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S

Shawn C. Chafe

mcmaster university

26H-index
155Paper Count
3.4KCitation Count
Published Papers 33
Publication Date
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uPAR is highly expressed in recurrent glioblastoma and represents a candidate CAR T cell target
errScience Translational Medicine
IF14.6
err2026-05-13
err0
PREAI
errWilliam T. Maich; Muhammad Vaseem Shaikh; Anish Puri; Martin A. Rossotti; Shan Grewal; Aapti Khanna; Alisha Anand; Nicholas Mikolajewicz; Mathieu P. Seyfrid; Dillon A. McKenna; Minomi Subapanditha; Daniel Mobilio; Greg Hussack; Joey G. Sheff; Jennifer J. Hill; Mo Taleb; Jacek M. Kwiecien; Sabra Salim; Neil Savage; Bill Wang; Sunjay Sharma; Abdelsimar Omar; Chirayu Chokshi; Kui Zhai; Shawn C. Chafe; Jason Moffat; Thomas Kislinger; Chitra Venugopal; Kevin A. Henry; Sheila K. Singh
errShare
errSave
Emerging paradigms in the study of brain metastases
errScience Signaling
IF6.6
err2026-04-07
err0
PREAI
errShawn C. Chafe; Daniel Mobilio; Kui Zhai; Agata M. Kieliszek; Chitra Venugopal; Sheila K. Singh
errShare
errSave
Pan-cancer N-glycoproteomic atlas of patient-derived xenografts uncovers FAT2 as an actionable surface target
errCell Reports Medicine
IF10.6
err2026-01-23
err0
errOAAI
errMeinusha Govindarajan; Salvador Mejia-Guerrero; Shawn C. Chafe; Shahbaz Khan; Wei Shi; Matthew Waas; Martin A. Rossotti; Amanda Khoo; Lydia Y. Liu; Vladimir Ignatchenko; Simona Principe; Lusia Sepiashvili; Greg Hussack; Nazanin Tatari; Chitra Venugopal; Petar Miletic; Maxwell Topley; Shan Grewal; Dillon McKenna; Lucas C. Asselstine
errShare
errSave
Reactive oligodendrocytes promote glioblastoma progression through CCL5/CCR5-mediated glioma stem cell maintenance
errNeuron
IF15
err2026-01-21
err0
PREAI
errNicholas Mikolajewicz; Kui Zhai; Anish Puri; Petar Miletic; Nazanin Tatari; Jiarun Wei; Neil Savage; Zhi Huang; Qian Huang; Seon Yong Lee; Mahta Jan-Ahmadnejad; Roseanne Nguyen; David Chen; Tiegan Korman; Daniel Mobilio; Maxwell Topley; Jack Qinyu Lu; Matthew R. Voisin; Zsolt Zador; Shawn C. Chafe
errShare
errSave
A GENOME-WIDE IN VIVO CRISPR ACTIVATION SCREEN IDENTIFIES BACE1 AS A THERAPEUTIC VULNERABILITY OF LUNG CANCER BRAIN METASTASIS
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errChafe, Shawn; Zhai, Kui; Aghaei, Nikoo; Miletic, Petar; Huang, Zhi; Brown, Kevin; Mobilio, Daniel; Young, Daniel; Suk, Yujin; Grewal, Shan; Mckenna, Dillon; Alizada, Zahra; Kieliszek, Agata; Lam, Fred; Escudero, Laura; Huang, Qian; Huebner, Ariana; Lu, Jack; Ang, Patrick; Anand, Alisha; Custers, Stefan; Apel, Erika; Slassi, Sarah; Brakel, Benjamin; Kim, Jongmyung; Liu, James; Bassey-Archibong, Blessing; Abdo, Rober; Shargall, Yaron; Lu, Jian-Qiang; Cutz, Jean-Claude; Zhang, Qi; Li, Shawn; Venugopal, Chitra; Hynds, Robert; Dufour, Antoine; Moffat, Jason; Swanton, Charles; Bao, Shideng; Singh, Sheila
errShare
errSave
29 SNAT2 AS A NOVEL TARGETABLE VULNERABILITY IN RECURRENT GLIOBLASTOMA
errNeuro-Oncology Advances
IF4.1
err2025-08-31
err0
errOAAI
errAnish Puri; Jose C Bozelli Jr; William Maich; Dillon McKenna; Manoj Singh; Benjamin Brakel; Lucas Asselstine; Shawn C Chafe; Chitra Venugopal; Philip Britz-McKibbin; Sheila K Singh
errShare
errSave
A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis
errScience Translational Medicine
IF14.6
err2025-07-02
