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Thomas Helleday

karolinska institutet

84H-index
687Paper Count
3.6WCitation Count
Published Papers 244
Publication Date
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Targeting NFATc1-regulated MTHFD2 one-carbon metabolism to suppress sustained T-cell-mediated inflammation in rheumatoid arthritis
errSignal Transduction and Targeted Therapy
IF52.7
err2026-06-10
err0
errOAAI
errTheodora Manolakou; Jianyu Shen; Sanjaykumar Boddul; Martina Samiotaki; Michail Angelos Panagias; George Sentis; Tarcília Aparecida Silva; Alexandra Argyriou; Dionysis Nikolopoulos; Kumar Sanjiv; Karine Chemin; Fredrik Wermeling; Martin Henriksson; Ana Slipicevic; Per-Johan Jakobsson; Katerina Chatzidionysiou; Thomas Helleday
errShare
errSave
Structural basis for uracil removal from DNA by human SMUG1
errNature Communications
IF15.7
err2026-06-02
err0
errOAAI
errJulian M. Ludäscher; Emma Scaletti Hutchinson; Guillem Vila-Julià; Ann-Sofie Jemth; Saher Shahid; Elisee Wiita; Israel Cabeza de Vaca; Szymon Pach; Lukas Gajdos; Swati Aggarwal; Ellen Walse; Oliver Mortusewicz; Thomas Helleday; Jens Carlsson; Pål Stenmark
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errSave
TGF-α/EGFR-mediated lymphatic metastasis reveals a repositionable therapeutic target in breast cancer
errnpj Breast Cancer
IF7.6
err2026-04-03
err0
errOAAI
errWenyang Shi; Yueyun Pan; Bhavik Rathod; Yuhan Wang; Zhi Wang; Jianyu Shen; Francesca Gatto; Mingzhi Liu; Yizhe Sun; Margareta Wilhelm; Thomas Helleday; Maria H. Ulvmar; Sara H. Windahl; Mikael C. I. Karlsson; Jonas Fuxe
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errSave
Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1
errRSC Chem. Biol.
IF3.1
err2025-10-29
err0
errOAAI
errEmily C. Hank; Nicholas D'Arcy-Evans; Emma Rose Scaletti; Carlos Benítez-Buelga; Olov Wallner; Florian Ortis; Kaixin Zhou; Liuzhen Meng; Alicia del Prado; Patricia Calvo; Ingrid Almlöf; Elisee Wiita; Karen Nierlin; Sara Kosenina; Andreas Krämer; Alice Eddershaw; Mario Kehler; Maeve Long; AnnSofie Jemth; Holly Dawson; Josephine Stewart; Adam Dickey; Mikhael Elijah Astorga; Marek Varga; Evert Homan; Martin Scobie; Stefan Knapp; Leandro Sastre; Pål Stenmark; Miguel de Vega; Thomas Helleday; Maurice Michel
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errSave
Giving an Enzyme Scissors: Serotonin Derivatives as Potent Organocatalytic Switches for DNA Repair Enzyme OGG1
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-10-01
err0
PREAI
errVarga, Marek; Ortis, Florian; Del Prado, Alicia; Eddershaw, Alice; Scaletti Hutchinson, Emma; Hank, Emily C.; Zhou, Kaixin; Rudolfova, Natalie; Dodaro, Alessia; Wiita, Elisee; Almlof, Ingrid; Karsten, Stella; Mamonov, Kirill; Ahmed, Sara H.; Bentley, Kirsty; Wallner, Olov; Homan, Evert J.; Scobie, Martin; Helleday, Thomas; Prejano, Mario; Stenmark, Pal; de Vega, Miguel; Watson, Allan J. B.; Michel, Maurice
errShare
errSave
In vivo antiviral activity of two newly developed compounds reduces the harmful effects of ZIKV in chicken embryos
errBiochemical and Biophysical Research Communications
IF2.2
err2025-08-20
