Not logged in Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor Czako, Barbara; Sun, Yuting; McAfoos, Timothy; Cross, Jason B.; Leonard, Paul G.; Burke, Jason P.; Carroll, Christopher L.; Feng, Ningping; Harris, Angela L.; Jiang, Yongying; Kang, Zhijun; Kovacs, Jeffrey J.; Mandal, Pijus; Meyers, Brooke A.; Mseeh, Faika; Parker, Connor A.; Yu, Simon S.; Williams, Christopher C.; Wu, Qi; Di Francesco, Maria Emilia; Draetta, Giulio; Heffernan, Timothy; Marszalek, Joseph R.; Kohl, Nancy E.; Jones, Philip Share Save
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme Hamilton, Matthew M.; Mseeh, Faika; McAfoos, Timothy J.; Leonard, Paul G.; Reyna, Naphtali J.; Harris, Angela L.; Xu, Alan; Han, Michelle; Soth, Michael J.; Czako, Barbara; Theroff, Jay P.; Mandal, Pijus K.; Burke, Jason P.; Virgin-Downey, Brett; Petrocchi, Alessia; Pfaffinger, Dana; Rogers, Norma E.; Parker, Connor A.; Yu, Simon S.; Jiang, Yongying; Krapp, Stephan; Lammens, Alfred; Trevitt, Graham; Tremblay, Martin R.; Mikule, Keith; Wilcoxen, Keith; Cross, Jason B.; Jones, Philip; Marszalek, Joseph R.; Lewis, Richard T. Share Save
Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib Sun, Yuting; Meyers, Brooke A.; Czako, Barbara; Leonard, Paul; Mseeh, Faika; Harris, Angela L.; Wu, Qi; Johnson, Sarah; Parker, Connor A.; Cross, Jason B.; Di Francesco, Maria Emilia; Bivona, Benjamin J.; Bristow, Christopher A.; Burke, Jason P.; Carrillo, Caroline C.; Carroll, Christopher L.; Chang, Qing; Feng, Ningping; Gao, Guang; Gera, Sonal; Giuliani, Virginia; Huang, Justin K.; Jiang, Yongying; Kang, Zhijun; Kovacs, Jeffrey J.; Liu, Chiu-Yi; Lopez, Anastasia M.; Ma, Xiaoyan; Mandal, Pijus K.; McAfoos, Timothy; Miller, Meredith A.; Mullinax, Robert A.; Peoples, Michael; Ramamoorthy, Vandhana; Seth, Sahil; Spencer, Nakia D.; Suzuki, Erika; Williams, Christopher C.; Yu, Simon S.; Zuniga, Andy M.; Draetta, Giulio F.; Marszalek, Joseph R.; Heffernan, Timothy P.; Kohl, Nancy E.; Jones, Philip Share Save
Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties Soth, Michael J.; Le, Kang; Di Francesco, Maria Emilia; Hamilton, Matthew M.; Liu, Gang; Burke, Jason P.; Carroll, Chris L.; Kovacs, Jeffrey J.; Bardenhagen, Jennifer P.; Bristow, Christopher A.; Cardozo, Mario; Czako, Barbara; de Stanchina, Elisa; Feng, Ningping; Garvey, Jill R.; Gay, Jason P.; Do, Mary K. Geck; Greer, Jennifer; Han, Michelle; Harris, Angela; Herrera, Zachary; Huang, Sha; Giuliani, Virginia; Jiang, Yongying; Johnson, Sarah B.; Johnson, Troy A.; Kang, Zhijun; Leonard, Paul G.; Liu, Zhen; McAfoos, Timothy; Miller, Meredith; Morlacchi, Pietro; Mullinax, Robert A.; Palmer, Wylie S.; Pang, Jihai; Rogers, Norma; Rudin, Charles M.; Shepard, Hannah E.; Spencer, Nakia D.; Theroff, Jay; Wu, Qi; Xu, Alan; Yau, Ju Anne; Draetta, Giulio; Toniatti, Carlo; Heffernan, Timothy P.; Jones, Philip Share Save
Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1R Czako, Barbara; Marszalek, Joseph. R.; Burke, Jason P.; Mandal, Pijus; Leonard, Paul G.; Cross, Jason B.; Mseeh, Faika; Jiang, Yongying; Chang, Edward Q.; Suzuki, Erika; Kovacs, Jeffrey J.; Feng, Ningping; Gera, Sonal; Harris, Angela L.; Liu, Zhen; Mullinax, Robert A.; Pang, Jihai; Parker, Connor A.; Spencer, Nakia D.; Yu, Simon S.; Wu, Qi; Tremblay, Martin R.; Mikule, Keith; Wilcoxen, Keith; Heffernan, Timothy P.; Draetta, Giulio F.; Jones, Philip Share Save
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Discovery of IACS-13909, an allosteric SHP2 inhibitor that overcomes multiple mechanisms underlying osimertinib resistance Sun, Yuting; Meyers, Brooke A.; Johnson, Sarah B.; Harris, Angela L.; Czako, Barbara; Cross, Jason B.; Leonard, Paul G.; Mseeh, Faika; Di Francesco, Maria E.; Parker, Connor A.; Wu, Qi; Bristow, Christopher A.; Burke, Jason P.; Carrillo, Caroline C.; Carroll, Christopher L.; Chang, Qing; Feng, Ningping; Gera, Sonal; Guang, Gao; Huang, Justin Kwang-Lay; Jiang, Yongying; Kang, Zhijun; Kovacs, Jeffrey J.; Ma, Xiaoyan; Mandal, Pijus K.; McAfoos, Timothy; Mullinax, Robert A.; Peoples, Michael D.; Ramamoorthy, Vandhana; Seth, Sahil; Suzuki, Erika; Williams, Christopher Conrad; Yu, Simon S.; Zuniga, Andy M.; Draetta, Giulio F.; Marszalek, Joseph R.; Heffernan, Timothy P.; Kohl, Nancy E.; Jones, Philip Share Save
Promoting an anti-tumor immune environment with a novel, exquisitely selective CSF1R inhibitor Suzuki, Erika; Kovacs, Jeffrey J.; Spencer, Nakia D.; Sonal, Sonal; Feng, Ningping; Harris, Angela L.; Mullinax, Robert A.; Zuniga, Andy M.; Johnson, Sarah B.; Mahendra, Mikhila; Khor, Tin Oo; Mseeh, Faika; Liu, Zhen; Burke, Jason P.; Mikule, Keith; Tremblay, Martin; Heffernan, Timothy P.; Jones, Philip; Czako, Barbara; Marszalek, Joseph R. Share Save
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Discovery of Tricyclic Indoles That Potently Inhibit Mcl-1 Using Fragment-Based Methods and Structure-Based Design Burke, Jason P.; Bian, Zhiguo; Shaw, Subrata; Zhao, Bin; Goodwin, Craig M.; Belmar, Johannes; Browning, Carrie F.; Vigil, Dominico; Friberg, Anders; Camper, DeMarco V.; Rossanese, Olivia W.; Lee, Taekyu; Olejniczak, Edward T.; Fesik, Stephen W. Share Save
Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design Friberg, Anders; Vigil, Dominico; Zhao, Bin; Daniels, R. Nathan; Burke, Jason P.; Garcia-Barrantes, Pedro M.; Camper, DeMarco; Chauder, Brian A.; Lee, Taekyu; Olejniczak, Edward T.; Fesik, Stephen W. Share Save
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