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Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme Hamilton, Matthew M.; Mseeh, Faika; McAfoos, Timothy J.; Leonard, Paul G.; Reyna, Naphtali J.; Harris, Angela L.; Xu, Alan; Han, Michelle; Soth, Michael J.; Czako, Barbara; Theroff, Jay P.; Mandal, Pijus K.; Burke, Jason P.; Virgin-Downey, Brett; Petrocchi, Alessia; Pfaffinger, Dana; Rogers, Norma E.; Parker, Connor A.; Yu, Simon S.; Jiang, Yongying; Krapp, Stephan; Lammens, Alfred; Trevitt, Graham; Tremblay, Martin R.; Mikule, Keith; Wilcoxen, Keith; Cross, Jason B.; Jones, Philip; Marszalek, Joseph R.; Lewis, Richard T. Share Save
Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties Soth, Michael J.; Le, Kang; Di Francesco, Maria Emilia; Hamilton, Matthew M.; Liu, Gang; Burke, Jason P.; Carroll, Chris L.; Kovacs, Jeffrey J.; Bardenhagen, Jennifer P.; Bristow, Christopher A.; Cardozo, Mario; Czako, Barbara; de Stanchina, Elisa; Feng, Ningping; Garvey, Jill R.; Gay, Jason P.; Do, Mary K. Geck; Greer, Jennifer; Han, Michelle; Harris, Angela; Herrera, Zachary; Huang, Sha; Giuliani, Virginia; Jiang, Yongying; Johnson, Sarah B.; Johnson, Troy A.; Kang, Zhijun; Leonard, Paul G.; Liu, Zhen; McAfoos, Timothy; Miller, Meredith; Morlacchi, Pietro; Mullinax, Robert A.; Palmer, Wylie S.; Pang, Jihai; Rogers, Norma; Rudin, Charles M.; Shepard, Hannah E.; Spencer, Nakia D.; Theroff, Jay; Wu, Qi; Xu, Alan; Yau, Ju Anne; Draetta, Giulio; Toniatti, Carlo; Heffernan, Timothy P.; Jones, Philip Share Save
IACS-9779, a development candidate that inhibits 2,3-dioxygenase (IDO) activity by blocking heme incorporation into IDO apoenzyme Mseeh, Faika; Hamilton, Matthew M.; Marszalek, Joseph R.; Rogers, Norma E.; Parker, Connor A.; Yu, Simon S.; Liu, Zhen; Reyna, Naphtali J.; McAfoos, Timothy; Virgin-Downey, Brett W.; Leonard, Paul G.; Cross, Jason B.; Feng, Ningping; Harris, Angela L.; Zuniga, Andy M.; Mikule, Keith; Tremblay, Martin; Jiang, Yongying; Mahendra, Mikhila; Pang, Jihai; Wu, Qi; Xu, Quanyun; Heffernan, Timothy P.; Jones, Philip; Lewis, Richard T. Share Save
Discovery of an imidazopyridine series of potent human IDO1 inhibitors with robust target engagement in a preclinical tumor model Petrocchi, Alessia; Reyna, Naphtali J.; Mseeh, Faika; Parker, Connor A.; Yu, Simon; Xu, Quanyun; Feng, Ningping; Leonard, Paul; Rogers, Norma; Cross, Jason B.; Harris, Angela L.; Jiang, Yongying; Khor, Tin Oo; Mahendra, Mikhila G.; Pang, Jihai; Wu, Qi; Zuniga, Andy M.; McAfoos, Timothy; McAfoos, Timothy; Hamilton, Matthew M.; Marszalek, Joe R.; Mikule, Keith; Vancutsem, Paul; Wilcoxen, Keith; Tremblay, Martin; Jones, Philip; Lewis, Richard T. Share Save
Discovery of Orally Active Carboxylic Acid Derivatives of 2-Phenyl-5-trifluoromethyloxazole-4-carboxamide as Potent Diacylglycerol Acyltransferase-1 Inhibitors for the Potential Treatment of Obesity and Diabetes Qian, Yimin; Wertheimer, Stanley J.; Ahmad, Mushtaq; Cheung, Adrian Wai-Hing; Firooznia, Fariborz; Hamilton, Matthew M.; Hayden, Stuart; Li, Shiming; Marcopulos, Nicholas; McDermott, Lee; Tan, Jenny; Yun, Weiya; Guo, Liang; Pamidimukkala, Anjula; Chen, Yingsi; Huang, Kuo-Sen; Ramsey, Gwendolyn B.; Whittard, Toni; Conde-Knape, Karin; Taub, Rebecca; Rondinone, Cristina M.; Tilley, Jefferson; Bolin, David Share Save
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Health effects of depleted uranium on exposed Gulf War veterans McDiarmid, MA; Keogh, JP; Hooper, FJ; McPhaul, K; Squibb, K; Kane, R; DiPino, R; Kabat, M; Kaup, B; Anderson, L; Hoover, D; Brown, L; Hamilton, M; Jacobson-Kram, D; Burrows, B; Walsh, M Share Save
Transformation of human osteoblast cells to the tumorigenic phenotype by depleted uranium uranyl chloride Miller, AC; Blakely, WF; Livengood, D; Whittaker, T; Xu, JQ; Ejnik, JW; Hamilton, MM; Parlette, E; St John, T; Gerstenberg, HM; Hsu, H Share Save
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