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E

Enrico O. Purisima

National Research Council Canada

38H-index
130Paper Count
5.8KCitation Count
Published Papers 59
Publication Date
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Exploring rigid-backbone protein docking in biologics discovery: a test using the DARPin scaffold
errFRONTIERS IN MOLECULAR BIOSCIENCES
IF4
err2023-08-24
err0
errOAAI
errGaudreault, Francis; Baardsnes, Jason; Martynova, Yuliya; Dachon, Aurore; Hogues, Herve; Corbeil, Christopher R.; Purisima, Enrico O.; Arbour, Melanie; Sulea, Traian
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Solvated interaction energy: from small-molecule to antibody drug design
errFRONTIERS IN MOLECULAR BIOSCIENCES
IF4
err2023-06-07
err8
errOAAI
errPurisima, Enrico O. O.; Corbeil, Christopher R. R.; Gaudreault, Francis; Wei, Wanlei; Deprez, Christophe; Sulea, Traian
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Coevolved Canonical Loops Conformations of Single-Domain Antibodies: A Tale of Three Pockets Playing Musical Chairs
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2022-06-03
err6
errOAAI
errGaudreault, Francis; Corbeil, Christopher R.; Purisima, Enrico O.; Sulea, Traian
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Antibody mutations favoring pH-dependent binding in solid tumor microenvironments: Insights from large-scale structure-based calculations
errPROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
IF2.8
err2022-04-13
err5
PREAI
errWei, Wanlei; Corbeil, Christopher R.; Gaudreault, Francis; Deprez, Christophe; Purisima, Enrico O.; Sulea, Traian
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Redesigning an antibody H3 loop by virtual screening of a small library of human germline-derived sequences
errSCIENTIFIC REPORTS
IF3.9
err2021-11-01
err3
errOAAI
errCorbeil, Christopher R.; Manenda, Mahder Seifu; Sulea, Traian; Baardsnes, Jason; Picard, Marie-Eve; Hogues, Herve; Gaudreault, Francis; Deprez, Christophe; Shi, Rong; Purisima, Enrico O.
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Binding mechanism of a de novo coiled coil complex elucidated from surface forces measurements
errJOURNAL OF COLLOID AND INTERFACE SCIENCE
IF9.7
err2021-01-01
err2
PREAI
errShrestha, Buddha R.; Liberelle, Benoit; Murschel, Frederic; Purisima, Enrico O.; Sulea, Traian; De Crescenzo, Gregory; Banquy, Xavier
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Structure-based engineering of pH-dependent antibody binding for selective targeting of solid-tumor microenvironment
errMABS
IF7.3
err2019-11-28
err62
errOAAI
errSulea, Traian; Rohani, Nazanin; Baardsnes, Jason; Corbeil, Christopher R.; Deprez, Christophe; Cepero-Donates, Yuneivy; Robert, Alma; Schrag, Joseph D.; Parat, Marie; Duchesne, Melanie; Jaramillo, Maria L.; Purisima, Enrico O.; Zwaagstra, John C.
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Binding symmetry and surface flexibility mediate antibody self-association
errMABS
IF7.3
err2019-07-18
err14
errOAAI
errSchrag, Joseph D.; Picard, Marie-Eve; Gaudreault, Francis; Gagnon, Louis-Patrick; Baardsnes, Jason; Manenda, Mahder S.; Sheff, Joey; Deprez, Christophe; Baptista, Cassio; Hogues, Herve; Kelly, John F.; Purisima, Enrico O.; Shi, Rong; Sulea, Traian
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An accurate TMT-based approach to quantify and model lysine susceptibility to conjugation via N-hydroxysuccinimide esters in a monoclonal antibody
errSCIENTIFIC REPORTS
IF3.9
err2018-12-05
err7
errOAAI
errHill, Jennifer J.; Tremblay, Tammy-Lynn; Corbeil, Christopher R.; Purisima, Enrico O.; Sulea, Traian
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ProPOSE: Direct Exhaustive Protein-Protein Docking with Side Chain Flexibility
errJOURNAL OF CHEMICAL THEORY AND COMPUTATION
IF5.5
err2018-08-14
err21
