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Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism Elliott, Isabel G.; Fisher, Hayden; Chan, H. T. Claude; Inzhelevskaya, Tatyana; Mockridge, C. Ian; Penfold, Christine A.; Duriez, Patrick J.; Orr, Christian M.; Herniman, Julie; Muller, Kri T. J.; Essex, Jonathan W.; Cragg, Mark S.; Tews, Ivo Share Save
FcγRIIB (CD32B) antibodies enhance immune responses through activating FcγRs Simpson, Alexander P.; Oldham, Robert J.; Cox, Kerry L.; Taylor, Martin C.; James, Sonya; White, Ann L.; Bogdanov, Yury; Glennie, Martin J.; Frendeus, Bjoern; Cragg, Mark S.; Roghanian, Ali Share Save
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The ETS-family transcription factor PU.1 is a critical regulator of the inhibitory Fcγ receptor IIB expression in humans Carter, Matthew J.; Bogdanov, Yury D.; Smith, Rosanna C.; Cox, Kerry L.; Frampton, Sarah; Ferson, Lili; Foxall, Russel B.; Hussain, Khiyam; Strefford, Jonathan C.; Beers, Stephen A.; Cragg, Mark S. Share Save
CD40L and IL-4 suppress NK cell-mediated antibody-dependent cellular cytotoxicity through the HLA-E:NKG2A axis Graham, Lara, V; Horehajova, Ludmila; Haselager, Marco, V; Fisher, Jack G.; Roos, Jamie Lee; Foxall, Russell B.; John, Mel; Cox, Kerry L.; Oldham, Robert J.; Taylor, Martin C.; Ashton-Key, Margaret; Sale, Ben; Bartlett, Laura G.; Roghanian, Ali; Eldering, Eric; Vallejo, Andres F.; Forconi, Francesco; Khakoo, Salim, I; Cragg, Mark S.; Blunt, Matthew D. Share Save
Downhill running does not alter blood C1q availability or complement-dependent cytotoxicity of therapeutic monoclonal antibodies against haematological cancer cell lines in vitro Collier-Bain, Harrison D.; Brown, Frankie F.; Causer, Adam J.; Ross, Lois; Rothschild-Rodriguez, Daniela; Browne, Noah; Eddy, Rachel; Cleary, Kirstie L.; Gray, Juliet C.; Cragg, Mark S.; Moore, Sally; Murray, James; Turner, James E.; Campbell, John P. Share Save
Fc gamma receptors: Their evolution, genomic architecture, genetic variation, and impact on human disease Frampton, Sarah; Smith, Rosanna; Ferson, Lili; Gibson, Jane; Hollox, Edward J.; Cragg, Mark S.; Strefford, Jonathan C. Share Save
KIR2DS2+NK cells in cancer patients demonstrate high activation in response to tumour-targeting antibodies Graham, Lara V.; Fisher, Jack G.; Doyle, Amber D. P.; Sale, Ben; Del Rio, Luis; French, Albert J. E.; Mayor, Neema P.; Turner, Thomas R.; Marsh, Steven G. E.; Cragg, Mark S.; Forconi, Francesco; Khakoo, Salim I.; Blunt, Matthew D. Share Save
Cross-talk between ILC2 and Gata3high Tregs locally constrains adaptive type 2 immunity Stockis, Julie; Yip, Thomas; Moreno-Vicente, Julia; Burton, Oliver; Samarakoon, Youhani; Schuijs, Martijn J.; Raghunathan, Shwetha; Garcia, Celine; Luo, Weike; Whiteside, Sarah K.; Png, Shaun; Simpson, Charlotte; Monk, Stela; Sawle, Ashley; Yin, Kelvin; Barbieri, Johanna; Papadopoulos, Panagiotis; Wong, Hannah; Rodewald, Hans-Reimer; Vyse, Timothy; McKenzie, Andrew N. J.; Cragg, Mark S.; Hoare, Matthew; Withers, David R.; Fehling, Hans Joerg; Roychoudhuri, Rahul; Liston, Adrian; Halim, Timotheus Y. F. Share Save
Impact of isotype on the mechanism of action of agonist anti-OX40 antibodies in cancer: implications for therapeutic combinations Willoughby, Jane E.; Dou, Lang; Bhattacharya, Sabyasachi; Jackson, Heather; Seestaller-Wehr, Laura; Kilian, David; Bover, Laura; Voo, Kui S.; Cox, Kerry L.; Murray, Tom; John, Mel; Shi, Hong; Bojczuk, Paul; Jing, Junping; Niederer, Heather; Shepherd, Andrew J.; Hook, Laura; Hopley, Stephanie; Inzhelevskaya, Tatyana; Penfold, Chris A.; Mockridge, C. Ian; English, Vikki; Brett, Sara J.; Srinivasan, Roopa; Hopson, Christopher; Smothers, James; Hoos, Axel; Paul, Elaine; Martin, Stephen L.; Morley, Peter J.; Yanamandra, Niranjan; Cragg, Mark S. Share Save
A single bout of vigorous intensity exercise enhances the efficacy of rituximab against human chronic lymphocytic leukaemia B-cells ex vivo Collier-Bain, Harrison D.; Emery, Annabelle; Causer, Adam J.; Brown, Frankie F.; Oliver, Rebecca; Dutton, David; Crowe, Josephine; Augustine, Daniel; Graby, John; Leach, Shoji; Eddy, Rachel; Rothschild-Rodriguez, Daniela; Gray, Juliet C.; Cragg, Mark S.; Cleary, Kirstie L.; Moore, Sally; Murray, James; Turner, James E.; Campbell, John P. Share Save
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