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Discovery and development of a novel CNS-penetrating ATR inhibitor Bacha, Jeffrey; Truong, Sarah; Zhai, Beibei; Ramos, Louise; Marzban, Mona; Ghaidi, Fariba; Drew-Brook, Marshall; Guzzo, Pete; Issa, Ahmad; Khodabandeh, Mehran; Omar, Sara; Rolfe, Jason; Saberali, Seyed Ali; Singh, Kally; Chen, Xiaoqi; Brown, Dennis; Langlands, John; Daugaard, Mads Share Save
Discovery and development of novel CNS-penetrating PARP1-selective inhibitors Bacha, Jeffrey; Truong, Sarah; Ban, Fuqiang; Smith, Jason; Pandey, Mohit; Manskaia, Ekaterina; Zhai, Beibei; Ramos, Louise; Marzban, Mona; Ghaidi, Fariba; Adomat, Hans; Singh, Kally; Chen, Xiaoqi; Brown, Dennis; Langlands, John; Collins, Colin; Cherkasov, Artem; Daugaard, Mads Share Save
MODELING GLIOBLASTOMA TREATMENT RESPONSES: INSIGHTS INTO TUMOR PLASTICITY AND THE ROLE OF THE TUMOR MICROENVIRONMENT Sanz, M. de Lucas; Allahverdi, H.; Nosirov, B.; Sanchez, P. Moreno; Milan, M. Baroni; Lipsa, A.; Rezaeipour, M.; Dording, C.; Brown, D.; Langlands, J. M.; Grzyb, K.; Yabo, Y. A.; Zhang, J.; Heiland, D. H.; Michelucci, A.; Nazarov, P., V; Golebiewska, A. Share Save
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ASSESSMENT OF MOLECULAR ALTERATIONS IN NEWLY DIAGNOSED GBM MGMT-UNMETHYLATED PATIENTS TREATED WITH VAL-083 Kamiya-Matsuoka, Carlos; Weathers, Shaio-Pei; Yung, Alfred; Login, Monica; Majd, Nazanin; Brown, Dennis; Langlands, John; Schwartz, Richard; Knight, Stephanie; Puduvalli, Vinay; de Groot, John; O'Brien, Barbara Share Save
UTILIZING DEEP DOCKING AND ARTIFICIAL INTELLIGENCE FOR THE DISCOVERY OF NOVEL PARP1-SELECTIVE INHIBITORS FOR USE AGAINST BRAIN TUMORS Truong, Sarah; Ban, Fuqiang; Smith, Jason; Zhai, Beibei; Ramos, Louise; Marzban, Mona; Ghaidi, Fariba; Adomat, Hans; Chen, Xiaoqi; Langlands, John; Brown, Dennis; Bacha, Jeffrey; Collins, Colin; Cherkasov, Artem; Daugaard, Mads Share Save
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Pharmacological synthetic lethality by co-inhibition of PARP and HDAC enzymes Truong, Sarah; Ramos, Louise; Zhai, Beibei; Ghaidi, Fariba; Marzban, Mona; Adomat, Hans; Chen, Xiaoqi; Langlands, John; Brown, Dennis; Bacha, Jeffrey; Collins, Colin; Sorensen, Poul H.; Shen, Wang; Daugaard, Mads Share Save
Exploring the therapeutic effectiveness of EO3001 in the treatment of clear cell ovarian cancers with ARID1A mutations Ding, Yuchen; Li, Lucy Yuqin; Zhang, Joyce Yuhan; Kabeer, Farhia; Lam, TszYin; Kalantari, Forouh; Bacha, Jeffrey; Brown, Dennis; Kanekal, Sarath; Sankar, Neil; Lizardo, Michael; El-Naggar, Amal; Huntsman, David Share Save
Angiotensin II acts through Rac1 to upregulate pendrin: role of NADPH oxidase Pham, Truyen D.; Verlander, Jill W.; Chen, Chao; Pech, Vladimir; Kim, Hailey I.; Kim, Young Hee; Weiner, I. David; Milne, Ginger L.; Zent, Roy; Bock, Fabian; Brown, Dennis; Eaton, Amity; Wall, Susan M. Share Save
Small-molecule bifunctional inhibitors of PARP1/2 and HDAC enzymes Truong, Sarah; Ramos, Louise; Zhai, Beibei; Joshi, Jay; Ghaidi, Fariba; Marzban, Mona; Adomat, Hans; Chen, Charles; Langlands, John; Brown, Dennis; Bache, Jeffrey; Collins, Colin; Sorensen, Poul; Shen, Wang; Daugaard, Mads Share Save
Regulatory T cells play a crucial role in maintaining sperm tolerance and male fertility Barrachina, Ferran; Ottino, Kiera; Elizagaray, Maia Lina; Gervasi, Maria Gracia; Tu, Leona J.; Markoulaki, Styliani; Spallanzani, Raul G.; Capen, Diane; Brown, Dennis; Battistone, Maria Agustina Share Save
A pilot clinical study of orotecan (oral irinotecan HCl, VAL-413) in patients with recurrent pediatric solid tumors Bacha, Jeffrey; Brown, Dennis; Kanekal, Sarath; Sankar, Neil; Lopez, Lorena; Yam, Noymi; Wagner, Lars; Geller, James; Leggas, Markos; Thompson, Patrick; Osterheld, Javier Share Save
A bifunctional inhibitor of PARP and HDAC enzymes with activity in Ewing sarcoma 3D spheroid and metastasis models Truong, Sarah; Ramos, Louise; Zhai, Beibei; Joshi, Jay; Ghaidi, Fariba; Lizardo, Michael M.; Shyp, Taras; Langlands, John; Brown, Dennis; Bacha, Jeffrey; Sorensen, Poul; Shen, Wang; Daugaard, Mads Share Save
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Intracellular sites of AQP2 S256 phosphorylation identified using inhibitors of the AQP2 recycling itinerary Cheung, Pui W.; Boukenna, Mey; Babicz, Richard S. E.; Mitra, Shimontini; Kay, Anna; Paunescu, Theodor C.; Baylor, Noah; Liu, Chen-Chung Steven; V. Nair, Anil; Bouley, Richard; Brown, Dennis Share Save
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Neutrophils incite and macrophages avert electrical storm after myocardial infarction Grune, Jana; Lewis, Andrew J. M.; Yamazoe, Masahiro; Hulsmans, Maarten; Rohde, David; Xiao, Ling; Zhang, Shuang; Ott, Christiane; Calcagno, David M.; Zhou, Yirong; Timm, Kerstin; Shanmuganathan, Mayooran; Pulous, Fadi E.; Schloss, Maximillian J.; Foy, Brody H.; Capen, Diane; Vinegoni, Claudio; Wojtkiewicz, Gregory R.; Iwamoto, Yoshiko; Grune, Tilman; Brown, Dennis; Higgins, John; Ferreira, Vanessa M.; Herring, Neil; Channon, Keith M.; Neubauer, Stefan; Sosnovik, David E.; Milan, David J.; Swirski, Filip K.; King, Kevin R.; Aguirre, Aaron D.; Ellinor, Patrick T.; Nahrendorf, Matthias Share Save
Simultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury Mukherjee, Kamalika; Gu, Changkyu; Collins, Agnieszka; Mettlen, Marcel; Samelko, Beata; Altintas, Mehmet M.; Sudhini, Yashwanth R.; Wang, Xuexiang; Bouley, Richard; Brown, Dennis; Pedro, Bradley P.; Bane, Susan L.; Gupta, Vineet; Brinkkoetter, Paul T.; Hagmann, Henning; Reiser, Jochen; Sever, Sanja Share Save
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