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D

David A. Fidock

university of adelaide

95H-index
424Paper Count
3.4WCitation Count
Published Papers 217
Publication Date
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2-Amino-3; 4-Dihydroquinazolines Exhibit Potent Antimalarial Activity by Targeting Plasmepsin X
errACS Infectious Diseases
IF3.8
err2026-08-14
err0
PREAI
errMadeline G. Dans; Jon Kyle Awalt; Nghi Nguyen; Josephine Palandri; Anna Ngo; Kate E. Jarman; Jin H. Jeon; Tomas Yeo; Heekuk Park; Anne-Catrin Uhlemann; Emma Y. Mao; Maria R. Gancheva; Danny W. Wilson; Partha Mukherjee; Arnish Chakraborty; Mojca Kristan; Lindsay Stewart; Colin J. Sutherland; Delphine Baud; Stephen Brand; David A. Fidock; Paul F. Jackson; Alan F. Cowman; Brad E. Sleebs
errShare
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Genomic surveillance reveals co-occurrence of Plasmodium falciparum drug resistance variants across diverse transmission settings in Ethiopia
errNature Microbiology
IF19.4
err2026-08-05
err0
errOAAI
errAlemayehu Letebo; Leen N. Vanheer; Mengst Engdaw; Legesse Alamerie Ejigu; Dawit Hailu Alemayehu; Jimma Dinsa Deressa; Bethlehem Adnew; Abaysew Ayele; Migbaru Keffale Bezabih; Mulugeta Demisse; Tamrayehu Seyoum; Meklit Shiferaw; Heven Sime; Atsbeha Gebreegziabxier Weldemariam; Amanuel Shimelash; Elias B. Tafa; Wakweya Chali; Lina Alemayehu; Fikregabrail Aberra Kassa; Ayalew Jejaw Zeleke; Tajudin Abdurhaman Hamza; Abel Beliyu Tamirat; Tadesse Misganaw; Alayu Bogale; Zufan Yiheyis Abriham; Yasin Nasir; Gutema Jebessa; Metmiku Yohannes; Betelhem Akililu Kebede; Matiwos Kidane Ayele; Melat Abdo; Getinet Habtamu; Addisu Gizat; Jody Phelan; Bryce Matlock; David A. Fidock; Susana Campino; Ashenafi Assefa; Cristian Koepfli; Fekadu Massebo; Fitsum G. Tadesse
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Identification of genetic markers of quinine partial resistance in Plasmodium falciparum
errNature Microbiology
IF19.4
err2026-07-06
err0
errOAAI
errMariko Kanai; Sachel Mok; Tomas Yeo; Melanie J. Shears; Jin H. Jeon; Sunil K. Narwal; Leila S. Ross; Kharizta Wiradiputri; Meseret T. Haile; Abhai K. Tripathi; Godfree Mlambo; Jonathan Kim; Eva Gil-Iturbe; Heekuk Park; Tolla Ndiaye; John Okombo; Kurt E. Ward; Felix D. Rozenberg; Kate J. Fairhurst; Sydney M. Gavula; Talia S. Bloxham; Jessica L. Bridgford; Tanaya Sheth; Manuel Llinás; Marcus C. S. Lee; Jennifer L. Small-Saunders; Filippo Mancia; Matthias Quick; Anne-Catrin Uhlemann; Photini Sinnis; David Armand Fidock
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errSave
Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance
errNature Communications
IF15.7
err2026-04-01
err0
errOAAI
errJohn Okombo; Tolla Ndiaye; Tarrick Qahash; Igor M. R. Moura; Eva Gil-Iturbe; Laura M. Hagenah; Jessica L. Bridgford; Vinicius Bonatto; Kurt E. Ward; Tomas Yeo; Sunil K. Narwal; Lily V. Orta; Isla Anderson; Satish K. Dhingra; Charisse Flerida A. Pasaje; Heekuk Park; Jonathan Kim; Rafael V. C. Guido; Maria Belén Jiménez-Diaz; Iñigo Angulo-Barturen; Jacquin C. Niles; Filippo Mancia; Anne-Catrin Uhlemann; Sachel Mok; Matthias Quick; Elizabeth A. Winzeler; Didier Leroy; Manuel Llinás; Vandana Thathy; David A. Fidock
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Identification of α-Azacyclic Acetamide-Based Inhibitors of P. falciparum Na+ Pump (PfATP4) with Fast-Killing Asexual Blood-Stage Antimalarial Activity by Phenotypic Screening
errACS INFECTIOUS DISEASES
IF3.8
err2025-09-01
err0
PREAI
errCasas Jr, Arturo; Imlay, Leah S.; Thathy, Vandana; Fairhurst, Kate J.; Lehane, Adele M.; Lawong, Aloysus K.; Deni, Ioanna; Striepen, Josefine; Lee, Seungheon; Kumar, Ashwani; Xing, Chao; Niederstrasser, Hanspeter; Posner, Bruce A.; Laleu, Benoit; Charman, Susan A.; Fidock, David A.; Ready, Joseph M.; Phillips, Margaret A.