err0
PREAI
errMaikel Rosa de Oliveira; Karina Maria Wermann; Ana Paula Muterle Varela; Paula Rigon da Luz Soster; Chris Krebs Danilevicz; Miriãn Ferrão Maciel Fiuza; Fernanda Sales Luiza Vianna; Olov Wallner; Christina Kalderén; Thomas Helleday; Aleksandra Pettke; Lucas Rosa Fraga
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errSave
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
errFEBS Letters
IF3
err2025-07-27
err0
errOAAI
errEmma Scaletti Hutchinson; Robert Gustafsson Westergren; Ingrid Almlöf; Ann-Sofie Jemth; Martin Scobie; Ulrika Warpman Berglund; Thomas Helleday; Pål Stenmark
errShare
errSave
Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM
errNATURE COMMUNICATIONS
IF15.7
err2024-12-06
err0
errOAAI
errValerie, Nicholas C. K.; Sanjiv, Kumar; Mortusewicz, Oliver; Zhang, Si Min; Alam, Seher; Pires, Maria J.; Stigsdotter, Hannah; Rasti, Azita; Langelier, Marie-France; Rehling, Daniel; Throup, Adam; Purewal-Sidhu, Oryn; Desroses, Matthieu; Onireti, Jacob; Wakchaure, Prasad; Almloef, Ingrid; Bostrom, Johan; Bevc, Luka; Benzi, Giorgia; Stenmark, Pal; Pascal, John M.; Helleday, Thomas; Page, Brent D. G.; Altun, Mikael
errShare
errSave
A Phase I/II Study Investigating Karonudib in Patients with Refractory Haematological Malignancies
errBLOOD
IF23.1
err2024-11-05
err0
PREAI
errDeneberg, Stefan; Uggla, Bertil; Smith, Austin; Sandvall, Theresa; Klockare, Maria; Breuer, Olof; Berglund, Ulrika Warpman; Helleday, Thomas
errShare
errSave
Kinetic and structural characterization of NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis
errFEBS JOURNAL
IF4.2
err2024-06-29
err0
errOAAI
errScaletti, Emma R.; Unterlass, Judith E.; Almlof, Ingrid; Koolmeister, Tobias; Vallin, Karl S.; Kapsitidou, Despina; Tsuber, Viktoriia; Helleday, Thomas; Stenmark, Pal; Jemth, Ann-Sofie
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errSave
Mitotic MTH1 inhibitor TH1579 induces PD-L1 expression and inflammatory response through the cGAS-STING pathway
errONCOGENESIS
IF6.4
err2024-05-25
err3
errOAAI
errShen, Jianyu; Mancina, Emilio Guillen; Chen, Shenyu; Manolakou, Theodora; Gad, Helge; Berglund, Ulrika Warpman; Sanjiv, Kumar; Helleday, Thomas
errShare
errSave
High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue
errNATURE COMMUNICATIONS
IF15.7
err2024-04-24
err0
errOAAI
errZhang, Ning; Harbers, Luuk; Simonetti, Michele; Diekmann, Constantin; Verron, Quentin; Berrino, Enrico; Bellomo, Sara E.; Longo, Gabriel M. C.; Ratz, Michael; Schultz, Niklas; Tarish, Firas; Su, Peng; Han, Bo; Wang, Wanzhong; Onorato, Sofia; Grassini, Dora; Ballarino, Roberto; Giordano, Silvia; Yang, Qifeng; Sapino, Anna; Frisen, Jonas; Alkass, Kanar; Druid, Henrik; Roukos, Vassilis; Helleday, Thomas; Marchio, Caterina; Bienko, Magda; Crosetto, Nicola
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errSave
In-vitro assays for immuno-oncology drug efficacy assessment and screening for personalized cancer therapy: scopes and challenges
errEXPERT REVIEW OF CLINICAL IMMUNOLOGY
IF3.7
err2024-04-03
err2
errOAAI
errRahman, Md Marufur; Wells, Greg; Rantala, Juha K.; Helleday, Thomas; Muthana, Munitta; Danson, Sarah J.