err0
PREAI
errShawn C. Chafe; Kui Zhai; Nikoo Aghaei; Petar Miletic; Zhi Huang; Kevin R. Brown; Daniel Mobilio; Daniel Young; Yujin Suk; Shan Grewal; Dillon McKenna; Zahra Alizada; Agata M. Kieliszek; Fred C. Lam; Laura Escudero; Qian Huang; Ariana Huebner; Jack Lu; Patrick Ang; Alisha Anand; Stefan Custers; Erika Apel; Sarah Slassi; Benjamin Brakel; Jongmyung Kim; James K. C. Liu; Blessing Iquo Bassey-Archibong; Rober Abdo; Yaron Shargall; Jian-Qiang Lu; Jean-Claude Cutz; Qi Zhang; Shawn Shun-Cheng Li; Chitra Venugopal; Robert E. Hynds; Antoine Dufour; Jason Moffat; Charles Swanton; Shideng Bao; Sheila K. Singh
errShare
errSave
Identification of intratumoral bacteria that enhance breast tumor metastasis
errMBIO
IF4.7
err2025-02-11
err0
errOAAI
errGerbec, Zachary J.; Serapio-Palacios, Antonio; Metcalfe-Roach, Avril; Krekhno, Zakhar; Bar-Yoseph, Haggai; Woodward, Sarah E.; Pena-Diaz, Jorge; Nemirovsky, Oksana; Awrey, Shannon; Moreno, Sebastian H.; Beatty, Sean; Kong, Esther; Radisavljevic, Nina; Cirstea, Mihai; Chafe, Shawn; Mcdonald, Paul C.; Aparicio, Sam; Finlay, B. Brett; Dedhar, Shoukat
errShare
errSave
PYROPTOSIS IS AN ACQUIRED VULNERABILITY OF BRAIN METASTASES
errNEURO-ONCOLOGY
IF13.4
err2024-11-11
err0
PREAI
errMobilio, Daniel; Kieliszek, Agata; Peterson, Erik; Singh, Kanwaldeep; Zhai, Kui; Miletic, Petar; Gwynne, William; Ang, Patrick; Venugopal, Chitra; Chafe, Shawn; Berg, Tobias; Wahl, Daniel; Singh, Sheila
errShare
errSave
Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles
errCANCER & METABOLISM
IF5.3
err2024-10-03
err0
errOAAI
errAli, Hassan A.; Karasinska, Joanna M.; Topham, James T.; Johal, Danisha; Kalloger, Steve; Metcalfe, Andrew; Warren, Cassia S.; Miyagi, Anthony; Tao, Lan V.; Kevorkova, Maya; Chafe, Shawn C.; Mcdonald, Paul C.; Dedhar, Shoukat; Parker, Seth J.; Renouf, Daniel J.; Schaeffer, David F.
errShare
errSave
De novo GTP synthesis is a metabolic vulnerability for the interception of brain metastases
errCELL REPORTS MEDICINE
IF10.6
err2024-10-01
err0
errOAAI
errKieliszek, Agata M.; Mobilio, Daniel; Bassey-Archibong, Blessing I.; Johnson, Jarrod W.; Piotrowski, Mathew L.; de Araujo, Elvin D.; Sedighi, Abootaleb; Aghaei, Nikoo; Escudero, Laura; Ang, Patrick; Gwynne, William D.; Zhang, Cunjie; Quaile, Andrew; McKenna, Dillon; Subapanditha, Minomi; Tokar, Tomas; Shaikh, Muhammad Vaseem; Zhai, Kui; Chafe, Shawn C.; Gunning, Patrick T.; Montenegro-Burke, J. Rafael; Venugopal, Chitra; Magolan, Jakob; Singh, Sheila K.
errShare
errSave
Targeting axonal guidance dependencies in glioblastoma with ROBO1 CAR T cells
errNATURE MEDICINE
IF50
err2024-08-02
err0
PREAI
errChokshi, Chirayu R.; Shaikh, Muhammad Vaseem; Brakel, Benjamin; Rossotti, Martin A.; Tieu, David; Maich, William; Anand, Alisha; Chafe, Shawn C.; Zhai, Kui; Suk, Yujin; Kieliszek, Agata M.; Miletic, Petar; Mikolajewicz, Nicholas; Chen, David; Mcnicol, Jamie D.; Chan, Katherine; Tong, Amy H. Y.; Kuhlmann, Laura; Liu, Lina; Alizada, Zahra; Mobilio, Daniel; Tatari, Nazanin; Savage, Neil; Aghaei, Nikoo; Grewal, Shan; Puri, Anish; Subapanditha, Minomi; Mckenna, Dillon; Ignatchenko, Vladimir; Salamoun, Joseph M.; Kwiecien, Jacek M.; Wipf, Peter; Sharlow, Elizabeth R.; Provias, John P.; Lu, Jian-Qiang; Lazo, John S.; Kislinger, Thomas; Lu, Yu; Brown, Kevin R.; Venugopal, Chitra; Henry, Kevin A.; Moffat, Jason; Singh, Sheila K.