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errSave
Optimization and Characterization of the Antimalarial Activity of N-Aryl Acetamides that are Susceptible to Mutations in ROM8 and CSC1
errJournal of Medicinal Chemistry
IF6.8
err2025-07-18
err0
errOAAI
errWilliam Nguyen; Coralie Boulet; Madeline G. Dans; Katie Loi; Kate E. Jarman; Claudia B. G. Barnes; Tomas Yeo; Tanaya Sheth; Partha Mukherjee; Arnish Chakraborty; Mufuliat T. Famodimu; Michael J. Delves; Harry Pollard; Colin J. Sutherland; Rachael Coyle; Nicole Sevilleno; Nonlawat Boonyalai; Marcus C. S. Lee; Tayla Rabie; Lyn-Marié Birkholtz; Delphine Baud; Stephen Brand; Mrittika Chowdury; Tania F. de Koning-Ward; David A. Fidock; Paul R. Gilson; Brad E. Sleebs
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Plasmodium falciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity
errCell Chemical Biology
IF7.2
err2025-07-07
err0
PREAI
errFlore Nardella; Tiantian Jiang; Lushun Wang; Monica J. Bohmer; Subhoja Chakraborty; John Okombo; Jaeson Calla; Tatiane Macedo Silva; Samuel Pazicky; Jianwei Che; Jin Jeon; Evie Vincent; Nonlawat Boonyalai; Rachael Coyle; Mairi J. Buchanan; Samuel Schaefer; Daisy Chen; Amaan Khan; Emily Mayville; Mariana Laureano De Souza; Mayland Treat; Jordan Charlton; Patrick K. Tumwebaze; Seth Tjia; Lukas Montejo; Karen Cover; Philip J. Rosenthal; Roland A. Cooper; Zbynek Bozdech; Marcus C.S. Lee; Ratna Chakrabarti; Sanjay A. Desai; David A. Fidock; Jinhua Wang; Nathanael S. Gray; Elizabeth A. Winzeler; Debopam Chakrabarti
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errSave
Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-04-14
err0
PREAI
errAwalt, Jon Kyle; Ooi, Zi Kang; Ashton, Trent D.; Mansouri, Mahta; Calic, Petar P. S.; Zhou, Qingmiao; Vasanthan, Santhya; Lee, Serena; Loi, Katie; Jarman, Kate E.; Penington, Jocelyn S.; Qiu, Deyun; Zhang, Xinxin; Lehane, Adele M.; Mao, Emma Y.; Gancheva, Maria R.; Wilson, Danny W.; Giannangelo, Carlo; MacRaild, Christopher A.; Creek, Darren J.; Yeo, Tomas; Sheth, Tanaya; Fidock, David A.; Churchyard, Alisje; Baum, Jake; Famodimu, Mufuliat T.; Delves, Michael J.; Kristan, Mojca; Stewart, Lindsay; Sutherland, Colin J.; Coyle, Rachael; Jagoe, Hannah; Lee, Marcus C. S.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Baud, Delphine; Brand, Stephen; Jackson, Paul F.; Cowman, Alan F.; Dans, Madeline G.; Sleebs, Brad E.
