Michael A. Ihnat - Publications, H-index & Citations

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Michael A. Ihnat

university of oklahoma system

37H-index

142Paper Count

5.4KCitation Count

Published Papers 70

Publication Date

Synthesis, molecular modeling, biological and pharmacokinetic evaluation of hydroxy pyrimidinones and pyrimidinediones as novel LDHA inhibitors

European Journal of Medicinal Chemistry

IF5.9

2025-09-14

PREAI

Horrick Sharma; Ty Elliott; Amery Good; Pragya Sharma; Somrita Mondal; Lerin Luckett Chastain; Michael A. Ihnat

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Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2024-09-01

OAAI

Sharma, Horrick; Mondal, Somrita; Urquiza, Uzziah; Esparza, Colter; Bartlett, Seth; Santa -Pinter, Landon; Hill, Hanna; White, Madalyn; Sharma, Pragya; Luckett-Chastain, Lerin; Cooper, Anne; Rasel, Mohammad; Gao, Philip; Battaile, Kevin P.; Shukla, Surendra K.; Lovell, Scott; Ihnat, Michael A.

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Precision nephrotoxicity testing using 3D in vitro models

CELL AND BIOSCIENCE

IF6.2

2023-12-21

OAAI

Yu, Pengfei; Zhu, Hainan; Bosholm, Carol Christine; Beiner, Daniella; Duan, Zhongping; Shetty, Avinash K.; Mou, Steve S.; Kramer, Philip Adam; Barroso, Luis F.; Liu, Hongbing; Cheng, Kun; Ihnat, Michael; Gorris, Matthew A.; Aloi, Joseph A.; Woldemichael, Jobira A.; Bleyer, Anthony; Zhang, Yuanyuan

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Exploration of a Large Virtual Chemical Space: Identification of Potent Inhibitors of Lactate Dehydrogenase-A against Pancreatic Cancer

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2023-01-16

OAAI

Sharma, Horrick; Sharma, Pragya; Urquiza, Uzziah; Chastain, Lerin R.; Ihnat, Michael A.

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Silk fibers assisted long-term 3D culture of human primary urinary stem cells via inhibition of senescence-associated genes: Potential use in the assessment of chronic mitochondrial toxicity

MATERIALS TODAY ADVANCES

IF8

2022-08-01

OAAI

Ding, Huifen; George, Sunil; Leng, Xiaoyan Iris; Ihnat, Michael; Ma, Jian-Xing; Jiang, Guochun; Margolis, David; Dumond, Julie; Zhang, Yuanyuan

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3D Spheroids of Human Primary Urine-Derived Stem Cells in the Assessment of Drug-Induced Mitochondrial Toxicity

PHARMACEUTICS

IF5.5

2022-05-11

OAAI

Ding, Huifen; Jambunathan, Kalyani; Jiang, Guochun; Margolis, David M.; Leng, Iris; Ihnat, Michael; Ma, Jian-Xing; Mirsalis, Jon; Zhang, Yuanyuan

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TNF-Alpha as an Initiator of Allodynia and Anxiety-Like Behaviors in a Preclinical Model of PTSD and Comorbid Pain

FRONTIERS IN PSYCHIATRY

IF3.2

2021-08-25

OAAI

Dib, Patrick; Zhang, Yong; Ihnat, Michael A.; Gallucci, Randle M.; Standifer, Kelly M.

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Innovative Approaches in the Battle Against Cancer Recurrence: Novel Strategies to Combat Dormant Disseminated Tumor Cells

FRONTIERS IN ONCOLOGY

IF3.3

2021-04-27

OAAI

Sauer, Scott; Reed, Damon R.; Ihnat, Michael; Hurst, Robert E.; Warshawsky, David; Barkan, Dalit

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Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2021-04-01

OAAI

Choudhary, Shruti; Doshi, Arpit; Luckett-Chastain, Lerin; Ihnat, Michael; Hamel, Ernest; Mooberry, Susan L.; Gangjee, Aleem

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The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2021-01-01

OAAI

Xiang, Weiguo; Quadery, Tasdique M.; Hamel, Ernest; Luckett-Chastain, Lerin R.; Ihnat, Michael A.; Mooberry, Susan L.; Gangjee, Aleem

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Geochemical characterization and renal cell toxicity of water-soluble extracts from US Gulf Coast lignite

ENVIRONMENTAL GEOCHEMISTRY AND HEALTH

IF3.8

2018-10-01

PREAI

Ojeda, A. S.; Ford, S. D.; Gallucci, R. M.; Ihnat, M. A.; Philp, R. P.

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FLLL32, a curcumin analog, ameliorates intestinal injury in necrotizing enterocolitis

inflammation research

IF4.1

2017-06-01

OAAI

Eckert, Jeffrey; Scott, Brian; Lawrence, Shelley M.; Ihnat, Michael; Chaaban, Hala

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Interleukin (IL)-6 modulates transforming growth factor-β receptor I and II (TGF-βRI and II) function in epidermal keratinocytes

EXPERIMENTAL DERMATOLOGY

IF3.1

2017-03-08

OAAI

Luckett-Chastain, Lerin R.; Cottrell, Mackenzie L.; Kawar, Bethany M.; Ihnat, Michael A.; Gallucci, Randle M.

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AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1 α stabilization

CANCER LETTERS

IF10.1

2017-03-01

OAAI

Bastian, Anja; Matsuzaki, Satoshi; Humphries, Kenneth M.; Pharaoh, Gavin A.; Doshi, Arpit; Zaware, Nilesh; Gangjee, Aleem; Ihnat, Michael A.

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Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo [3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple -acting angiokinase inhibition as antitumor agents

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2017-01-01

OAAI

Pavana, Roheeth Kumar; Choudhary, Shruti; Bastian, Anja; Ihnat, Michael A.; Bai, Ruoli; Hamel, Ernest; Gangjee, Aleem

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Design and biological evaluation of substituted pyrrolo[3,2-d]pyrimidines as dual acting RTK and microtubule targeting agents

CANCER RESEARCH

IF16.6

2016-07-15

PREAI

Gangjee, Aleem; Shah, Khushbu; Dybdal-Hargreaves, Nicholas; Mooberry, Susan; Bastian, Anja; Ihnat, Michael

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Mechanistic evaluation of AG311-an OXPHOS inhibitor - as a potential treatment for breast cancer

CANCER RESEARCH

IF16.6

2016-07-15

PREAI

Bastian, Anja; Matsuzaki, Satoshi; Humphries, Kenneth M.; -Downs, Lora C. Bailey; Gangjee, Aleem; Ihnat, Michael A.

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Design, synthesis, and biological evaluation of thieno[2,3-d] and thieno[3,2-d]pyrimidines as dual acting RTK inhibitors and microtubule targeting antitumor agents

CANCER RESEARCH

IF16.6

2016-07-15

PREAI

Gangjee, Aleem; Islam, Farhana; Quadery, Tasdique Mohammad; Mooberry, Susan L.; Bastian, Anja; Ihnat, Michael A.

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Targeting dormant micrometastases: rationale, evidence to date and clinical implications

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY

IF4.2

2016-01-06

OAAI

Hurst, Robert E.; Bastian, Anja; Bailey-Downs, Lora; Ihnat, Michael A.

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Novel small molecule AG311 induces tumor cell death through inhibition of mitochondrial electron transport

CANCER RESEARCH

IF16.6

2015-08-01

PREAI

Bastian, Anja; Bailey-Downs, Lora C.; Thorpe, Jessica E.; Devambatia, Ravi Kumar Vyas; Gangjee, Aleem; Humphries, Kenneth M.; Ihnat, Michael A.

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Research Directions