Knowles, Jonathan; Aittokallio, Tero; Heckman, Caroline A.; Porkka, Kimmo; Kallioniemi, Olli; Wennerberg, Krister Share Save
Functional drug sensitivity and resistance profiling of AML patient cells defines a disease-specific combination of druggable signal addictions Pemovska, Tea; Yadav, Bhagwan; Karjalainen, Riikka; Kulesskiy, Evgeny; Kontro, Mika; Majumder, Muntasir Mamun; Turunen, Laura; Lindenschmidt, Ida; Lehto, Anna; Knowles, Jonathan; Heckman, Caroline; Porkka, Kimmo; Aittokallio, Tero; Kallioniemi, Olli; Wennerberg, Krister Share Save
Somatic STAT3 Mutations in Large Granular Lymphocytic Leukemia Koskela, Hanna L. M.; Eldfors, Samuli; Ellonen, Pekka; van Adrichem, Arjan J.; Kuusanmaki, Heikki; Andersson, Emma I.; Lagstrom, Sonja; Clemente, Michael J.; Olson, Thomas; Jalkanen, Sari E.; Majumder, Muntasir Mamun; Almusa, Henrikki; Edgren, Henrik; Lepisto, Maija; Mattila, Pirkko; Guinta, Kathryn; Koistinen, Pirjo; Kuittinen, Taru; Penttinen, Kati; Parsons, Alun; Knowles, Jonathan; Saarela, Janna; Wennerberg, Krister; Kallioniemi, Olli; Porkka, Kimmo; Loughran, Thomas P., Jr.; Heckman, Caroline A.; Maciejewski, Jaroslaw P.; Mustjoki, Satu Share Save
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