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Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH) Sundararamana, Sesh A.; Miller, Justin J.; Daleya, Ellora C.; O'Briena, Kelsey A.; Kasakc, Paulina; Danielsd, Abigail M.; Edwardse, Rachel L.; Heidelg, Kenneth M.; Bagueg, Darean A.; Wilsonh, Madeleine A.; Koelperh, Andrew J.; Kourtoglouh, Elexi C.; Whiteh, Alex D.; Augusth, Sloan A.; Appleh, Georgia A.; Rouambah, Regis W.; Durandh, Anthony J.; Estebh, John J.; Mulleri, Florian L.; Johnsonh, R. Jeremy; Hoopsh, Geoffrey C.; Dowdg, Cynthia S.; John, Audrey R. Odom Share Save
High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of Plasmodium falciparum Johannsen, Sandra; Gierse, Robin M.; Kru''ger, Arne; Edwards, Rachel L.; Nanna, Vittoria; Fontana, Anna; Zhu, Di; Masini, Tiziana; de Carvalho, Lais Pessanha; Poizat, Mael; Kieftenbelt, Bart; Hodge, Dana M.; Alvarez, Sophie; Bunt, Daan; Lacour, Antoine; Shams, Atanaz; Meissner, Kamila Anna; de Souza, Edmarcia Elisa; Dro''ge, Melloney; van Vliet, Bernard; den Hartog, Jack; Hutter, Michael C.; Held, Jana; Odom John, Audrey R.; Wrenger, Carsten; Hirsch, Anna K. H. Share Save
Phase 1 Open-Label Dose Escalation Trial for the Development of a Human Bacillus Calmette-Guérin Challenge Model for Assessment of Tuberculosis Immunity In Vivo Blazevic, Azra; Edwards, Rachel L.; Xia, Mei; Eickhoff, Christopher S.; Hamzabegovic, Fahreta; Meza, Krystal A.; Ning, Huan; Tennant, Janice; Mosby, Karla J.; Ritchie, James C.; Girmay, Tigisty; Lai, Lilin; Mccullough, Michele; Beck, Allison; Kelley, Colleen; Edupuganti, Srilatha; Kabbani, Sarah; Buchanan, Wendy; Makhene, Mamodikoe K.; Voronca, Delia; Cherikh, Sami; Goll, Johannes B.; Rouphael, Nadine G.; Mulligan, Mark J.; Hoft, Daniel F. Share Save
MEPicides: α,β-unsaturated Fosmidomycin N-Acyl Analogs as Efficient Inhibitors of Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate reductoisomerase Wang, Xu; Edwards, Rachel L.; Ball, Haley S.; Heidel, Kenneth M.; Brothers, Robert C.; Johnson, Claire; Haymond, Amanda; Girma, Misgina; Dailey, Allyson; Roma, Jose Santinni; Boshoff, Helena I.; Osbourn, Damon M.; Meyers, Marvin J.; Couch, Robin D.; Odom John, Audrey R.; Dowd, Cynthia S. Share Save
The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance Murithi, James M.; Deni, Ioanna; Pasaje, Charisse Flerida A.; Okombo, John; Bridgford, Jessica L.; Gnadig, Nina F.; Edwards, Rachel L.; Yeo, Tomas; Mok, Sachel; Burkhard, Anna Y.; Coburn-Flynn, Olivia; Istvan, Eva S.; Sakata-Kato, Tomoyo; Gomez-Lorenzo, Maria G.; Cowell, Annie N.; Wicht, Kathryn J.; Le Manach, Claire; Kalantarov, Gavreel F.; Dey, Sumanta; Duffey, Maelle; Laleu, Benoit; Lukens, Amanda K.; Ottilie, Sabine; Vanaerschot, Manu; Trakht, Ilya N.; Gamo, Francisco-Javier; Wirth, Dyann F.; Goldberg, Daniel E.; John, Audrey R. Odom; Chibale, Kelly; Winzeler, Elizabeth A.; Niles, Jacquin C.; Fidock, David A. Share Save
Structure-guided microbial targeting of antistaphylococcal prodrugs (vol 10, e66657, 2021) Miller, Justin J.; Shah, Ishaan T.; Hatten, Jayda; Barekatain, Yasaman; Mueller, Elizabeth A.; Moustafa, Ahmed M.; Edwards, Rachel L.; Dowd, Cynthia S.; Hoops, Geoffrey C.; Johnson, R. Jeremy; Planet, Paul; Muller, Florian L.; Jez, Joseph; Odom John, Audrey R. Share Save
Granzyme A Produced by γ9δ2 T Cells Activates ER Stress Responses and ATP Production, and Protects Against Intracellular Mycobacterial Replication Independent of Enzymatic Activity Rasi, Valerio; Wood, David C.; Eickhoff, Christopher S.; Xia, Mei; Pozzi, Nicola; Edwards, Rachel L.; Walch, Michael; Bovenschen, Niels; Hoft, Daniel F. Share Save
