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Alex B. Kleinpeter

national cancer institute

12H-index
26Paper Count
672Citation Count
Published Papers 17
Publication Date
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The Central Pore of HIV-1 Capsomers Promotes Sustained Stability of the Viral Capsid
errJournal of Molecular Biology
IF4.5
err2026-07-16
err0
errOAAI
errAlex B. Kleinpeter; Donna L. Mallery; Anna Albecka; Ryan C. Burdick; Nadine Renner; J. Ole Klarhof; Boglarka Vamos; Vinay K. Pathak; Leo C. James; Eric O. Freed
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errSave
Mechanisms of HIV-1 assembly, release and maturation
errNature Reviews Microbiology
IF103.3
err2026-06-11
err0
PREAI
errAlex B. Kleinpeter; Eric O. Freed
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errSave
Structural basis for HIV-1 capsid adaption to a deficiency in IP6 packaging
errNature Communications
IF15.7
err2025-09-01
err0
errOAAI
errYanan Zhu; Alex B. Kleinpeter; Juan S. Rey; Juan Shen; Yao Shen; Jialu Xu; Nathan Hardenbrook; Long Chen; Anka Lucic; Juan R. Perilla; Eric O. Freed; Peijun Zhang
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errSave
Author Correction: HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly
errNature Structural & Molecular Biology
IF10.1
err2025-08-29
err0
PREAI
errNadine Renner; Alex Kleinpeter; Donna L. Mallery; Anna Albecka; K. M. Rifat Faysal; Till Böcking; Adolfo Saiardi; Eric O. Freed; Leo C. James
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errSave
Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir
errMBIO
IF4.7
err2025-05-14
err0
errOAAI
errBriganti, Lorenzo; Annamalai, Arun S.; Bester, Stephanie M.; Wei, Guochao; Andino-Moncada, Jonathan R.; Singh, Satya P.; Kleinpeter, Alex B.; Tripathi, Meghna; Nguyen, Binh; Radhakrishnan, Rajalingam; Singh, Parmit K.; Greenwood, Juliet; Schope, Lauren I.; Haney, Reed; Huang, Szu-Wei; Freed, Eric O.; Engelman, Alan N.; Francis, Ashwanth C.; Kvaratskhelia, Mamuka
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errSave
HIV-1 adapts to lost IP6 coordination through second-site mutations that restore conical capsid assembly
errNATURE COMMUNICATIONS
IF15.7
err2024-09-13
err0
errOAAI
errKleinpeter, Alex; Mallery, Donna L.; Renner, Nadine; Albecka, Anna; Klarhof, J. Ole; Freed, Eric O.; James, Leo C.
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errSave
Structural Investigations of Interactions between the Influenza a Virus NS1 and Host Cellular Proteins
errVIRUSES-BASEL
IF3.5
err2023-10-07
err8
errOAAI
errBlake, Morgan E.; Kleinpeter, Alex B.; Jureka, Alexander S.; Petit, Chad M.
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errSave
Structural basis of HIV-1 maturation inhibitor binding and activity
errNATURE COMMUNICATIONS
IF15.7
err2023-03-04
err14
errOAAI
errSarkar, Sucharita; Zadrozny, Kaneil K.; Zadorozhnyi, Roman; Russell, Ryan W.; Quinn, Caitlin M.; Kleinpeter, Alex; Ablan, Sherimay; Meshkin, Hamed; Perilla, Juan R.; Freed, Eric O.; Ganser-Pornillos, Barbie K.; Pornillos, Owen; Gronenborn, Angela M.; Polenova, Tatyana
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HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly
errNATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
err2023-01-09
err24
errOAAI
errRenner, Nadine; Kleinpeter, Alex; Mallery, Donna L.; Albecka, Anna; Faysal, Rifat K. M.; Bocking, Till; Saiardi, Adolfo; Freed, Eric O.; James, Leo C.
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errSave
Enhanced Transmissibility and Decreased Virulence of HIV-1 CRF07_BC May Explain Its Rapid Expansion in China
errMICROBIOLOGY SPECTRUM
IF3.8
err2022-08-31
err22
errOAAI
errCheng, Zetao; Yan, Huanchang; Li, Qingmei; Ablan, Sherimay D.; Kleinpeter, Alex; Freed, Eric O.; Wu, Hao; Dzakah, Emmanuel Enoch; Zhao, Jianhui; Han, Zhigang; Wang, Haiying; Tang, Shixing
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errSave
CryoET structures of immature HIV Gag reveal six-helix bundle
errCOMMUNICATIONS BIOLOGY
IF5.1
err2021-04-16
err30
errOAAI
errMendonca, Luiza; Sun, Dapeng; Ning, Jiying; Liu, Jiwei; Kotecha, Abhay; Olek, Mateusz; Frosio, Thomas; Fu, Xiaofeng; Himes, Benjamin A.; Kleinpeter, Alex B.; Freed, Eric O.; Zhou, Jing; Aiken, Christopher; Zhang, Peijun
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errSave
A stable immature lattice packages IP6 for HIV capsid maturation
errSCIENCE ADVANCES
IF12.5
err2021-03-12
err42
errOAAI
errMallery, Donna L.; Kleinpeter, Alex B.; Renner, Nadine; Faysal, K. M. Rifat; Novikova, Mariia; Kiss, Leo; Wilson, Miranda S. C.; Ahsan, Bilal; Ke, Zunlong; Briggs, John A. G.; Saiardi, Adolfo; Bocking, Till; Freed, Eric O.; James, Leo C.
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errSave
VIRAL MATURATION How to package the RNA of HIV-1
errELIFE
IF0
err2020-11-17
err0
errOAAI
errKleinpeter, Alex; Freed, Eric O.
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errSave
HIV-1 Maturation: Lessons Learned from Inhibitors
errVIRUSES-BASEL
IF3.5
err2020-08-26
err69
errOAAI
errKleinpeter, Alex B.; Freed, Eric O.
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errSave
The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2020-01-24
err43
errOAAI
errJureka, Alexander S.; Kleinpeter, Alex B.; Tipper, Jennifer L.; Harrod, Kevin S.; Petit, Chad M.
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errSave
Cellular IP6 Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP6 Are Attenuated for Infection and Replication
errCELL REPORTS
IF6.9
err2019-12-01
err60
errOAAI
errMallery, Donna L.; Faysal, K. M. Rifat; Kleinpeter, Alex; Wilson, Miranda S. C.; Vaysburd, Marina; Fletcher, Adam J.; Novikova, Mariia; Bocking, Till; Freed, Eric O.; Saiardi, Adolfo; James, Leo C.
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errSave
Structural analyses reveal the mechanism of inhibition of influenza virus NS1 by two antiviral compounds
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2018-09-01
err28
errOAAI
errKleinpeter, Alex B.; Jureka, Alexander S.; Falahat, Sally M.; Green, Todd J.; Petit, Chad M.
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
A
Angela M. Gronenborn
H-index: 119 · Papers: 797
J
John A. G. Briggs
H-index: 81 · Papers: 335
A
Alan Engelman
H-index: 80 · Papers: 267
E
Eric O. Freed
H-index: 77 · Papers: 289
P
Peijun Zhang
H-index: 61 · Papers: 375
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