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Patrick R. Griffin

Scripps Research

91H-index
638Paper Count
3.7WCitation Count
Published Papers 171
Publication Date
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Structural determinants of non-covalent PPARγ inverse agonism and their therapeutic implications
errNature Communications
IF15.7
err2025-12-19
err0
errOAAI
errKuang-Ting Kuo; Bilel Bdiri; Yuanjun He; Ruben D. Garcia-Ordonez; Daniel P. McDougal; Claudia Ruiz; Mi Ra Chang; Michael D. Cameron; John B. Bruning; Theodore M. Kamenecka; Patrick R. Griffin
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errSave
A ternary switch model governing ERα ligand binding domain conformation
errNature Communications
IF15.7
err2025-11-24
err0
errOAAI
errDaniel P. McDougal; Jordan L. Pederick; Scott J. Novick; Blagojce Jovcevski; Annmaree K. Warrender; Bruce D. Pascal; Patrick R. Griffin; John B. Bruning
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errSave
The Structural Basis of RORγt Binding to Chromatin
errJOURNAL OF IMMUNOLOGY
IF3.4
err2025-11-01
err0
PREAI
errStrutzenberg, Timothy; Mann, Matthew; Li, Xiandu; Shin, Hyejeong; Kelsey, Jordan; Aiyer, Sriram; Yu, Jingting; Griffin, Patrick R.; Zheng, Ye; Lyumkis, Dmitry
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errSave
Structural insights into IMP2 dimerization and RNA binding
errJournal of Structural Biology
IF5.1
err2025-09-12
err0
errOAAI
errStephen A. Zorc; Paola Munoz-Tello; Timothy O’Leary; Xiaoyu Yu; Mithun Nag Karadi Giridhar; Alexander D. Hondros; Althea Hansel-Harris; Stefano Forli; Patrick R. Griffin; Douglas J. Kojetin; Raktim N. Roy; Michalina Janiszewska
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errSave
Development of clinically viable non-muscle myosin II small molecule inhibitors
errCell
IF42.5
err2025-07-01
err0
PREAI
errLaszlo Radnai; Erica J. Young; Carlos Kikuti; Katalin Toth; Minghai Zhou; Madalyn Hafenbreidel; Rebecca F. Stremel; Li Lin; Paolo Pasetto; Xiaomin Jin; Aagam Patel; Michael Conlon; Sherri B. Briggs; Leïla Heidsieck; H. Lee Sweeney; James Sellers; Teresa Krieger-Burke; William H. Martin; Jay Sisco; Steven Young; Paul Pearson; Gavin Rumbaugh; Gian Luca Araldi; Steven K. Duddy; Michael D. Cameron; Matthew Surman; Anne Houdusse; Patrick R. Griffin; Theodore M. Kamenecka; Courtney A. Miller
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errSave
MT-125 inhibits non-muscle myosin IIA and IIB and prolongs survival in glioblastoma
errCell
IF42.5
err2025-06-10
err0
errOAAI
errRajappa S. Kenchappa; Laszlo Radnai; Erica J. Young; Natanael Zarco; Li Lin; Athanassios Dovas; Christian T. Meyer; Ashley Haddock; Alice Hall; Katalin Toth; Peter Canoll; Naveen K.H. Nagaiah; Gavin Rumbaugh; Michael D. Cameron; Theodore M. Kamenecka; Patrick R. Griffin; Courtney A. Miller; Steven S. Rosenfeld
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errSave
Structural proteomics defines a sequential priming mechanism for the progesterone receptor
errNATURE COMMUNICATIONS
IF15.7
err2025-05-12
err0
errOAAI
errMann, Matthew D.; Wang, Min; Ferreon, Josephine C.; Tsoi, Phoebe S.; Suess, Michael P.; Jain, Antrix; Malovannaya, Anna; Alvarez, Roberto Vera; Pascal, Bruce D.; Kumar, Raj; Edwards, Dean P.; Griffin, Patrick R.
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errSave
Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation (vol 31, pg 1772, 2024)
errCELL CHEMICAL BIOLOGY
IF7.2
err2025-02-01
err0
PREAI
errMutlu, Beste; Sharabi, Kfir; Sohn, Jee Hyung; Yuan, Bo; Latorre-Muro, Pedro; Qin, Xin; Yook, Jin-Seon; Lin, Hua; Yu, Deyang; Camporez, Joao Paulo G.; Kajimura, Shingo; Shulman, Gerald I.; Hui, Sheng; Kamenecka, Theodore M.; Griffin, Patrick R.; Puigserver, Pere
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errSave
PPARG in osteocytes controls cell bioenergetics and systemic energy metabolism independently of sclerostin levels in circulation
errMOLECULAR METABOLISM
IF6.6
err2024-10-01
err0
errOAAI
errBaroi, Sudipta; Czernik, Piotr J.; Khan, Mohd Parvez; Letson, Joshua; Crowe, Emily; Chougule, Amit; Griff, Patrick R.; Rosen, Clifford J.; Lecka-Czernik, Beata
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errSave
Structure of phosphorylated-like RssB, the adaptor delivering σs to the ClpXP proteolytic machinery, reveals an interface switch for activation
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2023-12-01
err3
errOAAI
errBrugger, Christiane; Schwartz, Jacob; Novick, Scott; Tong, Song; Hoskins, Joel R.; Majdalani, Nadim; Kim, Rebecca; Filipovski, Martin; Wickner, Sue; Gottesman, Susan; Griffin, Patrick R.; Deaconescu, Alexandra M.
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errSave
