Not logged in Discovery and development of novel CNS-penetrating PARP1-selective inhibitors Bacha, Jeffrey; Truong, Sarah; Ban, Fuqiang; Smith, Jason; Pandey, Mohit; Manskaia, Ekaterina; Zhai, Beibei; Ramos, Louise; Marzban, Mona; Ghaidi, Fariba; Adomat, Hans; Singh, Kally; Chen, Xiaoqi; Brown, Dennis; Langlands, John; Collins, Colin; Cherkasov, Artem; Daugaard, Mads Share Save
Functional and Structural Characterization of Treatment-Emergent Nirmatrelvir Resistance Mutations at Low Frequencies in the Main Protease (Mpro) Reveals a Unique Evolutionary Route for SARS-CoV-2 to Gain Resistance Deschenes, Natalie M.; Perez-Vargas, Jimena; Zhong, Zoe; Thomas, Merrilee; Kenward, Calem; Mosimann, Wesley A.; Worrall, Liam J.; Waglechner, Nicholas; Li, Angel XinLiu; Maguire, Finlay; Aftanas, Patryk; Smith, Jason R.; Lim, Jared; Young, Robert N.; Cherkasov, Artem; Farooqi, Lubna; Moinuddin, Adnan; Siddiqi, Lina; Malik, Imaan; Lefebvre, Maxime; Paetzel, Mark; Strynadka, Natalie C. J.; Jean, Francois; McGeer, Allison; Kozak, Robert A. Share Save
Developing novel Lin28 inhibitors by computer aided drug design Matias-Barrios, Victor M.; Radaeva, Mariia; Rosellinny, Graciella; Jia, Qiongqiong; Xie, Ning; Villanueva, Monica; Ibrahim, Hanadi; Smith, Jason; Gleave, Martin; Lallous, Nada; Straus, Suzana K.; Cherkasov, Artem; Dong, Xuesen Share Save
Characterization of novel small molecule inhibitors of estrogen receptor-activation function 2 (ER-AF2) Foo, Jane; Gentile, Francesco; Massah, Shabnam; Morin, Helene; Singh, Kriti; Lee, Joseph; Smith, Jason; Ban, Fuqiang; Leblanc, Eric; Young, Robert; Strynadka, Natalie; Lallous, Nada; Cherkasov, Artem Share Save
UTILIZING DEEP DOCKING AND ARTIFICIAL INTELLIGENCE FOR THE DISCOVERY OF NOVEL PARP1-SELECTIVE INHIBITORS FOR USE AGAINST BRAIN TUMORS Truong, Sarah; Ban, Fuqiang; Smith, Jason; Zhai, Beibei; Ramos, Louise; Marzban, Mona; Ghaidi, Fariba; Adomat, Hans; Chen, Xiaoqi; Langlands, John; Brown, Dennis; Bacha, Jeffrey; Collins, Colin; Cherkasov, Artem; Daugaard, Mads Share Save
A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants Perez-Vargas, Jimena; Worrall, Liam J.; Olmstead, Andrea D.; Ton, Anh-Tien; Lee, Jaeyong; Villanueva, Ivan; Thompson, Connor A. H.; Dudek, Svenja; Ennis, Siobhan; Smith, Jason R.; Shapira, Tirosh; De Guzman, Joshua; Gang, Shutong; Ban, Fuqiang; Vuckovic, Marija; Bielecki, Michael; Kovacic, Suzana; Kenward, Calem; Hong, Christopher Yee; Gordon, Danielle G.; Levett, Paul N.; Krajden, Mel; Leduc, Richard; Boudreault, Pierre-Luc; Niikura, Masahiro; Paetzel, Mark; Young, Robert N.; Cherkasov, Artem; Strynadka, Natalie C. J.; Jean, Francois Share Save
Multifunctional metallochaperone modifications for targeting subsite cavities in mutant p53-Y220C Miller, Jessica J.; Kwan, Kalvin; Orvain, Christophe; Mellitzer, Georg; Smith, Jason; Lento, Cristina; Nouchikian, Lucienne; Omoregbee-Leichnitz, Sabrina; Sabatou, Marie; Wilson, Derek; Gaiddon, Christian; Storr, Tim Share Save
Large-Scale Virtual Screening for the Discovery of SARS-CoV-2 Papain-like Protease (PLpro) Non-covalent Inhibitors Garland, Olivia; Ton, Anh-Tien; Moradi, Shoeib; Smith, Jason R.; Kovacic, Suzana; Ng, Kurtis; Pandey, Mohit; Ban, Fuqiang; Lee, Jaeyong; Vuckovic, Marija; Worrall, Liam J.; Young, Robert N.; Pantophlet, Ralph; Strynadka, Natalie C. J.; Cherkasov, Artem Share Save
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Modification of amyloid-beta peptide aggregation via photoactivation of strained Ru(ii) polypyridyl complexes Bataglioli, Janaina C.; Gomes, Luiza M. F.; Maunoir, Camille; Smith, Jason R.; Cole, Houston D.; McCain, Julia; Sainuddin, Tariq; Cameron, Colin G.; McFarland, Sherri A.; Storr, Tim Share Save
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The first indoleamine-2,3-dioxygenase-1 (IDO1) inhibitors containing carborane Austin, Christopher J. D.; Kahlert, Jan; Issa, Fatiah; Reed, John H.; Smith, Jason R.; Ioppolo, Joseph A.; Ong, Jennifer A.; Jamie, Joanne F.; Hibbs, David; Rendina, Louis M. Share Save
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