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Gametocyte production and transmission fitness of African and Asian Plasmodium falciparum isolates with differential susceptibility to artemisinins
errANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
err2025-04-01
err0
errOAAI
errProellochs, Nicholas I.; Andolina, Chiara; Ramjith, Jordache; Stoter, Rianne; van Gemert, Geert-Jan; Graumans, Wouter; Campino, Susana; Vanheer, Leen N.; Okitwi, Martin; Tumwebaze, Patrick K.; Conrad, Melissa D.; Clark, Taane G.; Fidock, David A.; Menard, Didier; Mok, Sachel; Bousema, Teun
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TKK130 is a 3-Hydroxy-Propanamidine (HPA) with Potent Antimalarial In Vivo Activity and a High Barrier to Resistance
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-12-26
err0
PREAI
errKnaab, Tanja C.; Moritz, Alena; de Carvalho, Lais Pessanha; Klein, Saskia; Lungerich, Beate; Lohse, Katharina; Kruse, Linn; Mombo-Ngoma, Ghyslain; Orta, Lily; Thibaud, Jessica L.; de Villiers, Katherine A.; Fidock, David A.; Burckhardt, Bjoern B.; Held, Jana; Wittlin, Sergio; Kurz, Thomas
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Plasmodium falciparum African PfCRT Mutant Isoforms Conducive to Piperaquine Resistance Are Infrequent and Impart a Major Fitness Cost
errJOURNAL OF INFECTIOUS DISEASES
IF4.5
err2024-12-11
err0
PREAI
errHagenah, Laura M.; Yeo, Tomas; Schindler, Kyra A.; Jeon, Jin H.; Bloxham, Talia S.; Small-Saunders, Jennifer L.; Mok, Sachel; Fidock, David A.
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errSave
A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo
errPLOS PATHOGENS
IF4.9
err2024-12-09
err0
errOAAI
errXie, Stanley C.; Tai, Chia-Wei; Morton, Craig J.; Ma, Liting; Huang, Shih-Chung; Wittlin, Sergio; Du, Yawei; Hu, Yongbo; Dogovski, Con; Salimimarand, Mina; Griffin, Robert; England, Dylan; de la Cruz, Elisa; Deni, Ioanna; Yeo, Tomas; Burkhard, Anna Y.; Striepen, Josefine; Schindler, Kyra A.; Crespo, Benigno; Gamo, Francisco J.; Khandokar, Yogesh; Hutton, Craig A.; Rabie, Tayla; Birkholtz, Lyn-Marie; Famodimu, Mufuliat T.; Delves, Michael J.; Bolsher, Judith; Koolen, Karin M. J.; van der Laak, Rianne; Aguiar, Anna C. C.; Pereira, Dhelio B.; Guido, Rafael V. C.; Creek, Darren J.; Fidock, David A.; Dick, Lawrence R.; Brand, Stephen L.; Gould, Alexandra E.; Langston, Steven; Griffin, Michael D. W.; Tilley, Leann
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errSave
Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission
errSCIENCE ADVANCES
IF12.5
err2024-12-06
err0
errOAAI
errGomez-Gonzalez, Paula-Josefina; Gupta, Antima; Drought, Laura G.; Patel, Avnish; Okombo, John; van der Watt, Mariette; Walker-Gray, Ryan; Schindler, Kyra A.; Burkhard, Anna Y.; Yeo, Tomas; Narwal, Sunil K.; Bloxham, Talia S.; Flueck, Christian; Walker, Eloise M.; Rey, Joshua A.; Fairhurst, Kate J.; Reader, Janette; Park, Heekuk; Pollard, Harry G.; Stewart, Lindsay B.; Brandner-Garrod, Luke; Kristan, Mojca; Sterk, Geert-Jan; van Nuland, Youri M.; Manko, Emilia; van Schalkwyk, Donelly A.; Zheng, Yang; Leurs, Rob; Dechering, Koen J.; Aguiar, Anna Caroline C.; Guido, Rafael V. C.; Pereira, Dhelio B.; Tumwebaze, Patrick K.; Nosbya, Samuel L.; Rosenthal, Philip J.; Cooper, Roland A.; Palmer, Mike; Parkinson, Tanya; Burrows, Jeremy N.; Uhlemann, Anne-Catrin; Birkholtz, Lyn-Marie; Small-Saunders, Jennifer L.; Duffy, James; Fidock, David A.; Brown, Alan; Gardner, Mark; Baker, David A.
