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Transcriptional and functional effects of mavacamten in multiple porcine and human models with hypertrophic cardiomyopathy Kiselev, Elisa; Agyapong, Wilson; Jurgens, Bjarne; Mohr, Elisa; Chatterjee, Shambhabi; Hunkler, Hannah J.; Salman, Jawad; Cipriano, Giuseppe; Bentele, Marco; Liu, Junqing; Specht, Jonas; Menge, Kaja S.; Waleczek, Florian J. G.; Haas, Jonas A.; Derda, Anselm A.; Sonnenschein, Kristina; Gietz, Anika; Neumuller, Susanne; Pfanne, Angelika; Beetz, Oliver; Pflaum, Michael; Wiegmann, Bettina; Psaras, Yiangos; Toepfer, Christopher; Zweigerdt, Robert; Radocaj, Ante; Kraft, Theresia; Zeug, Andre; Ponimaskin, Evgeni; Korte, Wilhelm; Horke, Alexander; Ruhparwar, Arjang; Fuchs, Maximilian; Xiao, Ke; Bar, Christian; Weber, Natalie; Thum, Thomas Share Save
An ALPK3 truncation variant causing autosomal dominant hypertrophic cardiomyopathy is partially rescued by mavacamten Leinhos, Lisa; Robinson, Paul; Poloni, Giulia; Broadway-Stringer, Sophie; Beglov, Julia; Lokman, Adam B.; Douglas, Gillian; Nuthay, Sajjad; Fonseka, Oveena; Schmid, Manuel; Singer, Evie; Hooper, Charlotte; Thomson, Kate; Bagnall, Richard D.; Ingles, Jodie; Semsarian, Christopher; Ormondroyd, Elizabeth; Toepfer, Christopher N.; Davies, Benjamin; Redwood, Charles; Watkins, Hugh; Gehmlich, Katja Share Save
Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy Raj Murthi, Sarala; Petry, Andreas; Shashikadze, Bachuki; Stoeckl, Jan B.; Schmid, Manuel; Santamaria, Gianluca; Klingel, Karin; Kracun, Damir; Chen, Xinpei; Bauer, Sabine; Schmitt, Joachim P.; Flenkenthaler, Florian; Gorham, Josh; Toepfer, Christopher N.; Potesil, David; Hruska, Pavel; Zdrahal, Zbynek; Mayer, Zsuzsanna; Klop, Mathieu; Lehmann, Luisa; Qin, Yishi; Papanakli, Laura; Spielmann, Nadine; Moretti, Alessandra; Froehlich, Thomas; Ewert, Peter; Holdenrieder, Stefan; Seidman, Jonathan G.; Seidman, Christine E.; Goerlach, Agnes; Wolf, Cordula M. Share Save
Hypertrophic cardiomyopathy-associated mutations drive stromal activation via EGFR-mediated paracrine signaling Ewoldt, Jourdan K.; Wang, Miranda C.; McLellan, Micheal A.; Cloonan, Paige E.; Chopra, Anant; Gorham, Joshua; Li, Linqing; DeLaughter, Daniel M.; Gao, Xining; Lee, Joshua H.; Willcox, Jon A. L.; Layton, Olivia; Luu, Rebeccah J.; Toepfer, Christopher N.; Eyckmans, Jeroen; Seidman, Christine E.; Seidman, Jonathan G.; Chen, Christopher S. Share Save
Comparing the effects of chemical Ca2+dyes and R-GECO on contractility and Ca2+transients in adult and human iPSC cardiomyocytes Robinson, Paul; Sparrow, Alexander J.; Psaras, Yiangos; Steeples, Violetta; Simon, Jillian N.; Broyles, Connor N.; Chang, Yu-Fen; Brook, Frances A.; Wang, Ying-Jie; Blease, Andrew; Zhang, Xiaoyu; Abassi, Yama A.; Geeves, Michael A.; Toepfer, Christopher N.; Watkins, Hugh; Redwood, Charles; Daniels, Matthew J. Share Save
Mechanism based therapies enable personalised treatment of hypertrophic cardiomyopathy Margara, Francesca; Psaras, Yiangos; Wang, Zhinuo Jenny; Schmid, Manuel; Doste, Ruben; Garfinkel, Amanda C. C.; Repetti, Giuliana G. G.; Seidman, Jonathan G. G.; Seidman, Christine E. E.; Rodriguez, Blanca; Toepfer, Christopher N. N.; Bueno-Orovio, Alfonso Share Save