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errSave
The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation
errMOLECULAR ONCOLOGY
IF4.5
err2024-03-27
err0
errOAAI
errMarttila, Petra; Bonagas, Nadilly; Chalkiadaki, Christina; Stigsdotter, Hannah; Schelzig, Korbinian; Shen, Jianyu; Farhat, Crystal M.; Hondema, Amber; Albers, Julian; Wiita, Elisee; Rasti, Azita; Warpman Berglund, Ulrika; Slipicevic, Ana; Mortusewicz, Oliver; Helleday, Thomas
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errSave
Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence
errCELL DEATH & DISEASE
IF9.6
err2024-02-17
err2
errOAAI
errFabbrizi, Maria Rita; Nickson, Catherine M.; Hughes, Jonathan R.; Robinson, Emily A.; Vaidya, Karthik; Rubbi, Carlos P.; Kacperek, Andrzej; Bryant, Helen E.; Helleday, Thomas; Parsons, Jason L.
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errSave
MTHFD1/2 inhibitor TH9619 targets the DNA damage response and causes cancer-specific folate trapping with an unprecedented therapeutic window
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2023-12-01
err0
PREAI
errMartilla, Petra; Green, Alanna C.; Kiweler, Nicole; Chalkiadaki, Christina; Wiita, Elisee; Cookson, Victoria; Lesur, Antoine; Eiden, Kim; Bernhardin, Francois; Long, Maeve; Jemth, Ann-Sofie; Mortusewicz, Oliver; Homan, Evert; Bonagas, Nadilly; Ramos, Louise; Sanjiv, Kumar; Mancina, Emilio Guillen; Pham, Therese; Slipicevic, Ana; Henriksson, Martin; Meiser, Johannes; Helleday, Thomas
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errSave
Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response
errCANCER RESEARCH
IF16.6
err2023-11-03
err4
errOAAI
errRamos, Louise; Henriksson, Martin; Helleday, Thomas; Green, Alanna C.
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errSave
Efficacy assessment of targeted and immunotherapies for personalised treatment of melanoma using 2D and 3D ex-ivo assays
errANNALS OF ONCOLOGY
IF65.4
err2023-10-01
err0
errOAAI
errRahman, M. M.; Wells, G.; Rantala, J.; Helleday, T.; Muthana, M.; Danson, S.
errShare
errSave
The spatial landscape of clonal somatic copy number alterations in benign and malignant prostate epithelia
errCANCER RESEARCH
IF16.6
err2023-06-02
err0
PREAI
errErickson, Andrew; He, Mengxiao; Berglund, Emelie; Marklund, Maja; Mirzazadeh, Reza; Schultz, Niklas; Kvastad, Linda; Andersson, Alma; Bergenstrahle, Ludvig; Bergenstrahle, Joseph; Larsson, Ludvig; Galicia, Leire Alonso; Shamikh, Alia; Basmaci, Elisa; De Stahl, Teresita Diaz; Rajakumar, Timothy; Doultsinos, Dimitrios; Thrane, Kim; Ji, Andrew L.; Khavari, Paul A.; Tarish, Firaz; Tanoglidi, Anna; Maaskola, Jonas; Colling, Richard; Mirtti, Tuomas; Hamdy, Freddie C.; Woodcock, Dan J.; Helleday, Thomas; Mills, Ian G.; Lamb, Alastair D.; Lundeberg, Joakim
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errSave
OXC-101 shows favorable safety profile in first in human phase 1 trial in patients with advanced solid cancer
errCANCER RESEARCH
IF16.6
err2023-04-14
err0
PREAI
errYachnin, Jeffrey; Ny, Lars; Sandvall, Teresa; Sanjiv, Kumar; Scobie, Martin; Platzack, Bjorn; Barancewski, Pawel; Breuer, Olof; Gorgoulis, Vassilis; Pateras, Ioannis S.; Klockare, Maria; Smith, Austin; Berglund, Ulrika Warpman; Helleday, Thomas
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Research Directions

No research directions
Co-authors
Cooperation Journals
A
Adrian L. Harris
H-index: 187 · Papers: 2.1K
C
Chris P. Ponting
H-index: 135 · Papers: 518
A
Alfonso Valencia
H-index: 127 · Papers: 866
D
David E. Neal
H-index: 123 · Papers: 1.3K
V
Vilhelm A. Bohr
H-index: 120 · Papers: 702
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