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Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2024-12-01
err0
errOAAI
errAwalt, Jon Kyle; Su, Wenyin; Nguyen, William; Loi, Katie; Jarman, Kate E.; Penington, Jocelyn S.; Ramesh, Saishyam; Fairhurst, Kate J.; Yeo, Tomas; Park, Heekuk; Uhlemann, Anne-Catrin; Maity, Bikash Chandra; De, Nirupam; Mukherjee, Partha; Chakraborty, Arnish; Churchyard, Alisje; Famodimu, Mufuliat T.; Delves, Michael J.; Baum, Jake; Mittal, Nimisha; Winzeler, Elizabeth A.; Papenfuss, Anthony T.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Maier, Alexander G.; van Dooren, Giel G.; Baud, Delphine; Brand, Stephen; Fidock, David A.; Jackson, Paul F.; Cowman, Alan F.; Dans, Madeline G.; Sleebs, Brad E.
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A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants
errPLOS PATHOGENS
IF4.9
err2024-10-29
err0
errOAAI
errFerreira, Leticia Tiburcio; Cassiano, Gustavo Capatti; Alvarez, Luis Carlos Salazar; Okombo, John; Calit, Juliana; Fontinha, Diana; Gil-Iturbe, Eva; Coyle, Rachael; Andrade, Carolina Horta; Sunnerhagen, Per; Bargieri, Daniel Youssef; Prudencio, Miguel; Quick, Matthias; Cravo, Pedro V.; Lee, Marcus C. S.; Fidock, David A.; Costa, Fabio Trindade Maranhao
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errSave
Targeting PfCLK3 with Covalent Inhibitors: A Novel Strategy for Malaria Treatment
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-10-23
err0
errOAAI
errBrettell, Skye B.; Janha, Omar; Begen, Abbey; Cann, Gillian; Sharma, Saumya; Olaniyan, Niniola; Yelland, Tamas; Hole, Alison J.; Alam, Benazir; Mayville, Emily; Gillespie, Ross; Capper, Michael; Fidock, David A.; Milligan, Graeme; Clarke, David J.; Tobin, Andrew B.; Jamieson, Andrew G.
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errSave
Towards next-generation treatment options to combat Plasmodium falciparum malaria
errNATURE REVIEWS MICROBIOLOGY
IF103.3
err2024-10-04
err0
PREAI
errOkombo, John; Fidock, David A.
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errSave
Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2024-10-01
err3
errOAAI
errCalic, Petar P. S.; Ashton, Trent D.; Mansouri, Mahta; Loi, Katie; Jarman, Kate E.; Qiu, Deyun; Lehane, Adele M.; Roy, Sayantan; Rao, Gunturu P.; Maity, Bikash; Wittlin, Sergio; Crespo, Benigno; Gamo, Franciso-Javier; Deni, Ioanna; Fidock, David A.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Cowman, Alan F.; Jackson, Paul F.; Baud, Delphine; Brand, Stephen; Laleu, Benoit; Sleebs, Brad E.
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Antimalarial drug discovery: progress and approaches (vol 22, pg 807, 2023)
errNATURE REVIEWS DRUG DISCOVERY
IF101.8
err2024-09-13
err0
PREAI
errSiqueira-Neto, Jair L.; Wicht, Kathryn J.; Chibale, Kelly; Burrows, Jeremy N.; Fidock, David A.; Winzeler, Elizabeth A.
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The emergence of artemisinin partial resistance in Africa: how do we respond?
errLANCET INFECTIOUS DISEASES
IF31
err2024-09-01
err12
errOAAI
errRosenthal, Philip J.; Asua, Victor; Bailey, Jeffrey A.; Conrad, Melissa; Ishengoma, Deus S.; Kamya, Moses R.; Rasmussen, Charlotte; Tadesse, Fitsum G.; Uwimana, Aline; Fidock, David A.
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Research Directions

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Co-authors
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