Pathogenesis of Cardiomyopathy Caused by Variants in ALPK3, an Essential Pseudokinase in the Cardiomyocyte Nucleus and Sarcomere Agarwal, Radhika; Wakimoto, Hiroko; Paulo, Joao A.; Zhang, Qi; Reichart, Daniel; Toepfer, Christopher; Sharma, Arun; Tai, Angela C. C.; Lun, Mingyue; Gorham, Joshua; DePalma, Steven R.; Gygi, Steven P.; Seidman, J. G.; Seidman, Christine E. Share Save
Plakophilin-2 truncating variants impair cardiac contractility by disrupting sarcomere stability and organization Zhang, Kehan; Cloonan, Paige E.; Sundaram, Subramanian; Liu, Feng; Das, Shoshana L.; Ewoldt, Jourdan K.; Bays, Jennifer L.; Tomp, Samuel; Toepfer, Christopher N.; Marsiglia, Julia D. C.; Gorham, Joshua; Reichart, Daniel; Eyckmans, Jeroen; Seidman, Jonathan G.; Seidman, Christine E.; Chen, Christopher S. Share Save
Filamin C Cardiomyopathy Variants Cause Protein and Lysosome Accumulation Agarwal, Radhika; Paulo, Joao A.; Toepfer, Christopher N.; Ewoldt, Jourdan K.; Sundaram, Subramanian; Chopra, Anant; Zhang, Qi; Gorham, Joshua; DePalma, Steven R.; Chen, Christopher S.; Gygi, Steven P.; Seidman, Christine E.; Seidman, J. G. Share Save
Defining Diverse Disease Pathomechanisms Across Thick And Thin Filament Hypertrophic Cardiomyopathy Variants Toepfer, Christopher; Psaras, Yiangos; Margara, Francesca; Schmid, Manuel; Steeples, Violetta; Marsiglia, Julia D.; Garfinkel, Amanda; Repetti, Giuliana; Alfonso, Bueno-Orovio; Rodriguez, Blanca Share Save
CalTrack High-Throughput Automated Calcium Transient Analysis in Cardiomyocytes Psaras, Yiangos; Margara, Francesca; Cicconet, Marcelo; Sparrow, Alexander J.; Repetti, Giuliana G.; Schmid, Manuel; Steeples, Violetta; Wilcox, Jonathan A. L.; Bueno-Orovio, Alfonso; Redwood, Charles S.; Watkins, Hugh C.; Robinson, Paul; Rodriguez, Blanca; Seidman, Jonathan G.; Seidman, Christine E.; Toepfer, Christopher N. Share Save
GATA6 mutations in hiPSCs inform mechanisms for maldevelopment of the heart, pancreas, and diaphragm Sharma, Arun; Wasson, Lauren K.; Al Willcox, Jon; Morton, Sarah U.; Gorham, Joshua M.; DeLaughter, Daniel M.; Neyazi, Meraj; Schmid, Manuel; Agarwal, Radhika; Jang, Min Young; Toepfer, Christopher N.; Ward, Tarsha; Kim, Yuri; Pereira, Alexandre C.; DePalma, Steven R.; Tai, Angela; Kim, Seongwon; Conner, David; Bernstein, Daniel; Gelb, Bruce D.; Chung, Wendy K.; Goldmuntz, Elizabeth; Porter, George; Tristani-Firouzi, Martin; Srivastava, Deepak; Seidman, Jonathan G.; Seidman, Christine E. Share Save
Genetic Studies of Hypertrophic Cardiomyopathy in Singaporeans Identify Variants in TNNI3 and TNNT2 That Are Common in Chinese Patients Pua, Chee Jian; Tham, Nevin; Chin, Calvin W. L.; Walsh, Roddy; Khor, Chiea Chuen; Toepfer, Christopher N.; Repetti, Giuliana G.; Garfinkel, Amanda C.; Ewoldt, Jourdan F.; Cloonan, Paige; Chen, Christopher S.; Lim, Shi Qi; Cai, Jiashen; Loo, Li Yang; Kong, Siew Ching; Chiang, Charleston W. K.; Whiffin, Nicola; de Marvao, Antonio; Lio, Pei Min; Hii, An An; Yang, Cheng Xi; Le, Thu Thao; Bylstra, Yasmin; Lim, Weng Khong; Teo, Jing Xian; Padilha, Kallyandra; Silva, Gabriela V.; Pan, Bangfen; Govind, Risha; Buchan, Rachel J.; Barton, Paul J. R.; Tan, Patrick; Foo, Roger; Yip, James W. L.; Wong, Raymond C. C.; Chan, Wan Xian; Pereira, Alexandre C.; Tang, Hak Chiaw; Jamuar, Saumya Shekhar; Ware, James S.; Seidman, Jonathan G.; Seidman, Christine E.; Cook, Stuart A. Share Save
Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy Toepfer, Christopher N.; Garfinkel, Amanda C.; Venturini, Gabriela; Wakimoto, Hiroko; Repetti, Giuliana; Alamo, Lorenzo; Sharma, Arun; Agarwal, Radhika; Ewoldt, Jourdan F.; Cloonan, Paige; Letendre, Justin; Lun, Mingyue; Olivotto, Iacopo; Colan, Steve; Ashley, Euan; Jacoby, Daniel; Michels, Michelle; Redwood, Charles S.; Watkins, Hugh C.; Day, Sharlene M.; Staples, James F.; Padron, Raul; Chopra, Anant; Ho, Carolyn Y.; Chen, Christopher S.; Pereira, Alexandre C.; Seidman, Jonathan G.; Seidman, Christine E. Share Save
Genetic Variants Associated With Cancer Therapy-Induced Cardiomyopathy Garcia-Pavia, Pablo; Kim, Yuri; Alejandra Restrepo-Cordoba, Maria; Lunde, Ida G.; Wakimoto, Hiroko; Smith, Amanda M.; Toepfer, Christopher N.; Getz, Kelly; Gorham, Joshua; Patel, Parth; Ito, Kaoru; Willcox, Jonathan A.; Arany, Zoltan; Li, Jian; Owens, Anjali T.; Govind, Risha; Nunez, Beatriz; Mazaika, Erica; Bayes-Genis, Antoni; Walsh, Roddy; Finkelman, Brian; Lupon, Josep; Whiffin, Nicola; Serrano, Isabel; Midwinter, William; Wilk, Alicja; Bardaji, Alfredo; Ingold, Nathan; Buchan, Rachel; Tayal, Upasana; Pascual-Figal, Domingo A.; de Marvao, Antonio; Ahmad, Mian; Manuel Garcia-Pinilla, Jose; Pantazis, Antonis; Dominguez, Fernando; Baksi, A. John; O'Regan, Declan P.; Rosen, Stuart D.; Prasad, Sanjay K.; Lara-Pezzi, Enrique; Provencio, Mariano; Lyon, Alexander R.; Alonso-Pulpon, Luis; Cook, Stuart A.; DePalma, Steven R.; Barton, Paul J. R.; Aplenc, Richard; Seidman, Jonathan G.; Ky, Bonnie; Ware, James S.; Seidman, Christine E. Share Save
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SarcTrack An Adaptable Software Tool for Efficient Large-Scale Analysis of Sarcomere Function in hiPSC-Cardiomyocytes Toepfer, Christopher N.; Sharma, Arun; Cicconet, Marcelo; Garfinkel, Amanda C.; Muecke, Michael; Neyazi, Meraj; Willcox, Jon A. L.; Agarwal, Radhika; Schmid, Manuel; Rao, Jyoti; Ewoldt, Jourdan; Pourquie, Olivier; Chopra, Anant; Chen, Christopher S.; Seidman, Jonathan G.; Seidman, Christine E. Share Save
Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin Toepfer, Christopher N.; Wakimoto, Hiroko; Garfinkel, Amanda C.; McDonough, Barbara; Liao, Dan; Jiang, Jianming; Tai, Angela C.; Gorham, Joshua M.; Lunde, Ida G.; Lun, Mingyue; Lynch, Thomas L.; McNamar, James W.; Sadayappa, Sakthivel; Redwood, Charles S.; Watkins, Hugh C.; Seidma, Jonathan G.; Seidman, Christine E. Share Save
Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor Guo, Yuxuan; Jardin, Blake D.; Zhou, Pingzhu; Sethi, Isha; Akerberg, Brynn N.; Toepfer, Christopher N.; Ai, Yulan; Li, Yifei; Ma, Qing; Guatimosim, Silvia; Hu, Yongwu; Varuzhanyan, Grigor; VanDusen, Nathan J.; Zhang, Donghui; Chan, David C.; Yuan, Guo-Cheng; Seidman, Christine E.; Seidman, Jonathan G.; Pu, William T. Share Save
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