Not logged inDiscovery of ORIC-533, an Orally Bioavailable CD73 Inhibitor That Maintains Activity in High AMP Environments to Reverse Tumor Immunosuppression
Moore, Jared T.; Kawai, Hiroyuki; Blank, Brian R.; Wu, Kejia; Yeh, Chien-Hung; Zhu, Liusheng; Pham, Johnny D.; Rew, Yosup; Eksterowicz, John; Salaniwal, Sumeet; Sutimantanapi, Dena; Warne, Robert; Yuen, Natalie; Metzger, Todd C.; Chan, Brenda; Huang, Tom; Chen, Xi; Chen, Yuping; Duong, Frank; Kong, Wayne; Chang, Jae H.; Sun, Jessica D.; Zavorotinskaya, Tatiana; Ye, Quiping; Al-Sayah, Mohammad A.; Jackson, Erica; Junttila, Melissa R.; Fantin, Valeria R.; Ndubaku, Chudi O.; Sun, Daqing; Du, Xiaohui; Friedman, Lori S. .png)
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SaveDiscovery of STX-721, a Covalent, Potent, and Highly Mutant-Selective EGFR/HER2 Exon20 Insertion Inhibitor for the Treatment of Non-Small Cell Lung CancerMilgram, Benjamin C.; Borrelli, Deanna R.; Brooijmans, Natasja; Henderson, Jack A.; Hilbert, Brendan J.; Huff, Michael R.; Ito, Takahiro; Jackson, Erica L.; Jonsson, Philip; Ladd, Brendon; O'Hearn, Erin L.; Pagliarini, Raymond A.; Roberts, Simon A.; Ronseaux, Sebastien; Stuart, Darrin D.; Wang, Weixue; Guzman-Perez, Angel Share Save Share Save Share Save EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagationPribluda, Ariel; Daemen, Anneleen; Lima, Anthony Nelson; Wang, Xi; Hafner, Marc; Poon, Chungkee; Modrusan, Zora; Katakam, Anand Kumar; Foreman, Oded; Eastham, Jefferey; Hung, Jefferey; Haley, Benjamin; Garcia, Julia T.; Jackson, Erica L.; Junttila, Melissa R. Share Save NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinomaHegde, Ganapati V.; de la Cruz, Cecile; Giltnane, Jennifer M.; Crocker, Lisa; Venkatanarayan, Avinashnarayan; Schaefer, Gabriele; Dunlap, Debra; Hoeck, Joerg D.; Piskol, Robert; Gnad, Florian; Modrusan, Zora; de Sauvage, Frederic J.; Siebel, Christian W.; Jackson, Erica L. Share Save The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumorsHagenbeek, Thijs J.; Webster, Joshua D.; Kljavin, Noelyn M.; Chang, Matthew T.; Trang Pham; Lee, Ho-June; Klijn, Christiaan; Cai, Allen G.; Totpal, Klara; Ravishankar, Buvana; Yang, Naiying; Lee, Da-Hye; Walsh, Kevin B.; Hatzivassiliou, Georgia; de la Cruz, Cecile C.; Gould, Stephen E.; Wu, Xiumin; Lee, Wyne P.; Yang, Shuqun; Zhang, Zhixiang; Gu, Qingyang; Ji, Qunsheng; Jackson, Erica L.; Lim, Dae-Sik; Dey, Anwesha Share Save Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101)Rew, Yosup; Du, Xiaohui; Eksterowicz, John; Zhou, Haiying; Jahchan, Nadine; Zhu, Liusheng; Yan, Xuelei; Kawai, Hiroyuki; McGee, Lawrence R.; Medina, Julio C.; Huang, Tom; Chen, Chelsea; Zavorotinskaya, Tatiana; Sutimantanapi, Dena; Waszczuk, Joanna; Jackson, Erica; Huang, Elizabeth; Ye, Qiuping; Fantin, Valeria R.; Sun, Daqing Share Save A novel glucocorticoid receptor (GR) antagonist overcomes GR-mediated chemoresistance in triple-negative breast cancerJahchan, Nadine; Zhou, Haiying; Kong, Wayne; Mc