Assembly of JAZ-JAZ and JAZ-NINJA complexes in jasmonate signaling
errPLANT COMMUNICATIONS
IF11.6
err2023-11-01
err7
errOAAI
errZhou, X. Edward; Zhang, Yaguang; Yao, Jian; Zheng, Jie; Zhou, Yuxin; He, Qing; Moreno, Javier; Lam, Vinh Q.; Cao, Xiaoman; Sugimoto, Koichi; Vanegas-Cano, Leidy; Kariapper, Leena; Suino-Powell, Kelly; Zhu, Yuanye; Novick, Scott; Griffin, Patrick R.; Zhang, Feng; Howe, Gregg A.; Melcher, Karsten
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errSave
Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179
errSCIENCE SIGNALING
IF6.6
err2023-07-25
err4
errOAAI
errPatil, Dipak N.; Pantalone, Serena; Cao, Yan; Laboute, Thibaut; Novick, Scott J.; Singh, Shikha; Savino, Simone; Faravelli, Silvia; Magnani, Francesca; Griffin, Patrick R.; Singh, Appu K.; Forneris, Federico; Martemyanov, Kirill A.
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errSave
Hydrogen-Deuterium Exchange Epitope Mapping of Glycosylated Epitopes Enabled by Online Immobilized Glycosidase
errANALYTICAL CHEMISTRY
IF6.7
err2023-06-28
err5
errOAAI
errO'Leary, Timothy R. R.; Balasubramaniam, Deepa; Hughes, Kristin; Foster, Denisa; Boyles, Jeffrey; Coleman, Kristina; Griffin, Patrick R. R.
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errSave
Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90a
errMOLECULAR CELL
IF16.6
err2023-06-01
err19
errOAAI
errMu, A.; Wales, Thomas E.; Zhou, Haixia; Draga-Coleta, Sorin-Valeriu; Gorgulla, Christoph; Blackmore, Katherine A.; Mittenbuhler, Melanie J.; Kim, Caroline R.; Bogoslavski, Dina; Zhang, Qiuyang; Wang, Zi-Fu; Jedrychowski, Mark P.; Seo, Hyuk-Soo; Song, Kijun; Xu, Andrew Z.; Sebastian, Luke; Gygi, Steven P.; Arthanari, Haribabu; Dhe-Paganon, Sirano; Griffin, Patrick R.; Engen, John R.; Spiegelman, Bruce M.
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errSave
PPARγ Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles
errACS CHEMICAL BIOLOGY
IF3.8
err2023-05-05
err3
PREAI
errFrkic, Rebecca L.; Pederick, Jordan L.; Horsfall, Aimee J.; Jovcevski, Blagojce; Crame, Elise E.; Kowalczyk, Wioleta; Pukala, Tara L.; Chang, Mi Ra; Zheng, Jie; Blayo, Anne-Laure; Abell, Andrew D.; Kamenecka, Theodore M.; Harbort, Joshua S.; Harmer, Jeffrey R.; Griffin, Patrick R.; Bruning, John B.
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errSave
Osteocytes contribute via nuclear receptor PPAR-alpha to maintenance of bone and systemic energy metabolism
errFRONTIERS IN ENDOCRINOLOGY
IF4.6
err2023-04-18
err9
errOAAI
errChougule, Amit; Baroi, Sudipta; Czernik, Piotr J.; Crowe, Emily; Chang, Mi Ra; Griffin, Patrick R.; Lecka-Czernik, Beata
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errSave
Promoting childhood farm safety in Ireland
errFRONTIERS IN PUBLIC HEALTH
IF3.4
err2022-12-12
err2
errOAAI
errMcNamara, John; Mohammadrezaei, Mohammad; Griffin, Patrick
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errSave
Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro
errSCIENCE ADVANCES
IF12.5
err2022-12-09
err14
errOAAI
errYadav, Ruchi; Courouble, Valentine V.; Dey, Sanjay K.; Harrison, Jerry Joe E. K.; Timm, Jennifer; Hopkins, Jesse B.; Slack, Ryan L.; Sarafianos, Stefan G.; Ruiz, Francesc X.; Griffin, Patrick R.; Arnold, Eddy
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errSave
Patient-derived Siglec-6-targeting antibodies engineered for T-cell recruitment have potential therapeutic utility in chronic lymphocytic leukemia
errJOURNAL FOR IMMUNOTHERAPY OF CANCER
IF10.6
err2022-11-28
err6
errOAAI
errCyr, Matthew G.; Mhibik, Maissa; Qi, Junpeng; Peng, Haiyong; Chang, Jing; Gaglione, Erika M.; Eik, David; Herrick, John; Venables, Thomas; Novick, Scott J.; Courouble, Valentine V.; Griffin, Patrick R.; Wiestner, Adrian; Rader, Christoph
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errSave
Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection
errNATURE COMMUNICATIONS
IF15.7
err2022-10-06
err24
errOAAI
errWei, Guochao; Iqbal, Naseer; Courouble, Valentine V.; Francis, Ashwanth C.; Singh, Parmit K.; Hudait, Arpa; Annamalai, Arun S.; Bester, Stephanie; Huang, Szu-Wei; Shkriabai, Nikoloz; Briganti, Lorenzo; Haney, Reed; KewalRamani, Vineet N.; Voth, Gregory A.; Engelman, Alan N.; Melikyan, Gregory B.; Griffin, Patrick R.; Asturias, Francisco; Kvaratskhelia, Mamuka
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Research Directions

No research directions
Co-authors
Cooperation Journals
S
Steven P. Gygi
H-index: 195 · Papers: 1.0K
B
Bruce M. Spiegelman
H-index: 186 · Papers: 471
G
Gerald I. Shulman
H-index: 183 · Papers: 819
P
Peter G. Schultz
H-index: 159 · Papers: 880
T
Timothy R. Billiar
H-index: 140 · Papers: 1.2K
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