PREAI
errHogues, Herve; Gaudreault, Francis; Corbeil, Christopher R.; Deprez, Christophe; Sulea, Traian; Purisima, Enrico O.
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Application of Assisted Design of Antibody and Protein Therapeutics (ADAPT) improves efficacy of a Clostridium difficile toxin A single-domain antibody
errSCIENTIFIC REPORTS
IF3.9
err2018-02-02
err43
errOAAI
errSulea, Traian; Hussack, Greg; Ryan, Shannon; Tanha, Jamshid; Purisima, Enrico O.
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errSave
Binding pose and affinity prediction in the 2016 D3R Grand Challenge 2 using the Wilma-SIE method
errJOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
IF3.1
err2017-10-05
err3
PREAI
errHogues, Herve; Sulea, Traian; Gaudreault, Francis; Corbeil, Christopher R.; Purisima, Enrico O.
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errSave
Assessment of Solvated Interaction Energy Function for Ranking Antibody-Antigen Binding Affinities
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2016-07-14
err25
errOAAI
errSulea, Traian; Vivcharuk, Victor; Corbeil, Christopher R.; Deprez, Christophe; Purisima, Enrico O.
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errSave
Evaluation of the Wilma-SIE Virtual Screening Method in Community Structure-Activity Resource 2013 and 2014 Blind Challenges
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2015-08-24
err10
PREAI
errHogues, Herve; Sulea, Traian; Purisima, Enrico O.
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errSave
Small-Molecule Inhibitors of the Pseudaminic Acid Biosynthetic Pathway: Targeting Motility as a Key Bacterial Virulence Factor
errANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
err2014-12-01
err43
errOAAI
errMenard, Robert; Schoenhofen, Ian C.; Tao, Limei; Aubry, Annie; Bouchard, Patrice; Reid, Christopher W.; Lachance, Paule; Twine, Susan M.; Fulton, Kelly M.; Cui, Qizhi; Hogues, Herve; Purisima, Enrico O.; Sulea, Traian; Logan, Susan M.
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Shuttle-Cargo Fusion Molecules of Transport Peptides and the hD2/3 Receptor Antagonist Fallypride: A Feasible Approach To Preserve Ligand-Receptor Binding?
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2014-05-08
err5
PREAI
errWaengler, Carmen; Chowdhury, Shafinaz; Hoefner, Georg; Djurova, Petia; Purisima, Enrico O.; Bartenstein, Peter; Waengler, Bjoern; Fricker, Gert; Wanner, Klaus T.; Schirrmacher, Ralf
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Allosteric Noncompetitive Small Molecule Selective Inhibitors of CD45 Tyrosine Phosphatase Suppress T-Cell Receptor Signals and Inflammation In Vivo
errMOLECULAR PHARMACOLOGY
IF3
err2014-04-01
err31
PREAI
errPerron, Michael D.; Chowdhury, Shafinaz; Aubry, Isabelle; Purisima, Enrico; Tremblay, Michel L.; Saragovi, H. Uri
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Exhaustive docking and solvated interaction energy scoring: lessons learned from the SAMPL4 challenge
errJOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
IF3.1
err2014-01-29
err28
PREAI
errHogues, Herve; Sulea, Traian; Purisima, Enrico O.
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errSave
Exhaustive search and solvated interaction energy (SIE) for virtual screening and affinity prediction
errJOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
IF3.1
err2011-12-25
err19
PREAI
errSulea, Traian; Hogues, Herve; Purisima, Enrico O.
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errSave
Predicting hydration free energies of polychlorinated aromatic compounds from the SAMPL-3 data set with FiSH and LIE models
errJOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
IF3.1
err2011-12-22
err6
PREAI
errSulea, Traian; Purisima, Enrico O.
errShare
errSave

Research Directions

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