Weeney, Dan; Tracy, Ted; Stice, James; Sutimantanapi, Dena; Chen, Chelsea; Huang, Tom; Rew, Yosup; Du, Xiauhui; Zavorotinskaya, Tatiana; Sun, Daqing; Ye, Qiuping; Jackson, Erica; Fantin, Valeria Share Save Antibody-mediated stabilization of NRG1 induces behavioral and electrophysiological alterations in adult miceDominguez, Sara L.; Hegde, Ganapati V.; Hanson, Jesse E.; Xiang, Hong; Mandikian, Danielle; Boswell, C. Andrew; Chiu, Cecilia; Wu, Yan; Tsai, Siao Ping; Fleck, Daniel; Weber, Martin; Ngu, Hai; Scearce-Levie, Kimberly; Jackson, Erica L. Share Save Development of murine models to evaluate the impact of glucocorticoid receptor (GR) inhibition on chemotherapy responseJahchan, Nadine; Zhou, Haiying; Stice, James; Kong, Wayne; McWeeney, Dan; Sun, Daqing; Rew, Yosup; Du, Xiaohui; Zhu, Liusheng; Ye, Qiuping; Jackson, Erica L.; Fantin, Valeria Share Save Activation of AR signaling by mifepristone enhances prostate cancer growth and impairs enzalutamide responseZhou, Haiying; Jachan, Nadine; Singh, Mallika; Tran, Chris; McWeeney, Dan; Balbas, Minna; Schenkein, Emily; Zovorotinskaya, Tatiana; Jackson, Erica L.; Medina, Julio; Sun, Daqing; Rew, Yosup; Du, Xiaohui; Eksterowicz, John; Yan, Xuelei; Zhu, Liusheng; Ye, Qiuping; Fantin, Valeria Share Save An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cellsVinogradova, Maia; Gehling, Victor S.; Gustafson, Amy; Arora, Shilpi; Tindell, Charles A.; Wilson, Catherine; Williamson, Kaylyn E.; Guler, Gulfem D.; Gangurde, Pranoti; Manieri, Wanda; Busby, Jennifer; Flynn, E. Megan; Lan, Fei; Kim, Hyo-jin; Odate, Shobu; Cochran, Andrea G.; Liu, Yichin; Wongchenko, Matthew; Yang, Yibin; Cheung, Tommy K.; Maile, Tobias M.; Lau, Ted; Costa, Michael; Hegde, Ganapati V.; Jackson, Erica; Pitti, Robert; Arnott, David; Bailey, Christopher; Bellon, Steve; Cummings, Richard T.; Albrecht, Brian K.; Harmange, Jean-Christophe; Kiefer, James R.; Trojer, Patrick; Classon, Marie Share Save Share Save Share Save Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF-induced neutrophil recruitmentPhan, Vernon T.; Wu, Xiumin; Cheng, Jason H.; Sheng, Rebecca X.; Chung, Alicia S.; Zhuang, Guanglei; Tran, Christopher; Song, Qinghua; Kowanetz, Marcin; Sambrone, Amy; Tan, Martha; Meng, Y. Gloria; Jackson, Erica L.; Peale, Franklin V.; Junttila, Melissa R.; Ferrara, Napoleone Share Save Blocking NRG1 and Other Ligand-Mediated Her4 Signaling Enhances the Magnitude and Duration of the Chemotherapeutic Response of Non-Small Cell Lung CancerHegde, Ganapati V.; de la Cruz, Cecile C.; Chiu, Cecilia; Alag, Navneet; Schaefer, Gabriele; Crocker, Lisa; Ross, Sarajane; Goldenberg, David; Merchant, Mark; Tien, Janet; Shao, Lily; Roth, Leslie; Tsai, Siao-Ping; Stawicki, Scott; Jin, Zhaoyu; Wyatt, Shelby K.; Carano, Richard A. D.; Zheng, Yanyan; Sweet-Cordero, E. Alejandro; Wu, Yan; Jackson, Erica L. Share Save Share Save Share Save Share Save 
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