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SaveShare Save Share Save Share Save Share Save Share Save 5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology
Beaufils, Florent; Cmiljanovic, Natasa; Cmiljanovic, Vladimir; Bohnacker, Thomas; Melone, Anna; Marone, Romina; Jackson, Eileen; Zhang, Xuxiao; Sele, Alexander; Borsari, Chiara; Mestan, Jurgen; Hebeisen, Paul; Hillmann, Petra; Giese, Bernd; Zvelebil, Marketa; Fabbro, Doriano; Williams, Roger L.; Rageot, Denise; Wymann, Matthias P. Share Save Share Save Share Save PQR309: A potent, brain-penetrant, dual pan-PI3K/mTOR inhibitor with excellent oral bioavailability and tolerabilityCmiljanovic, Vladimir; Ettlin, Robert A.; Beautils, Florent; Dieterle, Walter; Hillmann, Petra; Mestan, Juergen; Melone, Anna; Bohnacker, Thomas; Lang, Marc; Cmiljanovic, Natasa; Giese, Bernd; Hebeisen, Paul; Wymann, Matthias P.; Fabbro, Doriano Share Save PQR309: Structure-based design, synthesis and biological evaluation of a novel, selective, dual pan-PI3K/mTOR inhibitorCmiljanovic, Vladimir; Cmiljanovic, Natasa; Marone, Romina; Beaufils, Florent; Zhang, Xuxiao; Zvelebil, Marketa; Hebeisen, Paul; Lang, Marc; Mestan, Juergen; Melone, Anna; Bohnacker, Thomas; Gaudio, Eugenio; Tarantelli, Chiara; Bertoni, Francesco; Ritschard, Reto; Pretre, Vincent; Wicki, Andreas; Fabbro, Doriano; Hillmann, Petra; Williams, Roger; Giese, Bernd; Wymann, Matthias P. Share Save Share Save Share Save Share Save Rapid Modulation of the Organic Anion Transporting Polypeptide 2B1 (OATP2B1, SLCO2B1) Function by Protein Kinase C-mediated InternalizationKoeck, Kathleen; Koenen, Anna; Giese, Bernd; Fraunholz, Martin; May, Karen; Siegmund, Werner; Hammer, Elke; Voelker, Uwe; Jedlitschky, Gabriele; Kroemer, Heyo K.; Grube, Markus Share Save Share Save Targeting Melanoma with Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin InhibitorsMarone, Romina; Erhart, Dominik; Mertz, Ann C.; Bohnacker, Thomas; Schnell, Christian; Cmiljanovic, Vladimir; Stauffer, Frederic; Garcia-Echeverria, Carlos; Giese, Bernd; Maira, Sauveur-Michel; Wymann, Matthias P. Share Save Share Save Share Save Share Save 
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