errShare
errSave
Targeting pyrimidine biosynthesis as a metabolic vulnerability in brain metastasis
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2023-12-01
err0
PREAI
errMobilio, Daniel; Singh, Sheila K.; Cahfe, Shawn C.
errShare
errSave
BACE1 cleaves EGFR to drive lung adenocarcinoma brain metastasis
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2023-12-01
err0
PREAI
errChafe, Shawn C.; Zhai, Kui; Singh, Sheila K.
errShare
errSave
Intratumoral Delivery of Chimeric Antigen Receptor T Cells Targeting CD133 Effectively Treats Brain Metastases
errCLINICAL CANCER RESEARCH
IF10.2
err2023-10-03
err6
PREAI
errKieliszek, Agata M.; Mobilio, Daniel; Upreti, Deepak; Bloemberg, Darin; Escudero, Laura; Kwiecien, Jacek M.; Alizada, Zahra; Zhai, Kui; Ang, Patrick; Chafe, Shawn C.; Vora, Parvez; Venugopal, Chitra; Singh, Sheila K.
errShare
errSave
A Carbonic Anhydrase IX/SLC1A5 Axis Regulates Glutamine Metabolism Dependent Ferroptosis in Hypoxic Tumor Cells
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2023-06-22
err12
errOAAI
errVenkateswaran, Geetha; McDonald, Paul C.; Chafe, Shawn C.; Brown, Wells S.; Gerbec, Zachary J.; Awrey, Shannon J.; Parker, Seth J.; Dedhar, Shoukat
errShare
errSave
Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma
errCANCER RESEARCH
IF16.6
err2023-04-04
err0
PREAI
errGwynne, William D.; Suk, Yujin Suk; Custers, Stefan; Mikolajewicz, Nicholas; Chan, Jeremy K.; Zador, Zsolt; Chafe, Shawn C.; Zhai, Kui; Escudero, Laura; Zhang, Cunjie; Zaslaver, Olga; Chokshi, Chirayu; Shaikh, Muhammad Vaseem; Bakhshinyan, David; Burns, Ian; Chaudhry, Iqra; Nachmani, Omri; Mobilio, Daniel; Maich, William T.; Mero, Patricia; Brown, Kevin R.; Quaile, Andrew T.; Venugopal, Chitra; Moffat, Jason; Montenegro-Burke, J. Rafael; Singh, Sheila K.
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errSave
An HLA-G/SPAG9/STAT3 axis promotes brain metastases
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2023-02-13
err5
errOAAI
errArchibong, Blessing Iquo Bassey-; Chokshi, Chirayu Rajendra; Aghaei, Nikoo; Kieliszek, Agata Monika; Tatari, Nazanin; McKenna, Dillon; Singh, Mohini; Subapanditha, Minomi Kalpana; Parmar, Arun; Mobilio, Daniel; Savage, Neil; Lam, Fred; Tokar, Tomas; Provias, John; Lu, Yu; Chafe, Shawn Christopher; Swanton, Charles; Hynds, Robert Edward; Venugopal, Chitra; Singh, Sheila Kumari
errShare
errSave
Dual Antigen T Cell Engagers Targeting CA9 as an Effective Immunotherapeutic Modality for Targeting CA9 in Solid Tumors
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2022-07-06
err7
errOAAI
errTatari, Nazanin; Zhang, Xiaoyu; Chafe, Shawn C.; McKenna, Dillon; Lawson, Keith A.; Subapanditha, Minomi; Shaikh, Muhammad Vaseem; Seyfrid, Mathieu; Savage, Neil; Venugopal, Chitra; Moffat, Jason; Singh, Sheila K.
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errSave
Hydrogen-deuterium exchange mass spectrometry reveals three unique binding responses of mAbs directed to the catalytic domain of hCAIX
errMABS
IF7.3
err2021-11-23
err3
errOAAI
errSheff, Joey G.; Kelly, John F.; Robotham, Anna; Sulea, Traian; Malenfant, Felix; L'Abbe, Denis; Duchesne, Melanie; Pelletier, Alex; Lefebvre, Jean; Acel, Andrea; Parat, Marie; Gosselin, Mylene; Wu, Cunle; Fortin, Yves; Baardsnes, Jason; Van Faassen, Henk; Awrey, Shannon; Chafe, Shawn C.; McDonald, Paul C.; Dedhar, Shoukat; Lenferink, Anne E. G.
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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Claudiu T. Supuran
H-index: 152 · Papers: 4.2K
B
B. Brett Finlay
H-index: 145 · Papers: 666
C
Charles Swanton
H-index: 137 · Papers: 1.2K
S
Samuel Aparício
H-index: 115 · Papers: 473
C
Connie J. Eaves
H-index: 103 · Papers: 598
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