Structure-guided microbial targeting of antistaphylococcal prodrugs Miller, Justin J.; Shah, Ishaan T.; Hatten, Jayda; Barekatain, Yasaman; Mueller, Elizabeth A.; Moustafa, Ahmed M.; Edwards, Rachel L.; Dowd, Cynthia S.; Planet, Paul J.; Muller, Florian L.; Jez, Joseph M.; John, Audrey R. Odom Share Save
Antimicrobial Prodrug Activation by the Staphylococcal Glyoxalase GloB Mikati, Marwa O.; Miller, Justin J.; Osbourn, Damon M.; Barekatain, Yasaman; Ghebremichael, Naomi; Shah, Ishaan T.; Burnham, Carey-Ann D.; Heidel, Kenneth M.; Yan, Victoria C.; Muller, Florian L.; Dowd, Cynthia S.; Edwards, Rachel L.; John, Audrey R. Odom Share Save
Potent, specific MEPicides for treatment of zoonotic staphylococci Edwards, Rachel L.; Heueck, Isabel; Lee, Soon Goo; Shah, Ishaan T.; Miller, Justin J.; Jezewski, Andrew J.; Mikati, Marwa O.; Wang, Xu; Brothers, Robert C.; Heidel, Kenneth M.; Osbourn, Damon M.; Burnham, Carey-Ann D.; Alvarez, Sophie; Fritz, Stephanie A.; Dowd, Cynthia S.; Jez, Joseph M.; John, Audrey R. Odom Share Save
Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13 Gnadig, Nina F.; Stokes, Barbara H.; Edwards, Rachel L.; Kalantarov, Gavreel F.; Heimsch, Kim C.; Kuderjavy, Michal; Crane, Audrey; Lee, Marcus C. S.; Straimer, Judith; Becker, Katja; Trakht, Ilya N.; John, Audrey R. Odom; Mok, Sachel; Fidock, David A. Share Save
The Plasmodium falciparum Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation Henrici, Ryan C.; Edwards, Rachel L.; Zoltner, Martin; van Schalkwyk, Donelly A.; Hart, Melissa N.; Mohring, Franziska; Moon, Robert W.; Nofal, Stephanie D.; Patel, Avnish; Flueck, Christian; Baker, David A.; John, Audrey R. Odom; Field, Mark C.; Sutherland, Colin J. Share Save
MEPicides: α,β-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria Wang, Xu; Edwards, Rachel L.; Bal, Haley; Johnson, Claire; Haymond, Amanda; Girma, Misgina; Manikkam, Michelle; Brothers, Robert C.; Mckay, Kyle T.; Arnett, Stacy D.; Osbourn, Damon M.; Alvarez, Sophie; Boshoff, Helena I.; Meyers, Marvin J.; Couch, Robin D.; John, Audrey R. Odom; Dowd, Cynthia S. Share Save
MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis Edwards, Rachel L.; Brothers, Robert C.; Wang, Xu; Maron, Maxim I.; Ziniel, Peter D.; Tsang, Patricia S.; Kraft, Thomas E.; Hruz, Paul W.; Williamson, Kim C.; Dowd, Cynthia S.; John, Audrey R. Odom Share Save
A Novel Fluorescence Resonance Energy Transfer-Based Screen in High-Throughput Format To Identify Inhibitors of Malarial and Human Glucose Transporters Kraft, Thomas E.; Heitmeier, Monique R.; Putanko, Marina; Edwards, Rachel L.; Ilagan, Ma Xenia G.; Payne, Maria A.; Autry, Joseph M.; Thomas, David D.; Odom, Audrey R.; Hruz, Paul W. Share Save
Structure-Activity Relationships of the MEPicides: N-Acyl and O-Linked Analogs of FR900098 as Inhibitors of Dxr from Mycobacterium tuberculosis and Yersinia pestis Jose, Geraldine San; Jackson, Emily R.; Haymond, Amanda; Johny, Chinchu; Edwards, Rachel L.; Wang, Xu; Brothers, R. Carl; Edelstein, Emma K.; Odom, Audrey R.; Boshoff, Helena I.; Couch, Robin D.; Dowd, Cynthia S. Share Save
Plasmodium IspD (2-C-Methyl-D-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target Imlay, Leah S.; Armstrong, Christopher M.; Masters, Mary Clare; Li, Ting; Price, Kathryn E.; Edwards, Rachel L.; Mann, Katherine M.; Li, Lucy X.; Stallings, Christina L.; Berry, Neil G.; O'Neill, Paul M.; Odom, Audrey R. Share Save
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Design, Synthesis, and Study of a Mycobactin-Artemisinin Conjugate That Has Selective and Potent Activity against Tuberculosis and Malaria Miller, Marvin J.; Walz, Andrew J.; Zhu, Helen; Wu, Chunrui; Moraski, Garrett; Moellmann, Ute; Tristani, Esther M.; Crumbliss, Alvin L.; Ferdig, Michael T.; Checkley, Lisa; Edwards, Rachel L.; Boshoff, Helena I. Share Save
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